High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 21, 2009, Pages 10471-10476

  Chang, Hui Hsiang ^a,b   Chen, Chin Shuh ^a   Lin, Jin Yuarn ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b TAJEN UNIVERSITY   (Taiwan)

Author keywords

Bronchoalveolar lavage fluid; Eosinophilic infiltration; High dose vitamin c supplementation; Ovalbumln sensltlzed and challenged mouse model; Th1 th2 cytokines

Indexed keywords

ASCORBIC ACID; CYTOKINE; OVALBUMIN;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; CANCER INVASION; DIET SUPPLEMENTATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; EOSINOPHIL; FEMALE; HELPER CELL; HUMAN; IMMUNOLOGY; LUNG LAVAGE; MOUSE; RANDOMIZATION; TH1 CELL; TH2 CELL;

ANIMALS; ASCORBIC ACID; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; FEMALE; HUMANS; LEUKEMIC INFILTRATION; MICE; MICE, INBRED BALB C; OVALBUMIN; RANDOM ALLOCATION; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS;

MUS;

EID: 70449111843     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf902403p     Document Type: Article

References (31)

1. Yazdanbakhsh, M.; Kremsner, P. G.; van Ree, R. Allergy, parasites, and the hygiene hypothesis, Science 2002, 296, 490-496.
2. Opal, S. M.; DePalo, V. A. Anti-inflammatory cytokines. Chest 2000, 117, 1162-1172.
3. (3) Morokata, T.; Ishikawa, J.; Yamada, T. Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines, Immunol. Lett. 1999, 70, 127-134. (Pubitemid 29467452)
4. (4) Riffo-Vasquez, Y.; Spina, D. Role of cytokines and chemokines in bronchial hyper-responsiveness and airway inflammation. Pharmacol. Ther. 2002, 94, 185-211. (Pubitemid 34756686)
5. (5) Kidd, P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease, Altern. Med. Rev. 2003, 8, 223-246. (Pubitemid 37099886)
6. Kay, A. B. Immunomodulation in asthma: mechanisms and possible pitfalls. Cirr. Opin. Pharmucol. 2003, 3, 220-226.
7. Jacob, R. A.; Sotoudeh, G. Vitamin. C Function and Status in Chronic Disease. Nutr. Clin. Care 2002, 5, 66-74.
8. Duarte, T. L.; Lunec, J. Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin G Free Radical Res. 2005, 39, 671-686.
9. Hatch, G. E. Asthma, inhaled oxidants, and dietary antioxidants. Am. J. Clin. Nutr. 1995, 61 (Suppl.), 625S-630S.
10. (10) de Luis, D. A.; Armentia, A.; Aller, R.; Asensio, A.; Sedano, E.; Izaola, O.; Cuellar, L. Dietary intake inpatients with asthma: a case control study. Nutrition 2005, 21, 320-324. (Pubitemid 40387930)
11. (11) Harik-Khan, R. I.; Muller, D. C.; Wise, R. A. Serum vitamin levels and the risk of asthma in children, Am. J. Epidemiol. 2004, 159, 351-357. (Pubitemid 38200768)
12. Omenaas, E.; Fluge, Ø.; Buist, A. S.; Vollmer, W. M.; Gulsvik, A. Dietary vitamin C intake is inversely related to cough and wheeze in young smokers, Respir. Med. 2003, 97, 134-142.
13. Tecklenburg, S. L.; Mickleborough, T. D.; Fly, A. D.; Bai, Y.; Stager, J. M. Ascorbic acid supplementation attenuates exerciseinduced bronchoconstriction in patients with asthma. Respir. Med. 2007, 101, 1770-1778.
14. (14) Fogarty, A.; Lewis, S. A.; Scrivener, S. L.; Antoniak, M.; Pacey, S.; Pringlew, M.; Britton, J. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin. Exp. Allergy 2003, 33, 1355-1359. (Pubitemid 37289930)
15. Chang, H. H.; Chen, G S.; Lin, J. Y. Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice, Lipids 2008, 43, 499-506.
16. Chang, H. H.; Chen, C. S.; Lin, J. Y. Dietary perilla oil lowers serum, lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. Food Chem. Toxicol. 2009, 47, 848-854.
17. Lin, J. Y.; Chen, M. L.; Lin, B. F. Ganoderma tsugae in vivo modulates Thl/Th2 and macrophage responses in an allergic murine model. Food Chem. Toxicol. 2006, 44, 2025-2032.
18. Bsoul, S. A.; Terezhaimy, G. T. Vitamin C in health and disease. J. Contemp. Dent. Pract. 2004, 5, 1-13.
19. Miao, M. S. Experimental Animal and Animal Experiment Technique (in Chinese); Beijing TCM Publishing House: China, 1997; pp 143-145.
20. Yu, B.; He, Q.; Gao, Z. The role of glucocorticosteroid and theophylline in asthmatic inflammation of murine model and the inhibition in NO production in lung. Chin. J. Tuberculosis Respir. Dis. 1998, 21, 664-667.
21. Ye, Y. L.; Huang, W. C.; Lee, Y. L.; Chiang, B. L. Interleukin-12 inhibits eotaxin secretion of cultured primary lung cells and alleviates airway inflammation in vivo. Cytokine 2002, 19, 76-84.
22. Murphy, K., Travers, P., Walport, M. Janeway's Immunobiology, 7th ed.; Garland. Science; Taylor & Francis Group: New York, 2008; pp 4-8.
23. (23) Kay, A. B.; Phipps, S.; Robinson, D. S. A role for eosinophils in airway remodeling in asthma. Trends Immunol. 2004, 25, 477-482. (Pubitemid 39490254)
24. Wills-Karp, M.; Karp, C. L. Eosinophils in asthma: remodeling a tangled tale, Science 2004, 305, 1726-1729.
25. (25) Boskabady, M. H.; Ziaei, T. Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs, Respirology 2003, 8, 473-478. (Pubitemid 38009642)
26. (26) Forastiere, F.; Pistelli, R.; Sestini, P.; Fortes, C.; Renzoni, E.; Rusconi, F.; Dell'Orco, V.; Ciccone, G.; Bisanti, L. Consumption of fresh, fruit rich in vitamin C and wheezing symptoms in children. Thorax 2000, 55, 283-288. (Pubitemid 30248797)
27. Misso, N. L. A.; Brooks-Wildhaber, J.; Ray, S.; Vally, H.; Thompson, P. J. Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma, Eur. Respir. J. 2005, 26, 257-264.
28. (28) Shidfar, F.; Baghai, N.; Keshavarz, A.; Ameri, A.; Shidfar, S. Comparison, of plasma and leukocyte vitamin C status between asthmatic and healthy subjects. East. Mediterr. Health J. 2005, 11, 87-95. (Pubitemid 43308571)
29. Jariwalla, R. J.; Harakeh, S. Antiviral and immunomodulatory activities of ascorbic acid. Subcell. Biochem. 1996, 25, 213-231.
30. Lee, K. S.; Kim, S. R.; Park, S. J.; Min, K. H.; Lee, K. Y.; Jin, S. M.; Yoo, W. H.; Lee, Y. G Antioxidant down-regulates interleukin-18 expression in asthma. Mol. Pharmacol. 2006, 70, 1184-1193.
31. Conti, P.; Kempuraj, D.; Kandere, K.; Gioacchino, M. D.; Barbacane, R. C.; Castellani, M. L.; Felaco, M.; Boucher, W.; Letoumeau, R.; Theoharides, T. C. IL-10, an inflammatory /inhibitory cytokine, but not always, Immunol. Lett. 2003, 86, 123-129.