Acute administration of metoprolol and enalaprilat reduces insulin-stimulated thermogenesis and skin blood flow

Journal of Internal Medicine

Volumn 239, Issue 5, 1996, Pages 399-406

  Tuominen, J A ^a   Eriksson, J G ^b   Koivisto, V A ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

ACE inhibitors; Beta blocking agents; Blood flow; Energy expenditure; Glucose uptake; Insulin sensitivity

Indexed keywords

ENALAPRILAT; GLUCOSE; INSULIN; METOPROLOL; PLACEBO;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENERGY EXPENDITURE; FOREARM BLOOD FLOW; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN BLOOD FLOW; THERMOGENESIS;

EID: 0030018114     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1996.473824000.x     Document Type: Article

References (36)

1. Ravussin E, Acheson KJ, Vernet O, Danforth E, Jequier E. Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity. J Clin Invest 1985; 76: 1268-73.
2. Gumbiner B, Thorburn AW, Henry RR. Reduced glucose induced thermogenesis is present in noninsulin-dependent diabetes mellitus without obesity. J Clin End Metab 1991; 72: 801-807b.
3. Blaak EE, van Baak MA, Kempen KP, Saris WH. Role of alpha-and beta-adrenoreceptors in sympathetically mediated thermogenesis. Am J Physiol 1993; 264: E11-E17.
4. Welle S, Schwartz RG, Statt M. Reduced metabolic rate during beta-adrenergic blockade in humans. Metabolism 1991; 40: 19-22.
5. Lundgren H, Björkman L, Keiding P, Lundmark S, Bengtsson C. Diabetes in patients with hypertension receiving pharmacological treatment. Br Med J 1988; 297: 512.
6. Wright AD, Barber SG, Kendall MJ, Poole PH. Beta-adrenoreceptor-blocking drugs and blood sugar control in diabetes mellitus. Br Med J 1979; 1: 59-61.
7. Helgeland A, Strommen R, Hagelund C, Tretli S. Enalapril, atenolol and hydrochlorotiazide in mild to moderate hypertension, a comparative multicentre study in general practice in Norway. Lancet 1986; 1: 72-5.
8. Pollare T, Lithell H, Selinus I, Berne C. Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects of carbohydrate and lipid metabolism in hypertensive patients. Br Med J 1989; 298: 152-7.
9. Ekberg G, Hansson B-G. Glucose tolerance and insulin release in hypertensive patients treated with the cardioselective β-receptor blocking agent metoprolol. Acta Med Scand 1977; 202: 393-7.
10. Rett K, Jauch KW, Wicklmayr M, Dietze G, Fink E, Mehnert H. Angiotensin converting enzyme inhibitors in diabetes: experimental and human experience. Postgrad Med J 1986; 62 (Suppl. 1): 59-64.
11. Torlone E, Rambotti AM, Perriello G, Botta G, Santeusanio F, Brunetti P, Bolli GB. ACE-inhibition increases hepatic and extrahepatic sensitivity to insulin in patients with Type 2 (non-insulin-dependent) diabetes mellitus and arterial hypertension. Diabetologia 1991; 34: 19-25.
12. Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorotiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 1989; 321: 68-73.
13. Paolisso G, Gambardella A, Verza M, D'Amore A, Sgambato S, Varricchio M: ACE inhibition improves insulin-sensitivity in aged insulin-resistant hypertensive patients. J Human Hypertension 1992; 6: 75-9.
14. Kodama J, Katayama S, Tanaka K, Itabashi A, Kawazu S, Ishii J. Effect of captopril on glucose concentration. Possible role of augmented postprandial forearm blood flow. Diabetes Care 1990; 13: 109-11.
15. Whitcroft IA, Thomas JM, Rawsthorne A, Wilkinson N, Thompson H. Effects of alpha and beta adrenoreceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics. Horm Metab Res 1990; 22: 2-6.
16. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity. hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 73-94.
17. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988; 255: E769-E774.
18. Baron AD, Laakso M, Brechtel G, Edelman SV. Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. J Clin Invest 1991; 87: 186-94.
19. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest 1990; 85: 844-52.
20. Karnik R, Valentin A, Slany J. Different effects of beta-1-adrenergic blocking agents with ISA or without ISA on peripheral blood flow. Angiology 1987; 38: 96-303.
21. Ventura HO, Frohlich ED, Messerli FH, Kobrin I, Kardon MB. Immediate regional blood flow distribution following angiotensin converting enzyme inhibition in patients with essential hypertension. Am J Med 1984; 76: 8-61.
22. Thorin D, Golay A, Simonson DC, Jequier E, Felber JP, DeFronzo RA. The effect of selective beta-adrenergic blockade on glucose-induced thermogenesis in man. Metabolism 1986; 35: 24-8.
23. Beck-Nielsen H, Groop LC: Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J Clin Invest 1994; 94: 714-21.
24. Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C. Widén E, Schalin C, Groop L. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1989; 321: 37-13.
25. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method of quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-E223.
26. Ebeling P, Bourey R, Koranyi L, Tuominen JA, Groop L, Henriksson J, Mueckler M, Sovijärvi A, Koivisto VA. Mechanism of enhanced insulin sensitivity in athletes: increased blood flow, muscle glucose transport protein (GLUT-4) concentration and glycogen synthase activity. J Clin Invest 1993; 92: 623-31.
27. Nilsson GE, Tenland T. Öberg PA: Evaluation of laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng 1980; 27: 97-604.
28. Tenland T. Laser Dopplerflowmetry - methods and microvascular applications (Thesis). Linköping: Linköping University Medical Dissertations, 136: 1986.
29. Yki-Järvinen H, Helve E, Koivisto VA. Hyperglycemia decreases glucose uptake in type 1 diabetes. Diabetes 1987; 36: 92-6.
30. Baron AD, Brechtel-Hook Ginger, Johnson Ann, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension 1993; 21: 9-35.
31. Helve E, Tuominen JA, Koivisto VA. Captopril does not acutely enhance insulin sensitivity. J Intern Med 1993; 234: 1-4.
32. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilatation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 172-9.
33. Astrup A, Simonsen L, Bülow J, Madsen J, Christensen NJ. Epinephrine mediates facultative carbohydrate-induced thermogenesis in human skeletal muscle. Am J Physiol 1989; 257: E340-E345.
34. Laville M, Cornu C, Normand S, Mithieux G, Beylot M, Riou JP. Decreased glucose-induced thermogenesis at the onset of obesity. Am J Clin Nutr 1993; 57: 51-6.
35. Bai TR, Webb D, Hamilton M. Treatment of hypertension with beta-adrenoreceptor blocking drugs. JR Coll Phys (London) 1982; 16: 39-41.
36. Hypertension in Diabetes Study Group. Hypertension in diabetes study III. Prospective study of therapy of hypertension in type 2 diabetic patients. Efficacy of ACE inhibition and β-blockade. Diabet Med 1994; 11: 73-82.