Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure

Free Radical Biology and Medicine

Volumn 32, Issue 3, 2002, Pages 246-256

  Suliman, Hagir B ^a   Carraway, Martha Sue ^a   Velsor, Leonard W ^b   Day, Brian J ^b   Ghio, Andrew J ^a   Piantadosi, Claude A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Carbon monoxide; Deletion; Free radicals; Hemin; mtDNA; Nitric oxide; PCR

Indexed keywords

3 (3,4 DICHLOROPHENYL) 1,2,3,4 OXATRIAZOLE 5 IMINE; 8 HYDROXYDEOXYGUANOSINE; CARBON MONOXIDE; CYTOCHROME C OXIDASE; ESTER DERIVATIVE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; HEME OXYGENASE 1; HEMIN; IRON; METHYL GROUP; MITOCHONDRIAL DNA; NITRIC OXIDE DONOR; OXIDIZING AGENT; PROTEIN BAX; PROTEIN BCL XL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TERT BUTYL HYDROPEROXIDE; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LEVEL; CODING; CONTROLLED STUDY; DNA DAMAGE; ENZYME INDUCTION; EXPOSURE; GENE DELETION; INCUBATION TIME; LIVER MITOCHONDRION; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIZATION; STRESS; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETICS; LIVER; METABOLISM; SPRAGUE DAWLEY RAT;

GEA;

ANIMALS; DEOXYGUANOSINE; DNA DAMAGE; DNA, MITOCHONDRIAL; GLUTATHIONE; HEMIN; IRON; LIVER; MALE; MITOCHONDRIA, LIVER; OXIDANTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036468238     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00797-3     Document Type: Article

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