The beat goes on: Spontaneous firing in mammalian neuronal microcircuits

Journal of Neuroscience

Volumn 24, Issue 42, 2004, Pages 9215-9219

  Häusser, Michael ^a   Raman, Indira M ^b   Otis, Thomas ^c   Smith, Spencer L ^c   Nelson, Alexandra ^d   Du Lac, Sascha ^d   Loewenstein, Yonatan ^e   Mahon, Séverine ^a   Pennartz, Cyriel ^f   Cohen, Ivan ^g,h   Yarom, Yosef ⁱ  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h BAYLOR COLLEGE OF MEDICINE   (United States)

ⁱ HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Action potential; Cerebellum; Channel; Hippocampus; Neuromodulation; Pacemaker

Indexed keywords

BIOPHYSICS; CELL ISOLATION; CONFERENCE PAPER; INHIBITION KINETICS; MOLECULAR DYNAMICS; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; VESTIBULAR NERVE;

ACTION POTENTIALS; ANIMALS; CIRCADIAN RHYTHM; HUMANS; MAMMALS; NEURAL INHIBITION; NEURONAL PLASTICITY; NEURONS; PURKINJE CELLS; VESTIBULAR NUCLEI;

EID: 7044233155     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3375-04.2004     Document Type: Conference Paper

References (45)

1. Alving BO (1968) Spontaneous activity in isolated somata of Aplysia pacemaker neurons. J Gen Physiol 51:29-45.
2. Ariano MA, Lewicki JA, Brandwein HJ, Murad F (1982) Immunohistochemical localization of guanylate cyclase within neurons of rat brain. Proc Natl Acad Sci USA 79:1316-1320.
3. Bellamy TC, Garthwaite J (2001) "cAMP-specific" phosphodiesterase contributes to cGMP degradation in cerebellar cells exposed to nitric oxide. Mol Pharmacol 59:54-61.
4. + current and A-current in rat suprachiasmatic nucleus neurones. J Physiol (Lond) 488:339-350.
5. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770.
6. Cohen I, Miles R (2000) Contributions of intrinsic and synaptic activities to the generation of neuronal discharges in in vitro hippocampus. J Physiol (Lond) 524:485-502.
7. Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R (2002) On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298:1418-1421.
8. Colwell CS (2000) Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus. Eur J Neurosci 12:571-576.
9. Darlington CL, Dutia MB, Smith PF (2002) The contribution of the intrinsic excitability of vestibular nucleus neurons to recovery from vestibular damage. Eur J Neurosci 15:1719-1727.
10. Do MT, Bean BP (2003) Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron 39:109-120.
11. Do MT, Bean BP (2004) Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. J Neurophysiol 92:726-733.
12. du Lac S (1995) Learning and memory in the vestibulo-ocular reflex. Annu Rev Neurosci 18:409-441.
13. el-Husseini AE, Bladen C, Vincent SR (1995) Expression of the olfactory cyclic nucleotide gated channel (CNG1) in the rat brain. NeuroReport 6:1459-1463.
14. Getting PA (1989) Emerging principles governing the operation of neural networks. Annu Rev Neurosci 12:185-204.
15. Ghez C, Thach WT (2000) The cerebellum. In: Principles of neural science, Ed 4 (Kandel ER, Schwartz JH, Jessell TM, eds), pp 832-852. New York: McGraw-Hill.
16. Grieco TM, Raman IM (2004) Production of resurgent current in NaV1.6-null Purkinje neurons by slowing sodium channel inactivation with beta-pompilidotoxin. J Neurosci 24:35-42.
17. Grieco TM, Afshari FS, Raman IM (2002) A role for phosphorylation in the maintenance of resurgent sodium current in cerebellar Purkinje neurons. J Neurosci 22:3100-3107.
18. Häusser M, Clark BA (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-678.
19. Hill RG, Simmonds MA, Straugn DW (1973) A comparative study of some convulsant substances as gamma-aminobutyiric acid antagonists in the feline cerebral cortex. Br J Pharmacol 49:37-51.
20. 2+ in single suprachiasmatic nucleus neurons. Neuron 38:253-263.
21. Ito M (1984) The cerebellum and neural control. New York: Raven.
22. Jackson AC, Yao GL, Bean BP (2004) Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. J Neurosci 24:7985-7998.
23. Khaliq ZM, Gouwens NW, Raman IM (2003) The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. J Neurosci 23:4899-4912.
24. Kohling R, Lucke A, Straub H, Speckmann EJ, Tuxhorn I, Wolf P, Pannek H, Oppel F (1998) Spontaneous sharp waves in human neocortical slices excised from epileptic patients. Brain 1998 121:1073-1087.
25. Llinas RR (1988) The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242:1654-1664.
26. Llinas R, Sugimori M (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J Physiol (Lond) 305:171-195.
27. Lohmann SM, Walter U, Miller PE, Greengard P, De Camilli P (1981) Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proc Natl Acad Sci USA 78:653-657.
28. McCormick DA, Huguenard JR (1992) A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol 68:1384-1400.
29. Nelson AB, Krispel CM, Sekirnjak C, du Lac S (2003) Long-lasting increases in intrinsic excitability triggered by inhibition. Neuron 40:609-620.
30. Penn AA, Shatz CJ (1999) Brain waves and brain wiring: the role of endogenous and sensory-driven neural activity in development. Pediatr Res 45:447-458.
31. Pennartz CMA, Bierlaagh MA, Geurtsen AMS (1997) Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current. J Neurophysiol 78:1811-1825.
32. Pennartz CMA, De Jeu MTG, Bos NPA, Schaap J, Geurtsen AMS (2002) Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock. Nature 416:286-290.
33. Raman IM, Bean BP (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 17:4517-4526.
34. Raman IM, Bean BP (1999) Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 19:1663-1674.
35. Raman IM, Bean BP (2001) Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80:729-737.
36. Raman IM, Sprunger LK, Meisler MH, Bean BP (1997) Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19:881-891.
37. Raman IM, Gustafson AE, Padgett D (2000) Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. J Neurosci 20:9004-9016.
38. Reppert SM, Weaver DR (2001) Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 63:647-676.
39. Schwartz WJ, Gross RA, Morton MT (1987) The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker. Proc Natl Acad Sci USA 84:1694-1698.
40. Shibuki K, Kimura S (1997) Dynamic properties of nitric oxide release from parallel fibers in rat cerebellar slices. J Physiol (Lond) 498:443-452.
41. Smith MR, Nelson AB, Du Lac S (2002) Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons. J Neurophysiol 87:2031-2042.
42. Smith SL, Otis TS (2003) Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade. J Neurosci 23:367-372.
43. Taddese A, Bean BP (2002) Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33:587-600.
44. h in rat cerebellar Purkinje neurons in vitro. J Physiol (Lond) 539:469-483.
45. Womack M, Khodakhah K (2002) Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. J Neurosci 22:10603-10612.