The contribution of the intrinsic excitability of vestibular nucleus neurons to recovery from vestibular damage

European Journal of Neuroscience

Volumn 15, Issue 11, 2002, Pages 1719-1727

  Darlington, Cynthia L ^a   Dutia, Mayank B ^b   Smith, Paul F ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Intrinsic properties; Pacemaker activity; Vestibular compensation; Vestibular nucleus neurons

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; GINKGO BILOBA EXTRACT; GINKGOLIDE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE RECEPTOR AGONIST; GLYCINE RECEPTOR ANTAGONIST; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

CELL ACTIVITY; CELL ISOLATION; DEAFFERENTATION; EYE DISEASE; MEMBRANE STEADY POTENTIAL; MOTOR DYSFUNCTION; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; VESTIBULAR DISORDER; VESTIBULAR NUCLEUS; VESTIBULAR SYSTEM;

ACTION POTENTIALS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; BIOLOGICAL CLOCKS; DENERVATION; HUMANS; NEURONAL PLASTICITY; NEURONS; RECOVERY OF FUNCTION; SYNAPTIC TRANSMISSION; VESTIBULAR NUCLEI; VESTIBULOCOCHLEAR NERVE DISEASES;

EID: 0036460140     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02024.x     Document Type: Review

References (138)

1. Anderson, P. (1984) Brain slice work: Some prospects. In Dingledine, R. (ed.), Brain Slices. Plenum Press, New York, pp. 375-380.
2. Av-Ron, E. & Vidal, P.P. (1999) Intrinsic membrane properties and dynamics of medial vestibular neurons: A simulation. Biol. Cybernet., 80, 383-392.
3. Babalian, A., Vibert, N., Assie, G., Serafin, M., Muhlethaler, M. & Vidal, P.P. (1997) Central vestibular networks in the guinea pig: Functional characterization in the isolated whole brain in vitro. Neuroscience, 81, 405-426.
4. Bobker, D.H. & Williams, J.T. (1990) Serotonin-mediated inhibitory postsynaptic potentials in guinea pig prepositus hypoglossi and feedback inhibition by serotonin. J. Physiol. (Lond.), 442, 447-462.
5. Cameron, S.A. & Dutia, M.B. (1997) Cellular basis of vestibular compensation: Changes in intrinsic excitability of MVN neurons. Neuroreport, 8, 2595-2599.
6. Cameron, S.A. & Dutia, M.B. (1999) Lesion-induced plasticity in rat vestibular nucleus neurons dependent on glucocorticoid receptor activation. J. Physiol. (Lond.), 518, 151-158.
7. Capocchi, G., Della Torre, G., Grassi, S., Pettorossi, V.E. & Zampolini, M. (1992) NMDA receptor-mediated long term modulation of electrically evoked field potentials in the rat medial vestibular nuclei. Exp. Brain Res., 90, 546-550.
8. Carpenter, D.O. & Hori, N. (1992) Neurotransmitter and peptide receptors on medial vestibular nucleus neurons. Ann. NY Acad. Sci., 656, 668-685.
9. Cochran, S.L., Kasik, P. & Precht, W. (1987) Pharmacological aspects of excitatory synaptic transmission to second-order vestibular neurons in the frog. Synapse, 1, 102-123.
10. Curthoys, I.S. & Halmagyi, G.M. (1995) Vestibular compensation: A review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J. Vest. Res., 5, 67-107.
11. Curthoys, I.S. & Halmagyi, G.M. (1999) Vestibular compensation. In Buttner, U. (ed.), Vestibular Dysfunction and its Therapy, Vol. 55. Karger, Basel, pp. 82-110.
12. Darlington, C.L., Gallagher, J.P. & Smith, P.F. (1995) In vitro electrophysiological studies of the vestibular nucleus complex. Prog. Neurobiol., 45, 335-346.
13. Darlington, C.L. & Smith, P.F. (1993) The intrinsic properties of vestibular nucleus neurons and recovery of motor function following peripheral vestibular deafferentation: Is there a link? Hum. Mov. Sci., 12, 195-209.
14. Darlington, C.L. & Smith, P.F. (1996) The recovery of static vestibular function following peripheral vestibular lesions in mammals: The intrinsic mechanism hypothesis. J. Vest. Res., 6, 185-201.
15. Darlington, C.L. & Smith, P.F. (2000) Molecular mechanisms of recovery from vestibular damage in mammals: Recent advances. Prog. Neurobiol., 62, 313-325.
16. Darlington, C.L., Smith, P.F. & Gilchrist, D.P.D. (1992) Comparison of the effects of ACTH-(4-10) on medial vestibular nucleus neurons in brainstem slices from labyrinthine-intact and compensated guinea pigs. Neurosci. Lett., 145, 97-99.
17. Darlington, C.L., Smith, P.F. & Hubbard, J.I. (1989) Neuronal activity in the guinea pig medial vestibular nucleus in vitro following chronic unilateral labyrinthectomy. Neurosci. Lett., 105, 143-148.
18. Darlington, C.L., Smith, P.F. & Hubbard, J.I. (1990) Guinea pig medial vestibular nucleus neurons in vitro respond to ACTH (4-10) at picomolar concentrations. Exp. Brain Res., 82, 637-640.
19. Dieringer, N. (1995) Vestibular compensation - Neural plasticity and its relations to functional recovery after labyrinthine lesions in frogs and other vertebrates. Prog. Neurobiol., 46, 97-129.
20. Dieringer, N. & Precht, W. (1977) Modification of synaptic input following unilateral labyrinthectomy. Nature., 269, 431-433.
21. Dieringer, N. & Precht, W. (1979) Mechanism of compensation for vestibular deficits in the frog. 1: Modifications of the excitatory commissural system. Exp. Brain Res., 36, 311-328.
22. Doi, K., Tsumoto, T. & Matsunaga, T. (1990) Action of excitatory amino acid antagonists on synaptic inputs to the rat medial vestibular nucleus: An electrophysiological study in vitro. Exp. Brain Res., 82, 254-262.
23. Dutia, M.B. & Johnston, A.R. (1998) Development of action potentials and apamin-sensitive after-potentials in mouse vestibular nucleus neurons. Exp. Brain Res., 118, 1458-1154.
24. Dutia, M.B., Johnston, A.R. & McQueen, D.S. (1992) Tonic activity of rat medial vestibular nucleus neurons in vitro and its inhibition by GABA. Exp. Brain Res., 88, 466-472.
25. Dutia, M.B., Neary, P. & McQueen, D.S. (1990) Action of cholinergic agents on spontaneously active rat medial vestibular nucleus neurones in vitro. J. Physiol. (Lond.), 425, 90P.
26. + on spontaneous neuronal activity in the surface layer of the rat medulla oblongata. Pflugers Arch., 371, 125-134.
27. Gallagher, J.P., Lewis, M.R. & Shinnick-Gallagher, P. (1985) An electrophysiological investigation of the rat medial vestibular nucleus in vitro. In Correia, M.J. & Perachio, A.A. (eds), Contemporary Sensory Neurobiology. A.R. Liss, New York, pp. 293-304.
28. Gallagher, J.P., Phelan, K.D. & Shinnick-Gallagher, P. (1992) Modulation of excitatory trasnmission at the rat medial vestibular nucleus synapse. Ann. NY Acad. Sci., 656, 630-644.
29. Gilchrist, D.P.D., Curthoys, I.S., Cartwright, A.D., Burgess, A.M., Topple, A.N. & Halmagyi, G.M. (1998) High acceleration impulsive rotations reveal severe long-term deficits of the horizontal vestibulo-ocular reflex in the guinea pig. Exp. Brain Res., 123, 242-254.
30. Gilchrist, D.P.D., Darlington, C.L. & Smith, P.F. (1996) An in vitro investigation of the effects of the ACTH/MSH-(4-9) analogue, Org 2766, on guinea pig medial vestibular nucleus neurons. Peptides, 17, 681-688.
31. Goldberg, J.M. (2000) Afferent diversity and the orgnization of central vestibular pathways. Exp. Brain Res., 130, 277-297.
32. Goto, F., Straka, H. & Dieringer, N. (2000) Expansion of afferent vestibular signals after the section of one of the vestibular nerve branches. J. Neurophysiol., 84, 581-584.
33. Goto, F., Straka, H. & Dieringer, N. (2001) Post-lesional vestibular reorganisation in frogs: Evidence for a basic reaction pattern after nerve injury. J. Neurophysiol., 85, 2643-2646.
34. Graham, B.P. & Dutia, M.B. (2001) Cellular basis of vestibular compensation: Analysis and modelling of the role of the commissural inhibitory system. Exp. Brain Res., 137, 387-396.
35. Grassi, S., Della Torre, G., Capocchi, G., Zamploni, M. & Pettorossi, V.E. (1995) The role of GABA in NMDA receptor-dependent long-term depression (LTD) of rat medial vestibular nuclei. Brain Res., 699, 183-191.
36. Grassi, S., Francescangeli, E., Goracci, G. & Pettorossi, V.E. (1998) Role of platelet-activating factor in long-term potentiation of the rat medial vestibular nuclei. J. Neurophysiol., 79, 3266-3271.
37. Grassi, S., Frondaroli, A., Pessia, M. & Pettorossi, V.E. (2001) Exogenous glutamate induces short- and long-term potentiation in the medial vestibular nuclei. Neuroreport, 12, 2329-2334.
38. Grassi, S., Malfagia, C. & Pettorossi, V.E. (1998) Effects of metabotropic glutamate receptor block on the synaptic transmission and plasticity in the rat medial vestibular nuclei. Neuroscience, 87, 159-169.
39. Gustave dit Duflo, S.D., Gestreau, C., Tighilet, B. & Lacour, M. (1999) Fos expression in the cat brainstem after unilateral vestibular neurectomy. Brain Res., 824, 1-17.
40. Hamann, K.F. & Lannou, J. (1988) Dynamic characteristics of vestibular nuclear neurons responses to vestibular and optokinetic stimulation during vestibular compensation. Acta Otolaryngol. (Stockh.) Suppl., 455, 1-19.
41. Him, A. & Dutia, M.B. (2001) Intrinsic excitability changes in vestibular nucleus neurons after unilateral deafferentation. Brain Res., 908, 58-66.
42. A receptors to the GABA-mediated inhibition of medial vestibular nucleus neurons in vitro. Neuroreport, 6, 1649-1652.
43. A receptors in the vestibular nucleus. Eur. J. Pharmacol., 301, 83-90.
44. Janssen, U., Richter-Landsberg, C. & Flohr, H. (1992a) Vestibular compensation affects endogenous phosphorylation of frog brain proteins. J. Neurochem., 58, 65-71.
45. Janssen, U., Richter-Landsberg, C., Oestreicher, A.B., De Graaf, P.N.E., Gispen, W.H. & Flohr, H. (1992b) Identification of a B-50-like protein in frog brain synaptosomes. Brain Res., 570, 21-26.
46. Johnston, A.R. & Dutia, M.B. (1996) Postnatal development of spontaneous tonic activity in mouse medial vestibular nucleus neurones. Neurosci. Lett., 219, 17-20.
47. B receptors during vestibular compensation. Neuroreport, 12, 597-600.
48. Johnston, A.R., Macleod, N.K. & Dutia, M.B. (1994) Ionic conductances contributing to spike repolarization and after-potentials in rat medial vestibular nucleus neurons. J. Physiol. (Lond.), 481, 61-67.
49. Johnston, A.R., Murnion, B., McQueen, D.S. & Dutia, M.B. (1993) Excitation and inhibition of rat medial vestibular nucleus neurons by 5-hydroxtryptamine. Exp. Brain Res., 93, 293-298.
50. Kasik, P., Cochran, S.L., Dieringer, N. & Precht, W. (1986) Evidence for an alteration in brainstem cholinergic pathways following unilateral labyrinthectomy in the frog. Brain Res., 363, 188-191.
51. Kerr, D.R., Sansom, A.J., Smith, P.F. & Darlington, C.L. (2000) Comparison of protein kinase activity and protein phosphorylation in prepositus hypoglossi and medial vestibular nuclei of labyrinthine-intact and labyrinthectomized guinea pigs. J. Vest. Res., 10, 107-117.
52. Kinney, G.A., Peterson, B.W. & Slater, N.T. (1994) The synaptic activation of N-methyl-D-aspartate receptors in the rat medial vestibular nucleus. J. Neurophysiol., 72, 1588-1595.
53. Kitahara, T., Takeda, N., Kiyama, H. & Kubo, T. (1998) Molecular mechanisms of vestibular compensation in the central vestibular system. Acta Otolaryngol. (Stockh.) Suppl., 539, 19-27.
54. Knopfel, T. (1987) Evidence for N-methyl-D-aspartic acid receptor-mediated modulation of the commissural input to central vestibular neurons of the frog. Brain Res., 426, 212-224.
55. Knopfel, T. & Dieringer, N. (1988) Lesion-induced vestibular plasticity in the frog: Are N-methyl-D-aspartate receptors involved? Exp. Brain Res., 72, 129-134.
56. Kobayashi, S. & Murakami, N. (1982) Thermosensitive neurons in slice preparations of rat medulla oblongata. Brain Res. Bull., 8, 721-726.
57. du Lac, S. & Lisberger, S.G. (1995) Membrane and firing properties of avian vestibular nucleus neurons in vitro. J. Comp. Physiol., 176, 641-651.
58. Lacour, M., Ez-Zaher, L. & Raymond, J. (1991) Plasticity mechanisms in vestibular compensation in the cat are improved by an extract of Ginkgo biloba (EGb 761). Pharmacol. Biochem. Behav., 40, 367-379.
59. Lapeyre, P.N.M. & de Waele, C. (1995) Dual glycinergic modulation of spontaneously active guinea pig medial vestibular nucleus neurons: An in vitro study. Neurosci. Lett., 188, 155-158.
60. Lewis, M.R., Gallagher, J.P. & Shinnick-Gallagher, P. (1987) An in vitro brain slice preparation to study the pharmacology of central vestibular neurons. J. Pharmacol. Meth., 18, 267-273.
61. Lewis, M.R., Phelan, K.D., Shinnick-Gallagher, P. & Gallagher, J.P. (1989) Primary afferent excitatory transmission recorded intracellularly in vitro from rat medial vestibular neurons. Synapse, 3, 149-153.
62. Lin, Y. & Carpenter, D.O. (1993) Medial vestibular neurons are endogenous pacemakers whose discharge is modulated by neurotransmitters. Cell. Mol. Neurobiol., 13, 601-613.
63. Lin, Y. & Carpenter, D.O. (1994) Direct excitatory opiate effects mediated by non-synaptic actions on rat medial vestibular neurons. Eur. J. Pharmacol., 262, 99-106.
64. Llinas, R.R. (1988) The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function. Science., 242, 1654-1664.
65. Llinas, R.R. & Muhlethaler, M. (1988a) An electrophysiological study of the in vitro, perfused brainstem-cerebellum of adult guinea pig. J. Physiol. (Lond.), 404, 215-240.
66. Llinas, R.R. & Muhlethaler, M. (1988b) Electrophysiology of guinea pig cerebellar nuclear cells in the in vitro brainstem-cerebellar preparation. J. Physiol. (Lond.), 404, 241-258.
67. Maclennan, K., Smith, P.F. & Darlington, C.L. (1996) The effects of ginkgolide B (BN52021) on guinea pig vestibular nucleus neurons in vitro: Importance of controlling for effects of dimethylsulphoxide (DMSO) vehicles. Neurosci. Res., 26, 395-399.
68. McCabe, B.F. & Ryu, J.H. (1969) Experiments on vestibular compensation. Laryngoscope, 79, 1728-1736.
69. McCabe, B.F., Ryu, J.H. & Sekitani, T. (1972) Further experiments on vestibular compensation. Laryngoscope, 82, 381-396.
70. Muhlethaler, M., de Curtis, M., Walton, K. & Llinas, R.R. (1993) The isolated and perfused brain of the guinea pig in vitro. Eur. J. Neurosci., 5, 915-926.
71. Newlands, S.D. & Perachio, A.A. (1990) Compensation of horizontal canal related activity in the medial vestibular nucleus following unilateral labyrinth ablation in the decerebrate gerbil: Type I neurons. Exp. Brain Res., 82, 359-372.
72. Newlands, S.D. & Perachio, A.A. (1991) Effect of T2 spinal transection on compensation of horizontal canal related activity in the medial vestibular nucleus following unilateral labyrinth ablation in the decerebrate gerbil. Brain Res., 541, 129-133.
73. Newsham-West, D., Darlington, C.L. & Smith, P.F. (1998) Potent effects of a selective cannabinoid receptor agonist on some medial vestibular nucleus neurons. Eur. J. Pharmacol., 348, R1-R2.
74. Paul, A., Sansom, A.J., Maclennan, K., Darlington, C.L. & Smith, P.F. (1998) The effects of steroids on vestibular compensation and vestibular nucleus neuronal activity in guinea pig. J. Vest. Res., 8, 201-207.
75. Peusner, K.D., Gamkrelidze, G. & Giaume, C. (1998) Potassium currents and excitability in second-order auditory and vestibular neurons. J. Neurosci. Res., 53, 511-520.
76. Peusner, K.D. & Giaume, C. (1989) Electrophysiological study of the tangential vestibular nucleus of the chick embryo in vitro. Exp. Brain Res., 74, 80-88.
77. Peusner, K.D. & Giaume, C. (1994) The first developing 'mixed' synapses between vestibular sensory neurons mediate glutamate chemical transmission. Neuroscience, 58, 99-113.
78. Phelan, K.D. & Gallagher, J.P. (1992) Direct muscarinic and nicotinic receptor-mediated excitation of rat medial vestibular nucleus neurons in vitro. Synapse, 10, 349-358.
79. Phelan, K.D., Nakamura, J. & Gallagher, J.P. (1990) Histamine depolarizes rat medial vestibular nucleus neurons recorded intracellularly in vitro. Neurosci. Lett., 109, 287-292.
80. Podda, M.V., Johnston, A.R., Tolu, E. & Dutia, M.B. (2001) Modulation of rat medial vestibular nucleus neurone activity by vasopressin and noradrenaline in vitro. Neurosci. Lett., 298, 91-94.
81. Pompeiano, O., Xerri, C., Gianni, S. & Manzoni, D. (1984) Central compensation of vestibular deficits; 2: Influences of roll tilt on different size lateral vestibular neurons after ipsilateral labyrinth deafferentation. J. Neurophysiol., 52, 18-38.
82. Precht, W., Shimazu, H. & Markham, C.H. (1966) A mechanism of central compensation of vestibular function following hemilabyrinthectomy. J. Neurophysiol., 29, 996-1010.
83. Rekling, J.C. & Laursen, A.M. (1989) Evidence for a persistent sodium conductance in neurons from the nucleus prepositus hypoglossi. Brain Res., 500, 276-286.
84. Ried, K.H., Edmonds, H.L., Schurr, A., Tseng, M.T. & West, C.A. (1988) Pitfalls in the use of brain slices. Prog. Neurobiol., 31, 1-18.
85. Ried, S., Maioli, C. & Precht, W. (1984) Vestibular nuclear neuronal activity in chronically labyrinthectomized cats. Acta Otolaryngol. (Stockh.), 98, 1-13.
86. Ris, L., Capron, B., de Waele, C., Vidal, P.P. & Godaux, E. (1997) Dissociations between behavioural recovery and restoration of vestibular activity in the unilabyrinthectomized guinea pig. J. Physiol. (Lond.), 500, 509-522.
87. Ris, L., Capron, B., De Waele, C., Vidal, P.P. & Godaux, E. (1999) Neck muscle activity after unilateral labyrinthectomy in the alert guinea pig. Exp. Brain Res., 124, 159-165.
88. Ris, L., Capron, B., Vibert, N., Vidal, P.P. & Godaux, E. (2001a) Modification of the pacemaker activity of vestibular neurons in brainstem slices during vestibular compensation in the guinea pig. Eur. J. Neurosci., 13, 2234-2240.
89. Ris, L., De Waele, C., Serafin, M., Vidal, P.P. & Godaux, E. (1995) Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig. J. Neurophysiol., 74, 2087-2099.
90. Ris, L. & Godaux, E. (1998) Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig. J. Neurophysiol., 80, 2352-2367.
91. Ris, L. & Godaux, E. (1998) Spike discharge regularity of vestibular neurons in labyrinthectomized guinea pigs. Neurosci. Lett., 253, 131-134.
92. Ris, L. & Godaux, E. (2001a) Voltage-gated calcium channels contribute to the pattern of the resting discharge in guinea pig medial vestibular nucleus neurons. Neurosci. Lett., 297, 142-144.
93. Ris, L., Hachemaoui, M., Vibert, N., Godaux, E., Vidal, P.P. & Moore, L.E. (2001b) Resonance of spike discharge modulation in neurons of the guinea pig medial vestibular nucleus. J. Neurophysiol., 86, 703-716.
94. Ris, L., Wattiez, R., De Waele, C., Vidal, P.P. & Godaux, E. (1998) Reappearance of activity in the vestibular neurones of labyrinthectomized guinea pigs is not delayed by cycloheximide. J. Physiol. (Lond.) 512, 533-541.
95. Ris, L., Wattiez, R., Falmagne, P. & Godaux, E. (1999) Changes in protein expression in the vestibular nuclei during vestibular compensation. Neuroreport, 10, 3333-3339.
96. Sakai, N., Ujihara, H., Ishihara, K., Sasa, M. & Tanaka, C. (1996) Electrophysiological and pharmacological characteristics of ionotropic glutamate receptors in medial vestibular nucleus neurons: A whole cell patch clamp study in acutely dissociated neurons. Jap. J. Pharmacol., 72, 335-346.
97. Sansom, A.J., Brent, V.A., Jarvie, P.E., Darlington, C.L., Smith, P.F., Laverty, R. & Rostas, J.A.P. (1997) In vitro phosphorylation of medial vestibular nucleus and prepositus hypoglossi proteins during behavioural recovery from unilateral vestibular deafferentation in guinea pig. Brain Res., 778, 166-177.
98. Serafin, M., de Waele, C., Khateb, A., Vidal, P.P. & Muhlethaler, M. (1991a) Medial vestibular nucleus in the guinea pig I: Intrinsic membrane peroperties in brainstem slices. Exp. Brain Res., 84, 417-425.
99. Serafin, M., de Waele, C., Khateb, A., Vidal, P.P. & Muhlethaler, M. (1991b) Medial vestibular nucleus in the guinea pig II: Ionic basis of intrinsic membrane properties in brainstem slices. Exp. Brain Res., 84, 426-433.
100. Serafin, M., Khateb, A., de Waele, C., Vidal, P.P. & Muhlethaler, M. (1990) Low threshold calcium spikes in medial vestibular nuclei neurones in vitro: A role in the generation of the nystagmus quick phase in vivo? Exp. Brain Res., 82, 187-190.
101. Serafin, M., Khateb, A., de Waele, C., Vidal, P.P. & Muhlethaler, M. (1992) Medial vestibular nucleus in the guinea pig: NMDA-induced oscillations. Exp. Brain Res., 88, 187-192.
102. Serafin, M., Khateb, A., Vibert, N., Vidal, P.P. & Muhlethaler, M. (1993) Medial vestibular nucleus in the guinea pig: Histaminergic receptors in vitro. Exp. Brain Res., 93, 242-248.
103. Shimazu, H. & Precht, W. (1965) Tonic and kinetic responses of cats vestibular neurons to horizontal angular accleleration. J. Neurophysiol., 28, 991-1013.
104. Shimazu, H. & Precht, W. (1966) Inhibition of central vestibular neurons from the contralateral labyrinth and its mediating pathway. J. Neurophysiol., 29, 467-492.
105. Smith, P.F. & Curthoys, I.S. (1988) Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy. Brain Res., 44, 308-319.
106. Smith, P.F. & Curthoys, I.S. (1989) Mechanisms of recovery following unilateral labyrinthectomy: A review. Brain Res. Rev., 14, 155-180.
107. Smith, P.F. & Darlington, C.L. (1992a) Effects of N-methyl-D-aspartate receptor antagonists on vestibular compensation in the guinea pig: In vivo and in vitro studies. In Berthoz, A., Graf, W. & Vidal, P.P. (eds), The Head/Neck Sensorimotor System. Oxford University Press, New York-Oxford, pp. 631-635.
108. Smith, P.F. & Darlington, C.L. (1992b) Comparison of the effects of NMDA antagonists on medial vestibular nucleus neurons in brainstem slices from labyrinthine-intact and chronically labyrinthectomized guinea pigs. Brain Res., 590, 345-349.
109. Smith, P.F., Darlington, C.L. & Hubbard, J.I. (1990) Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus. Brain Res., 513, 149-151.
110. Smith, P.F., Darlington, C.L. & Hubbard, J.I. (1991) Evidence for inhibitory amino acid receptors on guinea pig medial vestibular nucleus neurons in vitro. Neurosci. Lett., 121, 244-246.
111. Straka, H. & Dieringer, N. (1993) Electrophysiological and pharmacological characterization of vestibular inputs to identified frog abducens motoneurons and internuclear neurons in vitro. Eur. J. Neurosci., 5, 251-260.
112. Straka, H., Reichenberger, I. & Dieringer, N. (1996) Size-related properties of vestibular afferent fibers in the frog: Uptake of and immunoreactivity for glycine and aspartate/glutamate. Neuroscience, 70, 685-696.
113. Sulaiman, M.R. & Dutia, M.B. (1998) Opioid inhibition of rat medial vestibular nucleus neurones in vitro and its dependence on age. Exp. Brain Res., 122, 196-202.
114. Sulaiman, M.R., Niklasson, M., Tham, R. & Dutia, M.B. (1999) Modulation of vestibular function by nociceptin orphanin FQ: An in vivo and in vitro study. Brain Res., 828, 74-82.
115. Takahashi, Y. & Kubo, T. (1997) Excitatory synaptic transmission in the rat medial vestibular nucleus. Acta Otolaryngol. (Stockh.) Suppl., 528, 56-58.
116. Takahashi, Y., Takahashi, M.P., Tsumoto, T., Doi, K. & Matsunaga, T. (1994b) Synaptic input-induced increase in intraneuronal calcium in the medial vestibular nucleus of young rats. Neurosci. Res., 21, 59-69.
117. Takahashi, Y., Tsumoto, T. & Kubo, T. (1994a) NMDA receptors contribute to afferent synaptic transmission in the medial vestibular nucleus of young rats. Brain Res., 659, 287-291.
118. Tighilet, B. & Lacour, M. (2001) Gamma aminobutyric acid (GABA) immunoreactivity in the vestibular nuclei of normal and unilateral vestibular neurectomized cats. Eur. J. Neurosci., 13, 2255-2267.
119. Ujihara, H., Akaike, A., Sasa, M. & Takaori, S. (1988) Electrophysiological evidence for cholinoceptive neurons in the medial vestibular nucleus: Studies on rat brainstem in vitro. Neurosci. Lett., 93, 231-235.
120. Ujihara, H., Akaike, A., Sasa, M. & Takaori, S. (1989) Muscarinic regulation of spontaneously active medial vestibular neurons in guinea pig. Neurosci. Lett., 106, 205-210.
121. Vibert, N., Babalian, A., Serafin, M., Gasc, M., Muhlethaler, M. & Vidal, P.-P. (1999a) Plastic changes underlying vestibular compensation in the guinea pig persist in isolated, in vitro whole brain preparations. Neuroscience, 93, 413-432.
122. Vibert, N., Bantikyan, A., Babalian, A., Serafin, M., Muhlethaler, M. & Vidal, P.-P. (1999b) Post-lesional plasticity in the central nervous system of the guinea pig: A 'top-down' process? Neuroscience, 94, 1-5.
123. Vibert, N., Beraneck, M., Bantikyan, A. & Vidal, P.-P. (2000) Vestibular compensation modifies the sensitivity of vestibular neurones to inhibitory amino acids. Neuroreport, 11, 1921-1927.
124. Vibert, N., de Waele, C., Serafin, M., Babalian, A., Muhlethaler, M. & Vidal, P.-P. (1997) The vestibular system as a model of sensorimotor transformations. A combined in vivo and in vitro approach to study the cellular mechanisms of gaze and posture stabilization in mammals. Prog. Neurobiol., 51, 243-286.
125. Vibert, N., Serafin, M., Crambes, O., Vidal, P.-P. & Muhlethaler, M. (1995c) Dopaminergic agonists have both presynaptic and postsynaptic effects on the guinea pig's medial vestibular nucleus neurons. Eur. J. Neurosci., 7, 555-562.
126. Vibert, N., Serafin, M., Vidal, P.-P. & Muhlethaler, M. (1994) Pharmacological properties of medial vestibular neurones in the guinea pig in vitro. In Delgado-Garcia, J.M., Godaux, E. and Vidal, P.-P. (eds), Information Processing Underlying Gaze Control. Pergamon Press, New York, pp. 159-173.
127. Vibert, N., Serafin, M., Vidal, P.-P. & Muhlethaler, M. (1996) Effects of substance P on medial vestibular nucleus neurons in guinea pig brainstem slices. Eur. J. Neurosci., 8, 1030-1036.
128. Vibert, N., Serafin, M., Vidal, P.-P. & Muhlethaler, M. (1995a) Direct and indirect effects of muscimol on medial vestibular nucleus neurones in guinea-pig brainstem slices. Exp. Brain Res., 104, 351-356.
129. Vibert, N., Serafin, M., Vidal, P.-P. & Muhlethaler, M. (1995b) Effects of baclofen on medial vestibular nucleus neurones in guinea-pig brainstem slices. Neurosci. Lett., 183, 193-197.
130. Vidal, P.-P., Vibert, N., Serafin, M., Babalian, A.M., Muhlethaler, M. & de Waele, C. (1999) Intrinsic physiological and pharmacological properties of central vestibular neurons. Adv. Oto-Rhino-Laryngol., 55, 26-81.
131. de Waele, C., Loquet, G., Campos Torres, A. & Vidal, P.-P. (2000) Lack of growth-associated protein-43 reemergence or of growth-associated protein-43 mRNA modulation in deafferented vestibular nuclei during the first 6 weeks after unilateral inner ear lesion. Exp. Brain Res., 132, 464-475.
132. de Waele, C., Serafin, M., Khateb, A., Yabe, T., Vidal, P.-P. & Muhlethaler, M. (1993) Medial vestibular nucleus in the guinea pig: Apamin-induced rhythmic burst-firing - An in vitro and in vivo study. Exp. Brain Res., 95, 213-222.
133. Waespe, W., Schwartz, U. & Wolfensberger, M. (1992) Firing characteristics of vestibular nuclei neurons in the alert monkey after bilateral vestibular neurectomy. Exp. Brain Res., 89, 311-322.
134. Wang, J.J. & Dutia, M.B. (1995) Effects of histamine and betahistine on rat medial vestibular nucleus neurones: Possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness. Exp. Brain Res., 105, 18-16.
135. Wilson, V.J. & Melvill Jones, G. (1979). Mammalian Vestibular Physiology. Plenum, New York,.
136. Xerri, C., Gianni, S., Manzoni, D. & Pompeiano, O. (1983) Compensation of central vestibular deficits; 1: Response characteristics of lateral vestibular nucleus neurons to roll tilt after ipsilateral labyrinth deafferentation. J. Neurophyysiol., 50, 428-448.
137. Yamanaka, T., Him, A., Cameron, S.A. & Dutia, M.B. (2000) Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurons after unilateral labyrinthectomy. J. Physiol. (Lond.), 523, 413-424.
138. Zennou-Azogui, Y., Borel, L., Lacour, M., Ez-Zaher, L. & Ouaknine, M. (1993) Recovery of head postural control following unilateral vestibular neurectomy in the cat. Acta Otolaryngol. (Stockh.) Suppl., 509, 1-19.