Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 23, 2004, Pages 5793-5797

  Manley, Paul W ^a   Breitenstein, Werner ^a   Brüggen, Josef ^a   Cowan Jacob, Sandra W ^a   Furet, Pascal ^a   Mestan, Jürgen ^a   Meyer, Thomas ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Gleevec; Tyrosine kinase

Indexed keywords

ANILINE DERIVATIVE; BCR ABL PROTEIN; DIMETHYLAMINOANILINE DERIVATIVE; IMATINIB; PROTEIN KINASE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; ONCOGENE; THROMBOCYTE;

ANIMALS; CELL LINE, TUMOR; GENES, ABL; HUMANS; MICE; PIPERAZINES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; UREA;

EID: 7044231291     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.042     Document Type: Article

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