The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques

Electrophoresis

Volumn 30, Issue 15, 2009, Pages 2720-2727

  Groessl, Michael ^a   Bytzek, Anna ^a   Hartinger, Christian G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Capillary electrophoresis; Hyphenated techniques; Metal based drugs; MS; Protein binding

Indexed keywords

BIOCHEMISTRY; BODY FLUIDS; GALLIUM COMPOUNDS; IRON COMPOUNDS; PROTEINS; TRANSITION METALS;

HIGH AFFINITY; HIGH-ABUNDANCE PROTEINS; HUMAN SERUM PROTEINS; HYPHENATED TECHNIQUES; IRON-CONTAINING; METAL-BASED DRUG; MS; PROTEIN-BINDING; SERUM PROTEINS; SOFT DONOR;

CAPILLARY ELECTROPHORESIS;

ALBUMIN; CARBONIC ACID; GALLIUM NITRATE; TRANSFERRIN; TRIS (8 OXYQUINOLINATO)GALLIUM NITRATE; UNCLASSIFIED DRUG; 8 QUINOLINOL; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; GALLIUM; IRON; ORGANOMETALLIC COMPOUND; SERUM ALBUMIN; TRIS(8 QUINOLINOLATO)GALLIUM (III); TRIS(8-QUINOLINOLATO)GALLIUM (III);

ARTICLE; BINDING SITE; CALIBRATION; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; IRON BINDING CAPACITY; MASS SPECTROMETRY; PH; PROTEIN BINDING; SEPARATION TECHNIQUE; BINDING COMPETITION; BIOLOGICAL MODEL; BLOOD; KINETICS; METABOLISM; METHODOLOGY;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CALIBRATION; ELECTROPHORESIS, CAPILLARY; GALLIUM; GALLIUM ISOTOPES; HUMANS; HYDROGEN-ION CONCENTRATION; IRON; KINETICS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; ORGANOMETALLIC COMPOUNDS; OXYQUINOLINE; PROTEIN BINDING; SERUM ALBUMIN; TRANSFERRIN;

EID: 70350767292     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200800745     Document Type: Article

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