Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE

Electrophoresis

Volumn 28, Issue 13, 2007, Pages 2235-2240

  Timerbaev, Andrei R ^a,b   Foteeva, Lidia S ^a   Rudnev, Alexander V ^a   Abramski, Jan K ^c   Połeć Pawlak, Katarzyna ^c   Hartinger, Christian G ^b   Jarosz, Maciej ^c   Keppler, Bernhard K ^b  

^a VERNADSKY INSTITUTE OF GEOCHEMISTRY AND ANALYTICAL CHEMISTRY   (Russian Federation)

^b UNIVERSITY OF VIENNA   (Austria)

^c WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

ACE; CE; Protein metallodrug adducts; Ruthenium complexes; Stability studies

Indexed keywords

ASCORBIC ACID; BODY FLUIDS; ELECTROPHORESIS; INDUCTIVELY COUPLED PLASMA; PHYSIOLOGICAL MODELS; PHYSIOLOGY; PLASMA STABILITY; RATE CONSTANTS; RUTHENIUM COMPOUNDS;

ACE; ANTI-CANCER AGENTS; CE; EXTRACELLULAR; KINETIC ASSAY; PROTEIN-METALLODRUG ADDUCT; REDUCTANTS; RUTHENIUM COMPLEXES; SERUM PROTEINS; STABILITY STUDY;

PROTEINS;

ALBUMIN; ASCORBIC ACID; GLUTATHIONE; INDAZOLIUM TETRACHLOROBIS(INDAZOLE)RUTHENATE; PLASMA PROTEIN; RUTHENIUM COMPLEX; TETRACHLOROBIS(1H INDAZOLE)RUTHENATE; TRANSFERRIN; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CAPILLARY ELECTROPHORESIS; CELL LEVEL; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; IN VITRO STUDY; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION;

EID: 34447517227     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200600707     Document Type: Article

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