Nociceptin/orphanin FQ and NOP receptor gene regulation after acute or repeated social defeat stress

Neuropeptides

Volumn 43, Issue 6, 2009, Pages 507-514

  Green, Megan K ^a   Devine, Darragh P ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Amygdala; Hypothalamus; Limbic system; N OFQ; Nociceptin; NOP; Orphanin FQ; Paraventricular nucleus; PVN; Stress

Indexed keywords

MESSENGER RNA; NOCICEPTIN; NOCICEPTIN RECEPTOR; SULFUR 35;

ACUTE STRESS; AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN REGION; CONTROLLED STUDY; ENDOCRINE DISEASE; FOREBRAIN; GENE EXPRESSION REGULATION; HISTOCHEMISTRY; HORMONAL REGULATION; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LIMBIC SYSTEM; LONG EVANS RAT; MALE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RNA PROBE; SOCIAL STRESS; THALAMUS MIDLINE NUCLEUS; UPREGULATION;

ANIMALS; BRAIN; FEMALE; GENE EXPRESSION REGULATION; MALE; OPIOID PEPTIDES; PROTEIN PRECURSORS; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; RECEPTORS, OPIOID; RNA, MESSENGER; SOCIAL BEHAVIOR; STRESS, PSYCHOLOGICAL;

RATTUS; RODENTIA;

EID: 70350735987     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2009.08.003     Document Type: Article

References (40)

1. Buwalda B., Felszeghy K., Horvath K.M., Nyakas C., de Boer S.F., Bohus B., and Koolhaas J.M. Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat. Physiol. Behav. 72 (2001) 349-354
2. Buwalda B., Kole M.H., Veenema A.H., Huininga M., de Boer S.F., Korte S.M., and Koolhaas J.M. Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning. Neurosci. Biobehav. Rev. 29 (2005) 83-97
3. Calfa G., Volosin M., and Molina V.A. Glucocorticoid receptors in lateral septum are involved in the modulation of the emotional sequelae induced by social defeat. Behav. Brain Res. 172 (2006) 324-332
4. Chung K.K., Martinez M., and Herbert J. Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats. Neuroscience 92 (1999) 613-625
5. Covington III H.E., and Miczek K.A. Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine self-administration "binges". Psychopharmacol 158 (2001) 388-398
6. Dautzenberg F.M., Wichmann J., Higelin J., Py-Lang G., Kratzeisen C., Malherbe P., Kilpatrick G.J., and Jenck F. Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo. J. Pharmacol. Exp. Ther. 298 (2001) 812-819
7. de Goeij D., Jezova D., and Tilders F.J. Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus. Brain Res. 577 (1992) 165-168
8. Devine D.P., Hoversten M.T., Ueda Y., and Akil H. Nociceptin/orphanin FQ content is decreased in forebrain neurons during acute stress. J. Neuroendocrinol. 15 (2003) 69-74
9. Devine D.P., Watson S.J., and Akil H. Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis. Neuroscience 102 (2001) 541-553
10. Ebner K., Wotjak C.T., Landgraf R., and Engelmann M. Neuroendocrine and behavioral response to social confrontation: residents versus intruders, active versus passive coping styles. Horm. Behav. 47 (2005) 14-21
11. Fernandez F., Misilmeri M.A., Felger J.C., and Devine D.P. Nociceptin/orphanin FQ increases anxiety-related behaviour and circulating levels of corticosterone during neophobic tests of anxiety. Neuropsychopharmacology 29 (2004) 59-71
12. Gavioli E.C., Marzola G., Guerrini R., Bertorelli R., Zucchini S., De Lima T.C., Rae G.A., Salvadori S., Regoli D., and Caló G. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur. J. Neurosci. 17 (2003) 1987-1990
13. Gavioli E.C., Rae G.A., Caló G., Guerrini R., and De Lima T.C. Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test. Br. J. Pharmacol. 136 (2002) 764-772
14. Gavioli E.C., Rizzi A., Marzola G., Zucchini S., Regoli D., and Calo' G. Altered anxiety-related behavior in nociceptin/orphanin FQ receptor gene knockout mice. Peptides 28 (2007) 1229-1239
15. Gavioli E.C., Vaughan C.W., Marzola G., Guerrini R., Mitchell V.A., Zucchini S., De Lima T.C., Rae G.A., Salvadori S., Regoli D., and Calo' G. Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice. Naunyn Schmiedebergs Arch. Pharmacol. 369 (2004) 547-553
16. Green M.K., Barbieri E.V., Brown B.D., Chen K.-W., and Devine D.P. Roles of the bed nucleus of stria terminalis and of the amygdala in N/OFQ-mediated anxiety and HPA axis activation. Neuropeptides 41 (2007) 399-410
17. Griebel G., Perrault G., and Sanger D.J. Orphanin FQ, a novel neuropeptide with anti-stress-like activity. Brain Res. 836 (1999) 221-224
18. Harbuz M.S., and Lightman S.L. Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat. J. Endocrinol. 122 (1989) 705-711
19. Heinrichs S.C., Pich E.M., Miczek K.A., Britton K.T., and Koob G.F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res. 581 (1992) 190-197
20. Herman J.P., and Cullinan W.E. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 20 (1997) 78-84
21. Jenck F., Moreau J.-L., Martin J.R., Kilpatrick G.J., Reinscheid R.K., Monsma Jr. F.J., Nothacker H.-P., and Civelli O. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Proc. Natl. Acad. Sci. USA 94 (1997) 14854-14858
22. Jenck F., Wichmann J., Dautzenberg F.M., Moreau J.L., Ouagazzal A.M., Martin J.R., Lundstrom K., Cesura A.M., Poli S.M., Roever S., Kolczewski S., Adam G., and Kilpatrick G. A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. Proc. Natl. Acad. Sci. USA 97 (2000) 4938-4943
23. Kabbaj M., Devine D.P., Savage V.R., and Akil H. Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules. J. Neurosci. 20 (2000) 6983-6986
24. Kamei J., Matsunawa Y., Miyata S., Tanaka S., and Saitoh A. Effects of nociceptin on the exploratory behavior of mice in the hole-board test. Eur. J. Pharmacol. 489 (2004) 77-87
25. Koolhaas J.M., de Boer S.F., De Rutter A.J., Meerlo P., and Sgoifo A. Social stress in rats and mice. Acta Physiol. Scand. Suppl. 640 (1997) 69-72
26. 2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats. Neuroscience 141 (2006) 2051-2057
27. Martinez M., Phillips P.J., and Herbert J. Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats. Eur. J. Neurosci. 10 (1998) 20-33
28. Matsuda S., Peng H., Yoshimura H., Wen T.C., Fukuda T., and Sakanaka M. Persistent c-fos expression in the brains of mice with chronic social stress. Neurosci. Res. 26 (1996) 157-170
29. Miczek K.A., Covington III H.E., Nikulina Jr. E.M., and Hammer R.P. Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits. Neurosci. Biobehav. Rev. 27 (2004) 787-802
30. 14Tyr]-orphanin FQ binding. J. Comp. Neurol. 412 (1999) 563-605
31. Neal Jr. C.R., Mansour A., Reinscheid R.K., Nothacker H.-P., Civelli O., and Watson Jr. S.J. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J. Comp. Neurol. 406 (1999) 503-547
32. Nicholson J.R., Akil H., and Watson S.J. Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors. Neuroscience 115 (2002) 637-643
33. Nikulina E.M., Covington III H.E., Ganschow L., Hammer Jr. R.P., and Miczek K.A. Long-term behavioral and neuronal cross-sensitization to amphetamine induced by repeated brief social defeat stress: fos in the ventral tegmental area and amygdala. Neuroscience 123 (2004) 857-865
34. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press, San Diego, CA
35. Redrobe J.P., Caló G., Regoli D., and Quirion R. Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test. Naunyn Schmiedebergs Arch. Pharmacol. 365 (2002) 164-167
36. Rizzi A., Gavioli E.C., Marzola G., Spagnolo B., Zucchini S., Ciccocioppo R., Trapella C., Regoli D., and Calo G. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies. J. Pharmacol. Exp. Ther. 321 (2007) 968-974
37. Rygula R., Abumaria N., Flugge G., Fuchs E., Ruther E., and Havemann-Reinecke U. Anhedonia and motivational deficits in rats: impact of chronic social stress. Behav. Brain Res. 162 (2005) 127-134
38. Tornatzky W., and Miczek K.A. Long-term impairment of autonomic circadian rhythms after brief intermittent social stress. Physiol. Behav. 53 (1993) 983-993
39. Varty G.B., Hyde L.A., Hodgson R.A., Lu S.X., McCool M.F., Kazdoba T.M., Del Vecchio R.A., Guthrie D.H., Pond A.J., Grzelak M.E., Xu X., Korfmacher W.A., Tulshian D., Parker E.M., and Higgins G.A. Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species. Psychopharmacology (Berl) 182 (2005) 132-143
40. Vitale G., Arletti R., Ruggieri V., Cifani C., and Massi M. Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats. Peptides 27 (2006) 2193-2200