Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test

British Journal of Pharmacology

Volumn 136, Issue 5, 2002, Pages 764-772

  Gavioli, Elaine C ^a   Rae, Giles A ^a   Calo’, Girolamo ^b   Guerrini, Remo ^b   De Lima, Thereza C M ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Anxiety; Mice; Nociceptin orphanin FQ; Nocistatin; Nocistatin C terminal hexapeptide; NOP receptor; Plus maze

Indexed keywords

NOCICEPTIN; NOCISTATIN; OPIATE PEPTIDE; HEXAPEPTIDE;

ANIMAL; ANXIETY; ARTICLE; CATTLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MAZE TEST; MOUSE; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; ANIMAL EXPERIMENT; ARM; BEHAVIOR; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; TIME; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; CATTLE; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MICE; OPIOID PEPTIDES; ANIMAL; COMPARATIVE STUDY; SUPPORT, NON-U.S. GOV'T;

EID: 0035987788     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704739     Document Type: Article

References (52)

1. Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats
2. Altered processing of pro-orphanin FQ/nociceptin and pro-opiomelanocortin-derived peptides in the brains of mice expressing defective pro-hormone convertase 2
3. Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system
4. Pharmacology of nociceptin and its receptor: A novel therapeutic target
5. Effect of nociceptin on alcohol intake in alcohol-preferring rats
6. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: Comparison with haloperidol
7. Opioid receptors
8. Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test
9. Nociceptin stimulates locomotion and exploratory behavior in mice
10. Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice
11. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide
12. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
13. Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice
14. Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord
15. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress
16. 1: Anxiolytic profile in the rat
17. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
18. Intracerebro-ventricular injections in mice. Some methodological refinements
19. Identification of human, rat and mouse nocistatin in brain and human nocistatin in brain and human cerebrospinal fluid
20. The use of a plus-maze to measure anxiety in the mouse
21. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
22. Pain: Nocistatin spells relief
23. Carboxyl terminal peptides derived from prepro-orphanin FQ/nociceptin (ppOFQ/N) are produced in the hypothalamus and possess analgesic bioactivities
24. 1 receptor
25. Functional antagonism of mu, kappa, and delta-opioid antinociception by orphanin FQ
26. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene
27. Orphanin FQ/nociceptin blocks acquisition of morphine place preference
28. Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
29. Effect of intrathecal nocistatin on the formalin-induced pain in mice versus that of nociceptin/orphanin FQ
30. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
31. 14Tyr]-orphanin FQ binding
32. Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices
33. Nocistatin, a peptide that blocks nociceptin action in pain transmission
34. Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: Its involvement in allodynic response to innocuous stimulus
35. Nocistatin: A novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
36. Nocistatin inhibits food intake in rats
37. 1, stimulates feeding in rats
38. Orphanin FQ is the major OFQ1-17-containing peptide produced in the rodent and monkey hypothalamus
39. Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor
40. The orphanin FQ/nociceptin gene: Structure, tissue distribution of expression and functional implications obtained from knockout mice
41. 3 receptor modulation of experimental anxiety in mice
42. 2, potentiates morphine analgesia
43. Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice
44. Endogenous nociceptin signalling and stress-induced analgesia
45. Anxiety, defence and the elevated plus-maze
46. 1 receptors
47. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats
48. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice
49. Functional studies using antibodies against orphanin FQ/nociceptin
50. Effects of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test
51. Ethological confirmatory factor analysis of anxiety-like behaviour in the murine elevated plus-maze
52. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia