Inotropic support during experimental endotoxemic shock: Part II. A comparison of levosimendan with dobutamine

Anesthesia and Analgesia

Volumn 109, Issue 5, 2009, Pages 1576-1583

  Cunha Goncalves, Doris ^a   Perez De Sa, Valeria ^a   Larsson, Anders ^b   Thörne, Johan ^c   Blomquist, Sten ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c HELSINGBORG HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN 70; DOBUTAMINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LACTIC ACID; LEVOSIMENDAN; NORADRENALIN; CARDIOTONIC AGENT; HYDRAZONE DERIVATIVE; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE, ESCHERICHIA COLI 0111 B4; OXYGEN; PYRIDAZINE DERIVATIVE; SIMENDAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOWMETRY; CALORIMETRY; CONTROLLED STUDY; CRYSTALLOID; DRUG DOSE INCREASE; DRUG EFFECT; ENDOTOXEMIA; FLUID RESUSCITATION; HEART OUTPUT; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEPATIC ARTERY; HEPATIC VEIN; HOMEOSTASIS; INOTROPISM; INTESTINE; INTRAVASCULAR CATHETER; LACTATE BLOOD LEVEL; LIVER PERFUSION; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; NONHUMAN; OXYGEN CONSUMPTION; OXYGENATION; PORTAL VEIN BLOOD FLOW; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SEPTIC SHOCK; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; SWINE; SYSTEMIC CIRCULATION; SYSTEMIC VASCULAR RESISTANCE; VENOUS OXYGEN TENSION; ANIMAL; BLOOD; BLOOD FLOW; BLOOD PRESSURE; BLOOD VOLUME; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DISEASE MODEL; DRUG COMBINATION; FLUID THERAPY; HEART RATE; HEMODYNAMICS; HYPOTENSION; LIVER CIRCULATION; MULTIMODALITY CANCER THERAPY; PATHOPHYSIOLOGY; TIME; VASCULAR RESISTANCE;

ANIMALS; BLOOD PRESSURE; BLOOD VOLUME; CARDIAC OUTPUT; CARDIOTONIC AGENTS; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DOBUTAMINE; DRUG THERAPY, COMBINATION; FLUID THERAPY; HEART RATE; HEMODYNAMICS; HYDRAZONES; HYPOTENSION; LACTIC ACID; LIPOPOLYSACCHARIDES; LIVER CIRCULATION; NOREPINEPHRINE; OXYGEN; PYRIDAZINES; REGIONAL BLOOD FLOW; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION; SWINE; TIME FACTORS; VASCULAR RESISTANCE;

EID: 70350710318     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e3181af40e0     Document Type: Article

References (44)

1. Beal AL, Cerra FB. Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. JAMA 1994;271:226-233
2. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34:17-60
3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-1377
4. Beale RJ, Hollenberg SM, Vincent JL, Parrillo JE. Vasopressor and inotropic support in septic shock: an evidence-based review. Crit Care Med 2004;32:S455-65
5. Hollenberg SM, Ahrens TS, Annane D, Astiz ME, Chalfin DB, Dasta JF, Heard SO, Martin C, Napolitano LM, Susla GM, Totaro R, Vincent JL, Zanotti-Cavazzoni S. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med 2004;32:1928-1948
6. Parrillo JE. Pathogenetic mechanisms of septic shock. N Engl J Med 1993;328:1471-1477
7. De Backer D, Moraine JJ, Berre J, Kahn RJ, Vincent JL. Effects of dobutamine on oxygen consumption in septic patients. Direct versus indirect determinations. Am J Respir Crit Care Med 1994;150:95-100
8. Zhang H, De Jongh R, De Backer D, Cherkaoui S, Vray B, Vincent JL. Effects of alpha- and beta-adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock. Crit Care Med 2001;29:581-588 (Pubitemid 32225301)
9. Sun Q, Tu Z, Lobo S, Dimopoulos G, Nagy N, Rogiers P, De Backer D, Vincent JL. Optimal adrenergic support in septic shock due to peritonitis. Anesthesiology 2003;98:888-896
10. Silverman HJ, Penaranda R, Orens JB, Lee NH. Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines. Crit Care Med 1993;21: 31-39
11. Yasuda S, Lew WY. Lipopolysaccharide depresses cardiac contractility and beta-adrenergic contractile response by decreasing myofilament response to Ca2- in cardiac myocytes. Circ Res 1997;81:1011-1020
12. Gulick T, Chung MK, Pieper SJ, Lange LG, Schreiner GF. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness. Proc Natl Acad Sci USA 1989;86:6753-6757
13. Matejovic M, Krouzecky A, Radej J, Novak I. Successful reversal of resistent hypodynamic septic shock with levosimendan. Acta Anaesthesiol Scand 2005;49:127-128
14. Morelli A, De Castro S, Teboul JL, Singer M, Rocco M, Conti G, De Luca L, Di Angelantonio E, Orecchioni A, Pandian NG, Pietropaoli P. Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 2005;31:638-644
15. Cunha-Goncalves D, Perez-de-Sa V, Dahm P, Grins E, Thorne J, Blomquist S. Cardiovascular effects of levosimendan in the early stages of endotoxemia. Shock 2007;28:71-77
16. Cunha-Goncalves D, Perez-de-Sa V, Grins E, Dahm PL, Thörne J, Blomquist S. Inotropic support during experimental endotoxemic shock: Part I. The effects of levosimendan on splanchnic perfusion. Anesth Analg 2009;109:1568-1575
17. Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994;330:1717-1722 (Pubitemid 24171030)
18. Leather HA, Ver Eycken K, Segers P, Herijgers P, Vandermeersch E, Wouters PF. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med 2003;31:2339-2343
19. Kivikko M, Lehtonen L, Colucci WS. Sustained hemodynamic effects of intravenous levosimendan. Circulation 2003;107:81-86
20. Oldner A, Konrad D, Weitzberg E, Rudehill A, Rossi P, Wanecek M. Effects of levosimendan, a novel inotropic calciumsensitizing drug, in experimental septic shock. Crit Care Med 2001;29:2185-2193
21. Dubin A, Murias G, Sottile JP, Pozo MO, Baran M, Edul VS, Canales HS, Etcheverry G, Maskin B, Estenssoro E. Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. Intensive Care Med 2007; 33:485-494
22. Yokoshiki H, Katsube Y, Sunagawa M, Sperelakis N. Levosimendan, a novel Ca2- sensitizer, activates the glibenclamidesensitive K- channel in rat arterial myocytes. Eur J Pharmacol 1997;333:249-259
23. Zager RA, Johnson AC, Lund S, Hanson SY, Abrass CK. Levosimendan protects against experimental endotoxemic acute renal failure. Am J Physiol Renal Physiol 2006;290:F1453-62
24. Gelman S, Mushlin PS. Catecholamine-induced changes in the splanchnic circulation affecting systemic hemodynamics. Anesthesiology 2004;100:434-439
25. Zanotti Cavazzoni SL, Dellinger RP. Hemodynamic optimization of sepsis-induced tissue hypoperfusion. Crit Care 2006;10(suppl 3):S2
26. Tell B, Majerus TC, Flancbaum L. Dobutamine in elderly septic shock patients refractory to dopamine. Intensive Care Med 1987;13:14-18
27. Schaffartzik W, Sanft C, Schaefer JH, Spies C. Different dosages of dobutamine in septic shock patients: determining oxygen consumption with a metabolic monitor integrated in a ventilator. Intensive Care Med 2000;26:1740-1746
28. Neviere R, Chagnon JL, Vallet B, Lebleu N, Marechal X, Mathieu D, Wattel F, Dupuis B. Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 1997;25:1371-1377
29. Hiltebrand LB, Krejci V, Sigurdsson GH. Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia. Anesthesiology 2004;100:1188-1197
30. Tenhunen JJ, Uusaro A, Karja V, Oksala N, Jakob SM, Ruokonen E. Apparent heterogeneity of regional blood flow and metabolic changes within splanchnic tissues during experimental endotoxin shock. Anesth Analg 2003;97:555-563, table of contents
31. Hollenberg Steven M. Vasopressor support in septic shock. Chest 2007;132:1678-1687
32. De Backer D, Vincent JL. Norepinephrine administration in septic shock: how much is enough? Crit Care Med 2002;30:1398-1399
33. Treggiari MM, Romand JA, Burgener D, Suter PM, Aneman A. Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock. Crit Care Med 2002;30:1334-1339
34. Levy RJ, Deutschman CS. Evaluating myocardial depression in sepsis. Shock 2004;22:1-10
35. Trzeciak S, Rivers EP. Clinical manifestations of disordered microcirculatory perfusion in severe sepsis. Crit Care 2005; 9(suppl 4):S20 - 6
36. Hayes MA, Timmins AC, Yau EH, Palazzo M, Watson D, Hinds CJ. Oxygen transport patterns in patients with sepsis syndrome or septic shock: influence of treatment and relationship to outcome. Crit Care Med 1997;25:926-936
37. De Backer D, Creteur J, Noordally O, Smail N, Gulbis B, Vincent JL. Does hepato-splanchnic VO2/DO2 dependency exist in critically ill septic patients? Am J Respir Crit Care Med 1998;157:1219-1225
38. Gore DC, Jahoor F, Hibbert JM, DeMaria EJ. Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 1996;224:97-102
39. Fink MP. Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 2001;17:219-237
40. Vary TC. Down regulation of pyruvate dehydrogenase complex in skeletal muscle during sepsis: implications for sepsis-induced hyperlactatemia sepsis 1999;2:303-312
41. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1991;99:956-962
42. Bellomo R, Kellum JA, Pinsky MR. Transvisceral lactate fluxes during early endotoxemia. Chest 1996;110:198-204
43. Chrusch C, Bands C, Bose D, Li X, Jacobs H, Duke K, Bautista E, Eschun G, Light RB, Mink SN. Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. Am J Respir Crit Care Med 2000;161:517-526
44. Creteur J, De Backer D, Sun Q, Vincent JL. The hepatosplanchnic contribution to hyperlactatemia in endotoxic shock: effects of tissue ischemia. Shock 2004;21:438-443