Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia

Neurobiology of Disease

Volumn 36, Issue 1, 2009, Pages 142-150

  Ahmed, Zubair ^a   Jacques, Steven J ^a   Berry, Martin ^a   Logan, Ann ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

AG1478 PD168393; DRGN; EGFR; Glia; Inhibitory CNS myelin; Neurite outgrowth; Neurotrophins

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; EPIDERMAL GROWTH FACTOR RECEPTOR; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; NERVE GROWTH FACTOR; NEUROTROPHIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DRUG MECHANISM; GLIA CELL; MALE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; SPINAL GANGLION;

ANALYSIS OF VARIANCE; ANIMALS; AXONS; CARBAZOLES; CELL PROLIFERATION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CULTURE MEDIA, CONDITIONED; CYCLIC AMP; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GANGLIA, SPINAL; GLIAL FIBRILLARY ACIDIC PROTEIN; INDOLE ALKALOIDS; MYELIN SHEATH; NERVE CRUSH; NERVE GROWTH FACTORS; NEUROGLIA; NEURONS; QUINAZOLINES; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; S100 PROTEINS; TRANSFECTION; TYRPHOSTINS;

EID: 69949085719     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.07.016     Document Type: Article

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