Impact of nose-only exposure system on pulmonary gene expression

Inhalation Toxicology

Volumn 21, Issue SUPPL. 1, 2009, Pages 74-82

  Thomson, Errol M ^a   Williams, Andrew ^b   Yauk, Carole L ^b   Vincent, Renaud ^a  

^a HEALTH CANADA   (Canada)

^b Environmental Health Sciences Bureau   (Canada)

Author keywords

Gene expression; Lungs; Microarray; mRNA; Nose only inhalation; Restraint stress

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN DELTA; CHEMOKINE RECEPTOR CXCR5; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; LEUCINE ZIPPER PROTEIN; LYMPHOTOXIN BETA; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 6; OXIDOREDUCTASE; PROTEIN BNIP3; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SESTRIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREATHING; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; IMMOBILIZATION STRESS; IMMUNE RESPONSE; LUNG TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMONIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOXICOGENETICS; WILD TYPE;

AIR POLLUTANTS; ANIMALS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INHALATION EXPOSURE; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RESTRAINT, PHYSICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, PSYCHOLOGICAL; TIME FACTORS; TOXICITY TESTS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

ANIMALIA; MUS;

EID: 70350671481     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370902962309     Document Type: Article

References (37)

1. Adamson, I. Y., Prieditis, H., Hedgecock, C. and Vincent, R. (2000). Zinc is the toxic factor in the lung response to an atmospheric particulate sample. Toxicol. Appl. Pharmacol. 166, 111-119.
2. Beato, M., Herrlich, P. and Schutz, G. (1995). Steroid hormone receptors: Many actors in search of a plot. Cell 83, 851-857.
3. Benjamini, Y. and Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 57, 289-300.
4. Carey, M. A., Bradbury, J. A., Seubert, J. M., Langenbach, R., Zeldin, D. C. and Germolec, D. R. (2005). Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J. Immunol. 175, 6878-6884.
5. Cassel, T. N. and Nord, M. (2003). C/EBP transcription factors in the lung epithelium. Am. J. Physiol Lung Cell Mol. Physiol 285, L773-L781.
6. Cui, X. G., Hwang, J. T. G., Qiu, J., Blades, N. J. and , Churchill, G. A. (2005). Improved statistical tests for differential gene expression by shrinking variance components. Biostatistics 6, 59-75.
7. Dennis, G., Jr., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C. and Lempicki, R. A. (2003). DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4, 3.
8. Eddleston, J., Herschbach, J., Wagelie-Steffen, A. L., Christiansen, S. C. and Zuraw, B. L. (2007). The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells. J. Allergy Clin. Immunol. 119, 115-122.
9. Elenkov, I. J. and , Chrousos, G. P. (2002). Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann. NY Acad. Sci. 966, 290-303.
10. Fujita, M., Shannon, J. M., Irvin, C. G., Fagan, K. A., Cool, C., Augustin, A. and Mason, R. J. (2001). Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol Lung Cell Mol. Physiol 280, L39-L49.
11. Ghoshal, K., Wang, Y., Sheridan, J. F. and , Jacob, S. T. (1998). Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J. Biol. Chem. 273, 27904-27910.
12. Ha, H. Y., Kim, K. S., Yeom, Y. I., Lee, J. K. and Han, P. L. (2003). Chronic restraint stress massively alters the expression of genes important for lipid metabolism and detoxification in liver. Toxicol. Lett. 146, 49-63.
13. Hermann, G., Tovar, C. A., Beck, F. M., Allen, C. and , Sheridan, J. F. (1993). Restraint stress differentially affects the pathogenesis of an experimental influenza viral infection in three inbred strains of mice. J. Neuroimmunol. 47, 83-94.
14. Jakab, G. J. and Hemenway, D. (1989). Restraint of animals required for noseonly inhalation toxicologic studies suppresses pulmonary antibacterial defences. Inhal. Toxicol. 1, 289-300.
15. Kassel, O. and Herrlich, P. (2007). Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects. Mol. Cell Endocrinol. 275, 13-29.
16. Leong, M. L., Maiyar, A. C., Kim, B., O'Keeffe, B. A. and Firestone, G. L. (2003). Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J. Biol. Chem. 278, 5871-5882.
17. Livak, K. J. and , Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408.
18. Mittelstadt, P. R. and , Ashwell, J. D. (2001). Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J. Biol. Chem. 276, 29603-29610.
19. Miyazaki, Y., Tashiro, T., Higuchi, Y., Setoguchi, M., Yamamoto, S., Nagai, H., Nasu, M. and Vassalli, P. (1995). Expression of osteopontin in a macrophage cell line and in transgenic mice with pulmonary fibrosis resulting from the lung expression of a tumor necrosis factor-alpha transgene. Ann. NY Acad. Sci. 760, 334-341.
20. Mossman, B. T., Lounsbury, K. M. and , Reddy, S. P. (2006). Oxidants and signaling by mitogen-activated protein kinases in lung epithelium. Am. J. Respir. Cell Mol. Biol. 34, 666-669.
21. Narciso, S. P., Nadziejko, E., Chen, L. C., Gordon, T. and Nadziejko, C. (2003). Adaptation to stress induced by restraining rats and mice in nose-only inhalation holders. Inhal. Toxicol. 15, 1133-1143.
22. Okuyama, K., Ohwada, K., Sakurada, S., Sato, N., Sora, I., Tamura, G., Takayanagi, M. and Ohno, I. (2007). The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine model of allergic asthma. Allergol. Int. 56, 29-35.
23. Persoons, J. H., Moes, N. M., Broug-Holub, E., Schornagel, K., Tilders, F. J. and Kraal, G. (1997). Acute and long-term effects of stressors on pulmonary immune functions. Am. J. Respir. Cell Mol. Biol. 17, 203-208.
24. Samet, J. M., Silbajoris, R., Huang, T. and Jaspers, I. (2002). Transcription factor activation following exposure of an intact lung preparation to metallic particulate matter. Environ. Health Perspect. 110, 985-990.
25. Sato, T., Yamamoto, H., Sawada, N., Nashiki, K., Tsuji, M., Muto, K., Kume, H., Sasaki, H., Arai, H., Nikawa, T., Taketani, Y. and Takeda, E. (2006). Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat. Toxicology 227, 248-261.
26. Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H. (2007). Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J. Biol. Chem. 282, 7522-7531.
27. Thomson, E., Kumarathasan, P., Goegan, P., Aubin, R. A. and Vincent, R. (2005). Differential regulation of the lung endothelin system by urban particulate matter and ozone. Toxicol. Sci. 88, 103-113.
28. Thomson, E.M., Williams, A., Yauk, C.L., and Vincent, R. (2009). Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation. Part. Fibre Toxicol. 6, 6.
29. Tibshirani, R. (2006). A simple method for assessing sample sizes in microarray experiments. BMC. Bioinformatics 7, 106.
30. van Eijl, S., van Oorschot, R., Olivier, B., Nijkamp, F. P. and Bloksma, N. (2006). Stress and hypothermia in mice in a nose-only cigarette smoke exposure system. Inhal. Toxicol. 18, 911-918.
31. Vincent, R., Bjarnason, S. G., Adamson, I. Y., Hedgecock, C., Kumarathasan, P., Guenette, J., Potvin, M., Goegan, P. and Bouthillier, L. (1997). Acute pulmonary toxicity of urban particulate matter and ozone. Am. J. Pathol. 151, 1563-1570.
32. Vincent, R., Kumarathasan, P., Goegan, P., Bjarnason, S. G., Guenette, J., Berube, D., Adamson, I. Y., Desjardins, S., Burnett, R. T., Miller, F. J. and Battistini, B. (2001). Inhalation toxicology of urban ambient particulate matter: Acute cardiovascular effects in rats. Res. Rep. Health Effects Inst. 5-54.
33. Wright, R. J., Rodriguez, M. and Cohen, S. (1998). Review of psychosocial stress and asthma: An integrated biopsychosocial approach. Thorax 53, 1066-1074.
34. Wu, H., Kerr, M. K., Cui, X. and , Churchill, G. A. (2003) MAANOVA: A software package for the analysis of spotted cDNA microarray experiments. In: The analysis of gene expression data: Methods and software (eds G., Parmigiani E. S., Garrett, R. A., Irizarry, and S., Zeger), pp. 313-431. Springer-Verlag, New York.
35. Yang, Y. H., Dudoit, S., Luu, P., Lin, D. M., Peng, V., Ngai, J. and , Speed, T. P. (2002). Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30, e15.
36. Yao, H., Yang, S. R., Edirisinghe, I., Rajendrasozhan, S., Caito, S., Adenuga, D., O'Reilly, M. A. and Rahman, I. (2008). Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS and fMLP in mice. Am. J. Respir. Cell Mol. Biol. 39, 7-18.
37. Yin, D., Zhang, Y., Stuart, C., Miao, J., Zhang, Y., Li, C., Zeng, X., Hanley, G., Moorman, J., Yao, Z. and Woodruff, M. (2006). Chronic restraint stress modulates expression of genes in murine spleen. J. Neuroimmunol. 177, 11-17.