Effect of zeaxanthin and antioxidant supplementation on vascular endothelial growth factor (VEGF) expression in apolipoprotein-e deficient mice

Current Eye Research

Volumn 34, Issue 7, 2009, Pages 543-552

  Fernández Robredo, Patricia ^a   Recalde, Sergio ^a   Arnáiz, Gonzalo ^a   Salinas Alamán, Angel ^b   Sádaba, Luis M ^b   Moreno Orduña, Maite ^a   García Layana, Alfredo ^b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

ApoE mice; Electron microscopy; Oxidative stress; Vascular endothelial growth factor; Zeaxanthin

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN E; ASCORBIC ACID; CHOLESTEROL; ISOPROSTANE DERIVATIVE; TRIACYLGLYCEROL; VASCULOTROPIN; XANTHOPHYLL; ZEAXANTHIN; ZINC SULFATE;

ANIMAL EXPERIMENT; ARTICLE; BASEMENT MEMBRANE; BRUCH MEMBRANE; CHOLESTEROL BLOOD LEVEL; CHOROID; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIET; DIET SUPPLEMENTATION; DRUG EFFECT; ELECTRON MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOGENATE; LIPID PEROXIDATION; LIVER; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RODENT; TRIACYLGLYCEROL BLOOD LEVEL; URINE; WILD TYPE;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; ASCORBIC ACID; BLOTTING, WESTERN; BRUCH MEMBRANE; CHOLESTEROL; CHOROID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; DIETARY SUPPLEMENTS; DINOPROST; HYPERLIPOPROTEINEMIA TYPE III; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED C57BL; RETINA; RETINAL PIGMENT EPITHELIUM; TOCOPHEROLS; TRIGLYCERIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XANTHOPHYLLS; ZINC;

EID: 70350648664     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680902963142     Document Type: Article

References (38)

1. Applegate E. Introduction: Nutritional and functional roles of eggs in the diet. J Am Coll Nutr 2000;19:495S-498S.
2. Loane E, Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, Beatty S. Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration. Surv Ophthalmol 2008;53:68-81.
3. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age-related macular degeneration: Systematic review and meta-analysis. BMJ 2007;335:755. Epub 2007, Oct 2008.
4. Olmedilla B, Granado F, Blanco I, Vaquero M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patientswith age-related cataracts:A2-y double-blind, placebocontrolled pilot study. Nutrition 2003;19:21-24.
5. Landrum JT, Bone RA, Joa H, Kilburn MD, Moore LL, Sprague KE. A one-year study of the macular pigment: The effect of 140 days of a lutein supplement. Exp Eye Res 1997;65:57-62.
6. Pratt S.Dietary prevention of age-related macular degeneration. J Am Optom Assoc 1999;70:39-47.
7. SnodderlyDM. Evidence for protection against age-relatedmacular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 1995;62:1448S-1461S.
8. Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci 2000;41:1200-1209.
9. Khachik F, Bernstein PS, GarlandDL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 1997;38:1802-1811.
10. Delcourt C, Carriere I, Delage M, Barberger-Gateau P, Schalch W. Plasma lutein and zeaxanthin and other carotenoids asmodifiable risk factors for age-relatedmaculopathy and cataract: The POLA Study. Invest Ophthalmol Vis Sci 2006;47:2329-2335.
11. Gale CR, Hall NF, Phillips DI, Martyn CN. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 2003;44:2461-2465.
12. Rodriguez-Rodriguez E, Ortega RM, Lopez-Sobaler AM, Aparicio A, Bermejo LM, Marin-Arias LI. The relationship between antioxidant nutrient intake and cataracts in older people. Int J Vitam Nutr Res 2006;76:359-366.
13. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA 1994;272:1413-1420.
14. Chaine G, Hullo A, Sahel J, et al. Case-control study of the risk factors for age-related macular degeneration. France-DMLA Study Group. Br J Ophthalmol 1998;82:996-1002.
15. Guymer RH, Chong EW.Modifiable risk factors for age-related macular degeneration. Med J Aust 2006;184:455-458.
16. van Leeuwen R, Ikram MK, Vingerling JR, Witteman JC, Hofman A, de Jong PT. Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: The Rotterdam Study. Invest Ophthalmol Vis Sci 2003;44:3771-3777. (Pubitemid 37047945)
17. Ong JM, Zorapapel NC, Rich KA, et al. Effects of cholesterol and apolipoprotein E on retinal abnormalities inApoE-deficient mice. Invest Ophthalmol Vis Sci 2001;42:1891-1900.
18. Dithmar S, Curcio CA, Le NA, Brown S, Grossniklaus HE. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci 2000;41:2035-2042.
19. Kliffen M, Lutgens E, Daemen MJ, de Muinck ED, Mooy CM, de Jong PT. The APO(*)E3-Leiden mouse as an animal model for basal laminar deposit. Br J Ophthalmol 2000;84:1415-1419.
20. Nespereira B, Perez-Ilzarbe M, Fernandez P, Fuentes AM, Paramo JA, Rodriguez JA. Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-Edeficient mice. Atherosclerosis 2003;171:67-73.
21. Group A-REDSR. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS Report No. 9. Arch Ophthalmol 2001;119:1439-1452.
22. Khachik F, deMoura FF, Chew EY, et al. The effect of lutein and zeaxanthin supplementation onmetabolites of these carotenoids in the serum of persons aged 60 or older. Invest Ophthalmol Vis Sci 2006;47:5234-5242.
23. Ortega RM, Palencia A, Lopez-Sobaler AM. Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. Br J Nutr 2006;96 Suppl 1:S89-93.
24. García-Layana A, Śainz C, Ferńandez P, Rodríguez JA. Lipids and age-related macular degeneration. Arch Soc Esp Oftalmol 2001;76:395-396.
25. Evereklioglu C, Er H, Doganay S, et al. Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patientswith age-relatedmacular degeneration. Doc Ophthalmol 2003;106:129-136.
26. Klein R, Klein BE, Tomany SC, Cruickshanks KJ. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology 2003;110:1273-1280.
27. Bartlett He Fau, Eperjesi F, Eperjesi F. A randomized controlled trial investigating the effect of lutein and antioxidant. Clin Nutr 2008;27:218-227. Epub 2008, Mar 2004.
28. BradfordMM.Arapid and sensitivemethod for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
29. Espinosa-Heidmann DG, Sall J, Hernandez EP, Cousins SW. Basal laminar deposit formation in APO B100 transgenic mice: Complex interactions between dietary fat, blue light, and vitamin E. Invest Ophthalmol Vis Sci 2004;45:260-266.
30. Miceli MV, Newsome DA, Tate DJ Jr, Sarphie TG. Pathologic changes in the retinal pigment epithelium and Bruch's membrane of fat-fed atherogenic mice. Curr Eye Res 2000;20:8-16.
31. Dithmar S, Sharara NA, Curcio CA, et al. Murine high-fat diet and laser photochemicalmodel of basal deposits in Bruchmembrane. Arch Ophthalmol 2001;119:1643-1649.
32. Witmer AN, Vrensen GF, Van Noorden CJ, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 2003;22:1-29.
33. Kannan R, Fau-Zhang N, Zhang N, Fau-Sreekumar PG, Sreekumar PG, Fau-Spee CK, et al. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative in polarized retinal pigment epithelial cells. Mol Vis 2006;12:1649-1659.
34. Fernandez-Robredo P, Rodriguez JA, Sadaba LM, Recalde S, Garcia-Layana A. Egg yolk improves lipid profile, lipid peroxidation, and retinal abnormalities in a murine model of genetic hypercholesterolemia. J Nutr Biochem 2008;19:40-48. Epub 2007.
35. Waisbourd M, Loewenstein A, Goldstein M, Leibovitch I. Targeting vascular endothelial growth factor: A promising strategy for treating age-related macular degeneration. Drugs Aging 2007;24:643-662.
36. Izumi-Nagai K, Nagai N, Ohgami K, et al. Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization. Arterioscler Thromb Vasc Biol 2007;27:2555-2562. Epub 2007.
37. Kowluru Ra, Menon B, Gierhart DL. Beneficial effect of zeaxanthin on retinal metablic abnormalities in diabetic. Invest Ophthalmol Vis Sci 2008;49:1645-1651.
38. Espinosa-Heidmann DG, Suner IJ, Catanuto P, Hernandez EP, Marin-Castano ME, Cousins SW. Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. Invest Ophthalmol Vis Sci 2006;47:729-737.