A novel biomimetic polymer scaffold design enhances bone ingrowth

Journal of Biomedical Materials Research - Part A

Volumn 91, Issue 3, 2009, Pages 795-805

  Geffre, Chris P ^a   Margolis, David S ^a   Ruth, John T ^a   DeYoung, Donald W ^b   Tellis, Brandi C ^a   Szivek, John A ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

CT; Biomimetic; Histomorphometry; Polybutylene terephthalate; Scaffolds

Indexed keywords

BIOMIMETIC POLYMERS; BIOMIMETIC SCAFFOLDS; BONE DEFECT; BONE FORMATION; BONE GROWTH; BONE INGROWTH; BONE TISSUE; HISTOMORPHOMETRY; POLYBUTYLENE TEREPHTHALATE; POLYMER SCAFFOLDS; POROUS ARCHITECTURES; SOLID FREE-FORM FABRICATION; TISSUE DEFECTS; TISSUE ENGINEERING APPLICATIONS; TRABECULAR BONES;

BIOMIMETICS; BONE; FUNCTIONAL POLYMERS; HISTOLOGY; POLYMERS; TISSUE ENGINEERING;

SCAFFOLDS;

BIOMIMETIC MATERIAL; POLYMER; TISSUE SCAFFOLD;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GRAFT; BONE GROWTH; CONTROLLED STUDY; EXPERIMENTAL DOG; NONHUMAN; POROSITY; TISSUE ENGINEERING; TRABECULAR BONE;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMIMETICS; BONE AND BONES; BONE SUBSTITUTES; OSTEOBLASTS; OSTEOGENESIS; PHENOTYPE; POLYESTERS; POLYMERS; POROSITY; TIME FACTORS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 70350627275     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32251     Document Type: Article

References (67)

1. Muscolo DL, Ayerza MA, Aponte-Tinao LA, Ranalletta M. Use of distal femoral osteoarticular allografts in limb salvage surgery. Surgical technique. J Bone Joint Surg Am 2006;88(Suppl 1 Part 2):305-321.
2. Sen MK, Miclau T. Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury 2007;38(Suppl 1):S75-S80.
3. Ayerza MA, Aponte-Tinao LA, Abalo E, Muscolo DL. Continuity and function of patellar tendon host-donor suture in tibial allograft. Clin Orthop Relat Res 2006;450:33-38. (Pubitemid 44342112)
4. Johari A, Shingade V, Lobo Gajiwala A, Shah V, C DL. The use of irradiated allograft in a paediatric population: An Indian experience. Cell Tissue Bank 2007;8:13-22.
5. Rajan GP, Fornaro J, Trentz O, Zellweger R. Cancellous allograft versus autologous bone grafting for repair of comminuted distal radius fractures: A prospective, randomized trial. J Trauma 2006;60:1322-1329. (Pubitemid 43916605)
6. Kessler P, Thorwarth M, Bloch-Birkholz A, Nkenke E, Neukam FW. Harvesting of bone from the iliac crest - Comparison of the anterior and posterior sites. Br J Oral Maxillofac Surg 2005;43:51-56. (Pubitemid 40090173)
7. Pacifico MD, Floyd D, Wood SH. Tibial stress fracture as a complication of free-fibula vascularised graft for mandibular reconstruction. Br J Plast Surg 2003;56:832-834. (Pubitemid 37461641)
8. Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C. Persistent iliac crest donor site pain: Independent outcome assessment. Neurosurgery 2002;50:510-516; discussion 516-517. (Pubitemid 36322833)
9. Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 2003;28:134-139. (Pubitemid 36110079)
10. Zimmermann CE, Borner BI, Hasse A, Sieg P. Donor site morbidity after microvascular fibula transfer. Clin Oral Investig 2001;5:214-219.
11. Buck BE, Malinin TI, Brown MD. Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS). Clin Orthop Relat Res 1989:129-136.
12. Lewandrowski KU, Rebmann V, Passler M, Schollmeier G, Ekkernkamp A, Grosse-Wilde H, Tomford WW. Immune response to perforated and partially demineralized bone allografts. J Orthop Sci 2001;6:545-555. (Pubitemid 34019564)
13. Pilliar RM. Porous-surfaced metallic implants for orthopedic applications. J Biomed Mater Res 1987;21(A1 Suppl):1-33.
14. Bush JL, Wilson JB, Vail TP. Management of bone loss in revision total knee arthroplasty. Clin Orthop Relat Res 2006;452:186-192. (Pubitemid 44690667)
15. Kirkpatrick JS, Venugopalan R, Beck P, Lemons J. Corrosion on spinal implants. J Spinal Disord Tech 2005;18:247-251.
16. Goodman SB. Wear particles, periprosthetic osteolysis and the immune system. Biomaterials 2007;28:5044-5048.
17. Parsons JR. Resorbable materials and composites. New concepts in orthopedic biomaterials. Orthopedics 1985;8:907-915.
18. Claase MB, Grijpma DW, Mendes SC, De Bruijn JD, Feijen J. Porous PEOT/PBT scaffolds for bone tissue engineering: Preparation, characterization, and in vitro bone marrow cell culturing. J Biomed Mater Res A 2003;64:291-300. (Pubitemid 37521449)
19. Liu Q, de Wijn JR, van Blitterswijk CA. Composite biomaterials with chemical bonding between hydroxyapatite filler particles and PEG/PBT copolymer matrix. J Biomed Mater Res 1998;40:490-497. (Pubitemid 28182894)
20. Radder AM, Leenders H, van Blitterswijk CA. Interface reactions to PEO/PBT copolymers (Polyactive) after implantation in cortical bone. J Biomed Mater Res 1994;28:141-151. (Pubitemid 24039006)
21. Radder AM, Leenders H, van Blitterswijk CA. Application of porous PEO/PBT copolymers for bone replacement. J Biomed Mater Res 1996;30:341-351. (Pubitemid 26075450)
22. Risbud M, Saheb DN, Jog J, Bhonde R. Preparation, characterization and in vitro biocompatibility evaluation of poly(butylene terephthalate)/wollastonite composites. Biomaterials 2001;22:1591-1597. (Pubitemid 32551908)
23. Sakkers RJ, Dalmeyer RA, de Wijn JR, van Blitterswijk CA. Use of bone-bonding hydrogel copolymers in bone: An in vitro and in vivo study of expanding PEO-PBT copolymers in goat femora. J Biomed Mater Res 2000;49:312-318.
24. Sakkers RJ, de Wijn JR, Dalmeyer RA, van Blitterswijk CA, Brand R. Evaluation of copolymers of polyethylene oxide and polybutylene terephthalate (polyactive): Mechanical behaviour. J Mater Sci Mater Med 1998;9:375-379. (Pubitemid 28344794)
25. Woodfield TB, Bezemer JM, Pieper JS, van Blitterswijk CA, Riesle J. Scaffolds for tissue engineering of cartilage. Crit Rev Eukaryot Gene Expr 2002;12:209-236.
26. Roessler M, Wilke A, Griss P, Kienapfel H. Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects: A clinically relevant pilot study with contrary results to previous animal studies. J Biomed Mater Res 2000;53:167-173. (Pubitemid 30171961)
27. Geffre CP, Bliss CL, Szivek JA, Deyoung DW, Ruth JT, Margolis DS. Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time. J Biomed Mater Res B Appl Biomater 2008;84:263-270.
28. Szivek JA, Bliss CL, Geffre CP, Margolis DS, DeYoung DW, Ruth JT, Schnepp AB, Tellis BC, Vaidyanathan RK. An instrumented scaffold can monitor loading in the knee joint. J Biomed Mater Res B Appl Biomater 2006;79:218-228.
29. Szivek JA, Margolis DS, Garrison BK, Nelson E, Vaidyanathan RK, DeYoung DW. TGF-beta1-enhanced TCP-coated sensate scaffolds can detect bone bonding. J Biomed Mater Res B Appl Biomater 2005;73:43-53. (Pubitemid 40478259)
30. Szivek JA, Roberto RF, Slack JM, Majeed BS. An implantable strain measurement system designed to detect spine fusion: Preliminary results from a biomechanical in vivo study. Spine 2002;27:487-497.
31. Bliss CL, Szivek JA, Tellis BC, Margolis DS, Schnepp AB, Ruth JT. Sensate scaffolds can reliably detect joint loading. J Biomed Mater Res B Appl Biomater 2007;81:30-39.
32. Claase MB, de Bruijn JD, Grijpma DW, Feijen J. Ectopic bone formation in cell-seeded poly(ethylene oxide)/poly(butylene terephthalate) copolymer scaffolds of varying porosity. J Mater Sci Mater Med 2007;18:1299-1307. (Pubitemid 47007601)
33. Goodman S, Toksvig-Larsen S, Aspenberg P. Ingrowth of bone into pores in titanium chambers implanted in rabbits: Effect of pore cross-sectional shape in the presence of dynamic shear. J Biomed Mater Res 1993;27:247-253. (Pubitemid 23027525)
34. Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes. J Biomed Mater Res A 2004;68:187-200. (Pubitemid 38035121)
35. Jones AC, Arns CH, Sheppard AP, Hutmacher DW, Milthorpe BK, Knackstedt MA. Assessment of bone ingrowth into porous biomaterials using MICRO-CT. Biomaterials 2007;28:2491-2504.
36. Klawitter JJ, Bagwell JG, Weinstein AM, Sauer BW. An evaluation of bone growth into porous high density polyethylene. J Biomed Mater Res 1976;10:311-323.
37. Mastrogiacomo M, Scaglione S, Martinetti R, Dolcini L, Beltrame F, Cancedda R, Quarto R. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials 2006;27:3230-3237. (Pubitemid 43348525)
38. Bobyn JD, Pilliar RM, Cameron HU, Weatherly GC. The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Orthop Relat Res 1980:263-270.
39. Flautre B, Descamps M, Delecourt C, Blary MC, Hardouin P. Porous HA ceramic for bone replacement: Role of the pores and interconnections - Experimental study in the rabbit. J Mater Sci Mater Med 2001;12:679-682. (Pubitemid 32826376)
40. Oh SH, Park IK, Kim JM, Lee JH. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 2007;28:1664-1671.
41. Robinson BP, Hollinger JO, Szachowicz EH, Brekke J. Calvarial bone repair with porous D,L-polylactide. Otolaryngol Head Neck Surg 1995;112:707-713.
42. Hollister SJ, Levy RA, Chu TM, Halloran JW, Feinberg SE. An image-based approach for designing and manufacturing craniofacial scaffolds. Int J Oral Maxillofac Surg 2000;29:67-71.
43. Hollister SJ, Maddox RD, Taboas JM. Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials 2002;23:4095-4103.
44. Shi T, Yue X, Xiong Z, Zhang R, Yan Y. Rapid manufacturing of degradable porous polymer bone scaffold. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2002;19:348-349.
45. Tellis BC, Szivek JA, Bliss CL, Margolis DS, Vaidyanathan RK, Calvert P. Trabecular scaffolds created using micro CT guided fused deposition modeling. J Mater Sci Eng-C 2008;28:171-178. (Pubitemid 350297869)
46. Cordaro NM, Szivek JA, DeYoung DW. Surface enhancements accelerate bone bonding to CPC-coated strain gauges. J Biomed Mater Res 2001;56:109-119.
47. Rabkin BA, Szivek JA, Schonfeld JE, Halloran BP. Long-term measurement of bone strain in vivo: The rat tibia. J Biomed Mater Res 2001;58:277-281.
48. Szivek JA, Anderson PL, DeYoung DW. In vivo strain measurements collected using calcium phosphate ceramic-bonded strain gauges. J Invest Surg 1997;10:263-273.
49. Battraw GA, Szivek JA, Anderson PL. Interface strength studies of calcium phosphate ceramic coated strain gauges. J Biomed Mater Res 1998;43:462-468.
50. Szivek JA, Nelson ER, Hajdu SD, Yablonski K, DeYoung DW. Transforming growth factor-beta1 accelerates bone bonding to a blended calcium phosphate ceramic coating: A dose-response study. J Biomed Mater Res A 2004;68:537-543. (Pubitemid 38250375)
51. Emmanual J, Hornbeck C, Bloebaum RD. A polymethyl methacrylate method for large specimens of mineralized bone with implants. Stain Technol 1987;62:401-410.
52. Martini F, Leichtle U, Lebherz C. Optimized polymethyl methacrylate-embedding enables exact section examination of the femur with an uncemented femoral stem. Z Orthop Ihre Grenzgeb 2001;139:531-535. (Pubitemid 34048761)
53. Parfitt AM. Bone histomorphometry: Proposed system for standardization of nomenclature, symbols, and units. Calcif Tissue Int 1988;42:284-286.
54. Kuhn JL, Goldstein SA, Ciarelli MJ, Matthews LS. The limitations of canine trabecular bone as a model for human: A biomechanical study. J Biomech 1989;22:95-107.
55. Fan H, Ikoma T, Tanaka J, Zhang X. Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterials. J Nanosci Nanotechnol 2007;7:808-813.
56. Tuzlakoglu K, Bolgen N, Salgado AJ, Gomes ME, Piskin E, Reis RL. Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering. J Mater Sci Mater Med 2005;16:1099-1104. (Pubitemid 41803733)
57. Simon JL, Michna S, Lewis JA, Rekow ED, Thompson VP, Smay JE, Yampolsky A, Parsons JR, Ricci JL. In vivo bone response to 3D periodic hydroxyapatite scaffolds assembled by direct ink writing. J Biomed Mater Res A 2007;83:747-758.
58. Wang H, Li Y, Zuo Y, Li J, Ma S, Cheng L. Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering. Biomaterials 2007;28:3338-3348. (Pubitemid 46693973)
59. Woo KM, Jun JH, Chen VJ, Seo J, Baek JH, Ryoo HM, Kim GS, Somerman MJ, Ma PX. Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 2007;28:335-343. (Pubitemid 44537377)
60. Chen VJ, Smith LA, Ma PX. Bone regeneration on computer-designed nano-fibrous scaffolds. Biomaterials 2006;27:3973-3979.
61. Szivek JA, Geffre CP, Margolis DS, Deyoung DW, Ruth JT, Harris DT. A cartilage covered "sensate" scaffold can be used to measure knee load changes in vivo following ACL disruption. 6th Combined Meeting of the Orthopaedic Research Societies; 2007 October; Honolulu, Hawaii.
62. Lee DA, Bader DL. Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res 1997;15:181-188.
63. Neidlinger-Wilke C, Grood ES, Wang J-C, Brand RA, Claes L. Cell alignment is induced by cyclic changes in cell length: Studies of cells grown in cyclically stretched substrates. J Orthop Res 2001;19:286-293. (Pubitemid 32331705)
64. Smith RL, Lin J, Trindade MC, Shida J, Kajiyama G, Vu T, Hoffman AR, van der Meulen MC, Goodman SB, Schurman DJ, Carter DR. Time-dependent effects of intermittent hydrostatic pressure on articular chondrocyte type II collagen and aggrecan mRNA expression. J Rehabil Res Dev 2000;37:153-161. (Pubitemid 30641243)
65. Waldman SD, Couto DC, Grynpas MD, Pilliar RM, Kandel RA. A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage. Osteoarthritis Cartilage 2006;14:323-330.
66. Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Hong J, Kandel RA. Effect of biomechanical conditioning on cartilaginous tissue formation in vitro. J Bone Joint Surg Am A 2003;85 (Suppl 2):101-105. (Pubitemid 36535051)
67. Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA. Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage. Tissue Eng 2004;10(9/10):1323-1331.