Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects: A clinically relevant pilot study with contrary results to previous animal studies

Journal of Biomedical Materials Research

Volumn 53, Issue 2, 2000, Pages 167-173

  Roessler, M ^a   Wilke, A ^a   Griss, P ^a   Kienapfel, Heino ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Bone defect; Bone ingrowth; Osteoconductive material; POLYACTIVE ; Resorbable polymer

Indexed keywords

BIOMATERIAL; COPOLYMER; MACROGOL; POLYETHYLENE TEREPHTHALATE;

ANTERIOR SPINE FUSION; ARTICLE; BONE CONDUCTION; BONE DEFECT; BONE GRAFT; BONE GROWTH; BONE PROSTHESIS; BONE REGENERATION; CLINICAL ARTICLE; FEMALE; HUMAN; ILIAC BONE; MALE; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; THREE DIMENSIONAL IMAGING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE REGENERATION; BONE SUBSTITUTES; FEMALE; HUMANS; ILIUM; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; PILOT PROJECTS; POLYESTERS; POLYETHYLENE GLYCOLS; SPINAL FUSION; SPINE; TOMOGRAPHY, X-RAY COMPUTED; TRANSPLANTATION, AUTOLOGOUS;

EID: 0034065220     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(2000)53:2<167::AID-JBM6>3.0.CO;2-J     Document Type: Article

References (51)

1. Andersson OH, Kansagniemi I. Calcium phosphate formation at the surface of bioactive glass in vitro. J Biomed Mater Res 1991;25:1019-1030.
2. Bakker D, van Blitterswijk CA, Hesseling SC, Daems WT Grote JJ. Tissue/biomaterial interface characteristics of four elstomers. A transmission electron microscopical study. J Biomed Mater Res 1990;24:277-293.
3. Bakker D, van Blitterswijk CA, Hesseling SC, Koerten HK, Kuijpers W, Grote JJ. Biocompatibility of a polyether urethane, polypropylene oxide and a polyether polyester coplymer. A qualitative and quantitative study of three alloplastic tympanic membrane materials in the rat middle ear. J Biomed Mater Res 1990;24:489-515.
4. van Blitterswijk CA, van den Brink J, Leenders H, Bakker D. The effect of PEO ratio on degradation, calcification and bone bonding of PEO/PBT copolymer (Polyactive). Cells Mater 1993;3:23-36.
5. van Blitterswijk CA, de Wijn JR, Leenders H, van den Brink J, Hesseling SC, Bakker D. A comparative study of the interactions of two calcium phosphates, PEO/PBT copolymer (Polyactive) and a silicone rubber with bone and fibrous tissue. Cells Mater 1993;3:11-22.
6. Bobyn JD, Pilliar RM, Cameron HU, Weatherly GC. The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Ortho 1980;150:263-270.
7. de Bruijn JD, Klein CPAT, de Grot K, van Blitterswijk CA. The ultrastructure of the hydroxyapatite interface in vitro. J Biomed Mater Res 1992;26:1365-1382.
8. Bulstra SK, Geesink RGT, Bakker D, Bulstra TH, Bouwmeester SJM, van der Linden AJ. Femoral canal occlusion in total hip replacement using a resorbable and flexible cement restrictor. J Bone Joint Surg Br 1996;78-B:892-898.
9. Dalton JE, Cook SD, Thomas KA, Kay JF. The effect of operative fit and hydroxyapatite coating on the mechanical and biological response to porous implants. J Bone Joint Surg Am 1995;77-A:97-110.
10. Gaillard ML, van den Brink J, van Blitterswijk CA, Luklinska ZB. Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo. J Mater Sci Mater Med 1994;5:424-428.
11. Gerngross H, Burri C, Kinzl L, Merk J, Müller GW. Komplikationen an den Entnahmestellen autologer Spongiosatransplantate. Akt Traumatol 1982;12:146-152.
12. Gotzen L. Weichteildefektsanierung durch autologe Spongiosa. Chirurg 1974;45:286-288.
13. Grob D. Probleme an der Entnahmestelle bei autologer Knochentransplantation. Unfallchirurg 1986;89:339-345.
14. Grote JJ, Bakker D, Hesseling SC, van Blitterswijk CA. New alloplastic tympnic membrane material. Am J Otol 1991;12: 329-335.
15. van Haastert RM, Grote JJ, van Blitterswijk CA. Osteoinduction within PEO/PBT copolymer implants in cranial defects using demineralized bone matrix. J Mater Sci Mater Med 1994;5: 764-769.
16. Hanft JR, Sprinkle RW, Surprenant MS, Werd MB. Implantable bone substitute materials. Clin Podia Med Surg 1995;12:437-455.
17. Hench LL, Splinter RJ, Allen WC, Greenlee TK. Bonding mechanism at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 1972;4:117-141.
18. Hirschfelder H. Dreidimensionale Oberflächenrekonstruktion aus computertomographischen Schnittbildern. Orthopäde 1989; 18:18-23.
19. Hürzeler MB, Einsele F, Leupolz M, Schmitz HJ, Strub JR. Bone augmentation using a synthetic bone graft in dogs. J Oral Rehab 1994;21:373-382.
20. Jensen SS, Aaboe M, Pinholt EM, Hansen HE, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants 1996;11:55-66.
21. Johner R. Zur Knochenheilung in Abhängigkeit von der Defektgröße. Helv Chir Acta 1972;39:409-411.
22. Kienapfel H, Griss P. Fixation by ingrowth. In: Callaghan JJ, Rosenberg AG, Rubash HE, editors. The adult hip. Philadelphia: Lippincott-Raven; 1998. p 201-209.
23. Kienapfel H, Sumner DR, Turner TM, Urban RM, Galante JO. Efficacy of autograft and freeze-dried allograft to enhance fixation of porous coated implants in the presence of interface gaps. Ortho Res 1992;10:423-433.
24. Klawitter JJ, Bagwell JG, Weinstein AM, Sauer BW, Pruitt JR. An evaluation of bone growth into porous high density polyethylene. J Biomed Mater Res 1976;10:311-323.
25. Kleinschmidt JC, Hollinger JO. Animal models in bone research. In: Habal MB, Reddi AH, editors. Bone grafts & bone substitutes. Philadelphia, London, Toronto: Saunders; 1992. p 133-146.
26. Kokubo T, Kushitani H, Ohtsuki C, Sakka S, Yamamuro T. Effects of ions dissolved from bioactive glass-ceramic on surface apatite formation. J Mater Sci Mater Med 1993;4:1-4.
27. Kummer B. Grundlagen der Pauwels-Theorie der funktionellen Anpassung des Knochens. Orthopäde 1995;24:387-393.
28. Kuner EH. Zur Leistungsfähigkeit autologer Spongiosa bei der Behandlung knöcherner Defekte. Mschr Unfallheilk 1972;75: 189-202.
29. Kurth A, Wassum P, Dietz U, Scale D. Dreidimensionale Darstellung der Becken- und Hüftregion am Computer zur präoperativen Planung von orthopädischen Eingriffen und Operationssimulation. Z Ortho 1997;135:120-123.
30. Li P, Bakker D, van Blitterswijk CA. The bone-bonding polymer Polyactive 80/20 induces hydroxycarbonate apatite formation in vitro. J Biomed Mater Res 1997;34:79-86.
31. van Loon JA, Leenders H, Goedemoed JH, van Blitterswswijk CA. Tissue reactions during long-term implantation in relation to degradation. A study of a range of PEO/PBT copolymers. Boston: Abstr 20th Ann Meet Soc Biomater; 1994. p 370.
32. Mandelkow HK, Hallfeldt KKJ, Kessler SB, Gayk M, Siebeck M, Schweiberer L. Knochenneubildung nach Implantation verschiedener Hydroxylapatitkeramiken. Unfallchirurg 1990;93: 376-379.
33. Meijer GJ, van Dooren A, Gaillard ML, Dalmeijer R, de Putter C, van Blitterswijk CA. Polyactive as a bone-filler in a beagle dog model. Int J Oral Maxillofac Surg 1996;25:210-216.
34. Meijer GJ, Starmans FJ, de Putter C, van Blitterswijk CA. The influence of a flexible coating on the bone stress around dental implants. J Oral Rehab 1995;22:105-111.
35. Mittelmeier H, Katthagen BD. Neue Wege des Knochenersatzes. Ortho Praxis 1984;20:389.
36. Mittelmeier W, Braun C, Gradinger R. Defektfrakturen am Unterschenkel - verschiedene Knochenersatzformen. Chirurg 1996;67:1087-1092.
37. Müller GW. Beschwerden und Komplikationen nach Spongiosaentnahmen am Becken. KlinischeStudie an 1000 Patienten. Med Dissertation, Univ Ulm: 1983.
38. Okumura M, van Blitterswijk CA, Koerten HK, Bakker D, de Groot K, Ohgushi H. Osteogenic response of bone marrow cells in porous Polyactive, a priliminary report. In: Doherty PJ et al., editors. Advances in biomaterials. Vol. 10. Amsterdam: Elsevier; 1992. p 343-347.
39. Rudder AM, van Blitterswijk CA. Abundant postoperative calcification of an elastomer: matrix calcium phosphate-polymer composite for bone reconstruction. J Mater Sci Mater Med 1994;5:320-325.
40. Radder AM, Davies JE, Leenders H, van Blitterswijk CA. Interfacial behavior of PEO/PBT copolymers (Polyactive) in a calvarial system: An in vitro study. J Biomed Mater Res 1994; 28:269-277.
41. Radder AM, Davies JE, Sodhi RNS, van der Meer SAT, Wolke JGC, van Blitterswijk CA. Post-operative carbonate-apatite formation in PEO/PBT copolymers (Polyactive). Cells Mater 1995;5:55-62.
42. Radder AM, Leenders H, van Blitterswijk CA. Application of porous PEO/PBT copolymers for bone replacement. J Biomed Mater Res 1996;30:341-351.
43. Radder AM, Leenders H, van Blitterswijk CA. Interface reactions to PEO/PBT copolymers (Polyactive) after implantation in cortical bone. J Biomed Mater Res 1994;28:141-151.
44. Rawlinson JN. Morbidity after anterior cervical decompression and fusion. The influence of the donor site on recovery, and the results of a trial of surgibone compared to autologous bone. Acta Neurochir Wien 1994;131:106-118.
45. Roesgen M. Die Regenerationsfähigkeit des Beckenkammes nach Spongiosaentnahme beim Menschen - Induktion durch Phosphatkeramiken? Teil 1. Unfallchirurg 1990;16:258-265.
46. Roesgen M. Die Regenerationsfähigkeit des Beckenkammes nach Spongiosaentnahme beim Menschen - Induktion durch Phosphatkeramiken? Teil 2. Unfallchirurg 1991;17:44-59.
47. Rueger JM. Knochenersatzmittel. State of the art und: Wohin gehen wir? Unfallchirurg 1996;99:228-236.
48. Sakkers RJB, Dalmeyer RAJ, Rozing PM, van Blitterswijk CA. Assessment of bioactivity for orthopedic coatings in a gap-healing model. J Biomed Mater Res 1997;36:265-273.
49. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Ortho 1986;205:299-308.
50. Soost F. Biocoral - ein alternativer Knochenersatz. Chirurg 1996;67:1193-1196
51. Thoma RJ, Hung TQ, Nyilas E, Haubold AO, Phillips RE. Metal ion complexation of poly(ester) urethanes. In: Gebelein CG, editor. Advances in biomedical polymers. New York: Plenum: 1987. p 131-145.