Neuromedin B induces angiogenesis via activation of ERK and Akt in endothelial cells

Experimental Cell Research

Volumn 315, Issue 19, 2009, Pages 3359-3369

  Park, Hyun Joo ^a   Kim, Su Ryun ^a   Bae, Soo Kyung ^b   Choi, Yoon Kyung ^c   Bae, Yun Hee ^b   Kim, Eok Cheon ^d   Kim, Woo Jean ^d   Jang, Hye Ock ^a   Yun, Il ^a   Kim, Young Myeong ^c   Bae, Moon Kyoung ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

^d Inha University School of Medicine   (South Korea)

Author keywords

Akt; Angiogenesis; Endothelial nitric oxide synthase (eNOS); Neuromedin B (NMB); Vascular endothelial cells

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROMEDIN B; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR DISEASE;

MAMMALIA; RATTUS;

EID: 70350617693     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.08.009     Document Type: Article

References (39)

1. Carmeliet P. Angiogenesis in health and disease. Nat. Med. 9 (2003) 653-660
2. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
3. Ribatti D., Conconi M.T., and Nussdorfer G.G. Nonclassic endogenous novel [corrected] regulators of angiogenesis. Pharmacol. Rev. 59 (2007) 185-205
4. Gonzalez N., Moody T.W., Igarashi H., Ito T., and Jensen R.T. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states. Curr. Opin. Endocrinol. Diabetes Obes. 15 (2008) 58-64
5. Ohki-Hamazaki H., Iwabuchi M., and Maekawa F. Development and function of bombesin-like peptides and their receptors. Int. J. Dev. Biol. 49 (2005) 293-300
6. Qu X., Xiao D., and Weber H.C. Biologic relevance of mammalian bombesin-like peptides and their receptors in human malignancies. Curr. Opin. Endocrinol. Diabetes 10 (2003) 60-71
7. Preston S.R., Miller G.V., and Primrose J.N. Bombesin-like peptides and cancer. Crit. Rev. Oncol. Hematol. 23 (1996) 225-238
8. Patel O., Shulkes A., and Baldwin G.S. Gastrin-releasing peptide and cancer. Biochim. Biophys. Acta 1766 (2006) 23-41
9. Martinez A., Zudaire E., Julian M., Moody T.W., and Cuttitta F. Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. Oncogene 24 (2005) 4106-4113
10. Matusiak D., Glover S., Nathaniel R., Matkowskyj K., Yang J., and Benya R.V. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2005) G718-G728
11. Moody T.W., Fagarasan M., Zia F., and Neuromedin B. stimulates arachidonic acid release, c-fos gene expression, and the growth of C6 glioma cells. Peptides 16 (1995) 1133-1140
12. Cardona C., Rabbitts P.H., Spindel E.R., Ghatei M.A., Bleehen N.M., Bloom S.R., and Reeve J.G. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cancer Res. 51 (1991) 5205-5211
13. 2+ and phosphoinositides. Biochem. J. 286 Pt. 2 (1992) 641-648
14. Vigne P., Feolde E., Van Renterghem C., Breittmayer J.P., and Frelin C. Properties and functions of a neuromedin-B-preferring bombesin receptor in brain microvascular endothelial cells. Eur. J. Biochem. 233 (1995) 414-418
15. Dong G., Chen Z., Li Z.Y., Yeh N.T., Bancroft C.C., and Van Waes C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 61 (2001) 5911-5918
16. Lee S.J., Namkoong S., Kim Y.M., Kim C.K., Lee H., Ha K.S., Chung H.T., Kwon Y.G., and Kim Y.M. Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H2836-H2846
17. Kim S.R., Bae S.K., Choi K.S., Park S.Y., Jun H.O., Lee J.Y., Jang H.O., Yun I., Yoon K.H., Kim Y.J., Yoo M.A., Kim K.W., and Bae M.K. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem. Biophys. Res. Commun. 357 (2007) 150-156
18. Rikitake Y., Hirata K., Kawashima S., Ozaki M., Takahashi T., Ogawa W., Inoue N., and Yokoyama M. Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 108-114
19. Murohara T., Asahara T., Silver M., Bauters C., Masuda H., Kalka C., Kearney M., Chen D., Symes J.F., Fishman M.C., Huang P.L., and Isner J.M. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J. Clin. Invest. 101 (1998) 2567-2578
20. Ziche M., and Morbidelli L. Nitric oxide and angiogenesis. J. Neuro-oncol. 50 (2000) 139-148
21. Erspamer V. Discovery, isolation, and characterization of bombesin-like peptides. Ann. N. Y. Acad. Sci. 547 (1988) 3-9
22. Minamino N., Kangawa K., and Matsuo H. Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 114 (1983) 541-548
23. Weber H.C. Regulation and signaling of human bombesin receptors and their biological effects. Curr. Opin. Endocrinol. Diabetes Obes. 16 (2009) 66-71
24. Carroll R.E., Matkowskyj K.A., Tretiakova M.S., Battey J.F., and Benya R.V. Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. Cell Growth Differ 11 (2000) 385-393
25. Kang J., Ishola T.A., Baregamian N., Mourot J.M., Rychahou P.G., Evers B.M., and Chung D.H. Bombesin induces angiogenesis and neuroblastoma growth. Cancer Lett. 253 (2007) 273-281
26. Moody T.W., Jensen R.T., Garcia L., Leyton J., and Nonpeptide neuromedin B. receptor antagonists inhibit the proliferation of C6 cells. Eur. J. Pharmacol 409 (2000) 133-142
27. Ohki-Hamazaki H., and Neuromedin B. Prog. Neurobiol. 62 (2000) 297-312
28. Kroog G.S., Sainz E., Worland P.J., Akeson M.A., Benya R.V., Jensen R.T., and Battey J.F. The gastrin-releasing peptide receptor is rapidly phosphorylated by a kinase other than protein kinase C after exposure to agonist. J. Biol. Chem. 270 (1995) 8217-8224
29. Benya R.V., Wada E., Battey J.F., Fathi Z., Wang L.H., Mantey S.A., Coy D.H., and Jensen R.T. Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors. Mol. Pharmacol. 42 (1992) 1058-1068
30. Lach E.B., Broad S., and Rozengurt E. Mitogenic signaling by transfected neuromedin B receptors in Rat-1 cells. Cell Growth Differ. 6 (1995) 1427-1435
31. Charlesworth A., and Rozengurt E. Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells. Oncogene 14 (1997) 2323-2329
32. Shu X., Wu W., Mosteller R.D., and Broek D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22 (2002) 7758-7768
33. Alemany R., van Koppen C.J., Danneberg K., Ter Braak M., and Meyer Zu Heringdorf D. Regulation and functional roles of sphingosine kinases, Naunyn Schmiedebergs Arch. Pharmacology 374 (2007) 413-428
34. Sessa W.C. The nitric oxide synthase family of proteins. J. Vasc. Res. 31 (1994) 131-143
35. Tai S.C., Robb G.B., and Marsden P.A. Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 405-412
36. Fukumura D., Gohongi T., Kadambi A., Izumi Y., Ang J., Yun C.O., Buerk D.G., Huang P.L., and Jain R.K. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 2604-2609
37. Min J.K., Cho Y.L., Choi J.H., Kim Y., Kim J.H., Yu Y.S., Rho J., Mochizuki N., Kim Y.M., and Oh G.T. Y.G. Kwon, Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice. Blood 109 (2007) 1495-1502
38. Bucci M., Roviezzo F., Posadas I., Yu J., Parente L., Sessa W.C., Ignarro L.J., and Cirino G. Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 904-908
39. Fong T.A., Shawver L.K., Sun L., Tang C., App H., Powell T.J., Kim Y.H., Schreck R., Wang X., Risau W., Ullrich A., Hirth K.P., and McMahon G. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 59 (1999) 99-106