Pigment epithelium-derived factor inhibits advanced glycation end-product-induced angiogenesis and stimulates apoptosis in retinal endothelial cells

Life Sciences

Volumn 85, Issue 21-22, 2009, Pages 719-731

  Sheikpranbabu, Sardarpasha ^a   Haribalaganesh, Ravinarayanan ^a   Banumathi, Elayappan ^a   Sirishkumar, Namagiri ^b   Lee, Kyung Jin ^c   Gurunathan, Sangiliyandi ^a  

^a KALASALINGAM UNIVERSITY   (India)

^b Meenakshi Mission Hospital   (India)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Advanced glycation end products (AGEs); Angiogenesis; Apoptosis; Caspase 3; Diabetic retinopathy; Pigment epithelium derived factor (PEDF)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADVANCED GLYCATION END PRODUCT; BOVINE SERUM ALBUMIN; CASPASE 3; DNA FRAGMENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ASSAY; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PLASMID; RETINA; SIGNAL TRANSDUCTION; SWINE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CATTLE; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; DNA FRAGMENTATION; ENDOTHELIUM; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCOSYLATION END PRODUCTS, ADVANCED; MORPHOLINES; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTORS; PROTO-ONCOGENE PROTEINS C-AKT; RETINA; SERPINS; SERUM ALBUMIN, BOVINE; SWINE;

BOVINAE; SUS;

EID: 70350596205     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.09.015     Document Type: Article

References (49)

1. Alessi D.R., Caudwell F.B., Andjelkovic M., Hemmings B.A., and Cohen P. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Letters 399 (1996) 333-338
2. Banumathi E., Haribalaganesh R., Sheik Pran Babu S., Sirish Kumar N., and Sangiliyandi G. High-yielding enzymatic method for isolation and culture of microvascular endothelial cells from bovine retinal blood vessels. Microvascular Research 77 (2009) 377-381
3. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., and Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96 (1999) 857-868
4. Cha S.T., Talavera D., Demir E., Nath A.K., and Sierra-Honigmann M.R. A method of isolation and culture of microvascular endothelial cells from mouse skin. Microvascular Research 70 (2005) 198-204
5. Chen L., Zhang S.S., Barnstable C.J., and Tombran-Tink J. PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases. Biochemical and Biophysical Research Communications 348 (2006) 1288-1295
6. Chibber R., Molinatti P.A., Rosatto N., Lambourne B., and Kohner E.M. Toxic action of advanced glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy. Diabetologia 40 (1997) 156-164
7. Cohen J., Sugita Y., Chader G.J., and Schwartz J.P. Recombinant forms of the neurotrophic factor pigment epithelium-derived factor activate cellular metabolism and inhibit proliferation of the RAW macrophage cell line. Neuroimmunomodulation 7 1 (2000) 51-58
8. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: A play in three Akts. Genes and Development 13 (1999) 2905-2927
9. Dawson D.W., Volpert O.V., Gillis P., Crawford S.E., Xu H., Benedict W., and Bouck N.P. Pigment epithelium derived factor: a potent inhibitor of angiogenesis. Science 285 (1999) 245-248
10. Duh E.J., Yang H.S., Suzuma Y.I., Miyagi M., Youngman E., Mori K., Katai M., Yan L., Suzuma K., West K., Davarya S., Tong P., Gehlbach P., Pearlman J., Crabb J.W., Aiello L.P., Campochiaro P.A., and Zack D.J. Pigment epithelium derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Investigative Ophthalmology and Visual Science 43 3 (2002) 821-829
11. Frye C.A., and Patrick C.W. Isolation and culture of rat microvascular endothelial cells. Invitro Cell Developmental Biology - Animal 38 (2002) 208-212
12. Goldin A., Beckman J.A., Schmidt A.M., and Creager M.A. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114 (2006) 597-605
13. Hori O., Brett J., Slattery T., Cao R., Zhang J., Chen J.X., Nagashima M., Lundh E.R., Vijay S., Nitecki D., Morser J., Stern D., and Schmidt A.M. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Journal of Biological Chemistry 270 (1995) 25752-25761
14. Hutching H., Maitre-Boube M., Tombran-Tink J., and Plouet J. Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes. Biochemical and Biophysical Research Communications 294 (2002) 764-769
15. Jiang B.H., Zheng J.Z., Aoki M., and Vogt P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proceedings of the National Academy of Sciences USA 97 (2000) 1749-1753
16. Kaji Y., Amano S., Usui T., Oshika T., Yamashiro K., Ishida S., Suzuki K., Tanaka S., Adamis A., Nagai R., and Horiuchi S. Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells. Investigative Ophthalmology and Visual Science 44 (2003) 521-528
17. Lander H.M., Tauras J.M., Ogiste J.S., Hori O., Moss R.A., and Schmidt A.M. Activation of the receptor for advanced glycation end products triggers a p21 ras dependent mitogen-activated protein kinase pathway regulated by oxidant stress. Journal of Biological Chemistry 272 (1997) 17810-17814
18. Moore T.C.B., Moore J.E., Haji Y., Frizzell N., Usui T., Poulaki V., Campbell I.L., Stitt A.W., Gardiner T.A., Archer D.B., and Adamis A.P. The role of advanced glycation end products in retinal microvascular leukostatis. Investigative Ophthalmology and Visual Science 44 (2003) 4457-4464
19. Nakae J., Park B.C., and Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway. Journal of Biological Chemistry 274 (1999) 15982-15985
20. Ren J.G., Jie C., and Talbot C. How PEDF prevents angiogenesis: a hypothesized pathway. Medical Hypothesis 64 (2005) 74-78
21. Rena G., Guo S.D., Cichy S.C., Unterman T.G., and Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. Journal of Biological Chemistry 274 (1999) 17179-17183
22. Sakata N., Meng J., and Takebayashi S. Effects of advanced glycation end products on the proliferation and fibronectin production of smooth muscle cells. Journal of Atherosclerosis and Thrombosis 7 (2000) 169-176
23. Shaul Y.D., and Seger R. The MEK/ ERK cascade: from signaling specificity to diverse functions. Biochimica et Biophysica Acta 1773 (2007) 1213-1226
24. Spranger J., Osterhoff M., Reimann M., Mohlig M., Ristow M., Francis M.K., Cristofalo V., Hammes H.P., Smith G., Boulton M., and Pfeiffer F.H. Loss of anti-angiogenic pigment epithelium derived factor in patients with angiogenic eye disease. Diabetes 50 (2002) 2641-2645
25. Stitt A.W., Bhaduri T., McMullen C.B., Gardiner T.A., and Archer D.B. Advanced glycation end products induce blood-retinal barrier dysfunction in normoglycemic rats. Molecular Cell Biology Research Communications 3 (2000) 380-388
26. Stitt A.W., and Curtis T.M. Advanced glycation and retinal pathology during diabetes. Pharmacological Reports 57 (2005) 156-168
27. Stitt A.W., McGoldrick C., Rice-McCaldin A., McCance D.R., Glenn J.V., Hsu D.K., Liu F.T., Throrpe S.R., and Gardiner T.A. Impaired retinal angiogenesis in diabetes: role of advanced glycation end products and galectin-3. Diabetes 53 (2005) 785-794
28. Su T., and Gilles M.C. A simple method for the invitro culture of human retinal capillary endothelial cells. Investigative Ophthalmology and Visual Science 33 (1992) 2809-2813
29. Su X., Sorenson C.M., and Sheibani N. Isolation and characterization of murine retinal endothelial cells. Molecular Vision 9 (2003) 171-178
30. Sugita Y., Becerra S.P., Chader G.J., and Schwartz J.P. Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. Journal of Neuroscience Research 49 6 (1997) 710-718
31. Tanaka N., Yonekura H., Yamagishi S., Fujimori H., Yamamoto Y., and Yamamoto H. The receptor for advanced glycation end products is induced by glycation products themselves and tumor necrosis factor-α through nuclear factor-κB and by 17β-estradiol through sp-1 in human vascular endothelial cells. Journal of Biological Chemistry 275 (2000) 25781-25790
32. Tang E.D., Nunez G., Barr F.G., and Guan K.L. Negative regulation of the forkhead transcription factor FKHR by Akt. Journal of Biological Chemistry 274 (1999) 16741-16746
33. Testa J.R., and Bellacosa A. AKT plays a central role in tumorigenesis. Proceedings of the National Academy of Sciences USA 98 (2001) 10983-10985
34. Tezuka M., Koyama N., Morisaki N., Saito Y., Yoshida S., Araki N., and Horiuchi S. Angiogenic effects of advanced glycation end products of the maillard reaction on cultured human umbilical cord vein endothelial cells. Biochemical and Biophysical Research Communications 193 2 (1993) 674-680
35. Toker A., and Cantly L.C. Signaling through the lipid products of phosphoinositide-3-OH kinase. Nature 387 (1997) 673-676
36. Tombran-Tink J., and Barnstable C.J. Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends in Molecular Medicine 9 (2003) 244-250
37. Triens C., Peraldi S.G., Murdaca J., and Obberghen E.V. Regulation of vascular endothelial growth factor expression by advanced glycation end products. Journal of Biological Chemistry 276 (2001) 43836-43841
38. Volpert O.V., Zaichuk T., Zhou W., Reiher F., Ferguson T.A., and Stuart M. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nature Medicine 8 (2002) 349-357
39. Wanger D.D., Olmsted J.B., and Marder V.J. Immunolocalization of von willebrand protein in weilbel-palade bodied of human endothelial cells. Journal of Biological Chemistry 95 (1982) 355-360
40. Wautier J.L., and Guillausseau P.J. Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metabolism (Paris) 21 (2001) 535-542
41. Wong H.C., Boulton M., Marshall J., and Clark P. Growth of retinal capillary endothelial using pericyte conditioned medium. Investigative Ophthalmology and Visual Science 28 (1987) 1767-1775
42. Yamagishi S., Matsui T., Inagaki Y., Nakamura K., Takeuchi M., Inoue H., Yoshida Y., and Imaizumi T. Pigment epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats. Ophthalmic Research 39 (2007) 92-97
43. Yamagishi S., Nakamura K., Matsui T., Inagaki Y., Takenaka K., Jinnouchi Y., Yoshida Y., Matasuura T., Narama I., Motomiya Y., Takeuchi M., Inoue H., and Yoshimura A. Bacula R, Imaizumi T. Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression. Journal of Biological Chemistry 281 (2006) 20213-20220
44. Yamagishi S., Takeuchi M., Inagaki Y., Nakamura K., Yoshida T., and Imaizumi T. Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. International Journal of Clinical and Pharmacological Research 23 (2003) 129-134
45. Yamagishi S., Yonekura H., Yamamoto Y., Katsuno K., Sato F., Mita I., Ooka H., Satozawa N., Kawakami T., Nomura M., and Yamamoto H. Advanced glycation end products-driven angiogenesis invitro. Journal of Biological Chemistry 272 (1997) 8723-8730
46. Yan S.D., Schmidt A.M., Anderson M., Zhang J., Bertt J., Zou Y.S., Pinsky D., and Stern D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. Journal of Biological Chemistry 269 (1994) 9889-9897
47. Yan Q., Vernon R.B., Hendrickson A.E., and Sage E.H. Primary culture and characterization of microvascular endothelial cells from macaca monkey retina. Investigative Ophthalmology and Visual Science 37 (1996) 2185-2194
48. Yoshida T., Yamagishi S., Nakamura K., Matsui T., Imaizumi T., Takeuchi M., Ueno T., and Sata M. Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end-product (AGE)-induced C-reactive protein expression in hepatoma cells by suppressing Rac-1 activation. FEBS Letters 580 (2006) 2788-2796
49. Zbigniew R.T., Robert M., Cohen T., and Chomczynski P. Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells invitro. Proceedings of the National Academy of Sciences USA 88 (1990) 617-621