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Volumn 74, Issue 13-14, 2009, Pages 1045-1050

DHEA effects on myocardial Akt signaling modulation and oxidative stress changes in aged rats

Author keywords

Aging; Akt; DHEA; Heart; Oxidative stress

Indexed keywords

GLUTATHIONE TRANSFERASE; PRASTERONE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE;

EID: 70350570660     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2009.08.005     Document Type: Article
Times cited : (18)

References (56)
  • 1
    • 33947377482 scopus 로고    scopus 로고
    • Might DHEA be considered a beneficial replacement therapy in the elderly?
    • Genazzani A.D., Lanzoni C., and Genazzani A.R. Might DHEA be considered a beneficial replacement therapy in the elderly?. Drugs Aging 24 3 (2007) 173-185
    • (2007) Drugs Aging , vol.24 , Issue.3 , pp. 173-185
    • Genazzani, A.D.1    Lanzoni, C.2    Genazzani, A.R.3
  • 2
    • 34347218955 scopus 로고    scopus 로고
    • Significance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases
    • Bácsi K., Kósa J., Lazáry A., Horváth H., Balla B., Lakatos P., et al. Significance of dehydroepiandrosterone and dehydroepiandrosterone sulfate in different diseases. Orvosi Hetilap 148 14 (2007) 651-657
    • (2007) Orvosi Hetilap , vol.148 , Issue.14 , pp. 651-657
    • Bácsi, K.1    Kósa, J.2    Lazáry, A.3    Horváth, H.4    Balla, B.5    Lakatos, P.6
  • 3
    • 34250667042 scopus 로고    scopus 로고
    • Research on the age-related changes in the nitric oxide pathway in the arteries of rats and the intervention effect of dehydroepiandrosterone
    • Wu S., Ruan Y., Yin M., and Lai W. Research on the age-related changes in the nitric oxide pathway in the arteries of rats and the intervention effect of dehydroepiandrosterone. Gerontology 53 4 (2007) 234-237
    • (2007) Gerontology , vol.53 , Issue.4 , pp. 234-237
    • Wu, S.1    Ruan, Y.2    Yin, M.3    Lai, W.4
  • 5
    • 0030598949 scopus 로고    scopus 로고
    • The relationship of natural androgens to coronary heart disease in males: a review
    • Alexandersen P., Haarbo J., and Christiansen C. The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 125 (1996) 1-13
    • (1996) Atherosclerosis , vol.125 , pp. 1-13
    • Alexandersen, P.1    Haarbo, J.2    Christiansen, C.3
  • 6
    • 33750098776 scopus 로고    scopus 로고
    • Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease - preliminary study
    • Rabijewski M., and Zgliczynski W. Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease - preliminary study. Endokrynologia Polska 56 6 (2005) 904-910
    • (2005) Endokrynologia Polska , vol.56 , Issue.6 , pp. 904-910
    • Rabijewski, M.1    Zgliczynski, W.2
  • 7
    • 33846121333 scopus 로고    scopus 로고
    • Vascular cell senescence; contribution to atherosclerosis
    • Minamino T., and Komuro I. Vascular cell senescence; contribution to atherosclerosis. Circulation Research 100 1 (2007) 15-26
    • (2007) Circulation Research , vol.100 , Issue.1 , pp. 15-26
    • Minamino, T.1    Komuro, I.2
  • 8
    • 0018361475 scopus 로고
    • The role of arterial wall proteoglycan in arteriosclerosis
    • Picard J., Breton M., and Deudon E. The role of arterial wall proteoglycan in arteriosclerosis. La Semaine des Hôpitaux 55 (1979) 748-752
    • (1979) La Semaine des Hôpitaux , vol.55 , pp. 748-752
    • Picard, J.1    Breton, M.2    Deudon, E.3
  • 11
    • 84965028377 scopus 로고
    • Dehydroepiandrosterone and androsterone levels in human plasma: effect of age, sex, day-to-day and diurnal variation
    • Migeon C.J., Keller A.R., Lawrence B., and Shepard T.H. Dehydroepiandrosterone and androsterone levels in human plasma: effect of age, sex, day-to-day and diurnal variation. The Journal of Clinical Endocrinology and Metabolism 17 (1957) 1051-1062
    • (1957) The Journal of Clinical Endocrinology and Metabolism , vol.17 , pp. 1051-1062
    • Migeon, C.J.1    Keller, A.R.2    Lawrence, B.3    Shepard, T.H.4
  • 13
    • 0142057338 scopus 로고    scopus 로고
    • Dehydroepiandrosterone improves hepatic antioxidant systems after renal ischemia-reperfusion injury in rabbits
    • Yildirim A., Gumus M., Dalga S., Sahin Y.N., and Akcay F. Dehydroepiandrosterone improves hepatic antioxidant systems after renal ischemia-reperfusion injury in rabbits. Annals of Clinical and Laboratory Science 33 4 (2003) 459-464
    • (2003) Annals of Clinical and Laboratory Science , vol.33 , Issue.4 , pp. 459-464
    • Yildirim, A.1    Gumus, M.2    Dalga, S.3    Sahin, Y.N.4    Akcay, F.5
  • 14
    • 33745048514 scopus 로고    scopus 로고
    • Cardiac aldosterone
    • Yoshimura M. Cardiac aldosterone. Nippon Rinsho 64 5 (2006) 837-842
    • (2006) Nippon Rinsho , vol.64 , Issue.5 , pp. 837-842
    • Yoshimura, M.1
  • 15
    • 32144457524 scopus 로고    scopus 로고
    • Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7alpha-hydroxy- dehydroepiandrosterone in the rat
    • Pelissier M.A., Muller C., Hill M., and Morfin R. Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7alpha-hydroxy- dehydroepiandrosterone in the rat. Steroids 71 3 (2006) 240-248
    • (2006) Steroids , vol.71 , Issue.3 , pp. 240-248
    • Pelissier, M.A.1    Muller, C.2    Hill, M.3    Morfin, R.4
  • 16
    • 3142743863 scopus 로고    scopus 로고
    • The effect of dehydroepiandrosterone on renal ischemia-reperfusion-induced oxidative stress in rabbits
    • Aksoy Y., Yapanoglu T., Aksou H., and Yildirim A.K. The effect of dehydroepiandrosterone on renal ischemia-reperfusion-induced oxidative stress in rabbits. Urological Research 32 3 (2004) 93-96
    • (2004) Urological Research , vol.32 , Issue.3 , pp. 93-96
    • Aksoy, Y.1    Yapanoglu, T.2    Aksou, H.3    Yildirim, A.K.4
  • 21
    • 0036545912 scopus 로고    scopus 로고
    • The plasma redox state and ageing
    • Dröge W. The plasma redox state and ageing. Ageing Research Reviews 1 2 (2002) 257-278
    • (2002) Ageing Research Reviews , vol.1 , Issue.2 , pp. 257-278
    • Dröge, W.1
  • 22
    • 15944406071 scopus 로고    scopus 로고
    • Redox regulation of the signaling pathways leading to eNOS phosphorylation
    • Tanaka T., Nakamura H., Yodoi J., and Bloom E.T. Redox regulation of the signaling pathways leading to eNOS phosphorylation. Free Radical Biology & Medicine 38 9 (2005) 1231-1242
    • (2005) Free Radical Biology & Medicine , vol.38 , Issue.9 , pp. 1231-1242
    • Tanaka, T.1    Nakamura, H.2    Yodoi, J.3    Bloom, E.T.4
  • 26
    • 0242297825 scopus 로고    scopus 로고
    • Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects
    • Legrain S., and Girard L. Pharmacology and therapeutic effects of dehydroepiandrosterone in older subjects. Drugs Aging 20 13 (2003) 949-967
    • (2003) Drugs Aging , vol.20 , Issue.13 , pp. 949-967
    • Legrain, S.1    Girard, L.2
  • 27
    • 33746001106 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG)
    • Labrie F., Luu-The V., Martel C., Chernomoretz A., Calvo E., Morissette J., et al. Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG). Journal of Steroid Biochemistry & Molecular Biology 100 (2006) 52-58
    • (2006) Journal of Steroid Biochemistry & Molecular Biology , vol.100 , pp. 52-58
    • Labrie, F.1    Luu-The, V.2    Martel, C.3    Chernomoretz, A.4    Calvo, E.5    Morissette, J.6
  • 28
    • 29344451932 scopus 로고    scopus 로고
    • DHEA increases β-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats
    • Medina M.C., Souza L.C., Caperuto L.C., Anhê G.F., Amanso A.M., Teixeira V.P.A., et al. DHEA increases β-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats. FEBS Letters 580 (2006) 285-290
    • (2006) FEBS Letters , vol.580 , pp. 285-290
    • Medina, M.C.1    Souza, L.C.2    Caperuto, L.C.3    Anhê, G.F.4    Amanso, A.M.5    Teixeira, V.P.A.6
  • 29
    • 6344261633 scopus 로고    scopus 로고
    • The phosphatidylinositol/Akt/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo
    • Campbell C.S., Caperuto L.C., Hirata A.E., Araujo E.P., Velloso L.A., Saad M.J., et al. The phosphatidylinositol/Akt/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo. Life Sciences 76 1 (2004) 57-70
    • (2004) Life Sciences , vol.76 , Issue.1 , pp. 57-70
    • Campbell, C.S.1    Caperuto, L.C.2    Hirata, A.E.3    Araujo, E.P.4    Velloso, L.A.5    Saad, M.J.6
  • 30
    • 0021874569 scopus 로고
    • Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4′-epiadrimicynin mice
    • Llesuy S.F., Milei J., Molina H., Boveris A., and Milei S. Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4′-epiadrimicynin mice. Tumori 71 (1985) 241-249
    • (1985) Tumori , vol.71 , pp. 241-249
    • Llesuy, S.F.1    Milei, J.2    Molina, H.3    Boveris, A.4    Milei, S.5
  • 31
    • 0026064054 scopus 로고
    • Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver and muscle
    • Gonzalez-Flecha B., Llesuy S.F., and Boveris A. Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver and muscle. Free Radical Biology & Medicine 10 (1991) 93-100
    • (1991) Free Radical Biology & Medicine , vol.10 , pp. 93-100
    • Gonzalez-Flecha, B.1    Llesuy, S.F.2    Boveris, A.3
  • 32
    • 85014905187 scopus 로고
    • Pyrogallol autoxidation
    • Greenwald R.A. (Ed), CRC Press, Boca Raton, Florida
    • Marklund S.L. Pyrogallol autoxidation. In: Greenwald R.A. (Ed). Handbook of methods for oxygen radical research (1985), CRC Press, Boca Raton, Florida 243-247
    • (1985) Handbook of methods for oxygen radical research , pp. 243-247
    • Marklund, S.L.1
  • 33
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods in enzymology 105 (1984) 121-126
    • (1984) Methods in enzymology , vol.105 , pp. 121-126
    • Aebi, H.1
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophageT4
    • Laemmli V. Cleavage of structural proteins during the assembly of the head of bacteriophageT4. Nature 227 (1970) 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, V.1
  • 39
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 40
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G., Ouyang G., and Bao S. The activation of Akt/PKB signaling pathway and cell survival. Journal Cellular Molecular Medicine 1 (2005) 59-71
    • (2005) Journal Cellular Molecular Medicine , vol.1 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 41
    • 34948866710 scopus 로고    scopus 로고
    • AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation
    • Sussman M. AKT"ing lessons for stem cells: regulation of cardiac myocyte and progenitor cell proliferation. Trends in Cardiovascular Medicine 17 7 (2007) 235-240
    • (2007) Trends in Cardiovascular Medicine , vol.17 , Issue.7 , pp. 235-240
    • Sussman, M.1
  • 42
    • 34347224378 scopus 로고    scopus 로고
    • Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a galphai protein-dependent activation of phosphatidylinositol 3-kinase-Akt and regulation of antiapoptotic Bcl-2 expression
    • Liu D., Si H., Reynolds K.A., Zhen W., Jia Z., and Dillon J.S. Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a galphai protein-dependent activation of phosphatidylinositol 3-kinase-Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology 148 7 (2007) 3068-3076
    • (2007) Endocrinology , vol.148 , Issue.7 , pp. 3068-3076
    • Liu, D.1    Si, H.2    Reynolds, K.A.3    Zhen, W.4    Jia, Z.5    Dillon, J.S.6
  • 43
    • 20444438839 scopus 로고    scopus 로고
    • Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
    • Jiang Y., Miyazaki T., Honda A., Hirayama T., Yoshida S., Tanaka N., et al. Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone. Journal of Gastroenterology 40 5 (2005) 490-497
    • (2005) Journal of Gastroenterology , vol.40 , Issue.5 , pp. 490-497
    • Jiang, Y.1    Miyazaki, T.2    Honda, A.3    Hirayama, T.4    Yoshida, S.5    Tanaka, N.6
  • 45
    • 0037310339 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide
    • Cai H., Li Z., Davis M.E., Kanner W., Harrison D.G., and Dudley S.C. Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Molecular Pharmacology 63 (2003) 325-331
    • (2003) Molecular Pharmacology , vol.63 , pp. 325-331
    • Cai, H.1    Li, Z.2    Davis, M.E.3    Kanner, W.4    Harrison, D.G.5    Dudley, S.C.6
  • 47
    • 33846073928 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocite contractile dysfunction and protein damage
    • Wu S., Li Q., Du M., Li S., and Ren J. Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocite contractile dysfunction and protein damage. Clinical and Experimental Pharmacology and Physiology 34 (2007) 81-87
    • (2007) Clinical and Experimental Pharmacology and Physiology , vol.34 , pp. 81-87
    • Wu, S.1    Li, Q.2    Du, M.3    Li, S.4    Ren, J.5
  • 48
    • 0037411282 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    • Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Progress in Lipid Research 42 4 (2003) 318-343
    • (2003) Progress in Lipid Research , vol.42 , Issue.4 , pp. 318-343
    • Uchida, K.1
  • 49
    • 0042671381 scopus 로고    scopus 로고
    • 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions
    • Nakashima I., Liu W., Akhand A.A., Takeda K., Kawamoto Y., Kato M., et al. 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Molecular Aspects of Medicine 24 4-5 (2003) 231-238
    • (2003) Molecular Aspects of Medicine , vol.24 , Issue.4-5 , pp. 231-238
    • Nakashima, I.1    Liu, W.2    Akhand, A.A.3    Takeda, K.4    Kawamoto, Y.5    Kato, M.6
  • 51
    • 0030043905 scopus 로고    scopus 로고
    • Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats
    • Goldfarb A.H., McIntosh M.K., and Boyer B.T. Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats. Journal of Applied Physiology 80 2 (1996) 486-490
    • (1996) Journal of Applied Physiology , vol.80 , Issue.2 , pp. 486-490
    • Goldfarb, A.H.1    McIntosh, M.K.2    Boyer, B.T.3
  • 52
    • 0031577332 scopus 로고    scopus 로고
    • Cellular response to the redox active lipid peroxidation products: induction of glutathione-S-transferase P by 4-hydroxy-2-nonenal
    • Fukuda A., Nakamura Y., Ohigashi H., Osawa T., and Uchida K. Cellular response to the redox active lipid peroxidation products: induction of glutathione-S-transferase P by 4-hydroxy-2-nonenal. Biochemical and Biophysical Research Communications 236 (1997) 505-509
    • (1997) Biochemical and Biophysical Research Communications , vol.236 , pp. 505-509
    • Fukuda, A.1    Nakamura, Y.2    Ohigashi, H.3    Osawa, T.4    Uchida, K.5
  • 55
    • 0024474458 scopus 로고
    • Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats
    • Candi F., and Verdetti J. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Free Radical Biology & Medicine 7 1 (1989) 59-63
    • (1989) Free Radical Biology & Medicine , vol.7 , Issue.1 , pp. 59-63
    • Candi, F.1    Verdetti, J.2
  • 56
    • 0002807423 scopus 로고    scopus 로고
    • Antioxidant enzymes and their modification under oxidative stress conditions
    • Travacio M., and Llesuy S. Antioxidant enzymes and their modification under oxidative stress conditions. Ciência e Cultura 48 (1996) 9-13
    • (1996) Ciência e Cultura , vol.48 , pp. 9-13
    • Travacio, M.1    Llesuy, S.2


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