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Volumn 21, Issue 7, 2007, Pages 1488-1495

Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: The role of protein kinase Cδ

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; ARSENIC TRIOXIDE; BCR ABL PROTEIN; BORTEZOMIB; CASPASE 3; CYTOCHROME C; HYDROXYUREA; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN KINASE C DELTA; PROTEINASE INHIBITOR; ROTTLERIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 34250744640     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404735     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 0037668888 scopus 로고    scopus 로고
    • Current CML therapy: Progress and dilemma
    • Hehlmann R. Current CML therapy: Progress and dilemma. Leukemia 2003; 17: 1010-1012.
    • (2003) Leukemia , vol.17 , pp. 1010-1012
    • Hehlmann, R.1
  • 2
    • 2542500611 scopus 로고    scopus 로고
    • The biology of CML blast crisis
    • Calabretta B, Perrotti D. The biology of CML blast crisis. Blood 2004; 103: 4010-4022.
    • (2004) Blood , vol.103 , pp. 4010-4022
    • Calabretta, B.1    Perrotti, D.2
  • 3
    • 0033766732 scopus 로고    scopus 로고
    • Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells
    • Fernandez-Luna JL. Bcr-Abl and inhibition of apoptosis in chronic myelogenous leukemia cells. Apoptosis 2000; 5: 315-318.
    • (2000) Apoptosis , vol.5 , pp. 315-318
    • Fernandez-Luna, J.L.1
  • 4
    • 0030625902 scopus 로고    scopus 로고
    • Role of Bcr-Abl kinase in resistance to apoptosis
    • Samali A, Gorman AM, Cotter TG. Role of Bcr-Abl kinase in resistance to apoptosis. Adv Pharmacol 1997; 41: 533-552.
    • (1997) Adv Pharmacol , vol.41 , pp. 533-552
    • Samali, A.1    Gorman, A.M.2    Cotter, T.G.3
  • 5
    • 0037049772 scopus 로고    scopus 로고
    • Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML
    • Druker BJ. Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML. Oncogene 2002; 21: 8541-8546.
    • (2002) Oncogene , vol.21 , pp. 8541-8546
    • Druker, B.J.1
  • 6
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, La Rosee P, Muller MC, Lahaye T et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16: 2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3    La Rosee, P.4    Muller, M.C.5    Lahaye, T.6
  • 7
    • 33750615550 scopus 로고    scopus 로고
    • Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia
    • Kovitz C, Kantarjian H, Garcia-Manero G, Abruzzo LV, Cortes J. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006; 108 2811-2813.
    • (2006) Blood , vol.108 , pp. 2811-2813
    • Kovitz, C.1    Kantarjian, H.2    Garcia-Manero, G.3    Abruzzo, L.V.4    Cortes, J.5
  • 8
    • 0142213385 scopus 로고    scopus 로고
    • Philadelphia-negative acute lymphoblastic leukemia developing in a CML patient in imatinib mesylate-induced complete cytogenetic remission
    • Cherrier-De Wilde S, Rack K, Vannuffel P, Delannoy A, Hagemeijer A. Philadelphia-negative acute lymphoblastic leukemia developing in a CML patient in imatinib mesylate-induced complete cytogenetic remission. Leukemia 2003; 17: 2046-2048.
    • (2003) Leukemia , vol.17 , pp. 2046-2048
    • Cherrier-De Wilde, S.1    Rack, K.2    Vannuffel, P.3    Delannoy, A.4    Hagemeijer, A.5
  • 10
    • 33746160660 scopus 로고    scopus 로고
    • Proteasome inhibitor bortezomib for the treatment of multiple myeloma
    • Cavo M. Proteasome inhibitor bortezomib for the treatment of multiple myeloma. Leukemia 2006; 20: 1341-1352.
    • (2006) Leukemia , vol.20 , pp. 1341-1352
    • Cavo, M.1
  • 13
    • 33846216907 scopus 로고    scopus 로고
    • Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner
    • Cardoso F, Durbecq V, Laes JF, Badran B, Lagneaux L, Bex F et al. Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner. Mol Cancer Ther 2006; 5: 3042-3051.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3042-3051
    • Cardoso, F.1    Durbecq, V.2    Laes, J.F.3    Badran, B.4    Lagneaux, L.5    Bex, F.6
  • 14
    • 31544482800 scopus 로고    scopus 로고
    • Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
    • Yanamandra N, Colaco NM, Parquet NA, Buzzeo RW, Boulware D, Wright G et al. Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin Cancer Res 2006; 12: 591-599.
    • (2006) Clin Cancer Res , vol.12 , pp. 591-599
    • Yanamandra, N.1    Colaco, N.M.2    Parquet, N.A.3    Buzzeo, R.W.4    Boulware, D.5    Wright, G.6
  • 15
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack Jr JC, Liu R, Houston M, Abendroth K, Elliott PJ, Adams J et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition. Cancer Res 2001; 61: 3535-3540.
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr, J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6
  • 16
    • 3142554015 scopus 로고    scopus 로고
    • Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
    • Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood 2004; 104: 509-518.
    • (2004) Blood , vol.104 , pp. 509-518
    • Dai, Y.1    Rahmani, M.2    Pei, X.Y.3    Dent, P.4    Grant, S.5
  • 17
    • 0242493856 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571
    • Yu C, Rahmani M, Conrad D, Subler M, Dent P, Grant S. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood 2003; 102: 3765-3774.
    • (2003) Blood , vol.102 , pp. 3765-3774
    • Yu, C.1    Rahmani, M.2    Conrad, D.3    Subler, M.4    Dent, P.5    Grant, S.6
  • 18
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997; 89: 3354-3360.
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3    Li, X.S.4    Xiong, S.M.5    Qiu, Q.Y.6
  • 19
    • 0010740572 scopus 로고    scopus 로고
    • 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
    • 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood 1996; 88: 1052-1061.
    • (1996) Blood , vol.88 , pp. 1052-1061
    • Chen, G.Q.1    Zhu, J.2    Shi, X.G.3    Ni, J.H.4    Zhong, H.J.5    Si, G.Y.6
  • 20
    • 0035040975 scopus 로고    scopus 로고
    • Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia
    • Soignet SL. Clinical experience of arsenic trioxide in relapsed acute promyelocytic leukemia. Oncologist 2001; 6(Suppl 2): 11-16.
    • (2001) Oncologist , vol.6 , Issue.SUPPL. 2 , pp. 11-16
    • Soignet, S.L.1
  • 21
    • 33645498328 scopus 로고    scopus 로고
    • Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: Durable remissions with minimal toxicity
    • Mathews V, George B, Lakshmi KM, Viswabandya A, Bajel A, Balasubramanian P et al. Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: Durable remissions with minimal toxicity. Blood 2006; 107: 2627-2632.
    • (2006) Blood , vol.107 , pp. 2627-2632
    • Mathews, V.1    George, B.2    Lakshmi, K.M.3    Viswabandya, A.4    Bajel, A.5    Balasubramanian, P.6
  • 22
    • 85044557771 scopus 로고    scopus 로고
    • Prolonged molecular remission after arsenic trioxide and all-trans retinoic acid for acute promyelocytic leukemia relapsed after allogeneic stem cell transplantation
    • Grigg A, Kimber R, Szer J. Prolonged molecular remission after arsenic trioxide and all-trans retinoic acid for acute promyelocytic leukemia relapsed after allogeneic stem cell transplantation. Leukemia 2003; 17: 1916-1917.
    • (2003) Leukemia , vol.17 , pp. 1916-1917
    • Grigg, A.1    Kimber, R.2    Szer, J.3
  • 23
    • 0034142368 scopus 로고    scopus 로고
    • Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L)
    • Perkins C, Kim CN, Fang G, Bhalla KN. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood 2000; 95: 1014-1022.
    • (2000) Blood , vol.95 , pp. 1014-1022
    • Perkins, C.1    Kim, C.N.2    Fang, G.3    Bhalla, K.N.4
  • 25
    • 33845658305 scopus 로고    scopus 로고
    • Involvement of a Rho-ROCK-JNK pathway in arsenic trioxide-induced apoptosis in chronic myelogenous leukemia cells
    • Potin S, Bertoglio J, Breard J. Involvement of a Rho-ROCK-JNK pathway in arsenic trioxide-induced apoptosis in chronic myelogenous leukemia cells. FEBS Lett 2007; 581: 118-124.
    • (2007) FEBS Lett , vol.581 , pp. 118-124
    • Potin, S.1    Bertoglio, J.2    Breard, J.3
  • 26
    • 0036023045 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: Possible involvement of p38 MAP kinase
    • Shim MJ, Kim HJ, Yang SJ, Lee IS, Choi HI, Kim T. Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: Possible involvement of p38 MAP kinase. J Biochem Mol Biol 2002; 35: 377-383.
    • (2002) J Biochem Mol Biol , vol.35 , pp. 377-383
    • Shim, M.J.1    Kim, H.J.2    Yang, S.J.3    Lee, I.S.4    Choi, H.I.5    Kim, T.6
  • 27
    • 0033526358 scopus 로고    scopus 로고
    • Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations
    • Zhu XH, Shen YL, Jing YK, Cai X, Jia PM, Huang Y et al. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. J Natl Cancer Inst 1999; 91: 772-778.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 772-778
    • Zhu, X.H.1    Shen, Y.L.2    Jing, Y.K.3    Cai, X.4    Jia, P.M.5    Huang, Y.6
  • 28
    • 0021253492 scopus 로고
    • An alternative 7-ethoxyresorufin O-deethylase activity assay: A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity
    • Klotz AV, Stegeman JJ, Walsh C. An alternative 7-ethoxyresorufin O-deethylase activity assay: A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity. Anal Biochem 1984; 140: 138-145.
    • (1984) Anal Biochem , vol.140 , pp. 138-145
    • Klotz, A.V.1    Stegeman, J.J.2    Walsh, C.3
  • 29
    • 20944436253 scopus 로고    scopus 로고
    • Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms
    • Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH et al. Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cdelta-dependent mechanisms. Blood 2005; 105: 3714-3721.
    • (2005) Blood , vol.105 , pp. 3714-3721
    • Song, M.G.1    Gao, S.M.2    Du, K.M.3    Xu, M.4    Yu, Y.5    Zhou, Y.H.6
  • 30
    • 0141706672 scopus 로고    scopus 로고
    • Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
    • Ling YH, Liebes L, Zou Y, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003; 278: 33714-33723.
    • (2003) J Biol Chem , vol.278 , pp. 33714-33723
    • Ling, Y.H.1    Liebes, L.2    Zou, Y.3    Perez-Soler, R.4
  • 31
    • 1642263353 scopus 로고    scopus 로고
    • Involvement of protein kinase C-delta in DNA damage-induced apoptosis
    • Basu A. Involvement of protein kinase C-delta in DNA damage-induced apoptosis. J Cell Mol Med 2003; 7: 341-350.
    • (2003) J Cell Mol Med , vol.7 , pp. 341-350
    • Basu, A.1
  • 32
    • 3843061181 scopus 로고    scopus 로고
    • The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta
    • Durrant D, Liu J, Yang HS, Lee RM. The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. Biochem Biophys Res Commun 2004; 321: 905-908.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 905-908
    • Durrant, D.1    Liu, J.2    Yang, H.S.3    Lee, R.M.4
  • 33
    • 30044438364 scopus 로고    scopus 로고
    • Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK
    • Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ et al. Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. J Biol Chem 2005; 280: 42707-42714.
    • (2005) J Biol Chem , vol.280 , pp. 42707-42714
    • Zhao, K.W.1    Li, D.2    Zhao, Q.3    Huang, Y.4    Silverman, R.H.5    Sims, P.J.6
  • 34
    • 0029131231 scopus 로고
    • BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents
    • Bedi A, Barber JP, Bedi GC, el-Deiry WS, Sidransky D, Vala MS et al. BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents. Blood 1995; 86: 1148-1158.
    • (1995) Blood , vol.86 , pp. 1148-1158
    • Bedi, A.1    Barber, J.P.2    Bedi, G.C.3    el-Deiry, W.S.4    Sidransky, D.5    Vala, M.S.6
  • 35
    • 33845474265 scopus 로고    scopus 로고
    • Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors
    • Navas TA, Mohindru M, Estes M, Ma JY, Sokol L, Pahanish P et al. Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors. Blood 2006; 108: 4170-4177.
    • (2006) Blood , vol.108 , pp. 4170-4177
    • Navas, T.A.1    Mohindru, M.2    Estes, M.3    Ma, J.Y.4    Sokol, L.5    Pahanish, P.6
  • 36
    • 9944242716 scopus 로고    scopus 로고
    • p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
    • Hideshima T, Podar K, Chauhan D, Ishitsuka K, Mitsiades C, Tai YT et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 2004; 23 8766-8776.
    • (2004) Oncogene , vol.23 , pp. 8766-8776
    • Hideshima, T.1    Podar, K.2    Chauhan, D.3    Ishitsuka, K.4    Mitsiades, C.5    Tai, Y.T.6
  • 37
    • 1842861723 scopus 로고    scopus 로고
    • The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib
    • Yu C, Rahmani M, Dent P, Grant S. The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. Exp Cell Res 2004; 295: 555-566.
    • (2004) Exp Cell Res , vol.295 , pp. 555-566
    • Yu, C.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 38
    • 33745621044 scopus 로고    scopus 로고
    • Proteasome inhibition as novel treatment strategy in leukaemia
    • Vink J, Cloos J, Kaspers GJ. Proteasome inhibition as novel treatment strategy in leukaemia. Br J Haematol 2006; 134: 253-262.
    • (2006) Br J Haematol , vol.134 , pp. 253-262
    • Vink, J.1    Cloos, J.2    Kaspers, G.J.3
  • 39
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002; 20: 4420-4427.
    • (2002) J Clin Oncol , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3    Shea, T.C.4    Baldwin, A.S.5    Stahl, S.6
  • 41
    • 0035969124 scopus 로고    scopus 로고
    • Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z. Arsenic trioxide, a therapeutic agent for APL. Oncogene 2001; 20: 7146-7153.
    • Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z. Arsenic trioxide, a therapeutic agent for APL. Oncogene 2001; 20: 7146-7153.
  • 42
    • 1842454982 scopus 로고    scopus 로고
    • The enigmatic protein kinase Cdelta: Complex roles in cell proliferation and survival
    • Jackson DN, Foster DA. The enigmatic protein kinase Cdelta: Complex roles in cell proliferation and survival. FASEB J 2004; 18: 627-636.
    • (2004) FASEB J , vol.18 , pp. 627-636
    • Jackson, D.N.1    Foster, D.A.2
  • 43
    • 33744494283 scopus 로고    scopus 로고
    • Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo
    • Navas TA, Nguyen AN, Hideshima T, Reddy M, Ma JY, Haghnazari E et al. Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. Leukemia 2006; 20: 1017-1027.
    • (2006) Leukemia , vol.20 , pp. 1017-1027
    • Navas, T.A.1    Nguyen, A.N.2    Hideshima, T.3    Reddy, M.4    Ma, J.Y.5    Haghnazari, E.6
  • 44
    • 33750522657 scopus 로고    scopus 로고
    • Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis
    • Ramos AM, Fernandez C, Amran D, Esteban D, de Blas E, Palacios MA et al. Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. J Cell Physiol 2006; 209: 1006-1015.
    • (2006) J Cell Physiol , vol.209 , pp. 1006-1015
    • Ramos, A.M.1    Fernandez, C.2    Amran, D.3    Esteban, D.4    de Blas, E.5    Palacios, M.A.6
  • 46
    • 0037809345 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells
    • Kang SH, Song JH, Kang HK, Kang JH, Kim SJ, Kang HW et al. Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells. Exp Mol Med 2003; 35: 83-90.
    • (2003) Exp Mol Med , vol.35 , pp. 83-90
    • Kang, S.H.1    Song, J.H.2    Kang, H.K.3    Kang, J.H.4    Kim, S.J.5    Kang, H.W.6
  • 47
    • 0033775745 scopus 로고    scopus 로고
    • Molecular abnormalities in chronic myeloid leukemia: Deregulation of cell growth and apoptosis
    • Di Bacco A, Keeshan K, McKenna SL, Cotter TG. Molecular abnormalities in chronic myeloid leukemia: Deregulation of cell growth and apoptosis. Oncologist 2000; 5: 405-415.
    • (2000) Oncologist , vol.5 , pp. 405-415
    • Di Bacco, A.1    Keeshan, K.2    McKenna, S.L.3    Cotter, T.G.4
  • 48
    • 0037049768 scopus 로고    scopus 로고
    • Skorski T. BCR/ABL regulates response to DNA damage: The role in resistance to genotoxic treatment and in genomic instability. Oncogene 2002; 21: 8591-8604.
    • Skorski T. BCR/ABL regulates response to DNA damage: The role in resistance to genotoxic treatment and in genomic instability. Oncogene 2002; 21: 8591-8604.
  • 49
    • 0034693878 scopus 로고    scopus 로고
    • Regulation of cell death by the Abl tyrosine kinase
    • Wang JY. Regulation of cell death by the Abl tyrosine kinase. Oncogene 2000; 19: 5643-5650.
    • (2000) Oncogene , vol.19 , pp. 5643-5650
    • Wang, J.Y.1


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