Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition

Restorative Neurology and Neuroscience

Volumn 27, Issue 5, 2009, Pages 391-403

  Goh, Joshua O ^a   Park, Denise C ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; BEHAVIOR; BRAIN; COGNITION; HUMAN; LIFESPAN; LIFESTYLE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; NEUROIMAGING; NONHUMAN; PHOTOGRAPHY; PRIORITY JOURNAL; REVIEW; SOCIAL CONTROL; SYNAPSE;

ADULT; AGING; ANIMALS; BRAIN; COGNITION; HUMANS; MODELS, NEUROLOGICAL; NEURONAL PLASTICITY; SYNAPSES;

EID: 70350489112     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: 10.3233/RNN-2009-0493     Document Type: Review

References (121)

1. Baltes, P., & Lindenberger, U. (1997). Emergence of a powerful connection between sensory and cognitive functions across the adult life span: A new window to the study of cognitive aging? Psychol Aging, 12(1), 12-21.
2. Bartzokis, G., Lu, P. H., Tingus, K., Mendez, M. F., Richard, A., Peters, D. G., et al. (in press). Lifespan trajectory of myelin integrity and maximum motor speed. Neurobiol Aging.
3. Bennett, E. L., Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1996). Chemical and anatomical plasticity of brain. J Neuropsychiatry Clin Neurosci, 8(4), 459-470.
4. Berg, C. (2008). Everyday problem solving in context. In S. Hofer, & D. F. Alwin (Eds.), Handbook of Cognitive Aging: Interdisciplinary Perspectives (pp. 207-223). Los Angeles, CA: SAGE Publications.
5. Bherer, L., Kramer, A. F., Peterson, M. S., Colcombe, S., Erickson, K., & Becic, E. (2005). Training effects on dual-task performance: Are there age-related differences in plasticity of attentional control? Psychol Aging, 20(4), 695-709.
6. Boyke, J., Driemeyer, J., Gaser, C., Buchel, C., & May, A. (2008). Training-induced brain structure changes in the elderly. J Neurosci, 28(28), 7031-7035.
7. Braver, T. S.,&West, R. (2008). Working memory, executive control, and aging. In F. I. M. Craik, & T. A. Salthouse (Eds.), The Handbook of Aging and Cognition (3rd ed., pp. 311-372). New York, USA: Psychology Press.
8. Burke, S. N., & Barnes, C. A. (2006). Neural plasticity in the ageing brain. Nature Rev Neurosci, 7(1), 30-40.
9. Cabeza, R. (2002). Hemispheric asymmetry reduction in older adults: The HAROLD model. Psychol Aging, 17(1), 85-100.
10. Cabeza, R., Anderson, N. D., Locantore, J. K., & McIntosh, A. R. (2002). Aging gracefully: Compensatory brain activity in high-performing older adults. NeuroImage, 17(3), 1394-1402.
11. Cabeza, R., Grady, C. L., Nyberg, L., McIntosh, A. R., Tulving, E., Kapur, S., et al. (1997). Age-related differences in neural activity during memory encoding and retrieval: A positron emission tomography study. J Neurosci, 17(1), 391-400.
12. Castel, A. D. (2005). Memory for grocery prices in younger and older adults: The role of schematic support. Psychol Aging, 20(4), 718-721.
13. Castel, A. D. (2007). Aging and memory for numerical information: The role of specificity and expertise in associative memory. J Gerontol B Psychol Sci Soc Sci, 62(3), 194-196.
14. Castel, A. D., Farb, N. A. S., & Craik, F. I. M. (2007). Memory for general and specific value information in younger and older adults: Measuring the limits of strategic control. Mem Cognition, 35(4), 689-700.
15. Cohen, N. J., Poldrack, R. A.,&Eichenbaum, H. (1997). Memory for items and memory for relations in the procedural/declarative memory framework. Memory, 5(1), 131-178.
16. Colcombe, S., & Kramer, A. F. (2003). Fitness effects on the cognitive function of older adults: A meta-analytic study. Psychol Sci, 14(2), 125-130. (Pubitemid 37283096)
17. Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., et al. (2004). Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci USA, 101(9), 3316-3321.
18. Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., et al. (2006). Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci, 61(11), 1166-1170.
19. Craik, F. I. M. (2002). Human memory and aging. In L. Bäckman, & C. von Hofsten (Eds.), Psychology at the Turn of the Millennium (pp. 261-280). Hove, U.K.: Psychology Press.
20. Craik, F. I. M. (1977). Age differences in human memory. In J. E. Birren, & K. W. Schaie (Eds.), The Handbook of Psychology of Aging (pp. 384-420). New York, USA: Van Nostrand Reinhold.
21. Craik, F. I. M., & Byrd, M. (1982). Aging and cognitive deficits: The role of attentional resources. In F. I. Craik, & S. Trehub (Eds.), Aging and Cognitive Processes (pp. 191-211). New York, USA: Plenum.
22. Daselaar, S., Veltman, D., Rombouts, S., Raaijmakers, J., & Jonker, C. (2003). Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain, 126(1), 43-56.
23. Davatzikos, C., & Resnick, S. M. (2002). Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging. Cerebral Cortex, 12(7), 767-771.
24. Davis, S.W., Dennis, N. A., Daselaar, S. M., Fleck, M. S., & Cabeza, R. (2008). Que PASA? The Posterior Anterior Shift in Aging. Cerebral Cortex, 18(5), 1201-1209.
25. Dennis, N. A., & Cabeza, R. (2008). Neuroimaging of healthy cognitive aging. In F. I. M. Craik, & T. A. Salthouse (Eds.), The Handbook of Aging and Cognition (3rd ed., pp. 1-54). New York, USA: Psychology Press.
26. Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964). The effects of an enriched environment on the histology of the rat cerebral cortex. J Comp Neurol, 123, 111-120.
27. Diamond, M. C., Lindner, B., &Raymond, A. (1967). Extensive cortical depth measurements and neuron size increases in the cortex of environmentally enriched rats. J Comp Neurol, 131(3), 357-364.
28. Dreher, J. C., Meyer-Lindenberg, A., Kohn, P., & Berman, K. F. (2008). Age-related changes in midbrain dopaminergic regulation of the human reward system. Proc Natl Acad Sci USA, 105(39), 15106-15111.
29. Dunlosky, J., Kubat-Silman, A. K., & Hertzog, C. (2003). Training monitoring skills improves older adults' self-paced associative learning. Psychol Aging, 18(2), 340-345.
30. Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nat Med, 4(11), 1313-1317.
31. Geinisman, Y., deToledo-Morrell, L., Morrell, F., Persina, I. S., & Rossi, M. (1992). Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus, 2(4), 437-444.
32. Globus, A., Rosenzweig, M. R., Bennett, E. L., & Diamond, M. C. (1973). Effects of differential experience on dendritic spine counts in rat cerebral cortex. J Comp Physiol Psychol, 82(2), 175-181.
33. Gould, E., Tanapat, P., Hastings, N. B., & Shors, T. J. (1999). Neurogenesis in adulthood: A possible role in learning. Trends Cogn Sci, 3(5), 186-192.
34. Grady, C. L., McIntosh, A. R., Horwitz, B., Maisog, J. M., Ungerleider, L. G., Mentis, M. J., et al. (1995). Age-related reductions in human recognition memory due to impaired encoding. Science, 269(5221), 218-221.
35. Grady, C. L., Maisog, J. M., Horwitz, B., Ungerleider, L. G., Mentis, M. J., Salerno, J. A., et al. (1994). Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci, 14(3), 1450-1462.
36. Greenough, W. T., & Volkmar, F. R. (1973). Pattern of dendritic branching in occipital cortex of rats reared in complex environments. Exp Neurol, 40(2), 491-504.
37. Gutchess, A. H.,Welsh, R. C., Hedden, T., Bangert, A., Minear, M., Liu, L. L., et al. (2005). Aging and the neural correlates of successful picture encoding: Frontal activations compensate for decreased medial-temporal activity. J Cogn Neurosci, 17(1), 84-96.
38. Hasher, L., Lustig, C., & Zacks, R. (2007). Inhibitory mechanisms and the control of attention. In A. R. A. Conway, C. Jarrold, M. J. Kane, & J. N. Towse (Eds.),Variation in Working Memory (pp. 227-249). US: Oxford University Press.
39. Hasher, L.,&Zacks, R.T. (1988). Working memory, comprehension, and aging: A review and a new view. Psychol Learn Motiv, 22, 193-225.
40. Hasher, L., & Zacks, R. T. (1979). Automatic and efforful processes in memory. J Exp Psychol Gen, 108(3), 356-388.
41. Hattiangady, B., Rao, M. S., Shetty, G. A., & Shetty, A. K. (2005). Brain-derived neurotrophic factor, phosphorylated cyclicAMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus. Exp Neurol, 195(2), 353-371.
42. Head, D., Buckner, R. L., Shimony, J. S.,Williams, L. E., Akbudak, E., Conturo, T. E., et al. (2004). Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the alzheimer type: Evidence from diffusion tensor imaging. Cerebral Cortex, 14(4), 410-423.
43. Hedden, T., & Gabrieli, J. D. E. (2004). Insights into the ageing mind: A view from cognitive neuroscience. Nat Rev Neurosci, 5(2), 87-96.
44. Henke, K.,Weber, B., Kneifel, S.,Wieser, H. G., & Buck, A. (1999). Human hippocampus associates information in memory. Proc Natl Acad Sci USA, 96(10), 5884-5889.
45. Howard, D. V., Howard, J. H., Dennis, N. A., LaVine, S., & Valentino, K. (2008). Aging and implicit learning of an invariant association. J Gerontol B Psychol Sci Soc Sci, 63(2), 100-105.
46. Hultsch, D. F., Hertzog, C., Dixon, R. A., & Small, B. J. (1998). Memory Change in the Aged. New York, USA: Cambridge University Press.
47. Jennings, J. M., &Jacoby, L. L. (1993). Automatic versus intentional uses of memory: Aging, attention, and control. Psychol Aging, 8(2), 283-293.
48. Jessberger, S., & Gage, F. H. (2008). Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging, 23(4), 684-691.
49. Kaasinen, V., Vilkman, H., Hietala, J., Nägren, K., Helenius, H., Olsson, H., et al. (2000). Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol Aging, 21(5), 683-688.
50. Kempermann, G., Gast, D., & Gage, F. H. (2002). Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol, 52(2), 135-143.
51. Kempermann, G. (2008). The neurogenic reserve hypothesis: What is adult hippocampal neurogenesis good for? Trends Neurosci, 31(4), 163-169.
52. Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, 386(6624), 493-495.
53. Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experienceinduced neurogenesis in the senescent dentate gyrus. J Neurosci, 18(9), 3206-3212.
54. Kempermann, G.,Wiskott, L., & Gage, F. H. (2004). Functional significance of adult neurogenesis. Curr Opin Neurobiol, 14(2), 186-191.
55. Kempermann, G.,&Gage, F. H. (1999). Experience-dependent regulation of adult hippocampal neurogenesis: Effects of long-term stimulation and stimulus withdrawal. Hippocampus, 9(3), 321-332.
56. Keuker, J. I. H., Luiten, P. G. M., & Fuchs, E. (2003). Preservation of hippocampal neuron numbers in aged rhesus monkeys. Neurobiol Aging, 24(1), 157-165.
57. Kramer, A. F., Larish, J.,Weber, T. A.,&Bardell, L. (1999). Training for executive control: Task coordination strategies and aging. Attention and Performance XVII, 617-652.
58. Kramer, A. F., Hahn, S., & Gopher, D. (1999). Task coordination and aging: Explorations of executive control processes in the task switching paradigm. Acta Psychol, 101(2-3), 339-378.
59. Krech, D., Rosenzweig, M. R., & Bennett, E. L. (1960). Effects of environmental complexity and training on brain chemistry. J Comp Physiol Psychol, 53, 509-519.
60. Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G. (2006). Physical exercise prevents agerelated decline in precursor cell activity in the mouse dentate gyrus. Neurobiol Aging, 27(10), 1505-1513.
61. Kronenberg, G., Reuter, K., Steiner, B., Brandt, M. D., Jessberger, S., Yamaguchi, M., et al. (2003). Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. J Comp Neurol, 467(4), 455-463.
62. Kuhn, H. G., Dickinson-Anson, H., & Gage, F. H. (1996). Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J Neurosci, 16(6), 2027-2033.
63. Li, S. C., Lindenberger, U., & Sikström, S. (2001). Aging cognition: From neuromodulation to representation. Trends Cogn Sci, 5(11), 479-486.
64. Li, S. C., & Sikström, S. (2002). Integrative neurocomputational perspectives on cognitive aging, neuromodulation, and representation. Neurosci Biobehav Rev, 26(7), 795-808.
65. Lindenberger, U., Scherer, H., & Baltes, P. B. (2001). The strong connection between sensory and cognitive performance in old age: Not due to sensory acuity reductions operating during cognitive assessment. Psychol Aging, 16(2), 196-205.
66. Logan, J. M., Sanders, A. L., Snyder, A. Z., Morris, J. C., & Buckner, R. L. (2002). Under-recruitment and nonselective recruitment dissociable neural mechanisms associated with aging. Neuron, 33(5), 827-840.
67. Luo, L., & Craik, F. I. M. (2008). Aging and memory: A cognitive approach. Can J Psychiatry, 53(6), 346-353.
68. Luo, L., Hendriks, T., & Craik, F. I. (2007). Age differences in recollection: Three patterns of enhanced encoding. Psychol Aging, 22(2), 269-280.
69. MacDaniel, M. A., Einstein, G. O., & Jacoby, L. L. (2008). New considerations in aging and memory: The glass may be half full. In F. I. M. Craik, & T. A. Salthouse (Eds.), The Handbook of Aging and Cognition (3rd ed., pp. 251-310). New York, USA: Psychology Press.
70. Madden, D. J., Turkington, T. G., Provenzale, J. M., Denny, L. L., Hawk, T. C., Gottlob, L. R., et al. (1999). Adult age differences in the functional neuroanatomy of verbal recognition memory. Hum Brain Mapp, 7(2), 115-135.
71. Madden, D. J., & Langley, L. K. (2003). Age-related changes in selective attention and perceptual load during visual search. Psychol Aging, 18(1), 54-67.
72. Maguire, E. A., Spiers, H. J., Good, C. D., Hartley, T., Frackowiak, R. S. J., & Burgess, N. (2003). Navigation expertise and the human hippocampus: A structural brain imaging analysis. Hippocampus, 13(2), 250-259.
73. McNab, F., Varrone, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H., et al. (2009). Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science, 323(5915), 800-802.
74. Meiran, N., Gotler, A., & Perlman, A. (2001). Old age is associated with a pattern of relatively intact and relatively impaired taskset switching abilities. J Gerontol B Psychol Sci Soc Sci, 56(2), 88-102.
75. Moseley, M. (2002). Diffusion tensor imaging and aging - a review. NMR Biomed, 15(7-8), 553-560. (Pubitemid 36054515)
76. Nieto-Sampedro, M., & Nieto-Dýaz, M. (2005). Neural plasticity: Changes with age. J Neural Transm, 112(1), 3-27.
77. Nottebohm, F. (2002). Neuronal replacement in adult brain. Brain Res Bull, 57(6), 737-749.
78. Old, S. R., &Naveh-Benjamin, M. (2008). Differential effects of age on item and associative measures of memory: Ameta-analysis. Psychol Aging, 23(1), 104-118.
79. O'Sullivan, M., Jones, D. K., Summers, P. E., Morris, R. G., Williams, S. C., & Markus, H. S. (2001). Evidence for cortical disconnection as a mechanism of age-related cognitive decline. Neurology, 57(4), 632-638.
80. Park, D. C.,&Gutchess, A. (2005). Long-term memory and aging: A cognitive neuroscience perspective. In R. Cabeza, L. Nyberg, &D.C. Park (Eds.). Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging, (pp. 218-245). New York, USA: Oxford University Press.
81. Park, D. C., Polk, T. A., Park, R., Minear, M., Savage, A., & Smith, M. R. (2004). Aging reduces neural specialization in ventral visual cortex. Proc Natl Acad Sci USA, 101(35), 13091-13095.
82. Park, D. C., & Goh, J. O. S. (2009). Successful aging. In J. Cacioppo, & G. Berntson (Eds.), Handbook of Neuroscience for the Behavioral Sciences. Hoboken, NJ: John Wiley & Sons.
83. Park, D. C., & Reuter-Lorenz, P. (2009). The adaptive brain: Aging and neurocognitive scaffolding. Ann Rev Psychol, 60(1), 173-196.
84. Park, D. C., Welsh, R. C., Marshuetz, C., Gutchess, A. H., Mikels, J., Polk, T. A., et al. (2003). Working memory for complex scenes: Age differences in frontal and hippocampal activations. J Cogn Neurosci, 15(8), 1122-1134.
85. Park, D. C., Lautenschlager, G., Hedden, T., Davidson, N. S., Smith, A. D., & Smith, P. K. (2002). Models of visuospatial and verbal memory across the adult life span. Psychol Aging, 17(2), 299-320.
86. Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., et al. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA, 104(13), 5638-5643.
87. Persson, J., Lustig, C., Nelson, J. K., & Reuter-Lorenz, P. A. (2007). Age differences in deactivation: A link to cognitive control? J Cogn Neurosci, 19(6), 1021-1032.
88. Petersen, S. E., van Mier, H., Fiez, J. A., & Raichle, M. E. (1998). The effects of practice on the functional anatomy of task performance. Proc Natl Acad Sci USA, 95(3), 853-860.
89. Raz, N., & Rodrigue, K. M. (2006). Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev, 30(6), 730-748.
90. Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., et al. (2005). Regional brain changes in aging healthy adults: General trends, individual differences and modifiers. Cerebral Cortex, 15(11), 1676-1689.
91. Raz, N., & Rodrigue, K. M. (2006). Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev, 30(6), 730-748.
92. Rendell, P., Castel, A.,&Craik, F. (2005). Memory for proper names in old age: A disproportionate impairment? Q J Exp Psychol A, 58(1), 54-71.
93. Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003). Longitudinal magnetic resonance imaging studies of older adults: A shrinking brain. J Neurosci, 23(8), 3295-3301.
94. Reuter-Lorenz, P. A., Jonides, J., Smith, E. E., Hartley, A., Miller, A., Marshuetz, C., et al. (2000). Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. J Cogn Neurosci, 12(1), 174-187. (Pubitemid 30142792)
95. Reuter-Lorenz, P. A.,&Cappell, K. A. (2008). Neurocognitive aging and the compensation hypothesis. Curr Dir Psychol Sci, 17(3), 177-182.
96. Riege,W. H. (1971). Environmental influences on brain and behavior of year-old rats. Dev Psychobiol, 4(2), 157-167.
97. Rosen, A. C., Prull, M. W., O'Hara, R., Race, E. A., Desmond, J. E., Glover, G. H., et al. (2002). Variable effects of aging on frontal lobe contributions to memory. Neuroreport, 13(18), 2425-2428.
98. Rosen, A. C., Prull, M. W., Gabrieli, J. D., Stoub, T., O'Hara, R., Friedman, L., et al. (2003). Differential associations between entorhinal and hippocampal volumes and memory performance in older adults. Behav Neurosci, 117(6), 1150-1160.
99. Rosenzweig, E. S., & Barnes, C. A. (2003). Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition. Prog Neurobiol, 69(3), 143-179.
100. Rosenzweig, M. R., Krech, D., Bennett, E. L., & Diamond, M. C. (1962). Effects of environmental complexity and training on brain chemistry and anatomy: A replication and extension. J Comp Physiol Psychol, 55, 429-437.
101. Rossi, S., Miniussi, C., Pasqualetti, P., Babiloni, C., Rossini, P. M., & Cappa, S. F. (2004). Age-related functional changes of prefrontal cortex in long-term memory: A repetitive transcranial magnetic stimulation study. J Neurosci, 24(36), 7939-7944.
102. Roy, N. S., Wang, S., Jiang, L., Kang, J., Benraiss, A., Harrison- Restelli, C., et al. (2000). In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med, 6(3), 271-277.
103. Rypma, B., & D'Esposito, M. (2000). Isolating the neural mechanisms of age-related changes in human working memory. Nat Neurosci, 3(5), 509-515.
104. Salat, D. H., Buckner, R. L., Snyder, A. Z., Greve, D. N., Desikan, R. S. R., Busa, E., et al. (2004). Thinning of the cerebral cortex in aging. Cerebral Cortex, 14(7), 721-730.
105. Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychol Rev, 103(3), 403-428.
106. Sapolsky, R. M. (2001). Depression, antidepressants, and the shrinking hippocampus. Proc Natl Acad Sci USA, 98(22), 12320-12322.
107. Song, S., Marks, B., Howard, J. H., & Howard, D. V. (2009). Evidence for parallel explicit and implicit sequence learning systems in older adults. Behav Brain Res, 196(2), 328-332.
108. Stebbins, G. T., Carrillo, M. C., Dorfman, J., Dirksen, C., Desmond, J. E., Turner, D. A., et al. (2002). Aging effects on memory encoding in the frontal lobes. Psychol Aging, 17(1), 44-55.
109. Sullivan, E. V., Rohlfing, T., & Pfefferbaum, A. (2008). Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: Relations to timed performance. Neurobiol Aging. in press. Epub ahead of print, retrieved August 31 2009 from http://www.ncbi.nlm.nih.gov/pubmed/ 18495300.
110. Sullivan, E. V., & Pfefferbaum, A. (2006). Diffusion tensor imaging and aging. Neurosci Biobehav Rev, 30(6), 749-761.
111. Sullivan, E. V., Adalsteinsson, E., & Pfefferbaum, A. (2006). Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking. Cerebral Cortex, 16(7), 1030-1039.
112. Thomas, C., Moya, L., Avidan, G., Humphreys, K., Jung, K. J., Peterson, M. A., et al. (2008). Reduction in white matter connectivity, revealed by diffusion tensor imaging, may account for age-related changes in face perception. J Cogn Neurosci, 20(2), 268-284.
113. Turner, A. M., & Greenough, W. T. (1985). Differential rearing effects on rat visual cortex synapses. I. synaptic and neuronal density and synapses per neuron. Brain Res, 329(1-2), 195-203.
114. Valenzuela, M. J., Jones, M., Wen, W., Rae, C., Graham, S., Shnier, R., et al. (2003). Memory training alters hippocampal neurochemistry in healthy elderly. Neuroreport, 14(10), 1333-1337.
115. van Praag, H., Kempermann, G., & Gage, F. H. (1999). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci, 2(3), 266-270.
116. Verhaeghen, P., & Cerella, J. (2008). Everything we know about aging and response times: A meta-analytic integration. In S. Hofer, & D. F. Alwin (Eds.), Handbook of Cognitive Aging: Interdisciplinary Perspectives (pp. 134-150). Los Angeles, CA: SAGE Publications.
117. Wen, W., & Sachdev, P. (2004). The topography of white matter hyperintensities on brain MRI in healthy 60-to 64-year-old individuals. NeuroImage, 22(1), 144-154.
118. West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994). Differences in the pattern of hippocampal neuronal loss in normal ageing and alzheimer's disease. Lancet, 344(8925), 769-772.
119. West, R. W., & Greenough, W. T. (1972). Effect of environmental complexity on cortical synapses of rats: Preliminary results. Behav Biol, 7(2), 279-284.
120. Zacks, R. T., Hasher, L., & Li, K. Z. H. (2000). Human memory. In F. I. M. Craik, & T. A. Salthouse (Eds.), The Handbook of Aging and Cognition (2nd ed., pp. 293-357). Mahwah, NJ: Lawrence Erlbaum Associates.
121. Zolman, J. F., & Morimoto, H. (1962). Effects of age of training on cholinesterase activity in the brains of maze-bright rats. J Comp Physiol Psychol, 55, 794-800.