Evidence for an additional base-pairing element between the telomeric repeat and the telomerase RNA template in Kluyveromyces lactis and other yeasts

Molecular and Cellular Biology

Volumn 29, Issue 20, 2009, Pages 5389-5398

  Wang, Zhi Ru ^a,b   Guo, Leilei ^a   Chen, Lizhen ^a,c   McEachern, Michael J ^a  

^a University of Georgia   (United States)

^b SHANXI MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA; TELOMERASE;

ARTICLE; BASE PAIRING; GENE MUTATION; KLUYVEROMYCES; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; TELOMERE;

BASE PAIRING; KLUYVEROMYCES; RNA; TELOMERASE; TELOMERE; YEASTS;

KLUYVEROMYCES LACTIS;

EID: 70350462108     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00528-09     Document Type: Article

References (38)

1. Bechard, L. H., B. D. Butuner, G. J. Peterson, W. McRae, Z. Topcu, and M. J. McEachern. 2009. Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype. Mol. Cell. Biol. 29:626-639.
2. Bergeron, J., and G. Drouin. 2008. The evolution of 5S ribosomal RNA genes linked to the rDNA units of fungal species. Curr. Genet. 54:123-131.
3. Bertuch, A. A., and V. Lundblad. 2006. The maintenance and masking of chromosome termini. Curr. Opin. Cell Biol. 18:247-253.
4. Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. Chiu, M. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352. (Pubitemid 28063364)
5. Bosoy, D., and N. F. Lue. 2004. Yeast telomerase is capable of limited repeat addition processivity. Nucleic Acids Res. 32:93-101. (Pubitemid 38228608)
6. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
7. Deng, Y., S. S. Chan, and S. Chang. 2008. Telomere dysfunction and tumour suppression: the senescence connection. Nat. Rev. Cancer 8:450-458.
8. Eldridge, A. M., W. A. Halsey, and D. S. Wuttke. 2006. Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13. Biochemistry 45:871-879.
9. Evans, S. K., and V. Lundblad. 1999. Est1 and Cdc13 as comediators of telomerase access. Science 286:117-120.
10. Fitzpatrick, D. A., M. E. Logue, J. E. Stajich, and G. Butler. 2006. A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis. BMC Evol. Biol. 6:99.
11. Forstemann, K., and J. Lingner. 2005. Telomerase limits the extent of base pairing between template RNA and telomeric DNA. EMBO Rep. 6:361-366. (Pubitemid 40561629)
12. Fulton, T. B., and E. H. Blackburn. 1998. Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain. Mol. Cell. Biol. 18:4961-4970.
13. Greider, C. W., and E. H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337.
14. Greider, C. W., and E. H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413.
15. Gunisova, S., E. Elboher, J. Nosek, V. Gorkovoy, Y. Brown, J. F. Lucier, N. Laterreur, R. J. Wellinger, Y. Tzfati, and L. Tomaska. 2009. Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements. RNA 15:546-559.
16. Hathcock, K. S., Y. J. Chiang, and R. J. Hodes. 2005. In vivo regulation of telomerase activity and telomere length. Immunol. Rev. 205:104-113.
17. Jacob, N. K., R. Skopp, and C. M. Price. 2001. G-overhang dynamics at Tetrahymena telomeres. EMBO J. 20:4299-4308.
18. James, T. Y., F. Kauff, C. L. Schoch, P. B. Matheny, V. Hofstetter, C. J. Cox, G. Celio, C. Gueidan, E. Fraker, J. Miadlikowska, H. T. Lumbsch, A. Rauhut, V. Reeb, A. E. Arnold, A. Amtoft, J. E. Stajich, K. Hosaka, G. H. Sung, D. Johnson, B. O'Rourke, M. Crockett, M. Binder, J. M. Curtis, J. C. Slot, Z. Wang, A. W. Wilson, A. Schussler, J. E. Longcore, K. O'Donnell, S. Mozley-Standridge, D. Porter, P. M. Letcher, M. J. Powell, J. W. Taylor, M. M. White, G. W. Griffith, D. R. Davies, R. A. Humber, J. B. Morton, J. Sugiyama, A. Y. Rossman, J. D. Rogers, D. H. Pfister, D. Hewitt, K. Hansen, S. Hambleton, R. A. Shoemaker, J. Kohlmeyer, B. Volkmann-Kohlmeyer, R. A. Spotts, M. Serdani, P. W. Crous, K. W. Hughes, K. Matsuura, E. Langer, G. Langer, W. A. Untereiner, R. Lucking, B. Budel, D. M. Geiser, A. Aptroot, P. Diederich, I. Schmitt, M. Schultz, R. Yahr, D. S. Hibbett, F. Lutzoni, D. J. McLaughlin, J. W. Spatafora, and R. Vilgalys. 2006. Reconstructing the early evolution of fungi using a six-gene phylogeny. Nature 443:818-822.
19. Klobutcher, L. A., M. T. Swanton, P. Donini, and D. M. Prescott. 1981. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus. Proc. Natl. Acad. Sci. USA 78:3015-3019.
20. Krauskopf, A., and E. H. Blackburn. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383: 354-357. (Pubitemid 26321768)
21. Kurtzman, C. P. 2003. Phylogenetic circumscription of Saccharomyces, Kluyveromyces and other members of the Saccharomycetaceae, and the proposal of the new genera Lachancea, Nakaseomyces, Naumovia, Vanderwaltozyma and Zygotorulaspora. FEMS Yeast Res. 4:233-245.
22. Lustig, A. J., S. Kurtz, and D. Shore. 1990. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250: 549-553.
23. Marcand, S., E. Gilson, and D. Shore. 1997. A protein-counting mechanism for telomere length regulation in yeast. Science 275:986-990. (Pubitemid 27087716)
24. McEachern, M. J., and E. H. Blackburn. 1994. A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts. Proc. Natl. Acad. Sci. USA 91:3453-3457.
25. McEachern, M. J., and E. H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822-1834.
26. McEachern, M. J., and E. H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403-409.
27. McEachern, M. J., D. H. Underwood, and E. H. Blackburn. 2002. Dynamics of telomeric DNA turnover in yeast. Genetics 160:63-73.
28. Pennock, E., K. Buckley, and V. Lundblad. 2001. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104:387-396. (Pubitemid 32206459)
29. Sfeir, A. J., W. Chai, J. W. Shay, and W. E. Wright. 2005. Telomere-end processing the terminal nucleotides of human chromosomes. Mol. Cell 18: 131-138.
30. Shawi, M., and C. Autexier. 2008. Telomerase, senescence and ageing. Mech. Ageing Dev. 129:3-10.
31. Shippen-Lentz, D., and E. H. Blackburn. 1990. Functional evidence for an RNA template in telomerase. Science 247:546-552. (Pubitemid 20073673)
32. Smogorzewska, A., and T. de Lange. 2004. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73:177-208.
33. Tzfati, Y., T. B. Fulton, J. Roy, and E. H. Blackburn. 2000. Template boundary in a yeast telomerase specified by RNA structure. Science 288: 863-867. (Pubitemid 30257736)
34. Underwood, D. H., C. Carroll, and M. J. McEachern. 2004. Genetic dissection of the Kluyveromyces lactis telomere and evidence for telomere capping defects in TER1 mutants with long telomeres. Eukaryot. Cell 3:369-384.
35. Underwood, D. H., R. P. Zinzen, and M. J. McEachern. 2004. Template requirements for telomerase translocation in Kluyveromyces lactis. Mol. Cell. Biol. 24:912-923.
36. Verdun, R. E., and J. Karlseder. 2007. Replication and protection of telomeres. Nature 447:924-931.
37. Wray, L. V., M. M. Witte, R. C. Dickson, and M. I. Riley. 1987. Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiae. Mol. Cell. Biol. 7:1111-1121.
38. Yu, G. L., J. D. Bradley, L. D. Attardi, and E. H. Blackburn. 1990. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344:126-132.