Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage-fusion-bridge cycles of a 1q12∼23 amplicon

British Journal of Haematology

Volumn 147, Issue 4, 2009, Pages 484-494

  Sawyer, Jeffrey R ^a,b   Tian, Erming ^a   Thomas, Edward ^b   Koller, Mark ^b   Stangeby, Colin ^b   Sammartino, Gael ^b   Goosen, Linda ^b   Swanson, Charles ^b   Binz, Regina L ^b   Barlogie, Bart ^a   Shaughnessy, John ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Breakage fusion bridge cycles; Cytogenetics; Gene amplification; Multiple myeloma; Pericentromeric heterochromatin

Indexed keywords

AMPLICON; ARTICLE; CHROMOSOME 1Q; CHROMOSOME ARM; CHROMOSOME BREAKAGE; CHROMOSOME BREAKAGE FUSION BRIDGE CYCLE; CHROMOSOME G BAND; CHROMOSOME STRUCTURE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DELETION; HETEROCHROMATIN; HUMAN; HUMAN CELL; INVERTED REPEAT; MAJOR CLINICAL STUDY; METAPHASE CHROMOSOME; MULTIPLE MYELOMA; PRIORITY JOURNAL; SISTER CHROMATID; SPECTRAL KARYOTYPING;

CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 1; GENE AMPLIFICATION; GENE FUSION; HETEROCHROMATIN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MULTIPLE MYELOMA;

EID: 70350461710     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07869.x     Document Type: Article

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