Strain-dependent β-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 1 58-1, 2005, Pages

  Faulx, Michael D ^a   Ernsberger, Paul ^a   Vatner, Dorothy ^b   Hoffman, Robert D ^c   Lewis, William ^d   Strachan, Ryan ^a   Hoit, Brian D ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Echocardiography; Myocyte injury

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; BODY WEIGHT; CALCIFICATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; GRAVIMETRY; HEART INJURY; HEART LEFT VENTRICLE MASS; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; STIMULATION; STRAIN DIFFERENCE;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMEGALY; ECHOCARDIOGRAPHY; HEART; ISOPROTERENOL; MALE; MICE; MICE, INBRED STRAINS; MYOCARDIUM; ORGAN SIZE; RECEPTORS, ADRENERGIC, BETA; SPECIES SPECIFICITY;

EID: 21644436040     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00636.2004     Document Type: Article

References (28)

1. Arnett DKHY, Bella JN, Oberman A, Kitzman DW, Hopkins PN, Rao DC, and Devereux RB. Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: the HyperGEN study. Hypertension Genetic Epidemiology Network. Am J Hypertens 14: 1226-1230, 2001.
2. Arnett DKRP, Crow R, Folsom AR, Ekelund LG, Hutchinson R, Tyroler HA, Heiss G, and the ARIC Investigators. Black-white differences in electrocardiographic left ventricular mass and its association with blood pressure (the ARIC study). Am J Cardiol 74: 247-252, 1994.
3. Benjamin IJ, Jalil JE, Tan LB, Cho K, Weber KT, and Clark WA. Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res 65: 657-670, 1989.
4. Birnkrant DJ, Davis PB, and Ernsberger P. Visualization of high- and low-affinity β-adrenergic receptors in rat lung: upregulation by chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 265: L389-L394, 1993.
5. Bogoyevitch MA, Andersson MB, Gillespie-Brown J, Clerk A, Glennon PE, Fuller SJ, and Sugden PH. Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy. Biochem J 314: 115-121, 1996.
6. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
7. Burger A, Benicke M, Deten A, and Zimmer HG. Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol 281: H14-H21, 2001.
8. Engelhardt S, Hein L, Wiesmann F, and Lohse MJ. Progressive hypertrophy and heart failure in betal-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 96: 7059-7064, 1999.
9. Harjai K. Potential new cardiovascular risk factors: left ventricular hypertrophy, homocysteine, lipoprotein (a), triglycerides, oxidative stress, and fibrinogen. Ann Intern Med 131: 376-386, 1999.
10. Hoit BD, Kiatchoosakun S, Restivo J, Kirkpatrick D, Olszens K, Shao H, Pao YH, and Nadeau JH. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics 79: 679-685, 2002.
11. Kudej RK, Iwase M, Uechi M, Vatner DE, Oka N, Ishikawa Y, Shannon RP, Bishop SP, and Vatner SF. Effects of chronic beta-adrenergic receptor stimulation in mice. J Mol Cell Cardiol 29: 2735-2746, 1997.
12. Leenen FH, White R, and Yuan B. Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. Am J Physiol Heart Circ Physiol 281: H2410-H2416, 2001.
13. Levy DGR, Savage DD, Kannel WB, and Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart study. N Engl J Med 322: 1561-1566, 1990.
14. Molkentin JDDGI. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu Rev Physiol 63: 391-426, 2001.
15. Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, and Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem 275: 14466-14475, 2000.
16. Morisco C, Zebrowski DC, Vatner DE, Vatner SF, and Sadoshima J. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol 33: 561-573, 2001.
17. Nagano M, Higaki J, Nakamura F, Higashimori K, Nagano N, Mikami H, and Ogihara T. Role of cardiac angiotensin II in isoproterenol-induced left ventricular hypertrophy. Hypertension 19: 708-712, 1992.
18. Salomon Y, Londos C, and Rodbell M. A highly sensitive adenylate cyclase assay. Anal Blochem 58: 541-548, 1974.
19. Scheuer J. Catecholamines in cardiac hypertrophy. Am J Cardiol 83: 70H-74H, 1999.
20. Schluter KD, Frischkopf K, Flesch M, Rosenkranz S, Taimor G, and Piper HM. Central role for ornithine decarboxylase in beta-adrenoceptor mediated hypertrophy. Cardiovasc Res 45: 410-417, 2000.
21. Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, and Sonnenblick EH. β-Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol Heart Circ Physiol 275: H961-H968, 1998.
22. Tan LB, Benjamin IJ, and Clark WA. β-Adrenergic receptor desensitisation may serve a cardioprotective role. Cardiovasc Res 26: 608-614, 1992.
23. Teerlink JR, Pfeffer JM, and Pfeffer MA. Effect of left ventricular sphericity on the evolution of ventricular dysfunction in rats with diffuse isoproterenol-induced myocardial necrosis. J Card Fail 4: 45-56, 1998.
24. Teerlink JR, Pfeffer JM, and Pfeffer MA. Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats. Circ Res 75: 105-113, 1994.
25. Vatner DE, Asai K, Iwase M, Ishikawa Y, Wagner TE, Shannon RP, Homey CJ, and Vatner SF. Overexpression of myocardial Gsalpha prevents full expression of catecholamine desensitization despite increased beta-adrenergic receptor kinase. J Clin Invest 101: 1916-1922, 1998.
26. Vatner SF, Vatner DE, and Homey CJ. β-Adrenergic receptor signaling: an acute compensatory adjustment inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models. Circ Res 86: 502-506, 2000.
27. Zou Y, Komuro I, Yamazaki T, Kudoh S, Uozumi H, Kadowaki T, and Yazaki Y. Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy. J Biol Chem 274: 9760-9770, 1999.
28. Zou Y, Yao A, Zhu W, Kudoh S, Hiroi Y, Shimoyama M, Uozumi H, Kohmoto O, Takahashi T, Shibasaki F, Nagai R, Yazaki Y, and Komuro I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation 104: 102-108, 2001.