Mouse strain-specific differences in cardiac metabolic enzyme activities observed in a model of isoproterenol-induced cardiac hypertrophy

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 1-2, 2007, Pages 77-80

  Faulx, Michael D ^a,c   Chandler, Margaret P ^a   Zawaneh, Michael S ^a   Stanley, William C ^a   Hoit, Brian D ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Catecholamine hypertrophy; Mouse genetics; Oxidative metabolism

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CARNITINE PALMITOYLTRANSFERASE; CITRATE SYNTHASE; FATTY ACID; ISOPRENALINE; PYRUVATE DEHYDROGENASE; WATER;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; FATTY ACID BLOOD LEVEL; FREEZING; GRAVIMETRY; HEART; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; ORGAN WEIGHT; OXIDATION;

ACYL-COA DEHYDROGENASE; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CITRATE (SI)-SYNTHASE; HYPERTROPHY, LEFT VENTRICULAR; ISOPROTERENOL; KETONE OXIDOREDUCTASES; MALE; MICE; MICE, INBRED STRAINS; MYOCARDIUM; SPECIES SPECIFICITY;

EID: 33846111297     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04531.x     Document Type: Article

References (23)

1. Rosei EA, Muiesan ML. Early target organ damage and its reversibility: The heart. Clin. Exp. Hypertens. 2004; 26: 673-87.
2. Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH. Beta-adrenergic stimulation causes cardiocyte apoptosis: Influence of tachycardia and hypertrophy. Am. J. Physiol. 1998; 275: H961-8.
3. Leenen FH. Cardiovascular consequences of sympathetic hyperactivity. Can. J. Cardiol. 1999; 15 (Suppl. A): A2-7.
4. Gong G, Liu J, Liang P et al. Oxidative capacity in failing hearts. Am. J. Physiol. Heart Circ. Physiol. 2003; 285: H541-8.
5. Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail. Rev. 2002; 7: 175-85.
6. Wisnecki JA, Gertz EQ, Neese RA, Mayr M. Myocardial metabolism of free fatty acids: Studies with 14C labelled substrates in humans. J. Clin. Invest. 1987; 79: 359-66.
7. Huss JM, Kelly DP. Mitochondrial energy metabolism in heart failure: A question of balance. J. Clin. Invest. 2005; 115: 547-55.
8. Lehman JJ, Kelly DP. Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin. Exp. Pharmacol. Physiol. 2002; 29: 339-45.
9. Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am. J. Physiol. Heart Circ. Physiol. 1994; 36: H742-50.
10. Lucas DT, Aryal P, Szweda LI, Koch WJ, Leinwald LA. Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 2002; 284: H575-83.
11. Faulx MD, Ernsberger P, Vatner D et al. Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice. Am. J. Physiol. Heart Circ. Physiol. 2005; 289: H30-6.
12. Hoit BD, Kiatchoosakun S, Restivo J et al. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics 2002; 79: 679-85.
13. Panchal AR, Stanley WC, Kerner J, Sabbah HN. Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure. J. Cardiac Fail. 1998; 4: 121-6.
14. Hoppel CL, Tomec RJ. Carnitine palmityltransferase. Location of two enzymatic activities in rat liver mitochondria. J. Biol. Chem. 1972; 247: 832-41.
15. Sterk JP, Stanley WC, Hoppel CL, Kerner J. A radiochemical pyruvate dehydrogenase assay: Activity in heart. Anal. Biochem. 2003; 313: 179-82.
16. Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ. Res. 2004; 95: 568-78.
17. Belke DD, Larsen TS, Lopaschuk GD, Severson DL. Glucose and fatty acid metabolism in the isolated working mouse heart. Am. J. Physiol. 1999; 277: R1210-17.
18. Beck J, Lloyd S, Hafezparast M et al. Geneologies of mouse inbred strains. Nat. Genet. 2000; 24: 23-5.
19. Seymour AM, Chatham JC. The effects of hypertrophy and diabetes on cardiac pyruvate dehydrogenase activity. J. Mol. Cell. Cardiol. 1997; 29: 2771-8.
20. Sambandam N, Lopaschuk GD, Brownsey RW, Allard MF. Energy metabolism in the hypertrophied heart. Heart Fail. Rev. 2002; 7: 161-73.
21. Hohimer AR, Davis LE, Hatton DC. Repeated daily injections and osmotic pump infusion of isoproterenol cause similar increases in cardiac mass but have different effects on blood pressure. Can. J. Physiol. Pharmacol. 2005; 83: 191-7.
22. Chandler MP, Kerner J, Huang H et al. Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. Am. J. Physiol. Heart Circ. Physiol. 2004; 287: H1538-43.
23. Paolisso G, Gambardella A, Galzerano D et al. Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism 1994; 43: 174-9.