Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors containing α1-subunits

British Journal of Pharmacology

Volumn 157, Issue 8, 2009, Pages 1514-1522

  Lu, Y G ^a,b   Tang, Z Q ^b   Ye, Z Y ^a   Wang, H T ^b   Huang, Y N ^a,b   Zhou, K Q ^a   Zhang, M ^b   Xu, T L ^c   Chen, L ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Cell culture; Glycine receptor; Salicylate; Site directed mutagenesis; Transfection; Whole cell patch clamp

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR ALPHA1BETA; GLYCINE RECEPTOR ALPHA2; GLYCINE RECEPTOR ALPHA2BETA; GLYCINE RECEPTOR ALPHA3BETA; LEUCINE; PROTEIN SUBUNIT; SALICYLIC ACID; UNCLASSIFIED DRUG; VALINE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE CONDUCTANCE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFERIOR COLLICULUS; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; WHOLE CELL;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INFERIOR COLLICULI; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; SODIUM SALICYLATE; TRANSFECTION;

EID: 70350344963     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00321.x     Document Type: Article

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