Fluoxetine inhibition of glycine receptor activity in rat hippocampal neurons

Brain Research

Volumn 1239, Issue , 2008, Pages 77-84

  Ye, Zeng You ^a,b   Lu, Yun Gang ^a   Sun, Hao ^a   Cheng, Xin Ping ^a   Xu, Tian Le ^b   Zhou, Jiang Ning ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Antidepressant; Competitive inhibition; Fluoxetine associated seizure; Hippocampus; Subtype selectivity; Whole cell patch clamp

Indexed keywords

FLUOXETINE; GLYCINE RECEPTOR; NORFLUOXETINE; PICROTOXIN; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; CELL LINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; GLYCINE; HIPPOCAMPUS; HUMANS; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; PICROTOXIN; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; SEROTONIN UPTAKE INHIBITORS;

RATTUS;

EID: 53949123911     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.055     Document Type: Article

References (35)

1. Betz H., and Laube B. Glycine receptors: recent insights into their structural organization and functional diversity. J. Neurochem. 97 (2006) 1600-1610
2. Braitberg G., and Curry S.C. Seizure after isolated fluoxetine overdose. Ann. Emerg. Med. 26 (1995) 234-237
3. Chattipakorn S.C., and McMahon L.L. Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. J. Neurophysiol. 87 (2002) 1515-1525
4. Chattipakorn S.C., and McMahon L.L. Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus. J. Neurophysiol. 89 (2003) 1339-1342
5. Derry J.M., et al. A single point mutation of the GABA(A) receptor alpha5-subunit confers fluoxetine sensitivity. Neuropharmacology 52 (2007) 497-505
6. Eisensamer B., et al. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Mol. Psychiatry 8 (2003) 994-1007
7. Gentet L.J., and Clements J.D. Binding site stoichiometry and the effects of phosphorylation on human alpha1 homomeric glycine receptors. J. Physiol. 544 (2002) 97-106
8. Jiang P., et al. Mechanisms of modulation of pregnanolone on glycinergic response in cultured spinal dorsal horn neurons of rat. Neuroscience 141 (2006) 2041-2050
9. Karson C.N., et al. Human brain fluoxetine concentrations. J. NeuroPsychiatry Clin. Neurosci. 5 (1993) 322-329
10. Kirchner A., et al. Effects of taurine and glycine on epileptiform activity induced by removal of Mg2+ in combined rat entorhinal cortex-hippocampal slices. Epilepsia 44 (2003) 1145-1152
11. Li Y., and Xu T.L. State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport 13 (2002) 223-226
12. Malosio M.L., et al. Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. Embo. J. 10 (1991) 2401-2409
13. Mitchell S.J., and Silver R.A. Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38 (2003) 433-445
14. Mori M., et al. Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. J. Physiol. 539 (2002) 191-200
15. Murase K., et al. Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons. Neurosci. Lett. 103 (1989) 56-63
16. Ni Y.G., and Miledi R. Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 2036-2040
17. Oke A., et al. Dose-dependent seizure activity associated with fluoxetine therapy. Qjm. 94 (2001) 113-114
18. Pinna G., et al. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6222-6225
19. Pisani F., et al. Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice. Epilepsia 40 Suppl 10 (1999) S48-56
20. Pribilla I., et al. The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. Embo. J. 11 (1992) 4305-4311
21. Robinson R.T., et al. Fluoxetine increases GABA(A) receptor activity through a novel modulatory site. J. Pharmacol. Exp. Ther. 304 (2003) 978-984
22. Rosenstein D.L., et al. Seizures associated with antidepressants: a review. J. Clin. Psychiatry 54 (1993) 289-299
23. Sanchez C., and Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell. Mol. Neurobiol. 19 (1999) 467-489
24. Song W., et al. Glycine-gated chloride channels depress synaptic transmission in rat hippocampus. J. Neurophysiol. 95 (2006) 2366-2379
25. Sun H., et al. Quercetin subunit specifically reduces GlyR-mediated current in rat hippocampal neurons. Neuroscience 148 (2007) 548-559
26. Szasz B.K., et al. Direct inhibitory effect of fluoxetine on N-methyl-d-aspartate receptors in the central nervous system. Biol. Psychiatry 62 (2007) 1303-1309
27. Tallarida R., and Murray R. Manual of Pharmacologic Calculations with Computer Programs vol (1987), Springer-Verlag, New York
28. Tallarida R.J., et al. pA2 and receptor differentiation: a statistical analysis of competitive antagonism. Life Sci. 25 (1979) 637-654
29. Uzunova V., et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 3239-3244
30. Vandenberg R.J., et al. Distinct agonist-and antagonist-binding sites on the glycine receptor. Neuron 9 (1992) 491-496
31. Ware M.R., and Stewart R.B. Seizures associated with fluoxetine therapy. Dicp. 23 (1989) 428
32. Weber J.J. Seizure activity associated with fluoxetine therapy. Clin. Pharm. 8 (1989) 296-298
33. Ye J.H. Regulation of excitation by glycine receptors. Results Probl. Cell. Differ. 44 (2008) 123-143
34. Zhang L.H., et al. Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Biochem. Biophys. Res. Commun. 344 (2006) 721-726
35. Zhang L.H., et al. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 33 (2008) 701-711