Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

APMIS

Volumn 117, Issue 11, 2009, Pages 839-848

  Larsen, Nicolai Balle ^a   Heiberg Engel, Peter Johan ^b   Rasmussen, Merete ^a   Rasmussen, Lene Juel ^a,c  

^a ROSKILDE UNIVERSITY   (Denmark)

^b ROSKILDE HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Colorectal cancer; DNA mismatch repair; HMLH1; Metastasis

Indexed keywords

MISMATCH REPAIR PROTEIN; PROTEIN MLH1;

ADULT; AGED; ARTICLE; CANCER STAGING; COLORECTAL CANCER; DISTANT METASTASIS; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADENOSINE TRIPHOSPHATASES; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; RETROSPECTIVE STUDIES;

EID: 70350334857     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2009.02543.x     Document Type: Article

References (37)

1. Arnold CN, Goel A, Blum HE, Boland CR. Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis. Cancer 2004 104 : 2035 2047.
2. Umar A, Boland CR, Terdiman JP, Syngal S, de la Chapelle A, Rüschoff J, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004 96 : 261 268. (Pubitemid 38256271)
3. Kunkel TA, Bebenek K. DNA replication and fidelity. Annu Rev Biochem 2000 69 : 497 529.
4. Kunkel TA, Erie DA. DNA mismatch repair. Annu Rev Biochem 2005 74 : 681 710.
5. Strate LL, Syngal S. Hereditary colorectal cancer syndromes. Cancer Causes Control 2005 16 : 201 213.
6. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998 95 : 6870 6875.
7. Kim HC, Roh SA, Ga IH, Kim JS, Yu CS, Kim JC. CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer. J Gastroenterol Hepatol 2005 20 : 1920 1926.
8. Jass JR, Do KA, Simms LA, Iino H, Mynter C, Pillay SP, et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 1998 42 : 673 679.
9. Raut CP, Pawlik TM, Rodriquez-Bigas MA. Clinicopathologic features in colorectal cancer patients with microsatellite instability. Mutat Res 2004 568 : 275 282.
10. Clark AJ, Barnetson R, Farrington SM, Dunlop MG. Prognosis in DNA mismatch repair deficient colorectal cancer: are all MSI tumors equivalent? Fam Cancer 2004 3 : 85 91.
11. Buckowitz A, Knaebel HP, Benner A, Bläker H, Gebert J, Kienle P, et al. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 2005 92 : 1746 1753.
12. Malesci A, Laghi L, Bianchi P, Delconte G, Randolph A, Torri V, et al. Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. Clin Cancer Res 2007 13 : 3831 3839.
13. Meyers M, Hwang A, Wagner MW, Boothman DA. Role of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ Mol Mutagen 2004 44 : 249 264.
14. Jo WS, Carethers JM. Chemotherapeutic implications in microsatellite unstable colorectal cancer. Cancer Biomark 2006 2 : 51 60.
15. Carethers JM, Chauhan DP, Fink D, Nebel S, Bresalier RS, Howell SB, et al. Mismatch repair proficiency and in vitro response to 5-flurouracil. Gastroenterology 1999 117 : 123 131.
16. Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA. Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 2001 61 : 5193 5201.
17. Warusavitarne J, Ramanathan P, Kaufman A, Robinson BG, Schnitzler M. 5-Fluorouracil (5FU) treatment does not influence invasion and metastasis in microsatellite unstable (MSI-H) colorectal cancer. Int J Colorectal Dis 2006 21 : 625 631.
18. Ribic CM, Sargent DJ, Moore MJ, Thibodeau SN, French AJ, Goldberg RM, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003 349 : 247 257.
19. Carethers JM, Smith EJ, Behling CA, Nquyen L, Tajima A, Doctolero RT, et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology 2004 126 : 394 401.
20. Benatti P, Gafa R, Barana D, Marino M, Scarselli A, Pedroni M, et al. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res 2005 11 : 8332 8340.
21. Jacob S, Aguado M, Fallik D, Praz F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res 2001 61 : 6555 6562.
22. Magrini R, Bhonde MR, Hanski ML, Notter M, Scherübl H, Boland CR, et al. Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. Int J Cancer 2002 101 : 23 31.
23. Fallik D, Borrini F, Boige V, Viguier J, Jacob S, Miquel C, et al. Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res 2003 63 : 5738 5744.
24. Charara M, Edmonston TB, Burkholder S, Walters R, Anne P, Mitchell E, et al. Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. Anticancer Res 2004 24 : 3161 3168.
25. Bendardaf R, Lamlum H, Ristamäki R, Korkeila E, Syrjänen K, Pyrhönen S. Mismatch repair status is a predictive factor of tumor response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. Tumor Biol 2007 28 : 212 220.
26. Jass JR, Sobin LH, Wanatabe H. The WHO classification of gastrointestinal tumors: a commentary on the second edition. Cancer 1990 66 : 2162 2167.
27. Wang NP, Zee S, Zarbo RJ. Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas. Appl Immunohistochem 1995 3 : 99 107.
28. Plevová P, Krepelová A, Papezová M, Sedláková E, Curík R, Foretová L, et al. Immunohistochemical detection of the hMLH1 and hMSH2 proteins in hereditary non-polyposis colon cancer and sporadic colon cancer. Neoplasma 2004 51 : 275 284.
29. Lindor NM, Burgart LJ, Leontovich O, Goldberg RM, Cunningham JM, Sargent DJ, et al. Immunohistochemistry versus microsatellite Instability testing in phenotyping colorectal tumors. J Clin Oncol 2002 20 : 1043 1048.
30. Muskhelishvili L, Latendresse JR, Kodell RL, Henderson EB. Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67 (MIB-5) immunohistochemistry and in situ hybridization for histone mRNA. J Histochem Cytochem 2003 51 : 1681 1688.
31. Koopman M, Kortman GA, Mekenkamp L, Ligtenberg MJ, Hoogerbrugge N, Antonini NF, et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer 2009 100 : 266 273.
32. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 2003 33 : 61 5.
33. Fang JY, Lu R, Mikovits JA, Cheng ZH, Zhu HY, Chen YX. Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1. Cancer Lett 2006 233 : 124 130.
34. Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett 2003 192 : 75 82.
35. Blaker H, Graf M, Rieker RJ, Otto HF. Comparison of losses of heterozygosity and replication errors in primary colorectal carcinomas and corresponding liver metastases. J Pathol 1999 188 : 258 262.
36. Barnetson R, Eckstein R, Robinson B, Schnitzler M. There is no increase in frequency of somatic mutations in metastases compared with primary colorectal carcinomas with microsatellite instability. Genes Chromosomes Cancer 2003 38 : 149 156.
37. Liang JT, Huang KC, Lai HS, Lee PH, Cheng YM, Hsu HC, et al. High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection. Int J Cancer 2002 101 : 519 525.