Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats

Life Sciences

Volumn 85, Issue 19-20, 2009, Pages 704-710

  Peeyush, Kumar T ^a   Gireesh, G ^a   Jobin, Mathew ^a   Paulose, C S ^a  

^a Department of Physics   (India)

Author keywords

Acetylcholine esterase; Cholinergic receptor; Curcumin; Diabetes; Glut3; Insulin

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINERGIC RECEPTOR; CURCUMIN; GLUCOSE; GLUCOSE TRANSPORTER 3; INSULIN; INSULIN RECEPTOR; INSULIN ZINC SUSPENSION; LIGAND; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CEREBELLUM; CEREBELLUM DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; MALE; MORNING DOSAGE; MOTOR COORDINATION; NEUROPROTECTION; NONHUMAN; RADIORECEPTOR ASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROTAROD TEST; STREPTOZOCIN DIABETES;

ACETYLCHOLINESTERASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD GLUCOSE; CEREBELLUM; CURCUMIN; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TRANSPORTER TYPE 3; KINETICS; MALE; NEUROPROTECTIVE AGENTS; POSTURAL BALANCE; RATS; RATS, WISTAR; RECEPTOR, INSULIN; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS; RATTUS NORVEGICUS;

EID: 70350331099     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.09.012     Document Type: Article

References (72)

1. Abraham A., and Paulose C.S. Age related alterations in noradrenergic function in brain stem of streptozotocin-diabetic rats. Journal of Biochemistry Molecular Biology and Biophysics 31 (1999) 171-176
2. Adler L.E., Olincy A., Waldo M., Harris J.G., Griffith J., Stevens K., Flach K., Nagamoto H., Bickford P., and Leonard S. Schizophrenia, sensory gating, and nicotinic receptors. Schizophrenia Bulletin 24 2 (1998) 189-202
3. Ahren B. Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 43 4 (2000) 393-410
4. Allen G., Buxton R.B., Wong E.C., and Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science 275 5308 (1997) 1940-1943
5. Arison R.N., Ciaccio E.I., Glitzer M.S., Cassaro A.V., and Pruss M. Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes 16 1 (1967) 51-56
6. Bhardwaj S.K., Sandhu S.K., Sharma P., and Kaur G. Impact of diabetes on CNS: role of signal transduction cascade. Brain Research Bulletin 49 3 (1999) 155-162
7. Biju M.P., Pyroja S., Rajesh N.V., and Paulose C.S. Hepatic GABA A receptor functional regulation during liver cell proliferation. Hepatology Research 21 2 (2001) 136-146
8. Bitar M., Koulu M., Rapoport S.I., and Linnoila M. Dibetes induced alterations in brain monoamine metabolism in rats. Journal of Pharmacology and Experimental Therapeutics 236 2 (1986) 432-437
9. Blanchard J.G., and Duncan P.M. Effect of combinations of insulin, glucose and scopolamine on radial arm maze performance. Pharmacology Biochemistry and Behaviour 58 1 (1997) 209-214
10. Bonnefont-Rousselot D. Glucose and reactive oxygen species. Current Opinion in Clinical Nutrition and Metabolic Care 5 5 (2002) 561-568
11. Bymaster F.P., Shannon H.E., Rasmussen K., DeLapp N.W., Ward J.S., Calligaro D.O., Mitch C.H., Whitesitt C., Ludvigsen T.S., Sheardown M., Swedberg M., Rasmussen T., Olesen P.H., Jeppesen L., Sauerberg P., and Fink-Jensen A. Potential role of muscarinic receptors in schizophrenia. Life Sciences 64 6-7 (1999) 527-534
12. Cendelin J., Korelusova I., and Vozeh F. The effect of repeated rotarod training on motor skills and spatial learning ability in Lurcher mutant mice. Behavioural Brain Research 189 1 (2008) 65-74
13. Choeiri C., Staines W., Miki T., Seino S., and Messier C. Glucose transporter plasticity during memory processing. Neuroscience 130 3 (2005) 591-600
14. Commandeur J.N.M., and Vermeulen N.P.E. Cytotoxicity and cytoprotective activities of natural compounds - the case of curcumin. Xenobiotica 26 7 (1996) 667-680
15. De Filippi G., Baldwinson T., and Sher E. Evidence for nicotinic acetylcholine receptor activation in rat cerebellar slices. Pharmacology Biochemistry and Behaviour 70 4 (2001) 447-455
16. Dunham N.W., and Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. Journal of the American Pharmaceutical Association 46 3 (1957) 208-209
17. Eglen R.M., Choppin A., Dillon M.P., and Hegde S. Muscarinic receptor ligands and their therapeutic potential. Current Opinion in Chemical Biology 3 4 (1999) 426-432
18. Felder C.C., Bymaster F.P., Ward J., and DeLapp N. Therapeutic opportunities for muscarinic receptors in the central nervous system. Journal of Medicinal Chemistry 43 23 (2000) 4333-4353
19. Gao X., Kuo J., Jiang H., Deeb D., Liu Y., Divine G., Chapman R.A., Dulchavsky S.A., and Gautam S.C. Immunomodulatory activity of curcumin, suppression of lymphocyte proliferation, development of cell mediated cytotoxicity, and cytokine production in vitro. Biochemical Pharmacology 68 1 (2004) 51-61
20. Garris. Age diabetes associated alterations in regional brain norepinephrine concentrations and adrenergic populations in C57BL/KsL mice. Developmental Brain Research 51 3 (1990) 161-166
21. Gilon P., and Henquin J.C. Mechanisms and physiological significance of the cholinergic control of pancreatic β cell function. Endocrine Reviews 22 5 (2001) 565-604
22. Gireesh G., Balarama Kaimal S., Peeyush K.T., and Paulose C.S. Decreased muscarinic M1 receptor gene expression in the hypothalamus, brainstem, and pancreatic islets of streptozotocin-induced diabetic rats. Journal of Neuroscience Research 86 4 (2008) 947-953
23. Girod R., and Role L.W. Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine. Journal of Neuroscience 21 14 (2001) 5182-5190
24. Gispen W.H., and Biessels G.J. Cognition and synaptic plasticity in diabetes mellitus. Trends in Neurosciences 23 11 (2000) 542-549
25. 3H]DOPA in various regions of brain. Journal of Neurochemistry 13 8 (1966) 655-669
26. Gomeza J., Shannon H.E., Kostenis E., Felder C., Zhang L., Brodkin J., Grinberg A., Sheng H., and Wess J. Pronounced pharmacological deficits in M2 muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America 96 4 (1999) 1692-1697
27. Gould G.W., and Holman G.D. The glucose transporter - family, structure, function and tissue-specific expression. Biochemical Journal 295 Pt 2 (1993) 295-329
28. Green A., Ellis K.A., Ellis J., Bartholomeusz C.F., Ilic S., Croft R.J., Phan K.L., and Nathan P.J. Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans. Pharmacology, Biochemistry and Behavior 8 3 (2005) 575-584
29. Hohenegger M., and Rudas B. Kidney functions in experimental diabetic ketosis. Diabetologia 17 7 (1971) 334-338
30. Jacobson A.M., and Weinger K. Treating depression in diabetic patients, is there an alternative to medications. Annals of Internal Medicine 129 8 (1998) 656-657
31. Junod A., Lambert A.E., Staufferacher W., and Renold A.E. Diabetogenic action of streptozotocin relationship of dose to metabolic response. Journal of Clinical Investigation 48 11 (1969) 2129-2139
32. Kagan V.E., and Tyurina Y.Y. Recycling and redox cycling of phenolic antioxidants. Annals of the New York Academy of Sciences 854 (1998) 425-434
33. Kaimal S.B., Gireesh G., and Paulose C.S. Decreased GABAA receptor function in the brain stem during pancreatic regeneration in rats. Neurochemical Research 32 11 (2007) 1813-1822
34. Kanitkar M., Gokhale K., Galande S., and Bhonde R.R. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. British Journal of Pharmacology 155 5 (2009) 702-713
35. Kopf S.R., and Baratti C.M. The impairment of retention induced by insulin in mice may be mediated by a reduction in central cholinergic activity. Neurobiology of Learning and Memory 63 3 (1995) 220-228
36. Kopf S.R., Boccia M.M., and Baratti C.M. AF-DX 116, a presynaptic muscarinic receptor antagonist, potentiates the effects of glucose and reverses the effects of insulin on memory. Neurobiology of Learning and Memory 70 3 (1998) 305-313
37. Krebs D.L., and Parent M.B. The enhancing effects of hippocampal infusions of glucose are not restricted to spatial working memory. Neurobiology of Learning and Memory 83 2 (2005) 168-172
38. Kwok R.P.S., Walls E.K., and Juoria A.V. The concentration of copamine, 5-hydroxytryptamine, and some of their acid metabolites in the brain of genetically diabetic rats. Neurochemical Research 10 5 (1985) 611-616
39. Lackovic Z., Salkovic M., Kuci Z., and Relja M. Dopamine, norepinephrine and serotonin in the brain of diabetic rats and man. Journal of Neurochemistry 44 1 (1985) 94A
40. Lackovic Z., Salkovic M., Kuci Z., and Relja M. Effect of long-lasting diabetes mellitus on rat and human brain monoamines. Journal of Neurochemistry 541 1 (1990) 143-147
41. Lapp J.E. Effects of glycemic alterations and noun imagery on the learning of paired associates. Journal of Learning Disabilities 14 1 (1981) 35-38
42. Levin E.D., Bradley A., Addy N., and Sigurani N. Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience 109 4 (2002) 757-765
43. Levin B.E., Routh V.H., Kang L., Sanders N.M., and Dunn Meynell A.A. Neuronal glucosensing: what do we know after 50 years?. Diabetes 53 10 (2004) 2521-2528
44. Lowry O.H., Roserbrough N.J., Farr A.L., and Randall R.J. Protein measurement with folin phenol reagent. Journal of Biological Chemistry 193 1 (1951) 265-275
45. Marchall J.F. Further analysis of the resistance of the diabetic rat to d amphetamine pharmacology. Biochemistry and Behaviour 8 3 (1978) 281-286
46. Marchall J.F., Friedman M.I., and Heffner T.G. Reduced anorexic and locomotor-stimulant action of d-amphetamine in alloxan-diabetic rats. Brain Research 111 2 (1976) 428-432
47. McCall A.L., Van Bueren A.M., Moholt-Siebert M., Cherry N.J., and Woodward W.R. Immunohistochemical localization of the neuron-specific glucose transporter GLUT3 to neuropil in adult rat brain. Brain Research 659 1-2 (1994) 292-297
48. McNay E.C., Fries T.M., and Gold P.E. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proceedings of the National Academy of Sciences of the United States of America 97 6 (2000) 2881-2885
49. Meghana K., Sanjeev G., and Ramesh B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. European Journal of Pharmacology 577 1-3 (2007) 183-191
50. Messier C., and Destrade C. Insulin attenuates scopolamine-induced memory deficits. Psychobiology 22 1 (1994) 16-21
51. Miller J.S.M., Angeles F.M., Reuter B.K., Bobrowski P., and Sandoval M. Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis. BMC Complementary and Alternative Medicine 1 (2001) 11
52. Mohanan V.V., Kaimal S.B., and Paulose C.S. Decreased 5-HT1A receptor gene expression and 5HT1A receptor protein in the cerebral cortex and brain stem during pancreatic regeneration in rats. Neurochemical Research 30 1 (2005) 25-32
53. Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., Giardino I., and Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404 6779 (2000) 787-790
54. O'Leary K.T., and Leslie F.M. Developmental regulation of nicotinic acetylcholine receptor-mediated [3H] norepinephrine release from rat cerebellum. Journal of Neurochemistry 84 5 (2003) 952-959
55. Paulose C.S., Daksinamurthi K., Packer S., and Stephens L.N. Sympathetic simulation and hypertension in pyridoxine deficient adult rat. Hypertension 114 4 (1988) 387-391
56. Park C.R., Crofford O.B., and Kono T. Mediated nonactive transport of glucose in mammalian cells and its regulation. Journal of General Physiology 52 1 (1968) S296-S318
57. Rastogi M., Ojha R.P., Rajamanickam G.V., Agrawal A., Aggarwal A., and Dubey G.P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. Free Radical Research 42 11-12 (2008) 999-1005
58. Reno L.A., Zago W., and Markus R.P. Release of [3H]-l-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices. Neuroscience 124 3 (2004) 647-653
59. Rossi D.J., Hamann M., and Attwell D. Multiple modes of GABAergic inhibition of rat cerebellar granule cells. Journal of Physiology 548 Pt 1 (2003) 97-110
60. Saller C.F. Dopaminergic activity is reduced in diabetic rats. Neuroscience Letters 49 3 (1984) 301-306
61. Santucci A.C., Schroeder H., and Riccio D.C. Homeostatic disruption and memory effect of insulin administration in rats. Behavioral and Neural Biology 53 3 (1990) 321-333
62. Scatchard G. The attraction of proteins for small molecules and ions. Annals of the New York Academy of Sciences 51 2 (1949) 660-672
63. Seo K.-I., Choi M.-S., Jung U.J., Kim H.-J., Yeo J., Jeon S.-M., and Lee M.-K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Molecular Nutritional Food Research 52 9 (2008) 995-1004
64. Sharma S., Kulkarni S.K., and Chopra K. Curcumin the active principle turmeric Curcuma longa, ameliorates diabetic nephropathy in rats. Clinical and Experimental Pharmacology and Physiology 33 10 (2006) 940-945
65. Sudha B., and Paulose C.S. Induction of DNA synthesis in primary culture of rat hepatocyte by serotonin: possible involvement of serotonin S2 receptor. Hepatology 27 1 (1998) 62-66
66. Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., and Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals, down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutation Research 480 (2001) 243-268
67. Tannenbaum G.S. Growth hormone secretory dynamics in streptozotocin diabetes, evidence of a role for endogenous circulating somatostatin. Endocrinology 108 1 (1981) 76-82
68. Trulson M.E., Jacoby J.H., and Mckenzie R.C. Streptozotocin-induced diabetes reduces brain serotonin synthesis in rats. Journal of Neurochemistry 46 4 (1985) 1068-1078
69. Waxman S.G., and Sabin T.D. Diabetic truncal polyneuropathy. Archives of Neurology 38 1 (1981) 46
70. Wonnacott S. Presynaptic nicotinic ACh receptors. Trends in Neuroscience 20 2 (1997) 92-98
71. 3H] QNB in rat brain. Proceedings of the National Academy Sciences 71 5 (1981) 1725-1729
72. Zhaoa J., Zhaob Y., Zhenga W., Lub Y., Fengb G., and Yub S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Research 1229 (2008) 224-232