AF-DX 116, a presynaptic muscarinic receptor antagonist, potentiates the effects of glucose and reverses the effects of insulin on memory

Neurobiology of Learning and Memory

Volumn 70, Issue 3, 1998, Pages 305-313

  Kopf, Silvia R ^a   Boccia, Mariano M ^a   Baratti, Carlos M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Acetylcholine; Acetylcholine release; AF DX 116; Glucoregulation; Glucose; Inhibitory avoidance; Insulin; M2 antagonists; Memory; Muscarinic autoreceptors; Retention

Indexed keywords

AUTORECEPTOR; GLUCOSE; INSULIN; MUSCARINIC RECEPTOR BLOCKING AGENT; OTENZEPAD; PRESYNAPTIC RECEPTOR;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CHOLINERGIC NERVE; CONTROLLED STUDY; GLUCOSE BRAIN LEVEL; MALE; MEMORY CONSOLIDATION; MOUSE; NONHUMAN;

EID: 0031733995     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.1998.3855     Document Type: Article

References (48)

1. Baratti C. M., Kopf S. R. The post-training memory enhancement induced by physostigmine and oxotremorine in mice is not state-dependent. Neurobiology of Learning and Memory. 65:1996;121-124.
2. Baratti C. M., Opezzo J. W., Kopf S. R. Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116. Behavioral and Neural Biology. 60:1993;69-74.
3. Benton D., Owens D. S., Parker P. Blood glucose and human memory. Psychopharmacology. 113:1993;83-88.
4. 2. The Journal of Pharmacology and Experimental Therapeutics. 273:1995;273-279.
5. Brown J. H., Taylor P. Muscarinic receptor agonists and antagonists. Goodman and Gilman's The pharmacological basis of therapeutics. 1996;McGraw-Hill, New York. p. 141-160.
6. Davis S. N., Granner D. K. Insulin oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. Molinoff P. B., Ruddon R. W. Goodman and Gilman's The pharmacological basis of therapeutics. 1996;1487-1517 McGraw-Hill, New York.
7. 2. Drugs of the Future. 20:1995;157-164.
8. Engel W., Doods H., Wetzel B. AF-DX 116. Drugs of the Future. 15:1990;9-14.
9. Feuerstein T. J., Lehmann J., Sauermann W., v. Velthoven V., Jackisch R. The autoinhibitory feedback control of acetylcholine release form human neocortex tissue. Brain Research. 572:1992;64-71.
10. Feuerstein T. J., Seeger W. Modulation of acetylcholine release in human cortical slices: Possible implications for Alzheimer's disease. Pharmacology and Therapeutics. 74:1997;333-347.
11. Gibson G. E., Blass J. P. Impaired synthesis of acetylcholine in brain accompanying mild hypoxia and hypoglycemia. Journal of Neurochemistry. 27:1976;37-42.
12. Gibson G. E., Jope R., Blass J. P. Reduced synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain slices. Biochemistry Journal. 148:1975;17-23.
13. Giovannini M. G., Camilli F., Mundula A., Pepeu G. Glutamatergic regulation of acetylcholine output in different brain regions: A microdialysis study in the rat. Neurochemistry International. 25:1994;23-26.
14. Gold P. E. Modulation of memory processing: Enhancement of memory in rodents and humans. Squire L. R., Butters N. Neuropsychology of memory. 1992;402-414 Guilford, New York.
15. Hammer R., Giraldo E., Schiavi G. B., Monferini E., Ladinsky H. Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in rat. Life Sciences. 38:1986;1653-1662.
16. Jaffard R., Galey D., Micheau J., Durkin T. The cholinergic septo-hippocampal pathway and learning and memory. Will B. E., Schmitt P., Dalrimple-Alford J. C. Brain plasticity, learning and memory. 1985;167-181 Plenum, New York.
17. Kilbinger H. Presynaptic muscarinic modulating acetylcholine release. Trends in Pharmacological Sciences. 5:1984;103-105.
18. Kopf S. R. Efectos de la glucosa sobre la memoria. 1997;Universidad de Buenos AiresFacultad de Farmacia y Bioquímica.
19. Kopf S. R., Baratti C. M. Memory-improving actions of glucose: Involvement of a central cholinergic muscarinic mechanism. Behavioral and Neural Biology. 62:1994;237-243.
20. Kopf S. R., Baratti C. M. The impairment of retention induced by insulin in mice may be mediated by a reduction of central cholinergic activity. Neurobiology of Learning and Memory. 63:1995;220-228.
21. Kopf S. R., Baratti C. M. Effects of post-training administration of glucose on retention of a habituation response in mice: Participation of a central cholinergic mechanism. Neurobiology of Learning and Memory. 65:1996;253-260.
22. Kopf, S. R. Baratti, C. M. 1997, Effects of post-training administration of insulin on retention of a habituation response in mice: Participation of a central cholinergic mechanism.
23. 3. Brain Research. 496:1989;285-294.
24. Manning C. A., Parsons M. W., Gold P. E. Anterograde and retrograde enhancement of 24-h memory by glucose in elderly humans. Behavioral and Neural Biology. 58:1992;125-130.
25. 2. The Journal of Pharmacology and Experimental Therapeutics. 248:1989;1255-1260.
26. Matthies H., Rauca C., Liebman H. Changes in acetylcholine content of different brain regions of the rat during a learning experiment. Journal of Neurochemistry. 23:1974;1109-1113.
27. McGaugh J. L. Involvement of hormonal and neuromodulatory systems in the regulation of memory storage. Annual Review of Neuroscience. 12:1989;255-287.
28. Messier C., Destrade C. Insuline attenuates scopolamine-induced memory deficits. Psychobiology. 22:1994;16-21.
29. Messier C., Durkin T., Mrabet O., Destrade C. Memory improving action of glucose: Indirect evidence for a facilitation of hippocampal acetylcholine synthesis. Behavioral Brain Research. 30:1990;135-143.
30. Messier C., Gagnon M. Glucose regulation and cognitive function: Relation to Alzheimer's disease and diabetes. Behavioral Brain Research. 75:1996;991-1010.
31. Milne M. D., Rowe G. G., Sommers K., Muehrcke R. C., Crawford M. A. Observations on the pharmacology of mecamylamine. Clinical Science (Oxford). 62:1957;1395-1398.
32. 2. Brain Research. 524:1990;72-76.
33. Quastel J. H. Source of the acetyl group in acetylcholine. Jenden D. J. Cholinergic mecanisms and psychopharmacology. 1978;411-430 Plenum, New York.
34. Ragozzino M. E., Gold P. E. Glucose injections into the medial septum reverse the effects of intraseptal morphine infusions on hippocampal acetylcholine output and memory. Neuroscience. 68:1995;981-988.
35. Ragozzino, M. E. Unick, K. E. Gold, P. E. 1996, Hippocampal acetylcholine release during memory testing in rats: Augmentation by glucose, Proceedings of the National Academy of Sciences of the USA, 93, 4693, 4698, 1996.
36. Raiteri M., Leardi R., Marchi M. Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 228:1984;209-214.
37. Rauca C., Kammerer E., Matthies H. Choline uptake and permanent memory storage. Pharmacology, Biochemistry and Behavior. 13:1980;21-25.
38. 2. Synapse. 4:1989;115-125.
39. 2. Society of Neuroscience Abstracts. 15:1989;860.
40. 213. British Journal Pharmacology. 99:1990;753-761.
41. Richard J., Araujo D. M., Quirion R. Modulation of cortical acetylcholine release by cholinergic agents: An in vivo dialysis study. Society of Neurosciences Abstracts. 15:1989;1197.
42. 2. Society of Neurosciences Abstracts. 17:1991;787.
43. Siegel S. Nonparametric statistics for the behavioural sciences. 1956;McGraw-Hill, New York.
44. Starke K., Göthert M., Kilbinger H. Modulation of neurotransmitter release by presynaptic autoreceptors. Physiological Reviews. 69:1989;864-989.
45. Staubli U., Rogers G., Lynch G. Facilitation of glutamate receptors enhances memory. Proceedings of the National Academy of Sciences of the USA. 91:1994;777-781.
46. Szerb J. C. Characterization of presynaptic muscarinic receptors in central cholinergic neurons. Jenden D. J. Cholinergic mechanisms and psychopharmacology. 1977;49-60 Plenum, New York.
47. Taylor P. Acetylcholinesterase agents. Molinoff P. B., Ruddon R. W. Goodman and Gilman's The pharmacological basis of therapeutics. 1996;161-176 McGraw-Hill, New York.
48. Tucek S. Acetylcoenzime-A and the synthesis of acetylcholine in neurons: Reviews of recent progress. General Physiology and Biophysics. 2:1983;313-324.