Ergot alkaloids: Extent of human and animal exposure

World Mycotoxin Journal

Volumn 2, Issue 2, 2009, Pages 141-149

  Scott, P M ^a  

^a HEALTH CANADA   (Canada)

Author keywords

Ergopeptides; Ergotism; Grasses; Processing; Rye; Wheat

Indexed keywords

AGROCLAVINE; ALKALOID DERIVATIVE; ERGOCORNINE; ERGOCRISTINE; ERGOCRYPTINE; ERGOMETRINE; ERGOT ALKALOID; ERGOTAMINE; ERGOTAMINE DERIVATIVE; LYSERGIC ACID;

AUSTRALIA; BEER; BREAD; BREWING; CANADA; CLAVICEPS; CONFERENCE PAPER; COOKING; DENMARK; ENDOPHYTE; EPIDEMIC; ERGOTISM; ETHIOPIA; EUROPEAN UNION; FESCUE; FLOUR; FOOD CONTAMINATION; FRANCE; GERMANY; GRAIN; GRASS; HUMAN; INDIA; INTOXICATION; JAPAN; MIDDLE AGES; NEW ZEALAND; NONHUMAN; PERENNIAL RYEGRASS; RUSSIAN FEDERATION; RYE; SWEDEN; SWITZERLAND; UNITED KINGDOM; UNITED STATES; URUGUAY; WHEAT;

ANIMALIA; CLAVICEPS; FESTUCA ARUNDINACEA; LOLIUM PERENNE; NEOTYPHODIUM; POACEAE; SECALE CEREALE; TRITICUM AESTIVUM;

EID: 70350324886     PISSN: 18750710     EISSN: 18750796     Source Type: Journal    
DOI: 10.3920/WMJ2008.1109     Document Type: Conference Paper

References (118)

1. Adam, K. M., Misra, M. K. and Thoreson, D. R., 2004. Removal of ergot from barley by density separation. Applied Engineering in Agriculture 20: 39-43.
2. Amos, A. J., 1973. Ergot - recent work reduces the risks. Flour and Animal Feed Milling 155: 26-27.
3. Bacon, C. W., 1995. Toxic endophyte-infected tall fescue and range grasses: historic perspectives. Journal of Animal Science 73: 861-870.
4. Bacon, C. W., Porter, J. K. and Robbins, J. D., 1981. Ergot alkaloid biosynthesis by isolates of Balansia epichloë and B. henningsiana. Canadian Journal of Botany 59: 2534-2538.
5. Bacon, C. W., Lyons, P. C., Porter, J. K. and Robbins, J. D., 1986. Ergot toxicity from endophyte-infected grasses. Agronomy Journal 78: 106-116.
6. Bandyopadhyay, R., Frederickson, D. E., McLaren, N. W., Odvody, G. N. and Ryley, M. J., 1998. Ergot: a new disease threat to sorghum in the Americas and Australia. Plant Disease 82: 356-367.
7. Baumann, U., Hunziker, H. R. and Zimmerli, B., 1985. Mutterkornalkaloide in schweizerischen Getreideprodukten. Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene 76: 609-630.
8. Bennett, J. W. and Bentley, R., 1999. Pride and prejudice: the story of ergot. Perspectives in Biology and Medicine 42: 333-355.
9. Bhat, R. V., Roy, D. N. and Tulpule, P. G., 1976. The nature of alkaloids of ergoty pearl millet or bajra and its comparison with alkaloids of ergoty rye and ergoty wheat. Toxicology and Applied Pharmacology 36: 11-17.
10. Blaney, B. J., McKenzie, R. A., Walters, J. R., Taylor, L. F., Bewg, W. S., Ryley, M. J. and Maryam, R., 2000. Sorghum ergot (C. africana) associated with agalactia and feed refusal in pigs and dairy cattle. Australian Veterinary Journal 78: 102-107.
11. Bové, F. J., 1970. The story of ergot. Karger, Basel, Switzerland, 298 pp. Brunner, R., Stutz, P. L., Tscherter, H. and Stadler, P. A., 1979. Isolation of ergovaline, ergoptine, and ergonine, new alkaloids of the peptide type, from ergot sclerotia. Canadian Journal of Chemistry 57: 1638-1641.
12. Bundesinstitut für Risikobewertung (BfR), 2004. Mutterkornalkaloide in Roggenmehl. Stellungnahme des BfR vom 22. Januar 2004. Available at: http://www.bfr.bund.de/cm/208/mutterkornalkaloide-in-roggenmehl.pdf Accessed October 2008.
13. Bürk, G., Höbel, W. and Richt, A., 2006. Ergot alkaloids in cereal products. Results from the Bavarian Health and Food Safety Authority. Molecular Nutrition & Food Research 50: 437-442.
14. Canadian Grain Commission, 2004. Official grain grading guide. Canadian Grain Commission, Winnipeg, Manitoba, Canada. Available at: http://dsp-psd. pwgsc.gc.ca/Collection/A92-11-2004E.pdf Accessed October 2008.
15. Demeke, T., Kidane, Y. and Wuhib, E., 1979. Ergotism - a report on an epidemic, 1977-78. Ethiopian Medical Journal 17: 107-113.
16. Durix, A., Jaussaud, P., Garcia, P., Bonnaire, Y. and Bony, S., 1999. Analysis of ergovaline in milk using high-performance liquid chromatography with fluorimetric detection. Journal of Chromatography B 729: 255-263.
17. Dusemund, B., Altmann, H.-J. and Lampen, A., 2006. Mutterkornalkaloide in Lebensmitteln: II. Toxikologische Bewertung: Mutterkornalkaloid-kontaminierter Roggenmehle. Journal für Verbraucherschutz und Lebensmittelsicherheit 1: 150-152.
18. Eadie, M. J., 2001. Clinically significant drug interactions with agents specific for migraine attacks. CNS Drugs 15: 105-118.
19. Eadie, M. J., 2003. Convulsive ergotism: epidemics of the serotonin syndrome? Lancet Neurology 2: 429-434.
20. European Commission (EC), 2002. Directive 2002/32/EC of the European Parliament and of the Council of 7 May 2002 on undesirable substances in animal feed. Official Journal of the European Union L 140: 10-21.
21. European Commission (EC), 2006. Commission Regulation (EC) No 1572/2006 of 18 October 2006 amending Regulation (EC) No 824/2000 establishing procedures for the taking-over of cereals by intervention agencies and laying down methods of analysis for determining the quality of cereals. Official Journal of the European Union L 290: 29-34.
22. European Food Safety Authority (EFSA), 2005. Opinion of the scientific panel on contaminants in food chain on a request from the Commission related to ergot as undesirable substance in animal feed. The EFSA Journal 225: 1-27.
23. European Mycotoxin Awareness Network (EMAN), 2008. Ergot alkaloids factsheet. Available at: http://www.mycotoxins.org/ Accessed October 2008.
24. Faeth, S. H., Gardner, D. R., Hayes, C. J., Jani, A., Wittlinger, S. K. and Jones, T. A., 2006. Temporal and spatial variation in alkaloid levels in Achnatherum robustum, a native grass infected with the endophyte Neotyphodium. Journal of Chemical Ecology 32: 307-324.
25. Fajardo, J. E., Dexter, J. E., Roscoe, M. M. and Nowicki, T. W., 1995. Retention of ergot alkaloids in wheat during processing. Cereal Chemistry 72: 291-298.
26. Fink-Gremmels, J., 2005. Mycotoxins in forages. In: Diaz, D. E. (ed.) The mycotoxin blue book. Nottingham University Press, Nottingham, UK, pp. 249-268.
27. Flieger, M., Wurst, M. and Shelby, R., 1997. Ergot alkaloids - sources, structures and analytical methods. Folia Microbiologica 42: 3-30.
28. Food and Agriculture Organisation (FAO), 2004. Worldwide regulations for mycotoxins in food and feed in 2003. Food and nutrition paper no. 81. Food and Agriculture Organisation, Rome, Italy, 165 pp.
29. Friedman, M. and Dao, L., 1990. Effect of autoclaving and conventional and microwave baking on the ergot alkaloid and chlorogenic acid contents of morning glory (Ipomoea tricolor Cav. cv.) heavenly blue seeds. Journal of Agricultural and Food Chemistry 38: 805-808.
30. Fuller, J. G., 1968. The day of St. Anthony's fire. Macmillan, New York, NY, USA, 310 pp.
31. Gabbai, Lisbonne and Pourquier, 1951. Ergot poisoning at Pont St. Esprit. British Medical Journal 2: 650-651.
32. Gilles, K. A., Sibbitt, L. D. and Kiesling, R. L., 1972. Ergot: a recurring problem of grasses and small grains. Farm Research 29: 12-14.
33. Handeland, K. and Vikøren, T., 2005. Presumptive gangrenous ergotism in free-living moose and a roe. Journal of Wildlife Diseases 41: 636-642.
34. Hill, N. S., Thompson, F. N., Stuedemann, J. A., Rottinghaus, G. W., Ju, H. J., Dawe, D. L. and Hiatt III, E. E., 2001. Ergot alkaloid transport across ruminant gastric tissues. Journal of Animal Science 79: 542-549.
35. Hovermale, J. T. and Craig, A. M., 2001. Correlation of ergovaline and lolitrem B levels in endophyte-infected perennial ryegrass (Lolium perenne). Journal of Veterinary Diagnostic Investigation 13: 323-327.
36. Jegorov, A., 1999. Analytical chemistry of ergot alkaloids. In: Kien, V., Cvak, L. and Hardman, R. (eds.) Ergot: the genus Claviceps. Harwood Academic Publishers, Newark, NJ, USA, pp. 267-302.
37. Kleinerová, E. and Kybal, J., 1969. Ergot alkaloids. II. On the spectrum of ergot alkaloids contained in the sclerotia of Claviceps purpurea (Fr.) Tul. and Claviceps paspali Stev. et Hall. Folia Microbiologica (Praha) 14: 602-604.
38. Klug, C., Baltes, W., Krönert, W. and Weber, R., 1988. Methode zur Bestimmung von Mutterkornalkaloiden in Lebensmitteln [A method for the determination of ergot alkaloids in food]. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. 186: 108-113.
39. Kobel, H. and Sanglier, J.-J., 1986. Ergot alkaloids. In: Rehm, H.-J. and Reed, G. (eds.) Biotechnology, volume 4. VCH Verlagsgesellschaft, Weinheim, Germany, pp. 569-609.
40. Komarova, E. L. and Tolkachev, O. N., 2001a. The chemistry of peptide alkaloids. Part 1. Classification and chemistry of ergot peptides. Pharmaceutical Chemistry Journal 35: 504-513.
41. Komarova, E. L. and Tolkachev, O. N., 2001b. The chemistry of peptide alkaloids. Part 2. Analytical methods for determining ergot alkaloids. Pharmaceutical Chemistry Journal 35: 542-549.
42. Krishnamachari, K. A. and Bhat, R. V., 1976. Poisoning by ergoty bajra (pearl millet) in man. Indian Journal of Medical Research 64: 1624-1628.
43. Krska, R. and Crews, C., 2008. Significance, chemistry and determination of ergot alkaloids: a review. Food Additives and Contaminants: Part A 25: 722-731.
44. Krska, R., Stubbings, G., Macarthur, R. and Crews, C., 2008. Simultaneous determination of six major ergot alkaloids and their epimers in cereals and foodstuffs by LC-MS-MS. Analytical and Bioanalytical Chemistry 391: 563-576.
45. Lauber, U., Schnaufer, R., Gredziak, M. and Kiesswetter, Y., 2005. Analysis of rye grains and rye meals for ergot alkaloids. Mycotoxin Research 21: 258-262.
46. Løken, T., 1984. Ergot from meadow grass in Norway - chemical composition and toxicological effects in sheep. Nordisk Veterinaermedicin 36: 259-265.
47. Lombaert, G. A., Pellaers, P., Roscoe, V., Mankotia, M., Neil, R. and Scott, P. M., 2003. Mycotoxins in infant cereal foods from the Canadian retail market. Food Additives and Contaminants 20: 494-504.
48. Lorenz, K., 1979. Ergot on cereal grains. Critical Reviews in Food Science and Nutrition 11: 311-354.
49. Lorenz, N., Wilson, E. V., Machado, C., Schardl, C. L. and Tudzynski, P., 2007. Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis. Applied and Environmental Microbiology 73: 7185-7191.
50. Lu, F.-J., Chen, L. and Chen, W.-K., 1985. Determination of ergotamine in flour by high performance liquid chromatography. Journal of the Formosan Medical Association 84: 435-440.
51. Mainka, S., Dänicke, S., Böhme, H., Ueberschär, K. H., Polten, S. and Hüther, L., 2005a. The influence of ergot-contaminated feed on growth and slaughtering performance, nutrient digestibility and carry over of ergot alkaloids in growing-finishing pigs. Archives of Animal Nutrition 59: 377-395.
52. Mainka, S., Dänicke, S., Ueberschär, K.-H. and Graf von Reichenbach, H., 2005b. Zum Einfluss einer hydrothermischen Behandlung auf den Egotalkaloidgehalt von mutterkornbelasteten Roggen. Mycotoxin Research 21: 116-119.
53. Mainka, S., Dänicke, S., Böhme, H., Überschär, K.-H. and Liebert F., 2007a. On the composition of ergot and the effects of feeding two different ergot sources on piglets. Animal Feed Science and Technology 139: 52-68.
54. Mainka, S., Dänicke, S., Böhme, H., Überschär, K.-H. and Liebert F., 2007b. On the alkaloid content of ergot (Claviceps purpurea). Landbauforschung Völkenrode 57: 51-59.
55. Masloff, S., 2006. Ergot alkaloids in foods in foods: III. Ergot alkaloids in cereals and cereal products. (III. Mutterkornalkaloide in Getreide und Getreideprodukten. Journal für Verbraucherschutz und Lebensmittelsicherheit 1: 153-154.
56. McKeon, F. W. and Egan, D. A., 1971. Lameness in cattle fed ergotised silage. Irish Veterinary Journal 25: 67-69.
57. Merrill, M. L., Bohnert, D. W., Harmon, D. L., Craig, A. M. and Schrick, F. N., 2007. The ability of a yeast-derived cell wall preparation to minimize the toxic effects of high-ergot alkaloid tall fescue straw in beef cattle. Journal of Animal Science 85: 2596-2605.
58. Miles, C. O., Lane, G. A., Di Menna, M. E., Garthwaite, I., Piper, E. L., Ball, O. J.-P., Latch, G. C. M., Allen, J. M., Hunt, M. B., Bush, L. P., Min, F. K., Fletcher, I. and Harris, P. S., 1996. High levels of ergonovine and lysergic acid amide in toxic Achnatherum inebrians accompanying infection by an Acremonium-like endophytic fungus. Journal of Agricultural and Food Chemistry 44: 1285-1290.
59. Miyazaki, S., Ishizaki, I., Ishizaka, M., Kanbara, T. and Ishiguro-Takeda, Y., 2004. Lolitrem B residue in fat tissues of cattle consuming endophyte-infected perennial ryegrass straw. Journal of Veterinary Diagnostic Investigation 16: 340-342.
60. Möller, T., Brostedt, S. and Johansson, M., 1993. År mjöldrygan tillbaka i Sverige? Vår Föda 45: 308-311.
61. Molloy, J. B., Moore, C. J., Bruyeres, A. G., Murray, S. A. and Blaney, B. J., 2003. Determination of dihydroergosine in sorghum ergot using an immunoassay. Journal of Agricultural and Food Chemistry 51: 3916-3919.
62. Naudè, T. W., Botha, C. J., Vorster, J. H., Roux, C., Van der Linde, E. J., Van der Walt, S. I., Rottinghaus, G. E., Van Jaarsveld, L. and Lawrence, A. N., 2005. Claviceps cyperi, a new cause of severe ergotism in dairy cattle consuming maize silage and teff hay contaminated with ergotised Cyperus esculentus (nut sedge) on the Highveld of South Africa. Onderstepoort Journal of Veterinary Research 72: 23-37.
63. Odvody, G., Frederiksen, R. A., Isakeit, T., Frederickson, D., Kaufman, H., Dahlberg, J., Velasquez, R. and Torres, H., 1998. Sorghum ergot goes global in less than three years. APSnet June 8-30. Available at: http://www.apsnet.org/ online/feature/ergot/ Accessed October 2008.
64. Osborne, B. G. and Watson, R. D., 1980. Analysis of ergots from winter wheat in northern Scotland. Journal of the Agricultural Society, Cambridge 95: 239-240.
65. Panaccione, D. G. and Coyle, C. M., 2005. Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigatus. Applied and Environmental Microbiology 71: 3106-3111.
66. Parish, J. A., McCann, M. A., Watson, R. H., Hoveland, C. S., Hawkins, L. L., Hill, N. S. and Bouton, J. H., 2003a. Use of nonergot alkaloid-producing endophytes for alleviating tall fescue toxicosis in sheep. Journal of Animal Science 81: 1316-1322.
67. Parish J. A., McCann, M. A., Watson, R. H., Paiva, N. N., Hoveland, C. S., Parks, A. H., Upchurch, B. L., Hill, N. S. and Bouton, J. H., 2003b. Use of nonergot alkaloid-producing endophytes for alleviating tall fescue toxicosis in stocker cattle. Journal of Animal Science 81: 2856-2868.
68. Parkhaeva, A. I., 1979. [Excretion of ergot alkaloids with the milk] [in Russian]. Veterinariia (11): 76-77; cited by Wolff et al., 1995.
69. Pažoutová, S., Olšovská, J., Šulc, M., Chudíková, M. and Flieger, M., 2008. Claviceps nigricans and Claviceps grohii: their alkaloids and phylogenetic placement. Journal of Natural Products 71: 1085-1088.
70. Pfänder, H. J., Seiler, K. U. and Ziegler, A., 1985. Morgendliche 'Müsli'-Mahlzeit als Ursache einer chronischen Vergiftung mit Secale-Alkaloiden. Deutsches Ärzteblatt, Ausgabe B 82: 2013-2016.
71. Porter, J. K., 1995. Analysis of endophyte toxins: fescue and other grasses toxic to livestock. Journal of Animal Science 73: 871-880.
72. Porter, J. K., Bacon, C. W., Plattner, R. D. and Arrendale, R. F., 1987. Ergot peptide alkaloid spectra of Claviceps-infected tall fescue, wheat, and barley. Journal of Agricultural and Food Chemistry 35: 359-361.
73. Porter, J. K. and Thompson Jr., F. N., 1992. Effects of fescue toxicosis on reproduction in livestock. Journal of Animal Science 70: 1594-1603.
74. Powell, R. G. and Petroski, R. J., 1992. Alkaloid toxins in endophyte-infected grasses. Natural Toxins 1: 163-170.
75. Rasmussen, G., 1991. Ergot in grains: an overview. Report. no. F91011, Danish Food Directorate, Copenhagen, Denmark [in Danish].
76. Reed, K. F. M., Walsh, J. R., Cross, P. A., McFarlane, N. M. and Sprague, M. A., 2004. Ryegrass endophyte (Neotyphodium lolii) alkaloids and mineral concentrations in perennial ryegrass (Lolium perenne) from southwest Victorian pasture. Australian Journal of Experimental Agriculture 44: 1185-1194.
77. Řeháček, Z. and Sajdl, P., 1990. Ergot alkaloids-chemistry, biological effects, biotechnology. Bioactive molecules, volume 12. Elsevier, Amsterdam, the Netherlands, 383 pp.
78. Reicher, A., Elema, E. T., Zwaving, J. H. and Malingré, T. M., 1983, Alkaloids in ergot found on different Gramineae in the Netherlands. Pharmaceutisch Weekblad Scientific Edition 5: 234-238.
79. Reinhard, H., Rupp, H. and Zoller, O., 2008. Ergot alkaloids: quantitation and recognition challenges. Mycotoxin Research 24: 7-13.
80. Reshetilova, T. A., Solovyeva, T. F., Baskunov, B. P. and Kozlovsky, A. G., 1995. Study of the alkaloid composition of the food-infecting penicilles. Food Additives and Contaminants 12: 461-466.
81. Robbins, J. D., Porter, J. K. and Bacon, C. W., 1986. Occurrence and clinical manifestations of ergot and fescue toxicoses. In: Richard, J. L. and Thurston, J. R. (eds.) Diagnosis of mycotoxicoses. Martinus Nijhoff Publishers, Dordrecht, the Netherlands, pp. 61-74.
82. Rotter, R. G., Marquardt, R. R. and Young, J. C., 1985. Effect of ergot from different sources and of fractionated ergot on the performance of growing chicks. Canadian Journal of Animal Science 65: 953-961.
83. Ruano-Calderón, L. A. and Zermeño-Pohls, F., 2005. [Ergotism. A case report and review of the literature][Article in Spanish] Revista de Neurologia 40: 412-416.
84. Schiff Jr., P. L., 2006. Ergot and its alkaloids. American Journal of Pharmaceutical Education 70: article 98, 1-10.
85. Schoch, U. and Schlatter, C., 1985. Gesundheitsrisiken durch Mutterkorn in Getreide. Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene 76: 631-644.
86. Schumann. B., Dänicke, S., Meyer, U., Ueberschär, K. H. and Breves, G., 2007. Effects of different levels of ergot in concentrates on the growing and slaughtering performance of bulls and on carry-over into edible tissue. Archives of Animal Nutrition 61: 357-370.
87. Schwarz, P. B., Hill, N. S. and Rottinghaus, G. E., 2007. Fate of ergot (Claviceps purpurea) alkaloids during malting and brewing. Journal of the American Society of Brewing Chemists 65: 1-8.
88. Scott, P. M., 2007. Analysis of ergot alkaloids - a review. Mycotoxin Research 23: 113-121.
89. Scott, P. M. and Lawrence, G. A., 1980. Analysis of ergot alkaloids in flour. Journal of Agricultural and Food Chemistry 28: 1258-1261.
90. Scott, P. M. and Lawrence, G. A., 1982. Losses of ergot alkaloids during making of bread and pancakes. Journal of Agricultural and Food Chemistry 30: 445-450.
91. Scott, P. M., Lombaert, G. A., Pellaers, P., Bacler, S. and Lappi, J., 1992. Ergot alkaloids in grain foods sold in Canada. Journal of AOAC International 75: 773-779.
92. Sheridan, J. J., 1980. Some observations on selected mycoses and mycotoxicoses affecting animals in Ireland. Irish Veterinary Journal 34: 148-154.
93. Shuey, W. C., Connelly, F. J. and Maneval, R. D., 1973. Distribution of ergot in mill streams. The Northwestern Miller 280: 10-15.
94. Siegel, M. R., Latch, G. C. M., Bush, L. P., Fannin, F. F., Rowan, D. D., Tapper, B. A., Bacon, C. W. and Johnson, M. C., 1990. Fungal endophyte-infected grasses: alkaloid accumulation and aphid response. Journal of Chemical Ecology 16: 3301-3315.
95. Stange, K., Pohlmeier, H., Lübbesmeyer, A., Gumbinger, G., Schmitz, W. and Baumgart, P., 1998. Vascular ergotism through inhalation of grain dust [in German]. Deutsche Medizinische Wochenschrift 123: 1547-1450.
96. Storm, I. D., Rasmussen, P. H., Strobel, B. W. and Hansen, H. C., 2008. Ergot alkaloids in rye flour determined by solid-phase cation-exchange and high-pressure liquid chromatography with fluorescence detection. Food Additives and Contaminants 25: 338-346.
97. Sulyok, M., Krska, R. and Schuhmacher, R., 2007. A liquid chromatography/tandem mass spectrometric multi-mycotoxin method for the quantification of 87 analytes and its application to semi-quantitative screening of moldy food samples. Analytical and Bioanalytical Chemistry 389: 1505-1523.
98. TePaske, M. R., Powell, R. G. and Clement, S. L., 1993. Analyses of selected endophyte-infected grasses for the presence of loline-type and ergot-type alkaloids. Journal of Agricultural and Food Chemistry 41: 2299-2303.
99. Uhlig, S. and Petersen, D., 2008. Lactam ergot alkaloids (ergopeptams) as predominant alkaloids in sclerotia of Claviceps purpurea from Norwegian wild grasses. Toxicon 52: 175-85.
100. Uhlig, S., Vikøren, T., Ivanova, L. and Handeland, K., 2007. Ergot alkaloids in Norwegian wild grasses: a mass spectrometric approach. Rapid Communications in Mass Spectrometry 21: 1651-1660.
101. Urga, K., Debella, A., Medihn, Y. W., Agata, N., Bayu, A. and Zewdie, W., 2002. Laboratory studies on the outbreak of gangrenous ergotism associated with consumption of contaminated barley in Arsi, Ethiopia. Ethiopian Journal of Health Development 16: 317-323.
102. Van Dongen, P. W. J. and De Groot, A. N. J. A., 1995. History of ergot alkaloids from ergotism to ergometrine. European Journal of Obstetrics, Gynecology and Reproductive Biology 60: 109-116.
103. Whittemore, C. T., Macer, R. C., Miller, J. K. and Mantle, P. G., 1976. Some consequences of the ingestion by young and growing pigs of feed contaminated with ergot. Research in Veterinary Science 20: 61-69.
104. Wolff, J. and Ocker, H.-D., 1985. Einfluß des Backprozesses auf den Gehalt des Mutterkornalkaloids Egometrin. Getreide, Mehl und Brot 39: 110-113.
105. Wolff, J. and Richter, W., 1989. Chemische Untersuchungen an Mutterkorn. Getreide, Mehl und Brot 43: 103-107.
106. Wolff, J., Neudecker, C., Klug, C. and Weber, R., 1988. Chemische und toxikologische Untersuchungen über Mutterkorn in Mehl und Brot. Zeitschrift für Ernährungswissenschaft 27: 1-22.
107. Wolff, J., Ocker, H.-D. and Zwingelberg, H., 1983. Bestimmung von Mutterkornalkaloiden in Getreide und Mahlprodukten durch HPLC. Getreide, Mehl und Brot 37: 331-335.
108. Wolff, J., Richter, W. I. F. and Spann, B., 1995. Mutterkornalkaloide in der Milch? VDLUFA-Schriftenreihe 40: 521-524.
109. World Health Organization (WHO), 1990. Environmental criteria 105. Selected mycotoxins. Ochratoxins, trichothecenes, ergot. WHO, Geneva, Switzerland, 263 pp.
110. Wright, B. and Kenney, D., 2001. Ergot alkaloid (ergopeptine) toxicity in horse hay and pasture. Ontario Ministry of Agriculture, Food & Rural Affairs, Canada. Available at www.omafra.gov.on.ca/english/livestock/horses/ facts/info-ergot-alkaloid.htm Accessed October 2008.
111. Wright, R. G., Boyce, B., Van Dreumel, T., Hazlett, M. J. and Cross, D. L., 2001. Ergot alkaloid toxicity in foaling mares associated with eating cereal rye straw. Abstract presented at Equine Nutrition and Physiology Symposium, Lexington, KY, USA, 2001, May 28 [cited in Wright and Kenney (2001)].
112. Yates, S. G. and Powell, R. G., 1988. Analysis of ergopeptine alkaloids in endophyte-infected tall fescue. Journal of Agricultural and Food Chemistry 36: 337-340.
113. Young, J. C., 1979. Ergot contamination of feedstuffs. Feedstuffs 51: 23-33.
114. Young, J. C., 1981a. Variability in the content and composition of alkaloids found in Canadian ergot. I. Rye. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes 16: 83-111.
115. Young, J. C., 1981b. Variability in the content and composition of alkaloids found in Canadian ergot. II. Wheat. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes 16: 381-393.
116. Young, J. C. and Chen, Z.-J., 1982. Variability in the content and composition of alkaloid found in Canadian ergot. III. Triticale and barley. Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes 17: 93-107.
117. Young, J. C. and Marquardt, R. R., 1982. Effects of ergotamine tartrate on growing chickens. Canadian Journal of Animal Science 62: 1181-1191.
118. Young, J. C., Chen, Z.-J. and Marquardt, R. R., 1983. Reduction in alkaloid content of ergot sclerotia by chemical and physical treatment. Journal of Agricultural and Food Chemistry 31: 413-415.