Engineering Escherichia coli for an efficient aerobic fermentation platform

Journal of Biotechnology

Volumn 144, Issue 1, 2009, Pages 58-63

  Kang, Zhen ^a   Geng, Yanping ^a   Xia, Yong zhen ^a   Kang, Junhua ^a   Qi, Qingsheng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Acetate; Escherichia coli; Metabolic engineering; PHB

Indexed keywords

ACETATE; AEROBIC FERMENTATION; E. COLI; GENE MUTATIONS; HIGH GROWTH RATE; METABOLIC ENGINEERING; PHB; PHB ACCUMULATION; POLYHYDROXYBUTYRATE; WILD TYPES;

BIOCHEMISTRY; BIOMASS; FERMENTATION; GLUCOSE; METABOLISM;

ESCHERICHIA COLI;

ACETIC ACID; BACTERIAL PROTEIN; GLUCOSE; ISOCITRATE LYASE REGULATOR PROTEIN; PHOSPHATE ACETYLTRANSFERASE; PROTEIN PTSG; PYRUVATE OXIDASE B; UNCLASSIFIED DRUG;

AEROBIC FERMENTATION; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTERIUM MUTANT; BIOMASS; CONTROLLED STUDY; CULTURE MEDIUM; ESCHERICHIA COLI; GENE MUTATION; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ACETATES; AEROBIOSIS; CULTURE MEDIA; ESCHERICHIA COLI; FERMENTATION; GENETIC ENGINEERING; GLUCOSE; HYDROGEN-ION CONCENTRATION; METABOLIC NETWORKS AND PATHWAYS; OXIDATION-REDUCTION;

ESCHERICHIA COLI;

EID: 70350227008     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.06.021     Document Type: Article

References (34)

1. Abdel-Hamid A.M., Attwood M.M., and Guest J.R. Pyruvate oxidase contributes to the aerobic growth efficiency of Escherichia coli. Microbiology 147 (2001) 1483-1498
2. Akesson M., Karlsson E.N., Hagander P., Axelsson J.P., and Tocaj A. On-line detection of acetate formation in Escherichia coli cultures using dissolved oxygen responses to feed transients. Biotechnol. Bioeng. 64 (1999) 590-598
3. Andersen K.B., and von Meyenburg K. Are growth rates of Escherichia coli in batch cultures limited by respiration?. J. Bacteriol. 144 (1980) 114-123
4. Aristidou A.A., San K.Y., and Bennett G.N. Modification of central metabolic pathway in Escherichia coli to reduce acetate accumulation by heterologous expression of the Bacillus subtilis acetolactate synthase gene. Biotechnol. Bioeng. 44 (1994) 944-951
5. Cherrington C.A., Hinton M., and Chopra I. Effect of short-chain organic acids on macromolecular synthesis in Escherichia coli. J. Appl. Bacteriol. 68 (1990) 69-74
6. Chang D.E., Shin S., Rhee J.S., and Pan J.G. Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival. J. Bacteriol. 181 (1999) 6656-6663
7. Chou C.H., Bennett G.N., and San K.Y. Effect of modified glucose uptake using genetic engineering techniques on high-level recombinant protein production in Escherichia coli dense cultures. Biotechnol. Bioeng. 44 (1994) 952-960
8. Datsenko K.A., and Wanner B.L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 6640-6645
9. Delgado J., and Liao J.C. Inverse flux analysis for reduction of acetate excretion in Escherichia coli. Biotechnol. Prog. 13 (1997) 361-367
10. De Mey M., De Maeseneire S., Soetaert W., and Vandamme E. Minimizing acetate formation in E. coli fermentations. J. Ind. Microbiol. Biotechnol. 34 (2007) 689-700
11. Diaz-Ricci J.C., Regan L., and Bailey J.E. Effect of alteration of the acetic acid synthesis pathway on the fermentation pattern of Escherichia coli. Biotechnol. Bioeng. 38 (1991) 1318-1324
12. Dittrich C.R., Vadali R.V., Bennett G.N., and San K.Y. Redistribution of metabolic fluxes in the central aerobic metabolic pathway of E. coli mutant strains with deletion of the ackA-pta and poxB pathways for the synthesis of isoamyl acetate. Biotechnol. Prog. 21 (2005) 627-631
13. Eiteman M.A., and Altman E. Overcoming acetate in Escherichia coli recombinant protein fermentations. Trends Biotechnol. 24 (2006) 530-536
14. Farmer W.R., and Liao J.C. Reduction of aerobic acetate production by Escherichia coli. Appl. Environ. Microbiol. 63 (1997) 3205-3210
15. Gorke B., and Stulke J. Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat. Rev. Microbiol. 6 (2008) 613-624
16. Gui L., Sunnarborg A., and LaPorte D.C. Regulated expression of a repressor protein: FadR activates iclR. J. Bacteriol. 178 (1996) 4704-4709
17. Hosono K., Kakuda H., and Ichihara S. Decreasing accumulation of acetate in a rich medium by Escherichia coli on introduction of genes on a multicopy plasmid. Biosci. Biotechnol. Biochem. 59 (1995) 256-261
18. Kang Z., Wang Q., Zhang H., and Qi Q. Construction of a stress-induced system in Escherichia coli for efficient polyhydroxyalkanoates production. Appl. Microbiol. Biotechnol. 79 (2008) 203-208
19. Keasling J.D. Synthetic biology for synthetic chemistry. ACS Chem. Biol. 3 (2008) 64-76
20. Kleman G.L., Chalmers J.J., Luli G.W., and Strohl W.R. Glucose-stat, a glucose-controlled continuous culture. Appl. Environ. Microbiol. 57 (1991) 918-923
21. Kleman G.L., Chalmers J.J., Luli G.W., and Strohl W.R. A predictive and feedback control algorithm maintains a constant glucose concentration in fed-batch fermentations. Appl. Environ. Microbiol. 57 (1991) 910-917
22. Lerner C.G., and Inouye M. Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability. Nucl. Acids Res. 18 (1990) 4631
23. Lin H., Bennett G.N., and San K.Y. Effect of carbon sources differing in oxidation state and transport route on succinate production in metabolically engineered Escherichia coli. J. Ind. Microbiol. Biotechnol. 32 (2005) 87-93
24. Li R., Chen Q., Wang P.G., and Qi Q. A novel-designed Escherichia coli for the production of various polyhydroxyalkanoates from inexpensive substrate mixture. Appl. Microbiol. Biotechnol. 75 (2007) 1103-1109
25. Majewski R.A., and Domach M.M. Simple constrained-optimization view of acetate overflow in Escherichia coli. Biotechnol. Bioeng. 35 (1990) 732-738
26. March J.C., Eiteman M.A., and Altman E. Expression of an anaplerotic enzyme, pyruvate carboxylase, improves recombinant protein production in Escherichia coli. Appl. Environ. Microbiol. 68 (2002) 5620-5624
27. Paalme T., Tiisma K., Kahru A., Vanatalu K., and Vilu R. Glucose-limited fed-batch cultivation of Escherichia coli with computer-controlled fixed growth rate. Biotechnol. Bioeng. 35 (1990) 312-319
28. Roe A.J., O'Byrne C., McLaggan D., and Booth I.R. Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity. Microbiology 148 (2002) 2215-2222
29. Sambrook J., Fritsch E.F., and Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. (1989), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
30. San K.Y., Bennett G.N., Aristidou A.A., and Chou C.H. Strategies in high-level expression of recombinant protein in Escherichia coli. Ann. N. Y. Acad. Sci. 721 (1994) 257-267
31. Shiloach J., Kaufman J., Guillard A.S., and Fass R. Effect of glucose supply strategy on acetate accumulation, growth, and recombinant protein production by Escherichia coli BL21 (lambdaDE3) and Escherichia coli JM109. Biotechnol. Bioeng. 49 (1996) 421-428
32. Spiekermann P., Rehm B.H., Kalscheuer R., Baumeister D., and Steinbüchel A. A sensitive, viable-colony staining method using Nile red for direct screening of bacteria that accumulate polyhydroxyalkanoic acids and other lipid storage compounds. Arch. Microbiol. 171 (1999) 73-80
33. Wong M.S., Wu S., Causey T.B., Bennett G.N., and San K.Y. Reduction of acetate accumulation in Escherichia coli cultures for increased recombinant protein production. Metab. Eng. 10 (2008) 97-108
34. Yang Y., Aristidou A.A., San K., and Bennett G.N. Metabolic flux analysis of Escherichia coli deficient in the acetate production pathway and expressing the Bacillus subtilis acetolactate synthase. Metab. Eng. 1 (1999) 26-34