Salivary gland tumors: Immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67

Analytical and Quantitative Cytology and Histology

Volumn 31, Issue 5, 2009, Pages 280-287

  Ito, Fabio A ^a   Ito, Kazuhiro ^b   Coletta, Ricardo D ^a   Graner, Edgard ^a   De Almeida, Oslei P ^a   Lopes, Márcio A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Antonio Prudente Hospital   (Brazil)

Author keywords

EGF; EGFR; ErbB 2; FAS; Ki 67; Salivary gland cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; FATTY ACID SYNTHASE; KI 67 ANTIGEN;

ADENOID CYSTIC CARCINOMA; ADENOSQUAMOUS CARCINOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CARCINOGENESIS; CHILD; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND TUMOR;

ADENOMA, PLEOMORPHIC; ANTIGENS, CD95; CARCINOMA, ADENOID CYSTIC; CARCINOMA, MUCOEPIDERMOID; EPIDERMAL GROWTH FACTOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; MALE; MIDDLE AGED; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SALIVARY GLAND NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 70350220666     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Vered M, Braunstein E, Buchner A: Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin. Head Neck 2002;24:632-636 (Pubitemid 34734357)
2. Katopodi E, Patsouris E, Papanikolaou V, Karameris A, Douzinas E, Papanicolaou S: Immunohistochemical detection of epidermal growth factor and its receptor in salivary gland carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:266-268
3. Koski H, Konttinen YT, Hietanen J, Tervo T, Malmstrom M: Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in labial salivary glands in Sjögren's syndrome. J Rheumatol 1997;24:1930-1935 (Pubitemid 27431924)
4. Yamahara M, Fujito T, Ishikawa T, Shimosato T, Yokozaki H, Yasui W, Tahara E: Phenotypic expression of human epidermal growth factor in foetal submandibular gland and pleomorphic adenoma of salivary gland. Virchows Arch A Pathol Anat Histopathol 1988;412:301-306 (Pubitemid 18064566)
5. Tsukitani K, Tatemoto Y, Noda Y, Mori M, Hayashi T, Kato K: Immunohistochemical detection of human epidermal growth factor in submandibular glands and their tumors using a polyclonal antiserum and a monoclonal antibody. Histochemistry 1987;87:293-300 (Pubitemid 17139212)
6. Casalini P, Iorio MV, Galmozzi E, Menard S: Role of HER receptors family in development and differentiation. J Cell Physiol 2004;200:343-350 (Pubitemid 39006925)
7. Gschwantler-Kaulich D, Hudelist G, Koestler WJ, Czerwenka K, Mueller R, Helmy S, Ruecklinger E, Kubista E, Singer CF: EGFR activity in HER-2 over-expressing metastatic breast cancer: Evidence for simultaneous phosphorylation of Her-2/neu and EGFR. Oncol Rep 2005;14:305-311
8. Signoretti S, Montironi R, Manola J, Altimari A, Tam C, Bubley G, Balk S, Thomas G, Kaplan I, Hlatky L, Hahnfeldt P, Kantoff P, Loda M: Her-2-neu expression and progression toward androgen independence in human prostate cancer. J Natl Cancer Inst 2000;92:1918-1925 (Pubitemid 32036922)
9. Silva SD, Agostini M, Nishimoto IN, Coletta RD, Alves FA, Lopes MA, Kowalski LP, Graner E: Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma: A clinicopathological study. Oral Oncol 2004;40: 688-696
10. Cho KJ, Kim JY, Lee SS, Oh KK: Mucoepidermoid carcinoma of the salivary gland: A clinico-pathologic and immunohistochemical study for c-erbB-2 oncoprotein. J Korean Med Sci 1997;12:499-504 (Pubitemid 127711385)
11. Karja V, Syrjanen S, Kataja V, Syrjanen K: C-erbB-2 oncogene expression in salivary gland tumours. ORL J Otorhinolaryngol Relat Spec 1994;56:206-212 (Pubitemid 24183197)
12. Shintani S, Funayama T, Yoshihama Y, Alcalde RE, Ootsuki K, Terakado N, Matsumura T: Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: An immunohistochemical study. Anticancer Res 1995;15:2623-2626 (Pubitemid 26095072)
13. Jordan R, Dardick I, Lui E, Birek C: Demonstration of c-erbB-2 oncogene overexpression in salivary gland neoplasms by in situ hybridization. J Oral Pathol Med 1994;23:226-231 (Pubitemid 2089170)
14. Woodburn JR: The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999;82:241-250 (Pubitemid 29255919)
15. Arteaga CL: Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin Oncol 2002;29:3-9
16. Luftner D, Pollmann D, Schildhauer S, Sehouli J, Possinger K: Perspectives of immunotherapy in metastatic breast cancer. Anticancer Res 2005;25:4599-4604 (Pubitemid 41729519)
17. Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP, Chinnaiyan AM: Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res 2003;63:132-139 (Pubitemid 36070431)
18. Weed DT, Gomez-Fernandez C, Pacheco J, Ruiz J, Hamilton-Nelson K, Arnold DJ, Civantos FJ, Zhang J, Yasin M, Goodwin WJ, Carraway KL: MUC4 and ERBB2 expression in major and minor salivary gland mucoepidermoid carcinoma. Head Neck 2004;26:353-364 (Pubitemid 38436675)
19. Glisson B, Colevas AD, Haddad R, Krane J, El-Naggar A, Kies M, Costello R, Summey C, Arquette M, Langer C, Amrein PC, Posner M: HER2 expression in salivary gland carcinomas: Dependence on histological subtype. Clin Cancer Res 2004;10:944-946 (Pubitemid 38198894)
20. Giannoni C, el-Naggar AK, Ordoñez NG, Tu ZN, Austin J, Luna MA, Batsakis JG: C-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasms. Otolaryngol Head Neck Surg 1995;112:391-398
21. Agostini M, Silva SD, Zecchin KG, Coletta RD, Jorge J, Loda M, Graner E: Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. Oral Oncol 2004;40:728-735 (Pubitemid 38686910)
22. Kuhajda FP: Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology. Nutrition 2000;16: 202-208
23. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, Kolb HJ: Fatty-acid biosynthesis in man, a pathway of minor importance: Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler 1986;367:905-912
24. Swinnen JV, Roskams T, Joniau S, Van Poppel H, Oyen R, Baert L, Heyns W, Verhoeven G: Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer 2002;98:19-22 (Pubitemid 34113412)
25. Alò PL, Visca P, Marci A, Mangoni A, Botti C, Di TU: Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 1996;77: 474-482 (Pubitemid 26047568)
26. Visca P, Sebastiani V, Pizer ES, Botti C, De Carli P, Filippi S, Monaco S, Alo PL: Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma. Anticancer Res 2003;23:335-339 (Pubitemid 36358537)
27. Alò PL, Visca P, Framarino ML, Botti C, Monaco S, Sebastiani V, Serpieri DE, Di Tondo U: Immunohistochemical study of fatty acid synthase in ovarian neoplasms. Oncol Rep 2000;7:1383-1388
28. Visca P, Sebastiani V, Botti C, Diodoro MG, Lasagni RP, Romagnoli F, Brenna A, De Joannon BC, Donnorso RP, Lombardi G, Alo PL: Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res 2004;24:4169-4173 (Pubitemid 40468723)
29. Innocenzi D, Alò PL, Balzani A, Sebastiani V, Silipo V, La Torre G, Ricciardi G, Bosman C, Calvieri S: Fatty acid synthase expression in melanoma. J Cutan Pathol 2003;30:23-28 (Pubitemid 36152769)
30. Kusakabe T, Nashimoto A, Honma K, Suzuki T: Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. Histopathology 2002;40:71-79 (Pubitemid 34107384)
31. Takahiro T, Shinichi K, Toshimitsu S: Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Clin Cancer Res 2003;9:2204-2212 (Pubitemid 36687644)
32. Pizer ES, Chrest FJ, Digiuseppe JA, Han WF: Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res 1998;58:4611-4615
33. Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF, Pizer ES: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 2001;61:1493-1499 (Pubitemid 34292578)
34. Ito FA, Ito K, Vargas PA, de Almeida OP, Lopes MA: Salivary gland tumors in a Brazilian population: A retrospective study of 496 cases. Int J Oral Maxillofac Surg 2005;34:533-536 (Pubitemid 40790351)
35. Seifert G, Langrock I, Donath K: A pathological classification of pleomorphic adenoma of the salivary glands. HNO 1976; 24:415-426
36. Ellis GL, Auclair PL: Atlas of Tumor Pathology: Tumors of the Salivary Glands. Washington, DC, Armed Forces Institute of Pathology, 1996
37. Cossu M, Perra MT, Piludu M, Lantini MS: Subcellular localization of epidermal growth factor in human submandibular gland. Histochem J 2000;32:291-294 (Pubitemid 30459977)
38. Seshadri R, Firgaira FA, Horsfall DJ, McCaul K, Setlur V, Kitchen P: Clinical significance of HER-2/neu oncogene amplification in primary breast cancer: The South Australian Breast Cancer Study Group. J Clin Oncol 1993;11:1936-1942
39. Press MF, Pike MC, Hung G, Zhou JY, Ma Y, George J, Dietz- Band J, James W, Slamon DJ, Batsakis JG, El-Naggar AK: Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: Correlation with poor prognosis. Cancer Res 1994;54:5675-5682 (Pubitemid 24346266)
40. Milas L, Mason K, Hunter N, Petersen S, Yamakawa M, Ang K, Mendelsohn J, Fan Z: In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 2000;6:701-708
41. Shak S: Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer: Herceptin Multinational Investigator Study Group. Semin Oncol 1999;26:71-77
42. Yamada K, Iwai K, Okada Y, Mori M: Immunohistochemical expression of epidermal growth factor receptor in salivary gland tumours. Virchows Arch A Pathol Anat Histopathol 1989;415:523-531 (Pubitemid 19251331)
43. Gibbons MD, Manne U, Carroll WR, Peters GE, Weiss HL, Grizzle WE: Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Laryngoscope 2001;111:1373-1378 (Pubitemid 32730182)
44. Cho KJ, Lee SS, Lee YS: Proliferating cell nuclear antigen and c-erbB-2 oncoprotein expression in adenoid cystic carcinomas of the salivary glands. Head Neck 1999;21:414-419
45. Dori S, Vered M, David R, Buchner A: HER2/neu expression in adenoid cystic carcinoma of salivary gland origin: An immunohistochemical study. J Oral Pathol Med 2002;31:463-467 (Pubitemid 35045031)
46. Silva SD, Cunha IW, Rangel AL, Jorge J, Zecchin KG, Agostini M, Kowalski LP, Coletta RD, Graner E: Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch 2008;453:57-67
47. Swinnen JV, Heemers H, Deboel L, Foufelle F, Heyns W, Verhoeven G: Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene 2000;19:5173-5181 (Pubitemid 30835054)
48. Cattoretti G, Becker MH, Key G, Duchrow M, Schlüter C, Galle J, Gerdes J: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357-363 (Pubitemid 23013251)
49. Zhu Q, Tipoe GL, White FH: Proliferative activity as detected by immunostaining with Ki-67 and proliferating cell nuclear antigen in benign and malignant epithelial lesions of the human parotid gland. Anal Quant Cytol Histol 1999;21: 336-342 (Pubitemid 29383451)
50. Pich A, Chiusa L, Navone R: Prognostic relevance of cell proliferation in head and neck tumors. Ann Oncol 2004;15:1319-1329 (Pubitemid 39295019)
51. Pires FR, de Almeida OP, De Araújo VC, Kowalski LP: Prognostic factors in head and neck mucoepidermoid carcinoma. Arch Otolaryngol Head Neck Surg 2004;130:174-180 (Pubitemid 38182542)
52. Hicks J, Flaitz C: Mucoepidermoid carcinoma of salivary glands in children and adolescents: Assessment of proliferation markers. Oral Oncol 2000;36:454-460 (Pubitemid 30645981)
53. Skalova A, Lehtonen H, Von BK, Leivo I: Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: Clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol 1994;25:929-935 (Pubitemid 24292411)
54. Okabe M, Inagaki H, Murase T, Inoue M, Nagai N, Eimoto T: Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland. Mod Pathol 2001;14:1008-1014 (Pubitemid 32976789)