An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

Biochemical Pharmacology

Volumn 53, Issue 11, 1997, Pages 1569-1575

  Ghoshal, Kalpana ^a   Jacob, Samson T ^a,b  

^a The Chicago Medical College   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

5 fluorouracil; Lymphosarcoma; Pre rRNA processing; Ribosomal RNA binding protein; Splicing; U3 snoRNA

Indexed keywords

BINDING PROTEIN; FLUOROPYRIMIDINE; FLUOROURACIL; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN;

ANTINEOPLASTIC ACTIVITY; CELL PROLIFERATION; CROSS LINKING; DNA REPLICATION; DRUG MECHANISM; ENZYME ACTIVITY; LYMPHOSARCOMA; NOTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; RNA SPLICING; RNA TRANSLATION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ENDORIBONUCLEASES; FLUORODEOXYURIDYLATE; FLUOROURACIL; MICE; PROTEIN BIOSYNTHESIS; RNA PRECURSORS; RNA SPLICING; RNA, SMALL NUCLEAR; RNA-BINDING PROTEINS; TUMOR CELLS, CULTURED;

EID: 0030739913     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00040-3     Document Type: Note

References (50)

1. Tobias JS, Current role of chemotherapy in head and neck cancer. Drugs 43: 333-345, 1992.
2. Mayer RJ, Systemic therapy for colorectal cancer: An overview. Semin Oncol 18: 62-66, 1991.
3. Grem JL, Hoth DF, Hamilton JM, King SA and Leyland-Jones B, Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid. Cancer Treat Rep 71: 1249-1264, 1987.
4. Weckbecker G, Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators. Pharmacol Ther 50: 367-424, 1991.
5. Santi DV, McHenry CS and Sommer H, Mechanism of interaciton of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 3: 471-481, 1974.
6. Zhang Z-G, Harstrick A and Rustum YM, Mechanisms of resistance to fluoropyrimidines. Semin Oncol 19: 4-9, 1992.
7. Caradonna SJ, and Cheng Y-C, The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase α in the metabolism of FUdR in human tumor cells. Mol Pharmacol 18: 513-520, 1980.
8. Schuetz JD, Wallace HJ and Diasio RB, 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Res 44: 1358-1363, 1986.
9. Lonn U, Lonn S, Nylen U and Winblad G, 5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole. Cancer Res 49: 1085-1089, 1989.
10. Herrington MB and Takahashi I, Mutagenesis of bacteriophage PBS2. Mutat Res 20: 275-278, 1973.
11. Heimer R and Sartorelli AC, RNA-directed actions of 5-fluorouridine in hemin stimulated K-562 erythroleukemia cells. Cancer Biochem Biophys 12: 221-239, 1992.
12. Spiegelman S, Nayak R, Sawyer R, Stolfi R and Martin D, Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA. Cancer 45: 1129-1134, 1980.
13. Dolnick BJ and Pink JJ, Effects of 5-fluorouracil on dihydrofolate reductase and dihydrofolate reductase mRNA from methotrexate-resistant KB cells. J Biol Chem 260: 3006-3015, 1985.
14. Will CL and Dolnick BJ, 5-Fluorouracil augmentation of dihydrofolate reductase transcripts containing intervening sequences in methotrexate-resistant KB cells. Mol Pharmacol 29: 643-648, 1986.
15. Will CL and Dolnick BJ, 5-Fluorouracil augmentation of dihydrofolate reductase RNA containing contiguous exon and intron sequences in KB7B cells. J Biol Chem 262: 5433-5436, 1987.
16. Armstrong RD, Lewis M, Stern SG and Cadman EC, Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism. J Biol Chem 261: 7366-7371, 1986.
17. Doong SL and Dolnick BJ, 5-Fluorouracil substitution alters pre-mRNA splicing in vitro. J Biol Chem 263: 4467-4473, 1988.
18. Sierakowska H, Shukla RR, Dominski Z and Kole R, Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine. J Biol Chem 266: 19185-19191, 1989.
19. Lenz H, Manno DJ, Danenberg KD and Danenberg PV, Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing. J Biol Chem 269: 31962-31968, 1994.
20. Patton JR, In vitro splicing of pre-messenger RNA with extracts from 5-fluorouridine-treated cells. Biochem J 297: 297-301, 1994.
21. Tseng WC, Medina D and Randerath K, Specific inhibition of transfer RNA methylation and modification in tissues of mice treated with 5-fluorouracil. Cancer Res 38: 1250-1257, 1978.
22. Larson DE, Zahradka P and Sells BH, Control points in eukaryotic ribosome biogenesis. Cell Biol 69: 5-22, 1991.
23. Jacob ST, Regulation of ribosomal gene transcription. Biochem J 306: 617-626, 1995.
24. Eichler DC and Craig N, Processing of eukaryotic ribosomal RNA. Prog Nucleic Acid Res Mol Biol 49: 199-237, 1994.
25. David IB and Wellauer DK, A reinvestigation of 5′-3′ polarity in 40S ribosomal RNA precursor on Xenopus laevis. Cell 8: 443-448, 1976.
26. Wilkinson DS and Pitot HC, Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine. J Biol Chem 248: 63-68, 1973.
27. Stenram U, The effects of fluorouracil and actinomycin, single and combined, on the nucleolar ultrastructure of various tissues of the rat. Z Zellforsch Mikrosk Anat 94: 282-292, 1969.
28. Greenhalgh DA and Parish JH, Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells. Br J Cancer 61: 415-419, 1990.
29. Carrico CK and Glazer RI, Augmentation of the incorporation and distribution of 5-fluorouracil in ribosomal RNA. Biochem Biophys Res Commun 87: 664-760, 1979.
30. Glazer RI and Hartman KD, Analysis of the effect of 5-fluorouracil on the synthesis and translation of polysomal poly(A)RNA for Ehrlich ascites cells. Mol Pharmacol 19: 117-121, 1981.
31. Glazer RI and Legraverend M, The effect of 5-fluorouridine 5′-triphosphate on RNA transcribed in isolated nuclei in vitro. Mol Pharmacol 17: 279-282, 1980.
32. Glazer RI and Peale AL, The effect of 5-fluorouracil on the synthesis of nuclear RNA in L-1210 cells in vitro. Mol Pharmacol 16: 270-277, 1979.
33. Heidelberger C, Fluorinated pyrmidines and their nucleosides. In: Antineoplostic and Immunosuppressive Agents (Eds. Sartorelli AC and Johns DG) Vol. 2, pp. 193-231. Springer, New York, 1975.
34. Lu LW, Chiang GH, Tseng WC and Randerath K, Effects of 5-fluorouridine on modified nucleotides in mouse liver transfer RNA. Biochem Biophys Res Commun 73: 1075-1082, 1976.
35. Herrick D and Kufe DW, Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA. Mol Pharmacol 26: 135-140, 1984.
36. Kanamaru R, Kakuta H, Sato T, Ishioka C and Wakui A, The inhibitory effects of 5-fluorouracil on the metabolism of pre-ribosomal and ribosomal RNA in L-1210 cells in vitro. Cancer Chemother Pharmacol 17: 43-46, 1986.
37. Ghoshal K and Jacob ST, Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil. Cancer Res 54: 632-636, 1994.
38. Kass S, Tyc K, Steitz JA and Sollner-Webb B, The U3 small nuclear ribonucleoprotein function in the first step of preribosomal RNA processing. Cell 60: 897-908, 1990.
39. Beltrame M and Tollervey D, Identification and function analysis of two U3 binding sites on yeast pre-ribosomal RNA. EMBOJ 11: 1531-1542, 1992.
40. Reddy R and Busch H, Small nuclear RNAs: RNA sequences, structure and modifications. In: Structure and Functions of Major and Minor Small Nuclear Ribonucleoprotein Particies (Ed. Birnsteil ML), pp. 1-37. Springer, Berlin, 1988.
41. Stroke IL and Weiner AM, The 5′ end of U3 snRNA can be crosslinked in vivo to the external transcribed spacer of rat ribosomal RNA precursors. J Mol Biol 210: 497-512, 1989.
42. Maser RL and Calvet JP, U3 small nuclear RNA can be psoralen-cross-linked in vivo to the 5′ external transcribed spacer of pre-ribosomal RNA. Proc Natl Acad Sci USA 86: 6523-6527, 1989.
43. Tyc K and Steitz JA, A new interaction between the mouse 5′ external transcribed spacer of pre-rRNA and U3 snRNA detected by psoralen crosslinking. Nucleic Acids Res 20: 5375-5382, 1992.
44. Calvet JP and Pederson T, Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo. Cell 26: 363-370, 1981.
45. Lafontaine D and Tollervey D, Transacting factors in yeast pre-rRNA and pre-snoRNA processing. Biochem Cell Biol 73: 802-812, 1996.
46. Kass S and Sollner-Webb B, The first processing event occurs in a large complex: Analysis by gel retardation, sedimentation and UV crosslinking. Mol Cell Biol 10: 4920-4931, 1990.
47. Lengyel J and Penman S, hnRNA size and processing as related to different DNA content in two Dipterans: Drosophila and Aedes. Cell 5: 281-290, 1975.
48. Dolnick BJ and Pink JJ, 5-Fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells. J Biol Chem 258: 13299-13306, 1983.
49. Guthrie C, Messenger RNA splicing in yeast: Clues to why the spliceosome is a ribonucleoprotein. Science 253: 157-163, 1991.
50. Kyprianou N and Isaacs JT, "Thymineless" death in androgen-independent prostatic cancer cells. Biochem Biophys Res Commun 165: 73-81, 1989.