The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms

British Journal of Pharmacology

Volumn 157, Issue 5, 2009, Pages 804-817

  Spitzmaul, Guillermo ^a   Gumilar, Fernanda ^a   Dilger, James P ^b   Bouzat, Cecilia ^a,c  

^a UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

^b STONY BROOK UNIVERSITY   (United States)

^c Instituto de Investigaciones Bioquimicas Bahia Blanca   (Argentina)

Author keywords

AChR; Local anaesthetics; Non competitive inhibitor; Proadifen; Single channels

Indexed keywords

ADIPHENINE; CHOLINERGIC RECEPTOR; NICOTINIC RECEPTOR; PROADIFEN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DESENSITIZATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IC 50; LOCAL ANESTHESIA; PRIORITY JOURNAL; SKELETAL MUSCLE;

ACETYLCHOLINE; ANESTHETICS, LOCAL; ANIMALS; BINDING SITES; CELL LINE; DIPHENYLACETIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MICE; NICOTINIC ANTAGONISTS; PROADIFEN; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; TRANSFECTION;

EID: 70350161799     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00214.x     Document Type: Article

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