Electrophysiological characterization of chloride secretion across the jejunum and colon of pigs as affected by age and weaning

Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology

Volumn 179, Issue 7, 2009, Pages 883-896

  Leonhard Marek, Sabine ^a   Hempe, Julia ^a   Schroeder, Bernd ^a   Breves, Gerhard ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Ca activated Cl channels; CFTR; Intestine; Pig; Weaning

Indexed keywords

CHLORIDE CHANNEL; ISOPROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AGING; ANIMAL; ANIMAL DISEASE; ARTICLE; CELL MEMBRANE POTENTIAL; COLON; DIARRHEA; DRUG ANTAGONISM; DRUG POTENTIATION; FEMALE; GROWTH, DEVELOPMENT AND AGING; JEJUNUM; MALE; METABOLISM; ORCHIECTOMY; PHYSIOLOGY; SUCKLING; SWINE; SWINE DISEASE; WEANING;

AGING; ANIMALS; ANIMALS, SUCKLING; CHLORIDE CHANNELS; COLON; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIARRHEA; FEMALE; JEJUNUM; MALE; MEMBRANE POTENTIALS; ORCHIECTOMY; PROTEIN ISOFORMS; SWINE; SWINE DISEASES; WEANING;

SUIDAE; SUS;

EID: 70350158048     PISSN: 01741578     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00360-009-0371-3     Document Type: Article

References (56)

1. Barrett KE, Keely SJ (2000) Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 62:535-572.
2. Benos DJ (1982) Amiloride: a molecular probe of sodium transport in tissues and cells. Am J Physiol Cell Physiol 242:C131-C145.
3. Beubler E, Juan H (1978) PGE-release, blood flow and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa. Naunyn Schmiedebergs Arch Pharmacol 305:91-95.
4. Bijlsma PB, Kiliaan AJ, Scholten G, Heyman M, Groot JA, Taminiau JAJM (1996) Carbachol, but not forskolin, increases mucosal-to-serosal transport of intact protein in rat ileum in vitro. Am J Physiol 271:G147-G155 (Gastrointest Liver Physiol 34).
5. TgH(neoim)1Hgu congenic mice. J Comp Physiol B 177:61-73.
6. Boudry G, Lallès JP, Malbert CH, Bobillier E, Sève B (2002) Diet-related adaptation of the small intestine at weaning in pigs is functional rather than structural. J Pediatr Gastroenterol Nutr 34:180-187.
7. Boudry G, Péron V, Le Huërou-Luron I, Lallès JP, Sève B (2004) Weaning induces both transient and long-lasting modifications of absorptive, secretory and barrier properties of piglet intestine. J Nutr 134:2256-2262.
8. Bronsveld I, Mekus F, Bijman J, Ballmann M, Greipel J, Hundriser J, Halley DJJ, Laabs U, Busche R, De Jonge HR, Tümmler B, Veeze HJ, The European CF Twin and Sibling Study Consortium (2000) Residual chloride secretion in intestinal tissue of ΔF508 homozygous twins and siblings with cystic fibrosis. Gastroenterology 119:32-40.
9. Brown DR, Overend MF, Treder BG (1990) Neurohormonal regulation of ion transport in the porcine distal jejunum. Action of Somatostatin-14 and its natural and synthetic homologs. J Pharmacol Exp Ther 252:126-134.
10. Carlson D, Damgaard Poulsen H, Sehested J (2004) Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose, theophylline and 5-HT in piglet small intestinal mucosa. Comp Biochem Physiol A 137:757-765.
11. Chandan R, Hildebrand KR, Seybold VS, Soldani G, Brown DR (1991) Cholinergic neurons and muscarinic receptors regulate anion secretion in pig distal jejunum. Eur J Pharmacol 193:265-273.
12. Charizopoulou N, Wilke M, Dorsch M, Bot A, Jorna H, Jansen S, Stanke F, Hedrich HJ, Tümmler B (2006) Spontaneous rescue from cystic fibrosis in a mouse model. BMC Genet 7:18.
13. Clarke LL, Grubb BR, Yankaskas JR, Cotton CU, McKenzie A, Boucher RC (1994) Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proc Natl Acad Sci USA 91:479-483.
14. Cuthbert AW (2001) Assessment of CFTR chloride channel openers in intact normal and cystic fibrosis murine epithelia. Br J Pharmacol 132:659-668.
15. De Jonge HR, Ballmann M, Veeze H, Bronsveld I, Stanke F, Tümmler B, Sinaasappel M (2004) Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers. J Cyst Fibros 3:159-163.
16. Erlwanger KH, Unmack MA, Grøndahl ML, Skadhauge E, Thorbøll JE (1999) Effect of age on vasoactive intestinal polypeptide-induced short-circuit current in porcine jejunum. Comp Biochem Physiol A 124:29-33.
17. Farthing MJG (2000) Diarrhoea: a significant worldwide problem. Int J Antimicrob Agents 14:65-69.
18. Forsyth GW, Gabriel SE (1988) Chloride ion transport into pig jejunal brush-border membrane vesicles. J Physiol 402:555-564.
19. - channels: a newly emerging anion transport family. Pflügers Arch Eur J Physiol 443:S107-S110.
20. Gawenis LR, Boyle KT, Palmer BA, Walker NM, Clarke LL (2004) Lateral intercellular space volume as a determinant of CFTR-mediated anion secretion across small intestinal mucosa. Am J Physiol Gastrointest Liver Physiol 286:G1015-G1023.
21. Gibson A, Lewis AP, Affleck K, Aitken AJ, Meldrum E, Thompson N (2005) hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels. J Biol Chem 280:27205-27212.
22. Greger R, Nitschke RB, Lohrmann E, Burhoff I, Hropot M, Englert HC, Lang HJ (1991) Effects of arylaminobenzoate-type chloride channel blockers on equivalent short-circuit current in rabbit colon. Pflügers Arch Eur J Physiol 419:190-196.
23. Grøndahl ML, Hansen MB, Larsen IE, Skadhauge E (1996) Age and segmental differences in 5-hydroxytryptamine-induced hypersecretion in the pig small intestine. J Comp Physiol B 166:21-29.
24. Gruber AD, Gandhi R, Pauli BU (1998) The murine calcium-sensitive chloride channel (mCaCC) is widely expressed in secretory epithelia and in other select tissues. Histochem Cell Biol 110:43-49.
25. Hayden UI, Carey HV (1996) Cellular localization of cystic fibrosis transmembrane regulator protein in piglet and mouse intestine. Cell Tissue Res 283:209-213.
26. Holtug K, Skadhauge E (1991) Ion transport across isolated pig jejunum. Am J Physiol Gastrointest Liver Physiol 260:G220-G231.
27. Hryciw DH, Guggino WB (2000) Cystic fibrosis transmembrane conductance regulator and the outwardly rectifying chloride channel: a relationship between two chloride channels expressed in epithelial cells. Clin Exp Pharmacol Physiol 27:892-895.
28. Isaacs PET, Corbett CL, Riley AK, Hawker PC, Turnberg LA (1976) In vitro behaviour of human intestinal mucosa. J Clin Invest 58:535-542.
29. Jentsch TJ, Stein V, Weinreich F, Zdebik AA (2002) Molecular structure and physiological function of chloride channels. Physiol Rev 82:503-568.
30. Keely SJ, Barrett KE (2000) Regulation of chloride secretion: novel pathways and messengers. Ann NY Acad Sci 915:67-76.
31. Kimberg DV, Field M, Johnson J, Henderson A, Gershon E (1971) Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J Clin Invest 50:1218-1230.
32. Kirkup AJ, Edwards G, Weston AH (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br J Pharmacol 117:175-183.
33. Ko EA, Han J, Jung ID, Park WS (2008) Physiological roles of K+ channels in vascular smooth muscle cells. J Smooth Muscle Res 44:65-81.
34. Latorre R, Miller C (1983) Conduction and selectivity in potassium channels. J Membrane Biol 71:11-30.
35. Leonhard-Marek S, Daugschies A (1997) Electro- and transport physiological changes in pig proximal colon during parasitic infection. Comp Biochem Physiol 118A:345-347.
36. Liu X, Luo M, Zhang L, Ding W, Yan Z, Engelhardt JF (2007) Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia. Am J Respir Cell Mol Biol 36:313-323.
37. Loewen ME, Gabriel SE, Forsyth GW (2002) The calcium-dependent chloride conductance mediator pCLCA1. Am J Physiol Cell Physiol 283:C412-C421.
38. Loewen ME, Bekar LK, Walz W, Forsyth GW, Gabriel SE (2004) pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line. Am J Physiol Gastrointest Liver Physiol 287:G33-G41.
39. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJV, Verkman AS (2002) Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest 110:1651-1658.
40. McEwan GTA, Schousboe B, Nielsen CG, Skadhauge E (1990) Effect of age on the secretory capacity of pig small intestine in vivo and in vitro. Am J Physiol Gastrointest Liver Physiol 259:G474-G480.
41. Milla PJ (1998) Cystic fibrosis: present and future. Digestion 59:579-588.
42. Miller BG, Skadhauge E (1997) Effect of weaning in the pig on ileal ion transport measured in vitro. J Vet Med A 44:289-299.
43. Moeser AJ, Vander Klok C, Ryan KA, Wooten JG, Little D, Cook VL, Blikslager AT (2007a) Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol 292:G173-G181.
44. Moeser AJ, Ryan KA, Nighot PK, Blikslager AT (2007b) Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol 293:G413-G421.
45. Montagne L, Boudry G, Favier C, Le Huerou-Luron I, Lellès JP, Sève B (2007) Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning. Br J Nutr 97:45-57.
46. Ostedgaard LS, Rogers CS, Dong Q, Randak CO, Vermeer DW, Rokhlina T, Karp PH, Welsh MJ (2007) Processing and fuction of CFTR-ΔF508 are species-dependent. PNAS 104:15370-15375.
47. Perez M, Barber A, Ponz F (1997) Modulation of intestinal paracellular permeability by intracellular mediators and cytoskeleton. Can J Physiol Pharmacol 75:287-292.
48. Pluske JR, Hampson DJ, Williams IH (1997) Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livest Prod Sci 51:215-236.
49. Rogers CS, Stoltz DA, Meyerholz DK et al (2008) Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321:1837-1841.
50. Schultz BD, Singh AK, Devor DC, Bridges RJ (1999) Pharmacology of CFTR chloride channel activity. Physiol Rev 79(Suppl 1):S109-S144.
51. Schwiebert EM, Flotte T, Cutting GR, Guggino WB (1994) Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents. Am J Physiol Cell Physiol 266:C1464-C1477.
52. Seamon KB, Padgett W, Daly JW (1981) Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci USA 78:3363-3367.
53. Spreeuwenberg MAM, Verdonk JMAJ, Gaskins HR, Verstegen MWA (2001) Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning. J Nutr 131:1520-1527.
54. Strabel D, Diener M (1995) Evidence against direct activation of chloride secretion by carbachol in the rat distal colon. Eur J Pharmacol 274:181-191.
55. Thapar N, Sanderson IR (2004) Diarrhoea in children: an interface between developing and developed countries. Lancet 363:641-653.
56. Walsh KB, Long KJ, Shen X (1999) Structural and ionic determinants of 5-nitro-2-(3-phenylpropylamino)-benzoic acid block of the CFTR chloride channel. Br J Pharmacol 127:369-376.