-
1
-
-
43849104724
-
+ T cells
-
Ahlen, G., Soderholm, J., Tjelle, T., Kjeken, R., Frelin, L., Ho-glund, U., Blomberg, P., Fons, M., Mathiesen, I., and Sallberg, M. (2007). In vivo electroporation enhances the immunoge-nicity of hepatitis C virus nonstructural 3=4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells. J. Immunol. 179, 4741-4753.
-
(2007)
J. Immunol
, vol.179
, pp. 4741-4753
-
-
Ahlen, G.1
Soderholm, J.2
Tjelle, T.3
Kjeken, R.4
Frelin, L.5
Ho-Glund, U.6
Blomberg, P.7
Fons, M.8
Mathiesen, I.9
Sallberg, M.10
-
2
-
-
0031753867
-
Gene transfer into muscle by electroporation in vivo
-
Aihara, H., and Miyazaki, J. (1998). Gene transfer into muscle by electroporation in vivo. Nat. Biotechnol. 16, 867-870.
-
(1998)
Nat. Biotechnol
, vol.16
, pp. 867-870
-
-
Aihara, H.1
Miyazaki, J.2
-
3
-
-
18644379809
-
Electroporation as a ''prime=boost'' strategy for naked DNA vaccination against a tumor antigen
-
Buchan, S., Gronevik, E., Mathiesen, I., King, C.A., Stevenson, F.K., and Rice, J. (2005). Electroporation as a ''prime=boost'' strategy for naked DNA vaccination against a tumor antigen. J. Immunol. 174, 6292-6298.
-
(2005)
J. Immunol
, vol.174
, pp. 6292-6298
-
-
Buchan, S.1
Gronevik, E.2
Mathiesen, I.3
King, C.A.4
Stevenson, F.K.5
Rice, J.6
-
4
-
-
58049200809
-
Phase i trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
-
Daud, A.I., Deconti, R.C., Andrews, S., Urbas, P., Riker, A.I., Sondak, V.K., Munster, P.N., Sullivan, D.M., Ugen, K.E., Messina, J.L., and Heller, R. (2008). Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J. Clin. Oncol. 26, 5896-58903.
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 5896-58903
-
-
Daud, A.I.1
Deconti, R.C.2
Andrews, S.3
Urbas, P.4
Riker, A.I.5
Sondak, V.K.6
Munster, P.N.7
Sullivan, D.M.8
Ugen, K.E.9
Messina, J.L.10
Heller, R.11
-
5
-
-
33645530889
-
Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific
-
Di Genova, G., Roddick, J., Mcnicholl, F., and Stevenson, F.K. (2006). Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific. Blood 107, 2806-2813.
-
(2006)
Blood
, vol.107
, pp. 2806-2813
-
-
Di Genova, G.1
Roddick, J.2
McNicholl, F.3
Stevenson, F.K.4
-
6
-
-
33646830816
-
Epidermal DNA vaccine for influenza is immunogenic in humans
-
Drape, R.J., Macklin, M.D., Barr, L.J., Jones, S., Haynes, J.R., and Dean, H.J. (2006). Epidermal DNA vaccine for influenza is immunogenic in humans. Vaccine 24, 4475-4481.
-
(2006)
Vaccine
, vol.24
, pp. 4475-4481
-
-
Drape, R.J.1
MacKlin, M.D.2
Barr, L.J.3
Jones, S.4
Haynes, J.R.5
Dean, H.J.6
-
7
-
-
0034283956
-
Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice
-
Dupuis, M., Denis-Mize, K., Woo, C., Goldbeck, C., Selby, M.J., Chen, M., Otten, G.R., Ulmer, J.B., Donnelly, J.J., Ott, G., and McDonald, D.M. (2000). Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J. Immunol. 165, 2850-2858.
-
(2000)
J. Immunol
, vol.165
, pp. 2850-2858
-
-
Dupuis, M.1
Denis-Mize, K.2
Woo, C.3
Goldbeck, C.4
Selby, M.J.5
Chen, M.6
Otten, G.R.7
Ulmer, J.B.8
Donnelly, J.J.9
Ott, G.10
McDonald, D.M.11
-
8
-
-
25144498009
-
Early events of electroporation-mediated intramuscular DNA vaccination potentiate Th1-directed immune responses
-
Gronevik, E., Mathiesen, I., and Lomo, T. (2005). Early events of electroporation-mediated intramuscular DNA vaccination potentiate Th1-directed immune responses. J. Gene Med. 7, 1246-1254.
-
(2005)
J. Gene Med
, vol.7
, pp. 1246-1254
-
-
Gronevik, E.1
Mathiesen, I.2
Lomo, T.3
-
9
-
-
37549037877
-
Intradermal=subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques
-
Hirao, L.A., Wu, L., Khan, A.S., Satishchandran, A., Draghia-Akli, R., and Weiner, D.B. (2008). Intradermal=subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques. Vaccine 26, 440-448.
-
(2008)
Vaccine
, vol.26
, pp. 440-448
-
-
Hirao, L.A.1
Wu, L.2
Khan, A.S.3
Satishchandran, A.4
Draghia-Akli, R.5
Weiner, D.B.6
-
10
-
-
38949093002
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
-
Ishii, K.J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., and Akira, S. (2008). TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451, 725-729.
-
(2008)
Nature
, vol.451
, pp. 725-729
-
-
Ishii, K.J.1
Kawagoe, T.2
Koyama, S.3
Matsui, K.4
Kumar, H.5
Kawai, T.6
Uematsu, S.7
Takeuchi, O.8
Takeshita, F.9
Coban, C.10
Akira, S.11
-
11
-
-
33751207463
-
Clinical evaluation of pain and muscle damage induced by electroporation of skeletal muscle in humans [abstract 157]
-
Kjeken, R., Tjelle, T.E., Kvale, D., and Mathiesen, I. (2004). Clinical evaluation of pain and muscle damage induced by electroporation of skeletal muscle in humans [abstract 157]. Mol. Ther. 9, S60.
-
(2004)
Mol. Ther
, vol.9
-
-
Kjeken, R.1
Tjelle, T.E.2
Kvale, D.3
Mathiesen, I.4
-
12
-
-
66149110932
-
Elec-troporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus
-
Laddy, D.J., Yan, J., Khan, A.S., Andersen, H., Cohn, A., Greenhouse, J., Lewis, M., Manischewitz, J., King, L.R., Golding, H., Draghia-Akli, R., and Weiner, D.B. (2009). Elec-troporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus. J. Virol. 83, 4624-4630.
-
(2009)
J. Virol
, vol.83
, pp. 4624-4630
-
-
Laddy, D.J.1
Yan, J.2
Khan, A.S.3
Andersen, H.4
Cohn, A.5
Greenhouse, J.6
Lewis, M.7
Manischewitz, J.8
King, L.R.9
Golding, H.10
Draghia-Akli, R.11
Weiner, D.B.12
-
13
-
-
43949114521
-
Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation
-
Liu, J., Kjeken, R., Mathiesen, I., and Barouch, D.H. (2008). Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation. J. Virol. 82, 5643-5649.
-
(2008)
J. Virol
, vol.82
, pp. 5643-5649
-
-
Liu, J.1
Kjeken, R.2
Mathiesen, I.3
Barouch, D.H.4
-
14
-
-
0037108840
-
Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen
-
Lu, J., and Celis, E. (2002). Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen. Cancer Res. 62, 5807-5812.
-
(2002)
Cancer Res
, vol.62
, pp. 5807-5812
-
-
Lu, J.1
Celis, E.2
-
15
-
-
34248382494
-
Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques
-
Luckay, A., Sidhu, M.K., Kjeken, R., Megati, S., Chong, S.Y., Roopchand, V., Garcia-Hand, D., Abdullah, R., Braun, R., Montefiori, D.C., Rosati, M., Felber, B.K., Pavlakis, G.N., Mathiesen, I., Israel, Z.R., Eldridge, J.H., and Egan, M.A. (2007). Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J. Virol. 81, 5257-5269.
-
(2007)
J. Virol
, vol.81
, pp. 5257-5269
-
-
Luckay, A.1
Sidhu, M.K.2
Kjeken, R.3
Megati, S.4
Chong, S.Y.5
Roopchand, V.6
Garcia-Hand, D.7
Abdullah, R.8
Braun, R.9
Montefiori, D.C.10
Rosati, M.11
Felber, B.K.12
Pavlakis, G.N.13
Mathiesen, I.14
Israel, Z.R.15
Eldridge, J.H.16
Egan, M.A.17
-
16
-
-
61349180127
-
Fit for purpose? A case study: Validation of immuno-logical endpoint assays for the detection of cellular and humoral responses to anti-tumour DNA fusion vaccines
-
Mander, A., Chowdhury, F., Low, L., and Ottensmeier, C.H. (2009). Fit for purpose? A case study: Validation of immuno-logical endpoint assays for the detection of cellular and humoral responses to anti-tumour DNA fusion vaccines. Cancer Immunol. Immunother. 58, 789-800.
-
(2009)
Cancer Immunol. Immunother
, vol.58
, pp. 789-800
-
-
Mander, A.1
Chowdhury, F.2
Low, L.3
Ottensmeier, C.H.4
-
17
-
-
0032926935
-
Electropermeabilization of skeletal muscle enhances gene transfer in vivo
-
Mathiesen, I. (1999). Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther. 6, 508-514.
-
(1999)
Gene Ther
, vol.6
, pp. 508-514
-
-
Mathiesen, I.1
-
18
-
-
84925569642
-
-
U.S. Patent 6 110,161, August 29, 2000
-
Mathiesen, I., and Lømo, T. (1998). Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle. U.S. Patent 6,110,161, August 29, 2000 (http:= = www. freepatentsonline.com=6110161.html).
-
(1998)
Method for Introducing Pharmaceutical Drugs and Nucleic Acids into Skeletal Muscle
-
-
Mathiesen, I.1
Lømo, T.2
-
19
-
-
0032203216
-
Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle
-
Mir, L.M., Bureau, M.F., Rangara, R., Schwartz, B., and Scher-man, D. (1998). Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle. C.R. Acad. Sci. III 321, 893-899.
-
(1998)
C.R. Acad. Sci. III
, vol.321
, pp. 893-899
-
-
Mir, L.M.1
Bureau, M.F.2
Rangara, R.3
Schwartz, B.4
Scher-Man, D.5
-
20
-
-
33748795860
-
Microparticle-based technologies for vaccines
-
O'Hagan, D.T., Singh, M., and Ulmer, J.B. (2006). Microparticle-based technologies for vaccines. Methods 40, 10-19.
-
(2006)
Methods
, vol.40
, pp. 10-19
-
-
O'Hagan, D.T.1
Singh, M.2
Ulmer, J.B.3
-
21
-
-
2942564030
-
Enhancement of DNA vaccine potency in rhesus macaques by electropora-tion
-
Otten, G., Schaefer, M., Doe, B., Liu, H., Srivastava, I., Zur Me-gede, J., O'Hagan, D., Donnelly, J., Widera, G., Rabussay, D., Lewis, M.G., Barnett, S., and Ulmer, J.B. (2004). Enhancement of DNA vaccine potency in rhesus macaques by electropora-tion. Vaccine 22, 2489-2493.
-
(2004)
Vaccine
, vol.22
, pp. 2489-2493
-
-
Otten, G.1
Schaefer, M.2
Doe, B.3
Liu, H.4
Srivastava, I.5
Zur Me-Gede, J.6
O'Hagan, D.7
Donnelly, J.8
Widera, G.9
Rabussay, D.10
Lewis, M.G.11
Barnett, S.12
Ulmer, J.B.13
-
22
-
-
33646852606
-
Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation
-
Otten, G.R., Schaefer, M., Doe, B., Liu, H., Megede, J.Z., Donnelly, J., Rabussay, D., Barnett, S., and Ulmer, J.B. (2006). Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation. Vaccine 24, 4503-4509.
-
(2006)
Vaccine
, vol.24
, pp. 4503-4509
-
-
Otten, G.R.1
Schaefer, M.2
Doe, B.3
Liu, H.4
Megede, J.Z.5
Donnelly, J.6
Rabussay, D.7
Barnett, S.8
Ulmer, J.B.9
-
23
-
-
0032416018
-
The management of PSA failure after radical radiotherapy for localized prostate cancer
-
Parker, C.C., and Dearnaley, D.P. (1998). The management of PSA failure after radical radiotherapy for localized prostate cancer. Radiother. Oncol. 49, 103-110.
-
(1998)
Radiother. Oncol
, vol.49
, pp. 103-110
-
-
Parker, C.C.1
Dearnaley, D.P.2
-
24
-
-
0035423441
-
DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: Implications for cancer vaccines
-
Rice, J., Elliott, T., Buchan, S., and Stevenson, F.K. (2001). DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: Implications for cancer vaccines. J. Immunol. 167, 1558-1565.
-
(2001)
J. Immunol
, vol.167
, pp. 1558-1565
-
-
Rice, J.1
Elliott, T.2
Buchan, S.3
Stevenson, F.K.4
-
25
-
-
38549175830
-
DNA vaccines: Precision tools for activating effective immunity against cancer
-
Rice, J., Ottensmeier, C.H., and Stevenson, F.K. (2008). DNA vaccines: Precision tools for activating effective immunity against cancer. Nat. Rev. Cancer 8, 108-120.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 108-120
-
-
Rice, J.1
Ottensmeier, C.H.2
Stevenson, F.K.3
-
26
-
-
33646510798
-
Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells
-
Rols, M.P. (2006). Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells. Biochim. Bio-phys. Acta 1758, 423-428.
-
(2006)
Biochim. Bio-phys. Acta
, vol.1758
, pp. 423-428
-
-
Rols, M.P.1
-
27
-
-
1842479734
-
In vivo electroporation improves immune responses to DNA vaccination in sheep
-
Scheerlinck, J.P., Karlis, J., Tjelle, T.E., Presidente, P.J., Mathie-sen, I., and Newton, S.E. (2004). In vivo electroporation improves immune responses to DNA vaccination in sheep. Vaccine 22, 1820-1825.
-
(2004)
Vaccine
, vol.22
, pp. 1820-1825
-
-
Scheerlinck, J.P.1
Karlis, J.2
Tjelle, T.E.3
Presidente, P.J.4
Mathie-Sen, I.5
Newton, S.E.6
-
28
-
-
0031042591
-
Prostate-specific membrane antigen expression in normal and malignant human tissues
-
Silver, D.A., Pellicer, I., Fair, W.R., Heston, W.D., and Cordon-Cardo, C. (1997). Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin. Cancer Res. 3, 81-85.
-
(1997)
Clin. Cancer Res
, vol.3
, pp. 81-85
-
-
Silver, D.A.1
Pellicer, I.2
Fair, W.R.3
Heston, W.D.4
Cordon-Cardo, C.5
-
29
-
-
47349092030
-
In patients experiencing biochemical failure after radiotherapy, pretreatment risk group and PSA velocity predict differences in overall survival and biochemical failure-free interval
-
Soto, D.E., Andridge, R.R., Pan, C.C., Williams, S.G., Taylor, J.M., and Sandler, H.M. (2008). In patients experiencing biochemical failure after radiotherapy, pretreatment risk group and PSA velocity predict differences in overall survival and biochemical failure-free interval. Int. J. Radiat. Oncol. Biol. Phys. 71, 1295-1301.
-
(2008)
Int. J. Radiat. Oncol. Biol. Phys
, vol.71
, pp. 1295-1301
-
-
Soto, D.E.1
Andridge, R.R.2
Pan, C.C.3
Williams, S.G.4
Taylor, J.M.5
Sandler, H.M.6
-
30
-
-
0035336675
-
Sparking new frontiers: Using in vivo electroporation for genetic manipulations
-
Swartz, M., Eberhart, J., Mastick, G.S., and Krull, C.E. (2001). Sparking new frontiers: Using in vivo electroporation for genetic manipulations. Dev. Biol. 233, 13-21.
-
(2001)
Dev. Biol
, vol.233
, pp. 13-21
-
-
Swartz, M.1
Eberhart, J.2
Mastick, G.S.3
Krull, C.E.4
-
31
-
-
33646830656
-
A novel electroporation device for gene delivery in large animals and humans
-
Tjelle, T.E., Salte, R., Mathiesen, I., and Kjeken, R. (2006). A novel electroporation device for gene delivery in large animals and humans. Vaccine 24, 4667-4670.
-
(2006)
Vaccine
, vol.24
, pp. 4667-4670
-
-
Tjelle, T.E.1
Salte, R.2
Mathiesen, I.3
Kjeken, R.4
-
32
-
-
0037346983
-
DNA injection in combination with electroporation: A novel method for vaccination of farmed ruminants
-
Tollefsen, S., Vordermeier, M., Olsen, I., Storset, A.K., Reitan, L.J., Clifford, D., Lowrie, D.B., Wiker, H.G., Huygen, K., Hewinson. G., Mathiesen I., Tjelle T.E. 2003 DNA injection in combination with electroporation: A novel method for vaccination of farmed ruminants. Scand. J. Immunol 57 229-238
-
(2003)
Scand. J. Immunol
, vol.57
, pp. 229-238
-
-
Tollefsen, S.1
Vordermeier, M.2
Olsen, I.3
Storset, A.K.4
Reitan, L.J.5
Clifford, D.6
Lowrie, D.B.7
Wiker, H.G.8
Huygen, K.9
Hewinson, G.10
Mathiesen, I.11
Tjelle, T.E.12
-
33
-
-
33646568454
-
Gene-based vaccines: Recent technical and clinical advances
-
Ulmer, J.B., Wahren, B., and Liu, M.A. (2006). Gene-based vaccines: Recent technical and clinical advances. Trends Mol. Med. 12, 216-222.
-
(2006)
Trends Mol. Med
, vol.12
, pp. 216-222
-
-
Ulmer, J.B.1
Wahren, B.2
Liu, M.A.3
-
34
-
-
41549123253
-
The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods
-
Wang, S., Zhang, C., Zhang, L., Li, J., Huang, Z., and Lu, S. (2008). The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods. Vaccine 26, 2100-2110.
-
(2008)
Vaccine
, vol.26
, pp. 2100-2110
-
-
Wang, S.1
Zhang, C.2
Zhang, L.3
Li, J.4
Huang, Z.5
Lu, S.6
-
35
-
-
18144446323
-
Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
-
Widera, G., Austin, M., Rabussay, D., Goldbeck, C., Barnett, S.W., Chen, M., Leung, L., Otten, G.R., Thudium, K., Selby M.J., and Ulmer, J.B. (2000). Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J. Immunol. 164, 4635-4640. (Pubitemid 30238062)
-
(2000)
Journal of Immunology
, vol.164
, Issue.9
, pp. 4635-4640
-
-
Widera, G.1
Austin, M.2
Rabussay, D.3
Goldbeck, C.4
Barnett, S.W.5
Chen, M.6
Leung, L.7
Otten, G.R.8
Thudium, K.9
Selby, M.J.10
Ulmer, J.B.11
-
36
-
-
46349108117
-
Safety and immunogenicity of a bivalent cytomegalovirus DNA vaccine in healthy adult subjects
-
Wloch, M.K., Smith, L.R., Boutsaboualoy, S., Reyes, L., Han, C., Kehler, J., Smith, H.D., Selk, L., Nakamura, R., Brown, J.M., Marbury, T., Wald, A., Rolland, A., Kaslow, D., Evans, T., and Boeckh, M. (2008). Safety and immunogenicity of a bivalent cytomegalovirus DNA vaccine in healthy adult subjects. J. Infect. Dis. 197, 1634-1642.
-
(2008)
J. Infect. Dis
, vol.197
, pp. 1634-1642
-
-
Wloch, M.K.1
Smith, L.R.2
Boutsaboualoy, S.3
Reyes, L.4
Han, C.5
Kehler, J.6
Smith, H.D.7
Selk, L.8
Nakamura, R.9
Brown, J.M.10
Marbury, T.11
Wald, A.12
Rolland, A.13
Kaslow, D.14
Evans, T.15
Boeckh, M.16
-
37
-
-
0034466814
-
Enhancing B-and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer
-
Zucchelli, S., Capone, S., Fattori, E., Folgori, A., Di Marco, A., Casimiro, D., Simon, A.J., Laufer, R., La Monica, N., Cortese R., and Nicosia, A. (2000). Enhancing B-and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. J. Virol. 74, 11598-115607
-
(2000)
J. Virol
, vol.74
, pp. 11598-115607
-
-
Zucchelli, S.1
Capone, S.2
Fattori, E.3
Folgori, A.4
Di Marco, A.5
Casimiro, D.6
Simon, A.J.7
Laufer, R.8
La Monica, N.9
Cortese, R.10
Nicosia, A.11
|