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Volumn 871, Issue 1, 2008, Pages 44-54
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High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry
a,b
b
c
a
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Author keywords
Human plasma; LC MS MS; Liquid liquid extraction; m Chlorophenylpiperazine; Trazodone
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Indexed keywords
BODY FLUIDS;
CHEMICALS;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
CORRELATION METHODS;
CUSTOMER SATISFACTION;
ELECTRON BEAM LITHOGRAPHY;
FLUIDS;
HEXANE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
INDUSTRIAL ENGINEERING;
LIQUID CHROMATOGRAPHY;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLITES;
PLASMA (HUMAN);
PLASMA STABILITY;
PLASMAS;
PROBLEM SOLVING;
QUALITY ASSURANCE;
QUALITY FUNCTION DEPLOYMENT;
RELIABILITY;
SEPARATION;
SOLVENT EXTRACTION;
SPECTROMETERS;
SPECTROMETRY;
SPECTRUM ANALYSIS;
STANDARDS;
THROUGHPUT;
TOTAL QUALITY MANAGEMENT;
(I ,J) CONDITIONS;
ACCURACY AND PRECISION;
ANALYTES;
APPLIED (CO);
BIOEQUIVALENCE STUDY;
CHROMATOGRAPHIC SEPARATIONS;
CORRELATION COEFFICIENT (CC);
CYANO (CN) COLUMN;
ELSEVIER (CO);
HIGH QUALITY (HQ);
HIGH-THROUGHPUT (HT);
HUMAN PLASMAS;
INTERNAL STANDARD (IS);
ION TRANSITIONS;
ISOCRATIC CONDITIONS;
LC-MS/MS;
LINEAR DYNAMIC RANGE (LDR);
LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS MS);
LIQUID-LIQUID EXTRACTION (LLE);
LOW QUALITY (LQ);
LOWER LIMIT OF QUANTITATION (LLOQ);
MATRIX EFFECTS;
MULTIPLE-REACTION MONITORING (MRM);
N-HEXANE;
PROTONATED;
RUN TIME;
SIMULTANEOUS DETERMINATIONS;
STABILITY STUDIES;
TABLET FORMULATIONS;
TANDEM MASS SPECTROMETRY (MS/MS);
TRAZODONE;
UPPER LIMITS;
QUALITY CONTROL;
(3 CHLOROPHENYL)PIPERAZINE;
HEXANE;
ION;
NEFAZODONE;
TRAZODONE;
ACCURACY;
ARTICLE;
BIOEQUIVALENCE;
CLINICAL TRIAL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
CORRELATION COEFFICIENT;
DIET RESTRICTION;
DILUTION;
DRUG DETERMINATION;
EXTRACTION;
FEEDING;
HUMAN;
INDIAN;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
MALE;
MONITORING;
PLASMA;
PRIORITY JOURNAL;
QUALITY CONTROL;
RANDOMIZED CONTROLLED TRIAL;
SEPARATION TECHNIQUE;
STANDARD;
TABLET FORMULATION;
TANDEM MASS SPECTROMETRY;
TIME;
VALIDATION STUDY;
CHROMATOGRAPHY, LIQUID;
HUMANS;
PIPERAZINES;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
THERAPEUTIC EQUIVALENCY;
TRAZODONE;
CHROMATOGRAPHY;
EXTRACTION;
LIQUIDS;
MAMMALS;
MASS SPECTROSCOPY;
METABOLISM;
PLASMA;
QUALITY CONTROL;
RELIABILITY;
SPECTROMETERS;
STANDARDS;
THROUGHPUT;
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EID: 48049086981
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2008.06.046 Document Type: Article |
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Times cited : (38)
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References (28)
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