Dietary curcumin enhances benzo(a)pyrene-induced apoptosis resulting in a decrease in BPDE-DNA adducts in mice

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 28, Issue 2, 2009, Pages 121-131

  Garg, Rachana ^a   Maru, Girish ^a  

^a TATA MEMORIAL HOSPITAL   (India)

Author keywords

Apoptosis; Benzo(a)pyrene; Curcumin; DNA adducts

Indexed keywords

BENZO[A]PYRENE; CASPASE 3; CURCUMIN; DIHYDROXYBENZO[A]PYRENE OXIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THYMIDINE; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DILUTION; DNA ADDUCT; DNA SYNTHESIS; LIVER; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TURNOVER TIME;

MUS;

EID: 70350116653     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i2.40     Document Type: Article

References (45)

1. Hoffmann D, Schmeltz I, Hecht SS, Wynder EL. Tobacco carcinogenesis. In: Gelboin H, Ts'o POP, editors. Polycyclic hydrocarbons and cancer. New York: Academic Press; 1978: 85-117.
2. Niranjan BG, Wilson NM, Jefcoate CR, Avadhani NG. Hepatic mitochondrial cytochrome P- 450 system. Distinctive features of cytochrome P- 450 involved in the activation of aflatoxin B1 and benzo(a)pyrene. J Biol Chem. 1984;259:12495-12501
3. Patel R, Garg R, Erande S, Maru GB. Chemopreventive herbal anti-oxidants: current status and future perspectives. J Clin Biochem Nutr. 2007;40:82-91.
4. Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7.
5. Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr. 2004;44:97-111.
6. Huang MT, Smart RC, Wong CQ, Conney AH. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1988;48:5941-5946
7. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995;55:259-266
8. Deshpande SS, Ingle AD, Maru GB. Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis. Cancer Lett. 1998;123: 35-40.
9. Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol. 2001;39:541-547
10. Thapliyal R, Naresh KN, Rao KV, Maru GB. Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats. Toxicol Lett. 2003;139:45-54.
11. Farombi EO, Shrotriya S, Na HK, Kim SH, Surh YJ. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol. 2008;46:1279-1287
12. Singletary K, MacDonald C, Wallig M, Fisher C. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)- induced mammary tumorigenesis and DMBADNA adduct formation by curcumin. Cancer Lett. 1996;103:137-141
13. Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP. Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Nutr Cancer. 1998;30: 163-166
14. Thapliyal R, Deshpande SS, Maru GB. Mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived DNA adducts. Cancer Lett. 2002;175:79-88.
15. Huang MT, Wang ZY, Georgiadis CA, Laskin JD, Conney AH. Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylb enz[a]anthracene. Carcinogenesis. 1992;13:2183-2186
16. Lahiri M, Maru GB, Amonkar AJ, Bhide SV. Modulation of B(a)P induced DNA damage by some chemopreventive agents. In: Bhide SV, Maru GB, editors. Chemoprevention of Cancer. New Delhi: Omega Scientific Publishers; 1991. 152-161
17. Garg R, Gupta S, Maru GB. Dietary curcumin modulates transcriptional regulator(s) of phase I and phase II enzymes in benzo(a)pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis. 2008;29:1022-1032
18. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331
19. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363-398
20. Jee SH, Shen SC, Tseng CR, Chiu HC, Kuo ML. Curcumin induces a p53-dependent apoptosis in hu- man basal cell carcinoma cells. J Invest Dermatol. 1998;111:656-661
21. Jiang MC, Yang-Yen HF, Yen JJ, Lin JK. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr Cancer. 1996;26:111-120
22. Kuo ML, Huang TS, Lin JK. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta. 1996;1317:95-100.
23. Deeb D, Xu YX, Jiang H, Gao X, Janakiraman N, Chapman RA, Gautam SC. Curcumin (diferuloyl- methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells. Mol Cancer Ther. 2003;2:95-103.
24. Karunagaran D, Rashmi R, Kumar TR. Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets. 2005;5:117-129
25. Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S, Kuppusamy P. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther. 2007;6:178-184 (Pubitemid 46641620)
26. Sen S, Sharma H, Singh N. Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem Biophys Res Commun. 2005;331:1245-1252
27. Deshpande SS, Ingle AD, Maru GB. Inhibitory effects of curcumin-free aqueous turmeric extract on benzo[a]pyrene-induced forestomach papillomas in mice. Cancer Lett. 1997;118:79-85.
28. Afaq F, Saleem M, Aziz MH, Mukhtar H. Inhibition of 12-O- tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin. Toxicol Appl Pharmacol. 2004;195:361-369
29. Zhang YJ, Weksler BB, Wang L, Schwartz J, Santella RM. Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers. Atherosclerosis. 1998;140:325-331
30. Goldspink DF, Goldberg DL. Problems in the use of [Me-3H]-thymidine for the measurement of DNA synthesis. Biochem Biophys Acta 1973; 299:521-532
31. Burton K. Determination of DNA concentration with diphenylamine. Methods Enzymol. 1968;12(B):163-165
32. Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 2002;512:334-340
33. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995;80:293-299
34. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer. 2003;3:768-780
35. Alexandrov K, Rojas M, Bourgeois Y, Chouroulinkov I. The persistence of benzo[a]pyrene diol-epoxide deoxyguanosine adduct in mouse skin and its disappearance in rat skin. Carcinogenesis. 1983;4:1655-1657
36. Bjelogrlic NM, Makinen M, Stenback F, Vahakangas K. Benzo[a]pyrene-7,8- diol-9,10-epoxide-DNA adducts and increased p53 protein in mouse skin. Carcinogenesis. 1994;15:771-774
37. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995;55:259-266
38. Shankar S, Srivastava RK. Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/ AKT and mitochondrial p53 in curcumin (diferulolylmethane)- induced apoptosis in prostate cancer. Int J Oncol. 2007;30:905-918
39. Shankar S, Srivastava RK. Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis. 2007;28:1277-1286
40. Garg R, Ramchandani A, Maru GB. Curcumin decreases 12-o- tetradecanoylphorbol-13-acetate-induced protein kinase C translocation to modulate downstream targets in mouse skin. Carcinogenesis. 2008;29:1249-1257
41. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37-40.
42. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002;192:1-15.
43. Hu M, Du Q, Vancurova I, Lin X, Miller EJ, Simms HH, Wang P. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogenactivated protein kinase pathway. Crit Care Med. 2005;33:2571-2578
44. Andrysik Z, Machala M, Chramostova K, Hofmanova J, Kozubik A, Vondracek J. Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis. Toxicol Appl Pharmacol. 2006;211:198-208.
45. Mukherjee S, Roy M, Dey S, Bhattacharya RK. A mechanistic approach for modulation of arsenic toxicity in human lymphocytes by curcumin, an active constituent of medicinal herb curcuma longa linn. J Clin Biochem Nutr. 2007;41:32-42.