Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumorigenesis

Cancer Letters

Volumn 123, Issue 1, 1998, Pages 35-40

  Deshpande, Shailesh S ^a   Ingle, Arvind D ^a   Maru, Girish B ^a  

^a CANCER RESEARCH INSTITUTE   (India)

Author keywords

Curcumin free aqueous turmeric extract; DMBA; Ethanolic turmeric extract; Mammary tumors; Turmeric

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ALCOHOL; CURCUMIN; DRINKING WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BREAST CARCINOGENESIS; CANCER INCIDENCE; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CURCUMA LONGA; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CHEMOPREVENTION; CURCUMA; CURCUMIN; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; CURCUMA LONGA;

EID: 0032536140     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00400-X     Document Type: Article

References (22)

1. Ammon H.P.T., Wahl M.A. Pharmacology of Curcuma longa. Planta Med. 57:1991;1-7.
2. Srimal R.C., Dhawan B.N. Pharmacology of diferuloylmethane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. Pharmacol. 25:1973;447-452.
3. Sharma O.P. Antioxidant activity of curcumin and related compounds. Biochem. Pharmacol. 25:1976;1811-1812.
4. Nagabhushan M., Bhide S.V. Antimutagenic and anticarcinogenic action of turmeric (Curcuma longa). J. Nutr. Growth Cancer. 4:1987;82-89.
5. Azuine M.A., Bhide S.V. Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice. Nutr. Cancer. 17:1992;77-83.
6. Deshpande S.S., Ingle A.D., Maru G.B. Inhibitory effects of curcumin-free aqueous turmeric extract on benzo(a)pyrene-induced forestomach papillomas in mice. Cancer Lett. 118:1997;79-85.
7. Huang M.-T., Lou R.Y., Ma W., Newmark H.L., Reuhl K.R., Conney A.H. Inhibitory effects of dietary curcumin on forestomach, duodenal and colon carcinogenesis in mice. Cancer Res. 54:1994;5841-5847.
8. Huang M.-T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoyl phorbol-13-acetate. Cancer Res. 48:1988;5941-5946.
9. Huang M.-T., Wang Z.Y., Georgiadis C.A., Laskin J.D., Conney A.H. Inhibitory effects of curcumin on tumor initiation by benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene. Carcinogenesis. 54:1992;5841-5847.
10. Rao C.V., Rivenson A., Simi B., Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55:1995;259-266.
11. Pereira M.A., Grubbs C.J., Barnes L.H., Li H., Olson G.R., Eto I., Juliana M., Whitaker L.M., Kelloff G.J., Steele V.E., Lubet R.A. Effects of the phytochemicals, curcumin and quercetin upon azoxymethane induced colon cancer and 7,12 dimethylbenz(a)anthracene induced mammary cancer in rats. Carcinogenesis. 17:1996;1305-1311.
12. Bhide S.V., Azuine M.A., Lahiri M., Telang N.T. Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products. Breast Cancer Res. Treat. 30:1994;233-242.
13. Singletary K., MacDonald C., Wallig M., Fischer C. Inhibition of 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary tumorigenesis and DMBA-DNA adduct formation by curcumin. Cancer Lett. 103:1996;137-141.
14. Azuine M.A., Kayal J.J., Bhide S.V. Protective role of aqueous turmeric extract against mutagenicity of direct acting carcinogens as well as benzo(a)pyrene-induced genotoxicity and carcinogenicity. J. Cancer Res. Clin. Oncol. 118:1992;447-452.
15. Huggins C., Loraine C., Grand L.C., Brillantes F.P. Mammary cancer induced by a single feeding of polynuclear hydrocarbons and its suppression. Nature. 189:1961;204-207.
16. Russo I.H., Russo J. Mammary gland neoplasia in long-term rodent studies. Environ. Health Perspect. 104:1996;938-967.
17. Nagabhushan M., Amonkar A.J., Bhide S.V. In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem. Toxicol. 25:1987;545-547.
18. Susan M., Rao M.N. Induction of glutathione S-transferase activity by curcumin in mice. Arzneim. Forsch. 42:1992;962-964.
19. Srinivas L., Shalini V.K., Shailaja M. Turmerin, a water soluble antioxidant and peptide from turmeric (Curcuma longa). Arch. Biochem. Biophys. 292:1992;617-623.
20. Shalini V.K., Srinivas L. Lipid peroxides induced DNA damage: protection by turmeric (Curcuma longa). Mol. Cell. Biochem. 77:1987;3-10.
21. Frenkel K., Wei H., Bhimani R., Ye J., Zadunaisky J.A., Huang M.-T., Ferraro T., Conney A.H., Grunberger D. Inhibition of tumor promoter mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res. 53:1993;1255-1261.
22. Deschner E.E., Ruperto J., Wong G., Newmark H.L. Quercetin and rutin as inhibitor of azoxymethanol induced colonic neoplasia. Carcinogenesis. 12:1991;1193-1196.