Computational and experimental analyses converge to reveal a coherent yet malleable aptamer structure that controls chemical reactivity

Journal of the American Chemical Society

Volumn 131, Issue 41, 2009, Pages 14747-14755

  Tianjiao, Wang ^a,c   Hoy, Julie A ^a   Lamm, Monica H ^b   Nilsen Hamilton, Marit ^a,c  

^a IOWA STATE UNIVERSITY   (United States)

^b Iowa State University of Science and Technology   (United States)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMERS; BINDING INTERFACE; BINDING POCKETS; CHEMICAL GROUP; COMPUTATIONAL PREDICTIONS; CONTROL ACCESS; EXPERIMENTAL ANALYSIS; INDUCED FIT; MALACHITE GREEN; MG OXIDATION; MODEL SYSTEM; MOLECULAR DYNAMICS SIMULATIONS; SEQUENCE VARIATIONS; SMALL MOLECULES; STRUCTURAL FLEXIBILITIES; TARGET MOLECULE;

ACCESS CONTROL; BIOMOLECULES; CARBONATE MINERALS; CHEMICAL MODIFICATION; CHEMICAL REACTIVITY; MOLECULAR DYNAMICS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; OXIDATION; TARGETS;

MOLECULES;

APTAMER; MALACHITE GREEN;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; MOLECULAR DYNAMICS; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BINDING SITES; COMPUTER SIMULATION; HYDROXIDES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; ROSANILINE DYES;

EID: 70350074288     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902719q     Document Type: Article

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