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Volumn 45, Issue 6, 2009, Pages 403-421

Mapping the literature: Role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma

Author keywords

[No Author keywords available]

Indexed keywords

ACLACINOMYCIN; BROSTALLICIN; CARBOPLATIN; CHLOROZOTOCIN; CISPLATIN; CYSTEMUSTINE; DACARBAZINE; DOCETAXEL; DOXORUBICIN; ELLIPTINIUM; ETOPOSIDE; GEMCITABINE; IFOSFAMIDE; IMATINIB; INCYCLINIDE; MILTEFOSINE; MITOMYCIN C; MITOXANTRONE; MITOZOLOMIDE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINYLALANYL DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; NIMUSTINE; RALTITREXED; RUBITECAN; SOBLIDOTIN; TEMOZOLOMIDE; TOPOTECAN; TRABECTEDIN; TROFOSFAMIDE; UNINDEXED DRUG;

EID: 70350068771     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2009.45.6.1378934     Document Type: Review
Times cited : (15)

References (138)
  • 2
    • 45149090773 scopus 로고    scopus 로고
    • Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Casali, P.G., Jost, L., Sleijfer, S., Verweij, J., Blay, J.Y. Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008, (19, Suppl. 2): ii89-93.
    • (2008) Ann Oncol , Issue.19 SUPPL. 2
    • Casali, P.G.1    Jost, L.2    Sleijfer, S.3    Verweij, J.4    Blay, J.Y.5
  • 3
    • 20644443274 scopus 로고    scopus 로고
    • Radical operations for soft tissue sarcomas
    • viii
    • Kane, J.M. 3rd, Kraybill, W.G. Radical operations for soft tissue sarcomas. Surg Oncol Clin N Am 2005, 14(3): 633-48, viii.
    • (2005) Surg Oncol Clin N Am , vol.14 , Issue.3 , pp. 633-648
    • Kane III, J.M.1    Kraybill, W.G.2
  • 4
    • 20444368060 scopus 로고    scopus 로고
    • Surgical management of sarcomas
    • v
    • Cheng, E.Y. Surgical management of sarcomas. Hematol Oncol Clin North Am 2005, 19(3): 451-70, v.
    • (2005) Hematol Oncol Clin North Am , vol.19 , Issue.3 , pp. 451-470
    • Cheng, E.Y.1
  • 5
    • 9744229204 scopus 로고    scopus 로고
    • Radiation therapy in the management of adult soft tissue sarcomas
    • Habrand, J.L., Le Pechoux, C. Radiation therapy in the management of adult soft tissue sarcomas. Ann Oncol 2004, (15, Suppl. 4): iv187-91.
    • (2004) Ann Oncol , Issue.15 SUPPL. 4
    • Habrand, J.L.1    Le Pechoux, C.2
  • 6
    • 0036061260 scopus 로고    scopus 로고
    • The use of chemotherapy in soft-tissue sarcomas
    • Spira, A.I., Ettinger, D.S. The use of chemotherapy in soft-tissue sarcomas. Oncologist 2002, 7(4): 348-359
    • (2002) Oncologist , vol.7 , Issue.4 , pp. 348-359
    • Spira, A.I.1    Ettinger, D.S.2
  • 7
    • 0032956788 scopus 로고    scopus 로고
    • The role of chemotherapy in the treatment of adult soft tissue sarcomas
    • DOI 10.1159/000011924
    • O'Byrne, K., Steward, W.P. The role of chemotherapy in the treatment of adult soft tissue sarcomas. Oncology 1999, 56(1): 13-23. (Pubitemid 29043891)
    • (1999) Oncology , vol.56 , Issue.1 , pp. 13-23
    • O'Byrne, K.1    Steward, W.P.2
  • 8
    • 84921702657 scopus 로고    scopus 로고
    • Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma
    • CD003293
    • Bramwell, V.H., Anderson, D., Charette, M.L. Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma. Cochrane Database Syst Rev 2003, (3): CD003293.
    • (2003) Cochrane Database Syst Rev , Issue.3
    • Bramwell, V.H.1    Anderson, D.2    Charette, M.L.3
  • 9
    • 0033638388 scopus 로고    scopus 로고
    • Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft-tissue sarcoma: A meta-analysis and clinical practice guideline
    • Bramwell, V.H., Anderson, D., Charette, M. Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft-tissue sarcoma: A meta-analysis and clinical practice guideline. Sarcoma 2000, 4(3): 103-112
    • (2000) Sarcoma , vol.4 , Issue.3 , pp. 103-112
    • Bramwell, V.H.1    Anderson, D.2    Charette, M.3
  • 10
    • 0028856442 scopus 로고
    • The present state of the an in chemotherapy for soft tissue sarcomas in adults: The EORTC point of view
    • Verweij, J., Mouridsen, H.T., Nielssen, O.S. et al. The present state of the an in chemotherapy for soft tissue sarcomas in adults: The EORTC point of view. Crit Rev Oncol Hematol 1995, 20(3): 193-201.
    • (1995) Crit Rev Oncol Hematol , vol.20 , Issue.3 , pp. 193-201
    • Verweij, J.1    Mouridsen, H.T.2    Nielssen, O.S.3
  • 11
    • 23444454023 scopus 로고    scopus 로고
    • New drug developments for patients with metastatic soft tissue sarcoma
    • Hartmann, J.T., Patel, S. New drug developments for patients with metastatic soft tissue sarcoma. Curr Oncol Rep 2005, 7(4): 300-306 (Pubitemid 41149676)
    • (2005) Current Oncology Reports , vol.7 , Issue.4 , pp. 300-306
    • Hartmann, J.T.1    Patel, S.2
  • 12
    • 47749085982 scopus 로고    scopus 로고
    • Other endpoints in screening studies for soft tissue sarcomas
    • Verweij, J. Other endpoints in screening studies for soft tissue sarcomas. Oncologist 2008, 13(Suppl. 2): 27-31.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 2 , pp. 27-31
    • Verweij, J.1
  • 13
    • 47749119646 scopus 로고    scopus 로고
    • Selection of response criteria for clinical trials of sarcoma treatment
    • Schuetze, S.M., Baker, L.H., Benjamin, R.S., Canetta, R. Selection of response criteria for clinical trials of sarcoma treatment. Oncologist 2008, 13(Suppl. 2): 32-40.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 2 , pp. 32-40
    • Schuetze, S.M.1    Baker, L.H.2    Benjamin, R.S.3    Canetta, R.4
  • 14
    • 0036189675 scopus 로고    scopus 로고
    • Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
    • DOI 10.1016/S0959-8049(01)00398-7, PII S0959804901003987
    • Van Glabbeke, M., Verweij, J., Judson, I., Nielsen, O.S. Progression-free rote as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer 2002, 38(4): 543-9. (Pubitemid 34185394)
    • (2002) European Journal of Cancer , vol.38 , Issue.4 , pp. 543-549
    • Van Glabbeke, M.1    Verweij, J.2    Judson, I.3    Nielsen, O.S.4
  • 15
    • 0032806237 scopus 로고    scopus 로고
    • Progressive disease rate as a surrogate endpoint of phase II trials for non-small-cell lung cancer
    • DOI 10.1023/A:1008303921033
    • Sekine, I., Tamura, T., Kunitoh, H., Kubota, K., Shinkai, T., Kamiya, Y., Saijo, N. Progressive disease rate as a surrogate endpoint of phase II trials for non-small-cell lung cancer. Ann Oncol 1999, 10(6): 731-733 (Pubitemid 29342381)
    • (1999) Annals of Oncology , vol.10 , Issue.6 , pp. 731-733
    • Sekine, I.1    Tamura, T.2    Kunitoh, H.3    Kubota, K.4    Shinkai, T.5    Kamiya, Y.6    Saijo, N.7
  • 16
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata
    • DOI 10.1021/bi960306b
    • Pommier, Y., Kohlhagen, G., Bailly, C., Waring, M., Mazumder, A., Kohn, K.W. DNA sequence- and structure-selective alkylotion ofguanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 1996, 35(41): 13303-13309 (Pubitemid 26349423)
    • (1996) Biochemistry , vol.35 , Issue.41 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 19
    • 0035542848 scopus 로고    scopus 로고
    • Antitumor activity- and gene expression-based profiling of ecteinascidin et 743 and phthalascidin Pt 650
    • DOI 10.1016/S1074-5521(01)00082-5, PII S1074552101000825
    • Martinez, E.J., Corey, E.J., Owa, T. Antitumor activity- and gene expression-based profiling of ecteinascidin ET 743 and phthalascidin Pt 650. Chem Biol 2001, 8(12): 1151-1160 (Pubitemid 34029884)
    • (2001) Chemistry and Biology , vol.8 , Issue.12 , pp. 1151-1160
    • Martinez, E.J.1    Corey, E.J.2    Owa, T.3
  • 20
    • 35048860778 scopus 로고    scopus 로고
    • Trabectedin: A review of its use in the management of soft tissue sarcoma and ovarian cancer
    • Carter, N.J., Keam, S.J. Trabectedin: A review of its use in the management of soft tissue sarcoma and ovarian cancer. Drugs 2007, 67(15): 2257-2276
    • (2007) Drugs , vol.67 , Issue.15 , pp. 2257-2276
    • Carter, N.J.1    Keam, S.J.2
  • 23
    • 0036732039 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells
    • Furuta, T., Ueda, T., Aune, G., Sarasin, A., Kraemer, K.H., Pommier, Y. Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res 2002, 62(17): 4899-4902 (Pubitemid 34984411)
    • (2002) Cancer Research , vol.62 , Issue.17 , pp. 4899-4902
    • Furuta, T.1    Ueda, T.2    Aune, G.3    Sarasin, A.4    Kraemer, K.H.5    Pommier, Y.6
  • 24
    • 49849096707 scopus 로고    scopus 로고
    • Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin
    • Casado, J.A., Rio, P., Marco, E. et al. Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin. Mol Cancer Ther 2008, 7(5): 1309-1318
    • (2008) Mol Cancer Ther , vol.7 , Issue.5 , pp. 1309-1318
    • Casado, J.A.1    Rio, P.2    Marco, E.3
  • 26
    • 0142121506 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of Yondelis (ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
    • Twelves, C., Hoekman, K., Bowman, A. et al. Phase I and pharmacokinetic study of Yondelis (ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer 2003, 39(13): 1842-1851.
    • (2003) Eur J Cancer , vol.39 , Issue.13 , pp. 1842-1851
    • Twelves, C.1    Hoekman, K.2    Bowman, A.3
  • 29
    • 0035127175 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
    • Ryan, D.P., Supko, J.G., Eder, J.P. et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res 2001, 7(2): 231-242
    • (2001) Clin Cancer Res , vol.7 , Issue.2 , pp. 231-242
    • Ryan, D.P.1    Supko, J.G.2    Eder, J.P.3
  • 35
    • 33646401788 scopus 로고    scopus 로고
    • RECIST revisited: A review of validation studies on tumour assessment
    • Therasse, P., Eisenhauer, E.A., Verweij, J. RECIST revisited: A review of validation studies on tumour assessment. Eur J Cancer 2006, 42(8): 1031-1039
    • (2006) Eur J Cancer , vol.42 , Issue.8 , pp. 1031-1039
    • Therasse, P.1    Eisenhauer, E.A.2    Verweij, J.3
  • 36
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse, P., Arbuck, S.G., Eisenhauer, E.A. et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000, 92(3): 205-216
    • (2000) J Natl Cancer Inst , vol.92 , Issue.3 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 37
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • DOI 10.1016/0197-2456(89)90015-9
    • Simon, R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989, 10(1): 1-10. (Pubitemid 19099520)
    • (1989) Controlled Clinical Trials , vol.10 , Issue.1 , pp. 1-10
    • Simon, R.1
  • 38
    • 0023142209 scopus 로고
    • Cyclophosphamide versus ifosfamide: Final report of a randomized phase II trial in adult soft tissue sarcomas
    • DOI 10.1016/0277-5379(87)90075-7
    • Bramwell, V.H., Mouridsen, H.T., Santoro, A. et al. Cyclophosphamide versus ifosfamide: final report of a randomized phase II trial in adult soft tissue sarcomas. Eur J Cancer Clin Oncol 1987, 23(3): 311-321 (Pubitemid 17033680)
    • (1987) European Journal of Cancer and Clinical Oncology , vol.23 , Issue.3 , pp. 311-321
    • Bramwell, V.H.C.1    Mouridsen, H.T.2    Santoro, A.3
  • 40
    • 0034109686 scopus 로고    scopus 로고
    • Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: A phase II study of the Italian Sarcoma Group (ISG)
    • Toma, S., Tucci, A., Villani, G., Carteni, G., Spadini, N., Palumbo, R. Liposomal doxorubicin (Caelyx) in advanced pretreated soft tissue sarcomas: a phase II study of the Italian Sarcoma Group (ISG). Anticancer Res 2000, 20(1B): 485-491
    • (2000) Anticancer Res , vol.20 , Issue.1 B , pp. 485-491
    • Toma, S.1    Tucci, A.2    Villani, G.3    Carteni, G.4    Spadini, N.5    Palumbo, R.6
  • 43
    • 0037507379 scopus 로고    scopus 로고
    • Results of a 2-arm phase II study of 9-nitrocamptothecin in patients with advanced soft-tissue sarcomas
    • DOI 10.1002/cncr.11385
    • Patel, S.R., Beach, J., Papadopoulos, N., Burgess, M.A., Trent, J., Jenkins, J., Benjamin, R.S. Results of a 2-arm phase II study of 9-nitrocamptothecin in patients with advanced soft-tissue sarcomas. Cancer 2003, 97(11): 2848-2852 (Pubitemid 36605154)
    • (2003) Cancer , vol.97 , Issue.11 , pp. 2848-2852
    • Patel, S.R.1    Beach, J.2    Papadopoulos, N.3    Burgess, M.A.4    Trent, J.5    Jenkins, J.6    Benjamin, R.S.7
  • 44
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
    • Verweij, J., van Oosterom, A., Blay, J.Y. et al. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 2003, 39(14): 2006-2011
    • (2003) Eur J Cancer , vol.39 , Issue.14 , pp. 2006-2011
    • Verweij, J.1    Van Oosterom, A.2    Blay, J.Y.3
  • 46
    • 26444442333 scopus 로고    scopus 로고
    • A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma
    • Garcia Del Muro, X., Lopez-Pousa, A., Martin, J. et al. A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma. Cancer 2005, 104(8): 1706-1712
    • (2005) Cancer , vol.104 , Issue.8 , pp. 1706-1712
    • Garcia Del Muro, X.1    Lopez-Pousa, A.2    Martin, J.3
  • 47
    • 33646567780 scopus 로고    scopus 로고
    • An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma
    • DOI 10.1007/s10637-005-3537-1
    • Hartmann, J.T., Oechsle, K., Huober, J. et al. An open label, non-comparative phase II study of gemcitabine as salvage treatment for patients with pretreated adult type soft tissue sarcoma. Invest New Drugs 2006, 24(3): 249-253 (Pubitemid 43723900)
    • (2006) Investigational New Drugs , vol.24 , Issue.3 , pp. 249-253
    • Hartmann, J.T.1    Oechsle, K.2    Huober, J.3    Jakob, A.4    Azemar, M.5    Horger, M.6    Kanz, L.7    Bokemeyer, C.8
  • 48
    • 0019505696 scopus 로고
    • Doxorubicin cardiotoxicity: Assessment of late left ventricular dysfunction by radionuclide cineangiography
    • Gottdiener, J.S., Mathisen, D.J., Borer, J.S. et al. Doxorubicin cardiotoxlcity: Assessment of late left ventricular dysfunction by radionuclide cineangiography. Ann Intern Med 1981, 94(4, Pt. 1): 430-435 (Pubitemid 11103937)
    • (1981) Annals of Internal Medicine , vol.94 , Issue.4 I , pp. 430-435
    • Gottdiener, J.S.1    Mathisen, D.J.2    Borer, J.S.3
  • 49
    • 31444443149 scopus 로고    scopus 로고
    • Phase II clinical trial with pegylated liposomal doxorubicin (CAELYX®/Doxil®) and quality of life evaluation (EORTC QLQ-C30) in adult patients with advanced soft tissue sarcomas: A study of the Spanish Group for Research in Sarcomas (GEIS)
    • Poveda, A., Lopez-Pousa, A., Martin, J. et al. Phase II clinical trial with pegylated liposomal doxorubicin (CAELYX®/Doxil®) and quality of life evaluation (EORTC QLQ-C30) in adult patients with advanced soft tissue sarcomas: A study of the Spanish Group for Research in Sarcomas (GEIS). Sarcoma 2005, 9(3-4): 127-132
    • (2005) Sarcoma , vol.9 , Issue.3-4 , pp. 127-132
    • Poveda, A.1    Lopez-Pousa, A.2    Martin, J.3
  • 50
    • 0032466901 scopus 로고    scopus 로고
    • 2 until grade III granulocytopenia as second-line chemotherapy for anthracycline-pretreated advanced soft tissue sarcoma
    • 2 until grade III granulocytopenia as second-line chemotherapy for anthracycline-pretreated advanced soft tissue sarcoma. Tumori 1998, 84: 677-680 (Pubitemid 29086526)
    • (1998) Tumori , vol.84 , Issue.6 , pp. 677-680
    • Babovic, N.1    Jelic, S.2    Milanovic, N.3    Matkovic, S.4
  • 51
    • 0030726408 scopus 로고    scopus 로고
    • Phase II study of continuous-infusion high-dose ifosfamide in advanced and/or metastatic pretreated soft tissue sarcomas
    • DOI 10.1023/A:1008279426654
    • Palumbo, R., Palmeri, S., Antimi, M., Gatti, C., Raffo, P., Villani, G., Toma, S. Phase II study of continuous-infusion high-dose ifosfamide in advanced and/or metastatic pretreated soft tissue sarcomas. Ann Oncol 1997, 8(11): 1159-1162 (Pubitemid 27521226)
    • (1997) Annals of Oncology , vol.8 , Issue.11 , pp. 1159-1162
    • Palumbo, R.1    Palmeri, S.2    Antimi, M.3    Gatti, C.4    Raffo, P.5    Villani, G.6    Toma, S.7
  • 52
    • 0036892122 scopus 로고    scopus 로고
    • Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients
    • van Oosterom, A.T., Mouridsen, H.T., Nielsen, O.S. et al. Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients. Eur J Cancer 2002, 38(18): 2397-2406
    • (2002) Eur J Cancer , vol.38 , Issue.18 , pp. 2397-2406
    • Van Oosterom, A.T.1    Mouridsen, H.T.2    Nielsen, O.S.3
  • 53
    • 0029001008 scopus 로고
    • High-dose ifosfamide: Circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas
    • Le Cesne, A., Antoine, E., Spielmann, M. et al. High-dose ifosfamide: Circumvention of resistance to standard-dose ifosfamide in advanced soft tissue sarcomas. J Clin Oncol 1995, 13(7): 1600-1608
    • (1995) J Clin Oncol , vol.13 , Issue.7 , pp. 1600-1608
    • Le Cesne, A.1    Antoine, E.2    Spielmann, M.3
  • 54
    • 0024513428 scopus 로고
    • Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma
    • Antman, K.H., Ryan, L., Elias, A., Sherman, D., Grier, H.E. Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. J Clin Oncol 1989, 7(1): 126-131 (Pubitemid 19089091)
    • (1989) Journal of Clinical Oncology , vol.7 , Issue.1 , pp. 126-131
    • Antman, K.H.1    Ryan, L.2    Elias, A.3    Sherman, D.4    Grier, H.E.5
  • 55
    • 0025896516 scopus 로고
    • High-dose DTIC in advanced soft-tissue sarcomas in the adult. A phase II study of the E.O.R.T.C. Soft Tissue and Bone Sarcoma Group
    • Buesa, J.M., Mouridsen, H.T., van Oosterom, A.T. et al. High-dose DTIC in advanced soft-tissue sarcomas in the adult. A phase II study of the E.O.R.T.C. Soft Tissue and Bone Sarcoma Group. Ann Oncol 1991, 2(4): 307-309
    • (1991) Ann Oncol , vol.2 , Issue.4 , pp. 307-309
    • Buesa, J.M.1    Mouridsen, H.T.2    Van Oosterom, A.T.3
  • 56
    • 0032764436 scopus 로고    scopus 로고
    • Phase II study of oral trofosfamide as palliative therapy in pretreated patients with metastatic soft-tissue sarcoma
    • Kollmannsberger, C., Brugger, W., Hartmann, J.T., Maurer, F., Bohm, P., Kanz, L., Bokemeyer, C. Phase II study of oral trofosfamide as palliative therapy in pretreated patients with metastatic soft-tissue sarcoma. Anticancer Drugs 1999, 10(5): 453-456 (Pubitemid 30011978)
    • (1999) Anti-Cancer Drugs , vol.10 , Issue.4 , pp. 453-456
    • Kollmannsberger, C.1    Brugger, W.2    Hartmann, J.T.3    Maurer, F.4    Bohm, P.5    Kanz, L.6    Bokemeyer, C.7
  • 59
    • 44449159324 scopus 로고    scopus 로고
    • Gemcitabine/docetaxel - Welcome to a new standard
    • Fleming, G. Gemcitabine/docetaxel - welcome to a new standard. Gynecol Oncol 2008, 109(3): 313-315
    • (2008) Gynecol Oncol , vol.109 , Issue.3 , pp. 313-315
    • Fleming, G.1
  • 60
    • 39149123128 scopus 로고    scopus 로고
    • Trial methodology in soft tissue sarcomas; the 'one plus one is three or zero' phenomenon
    • Sleijfer, S., Verweij, J. Trial methodology in soft tissue sarcomas; The 'one plus one is three or zero' phenomenon. Ontologie 2008, 31(1-2): 6-8.
    • (2008) Ontologie , vol.31 , Issue.1-2 , pp. 6-8
    • Sleijfer, S.1    Verweij, J.2
  • 61
    • 0032922280 scopus 로고    scopus 로고
    • Gemcitabine in advanced stage soft tissue sarcoma: A phase II study
    • Amodio, A., Carpano, S., Manfredi, C. et al. Gemcitabine in advanced stage soft tissue sarcoma: A phase II study. Clin Ter 1999, 150: 17-20.
    • (1999) Clin Ter , vol.150 , pp. 17-20
    • Amodio, A.1    Carpano, S.2    Manfredi, C.3
  • 65
    • 53149109402 scopus 로고    scopus 로고
    • Gemcitabine at fixed dose-rate in patients with advanced soft-tissue sarcomas: A mono-institutional phase II study
    • Ferraresi, V., Ciccarese, M., Cercato, M.C. et al. Gemcitabine at fixed dose-rate in patients with advanced soft-tissue sarcomas: A mono-institutional phase II study. Cancer Chemother Pharmacol 2008, 63(1): 149-155
    • (2008) Cancer Chemother Pharmacol , vol.63 , Issue.1 , pp. 149-155
    • Ferraresi, V.1    Ciccarese, M.2    Cercato, M.C.3
  • 66
    • 18144448739 scopus 로고    scopus 로고
    • Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: A study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Verweij, J., Lee, S.M., Ruka, W. et al. Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: A study of the european organization for research and treatment of cancer soft tissue and bone sarcoma group. J Clin Oncol 2000, 18(10): 2081-2086 (Pubitemid 30324361)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.10 , pp. 2081-2086
    • Verweij, J.1    Lee, S.M.2    Ruka, W.3    Buesa, J.4    Coleman, R.5    Van Hoessel, R.6    Seynaeve, C.7    Di Paola, E.D.8    Van Glabbeke, M.9    Tonelli, D.10    Judson, I.R.11
  • 67
    • 0031869595 scopus 로고    scopus 로고
    • Phase II study of docetaxel in patients with advanced stage soft tissue sarcoma
    • Amodio, A., Carpano, S., Paoletti, G. et al. Phase II study of docetaxel in patients with advanced stage soft tissue sarcoma. Clin Ter 1998, 149(2): 121-125
    • (1998) Clin Ter , vol.149 , Issue.2 , pp. 121-125
    • Amodio, A.1    Carpano, S.2    Paoletti, G.3
  • 70
    • 34447572873 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: Results of sarcoma alliance for research through collaboration study 002
    • Maki, R.G., Wathen, J.K., Patel, S.R. et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002. J Clin Oncol 2007, 25(19): 2755-2763
    • (2007) J Clin Oncol , vol.25 , Issue.19 , pp. 2755-2763
    • Maki, R.G.1    Wathen, J.K.2    Patel, S.R.3
  • 71
    • 44449135941 scopus 로고    scopus 로고
    • Fixed-dose rate gemcitabine plus docetaxel as second-line therapy for metastatic uterine leiomyosarcoma: A Gynecologic Oncology Group phase II study
    • Hensley, M.L., Blessing, J.A., Degeest, K., Abulafia, O., Rose, P.G., Homesley, H.D. Fixed-dose rate gemcitabine plus docetaxel as second-line therapy for metastatic uterine leiomyosarcoma: A Gynecologic Oncology Group phase II study. Gynecol Oncol 2008, 109(3): 323-328
    • (2008) Gynecol Oncol , vol.109 , Issue.3 , pp. 323-328
    • Hensley, M.L.1    Blessing, J.A.2    Degeest, K.3    Abulafia, O.4    Rose, P.G.5    Homesley, H.D.6
  • 74
    • 56149098557 scopus 로고    scopus 로고
    • A FNCLCC French Sarcoma Group - GETO multicenter randomized phase II study of gemcitabine (G) versus gemcitabine and docetaxel (G+D) in patients with metastatic or relapsed leiomyosarcoma (LMS). TAXOGEM study
    • Abstract 10511
    • Duffaud, F., Bui, B., Penel, N. et al. A FNCLCC French Sarcoma Group - GETO multicenter randomized phase II study of gemcitabine (G) versus gemcitabine and docetaxel (G+D) in patients with metastatic or relapsed leiomyosarcoma (LMS). TAXOGEM study. J Clin Oncol 2008, 26: Abstract 10511.
    • (2008) J Clin Oncol , vol.26
    • Duffaud, F.1    Bui, B.2    Penel, N.3
  • 76
    • 0009424924 scopus 로고    scopus 로고
    • Consistent evidence of activity of Ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (STS): Results from a pooled analysis of three pivotal phase II clinical trials (P2CT) and safety profile of a 24h. infusion schedule
    • Abstract 114
    • Le Cesne, A., Misset, J.L., Demetri, G. et al. Consistent evidence of activity of Ecteinascidin (ET-743) in pretreated, advanced soft tissue sarcoma (STS): Results from a pooled analysis of three pivotal phase II clinical trials (P2CT) and safety profile of a 24h. infusion schedule. Eur J Cancer 2001, Suppl 6: Abstract 114.
    • (2001) Eur J Cancer , Issue.SUPPL. 6
    • Le Cesne, A.1    Misset, J.L.2    Demetri, G.3
  • 77
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
    • in press
    • Demetri, G.D., Chawla, S.P., von Mehren, M. et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules. J Clin Oncol 2009, (in press).
    • (2009) J Clin Oncol
    • Demetri, G.D.1    Chawla, S.P.2    Von Mehren, M.3
  • 79
    • 0032952928 scopus 로고    scopus 로고
    • Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: An analysis of 2,185 patients treated with anthracycline- Containing first-line regimens - a European organization for research and treatment of cancer soft tissue and bone sarcoma group study
    • Van Glabbeke, M., van Oosterom, A.T., Oosterhuis, J.W. et al. Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: An analysis of 2,185 patients treated with anthracycline-containing first-line regimens-a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group study. J Clin Oncol 1999, 17(1): 150-157 (Pubitemid 29022388)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.1 , pp. 150-157
    • Van Glabbeke, M.1    Van Oosterom, A.T.2    Oosterhuis, J.W.3    Mouridsen, H.4    Crowther, D.5    Somers, R.6    Verweij, J.7    Santoro, A.8    Buesa, J.9    Tursz, T.10
  • 84
    • 84857539120 scopus 로고    scopus 로고
    • Correlation between the pattern of DNA repair efficiency and the natural history of patients with advanced sarcoma treated with ET-743 (Yondelis)
    • Abst 7450
    • van Oosterom, A., Maki, R., Taron, M.A. et al. Correlation between the pattern of DNA repair efficiency and the natural history of patients with advanced sarcoma treated with ET-743 (Yondelis). 29th ESMO Congress Proc 2004, Abst 7450.
    • 29th ESMO Congress Proc 2004
    • Van Oosterom, A.1    Maki, R.2    Taron, M.A.3
  • 85
    • 84878699033 scopus 로고    scopus 로고
    • DNA repair functionality as a molecular signature for sensitivity(S)/resistance (R) in sarcoma patients (pts) treated with trabectedin (ET-743, YondelisR)
    • Oct
    • Schoffski, P., Grosso, F., Taron, M. et al. DNA repair functionality as a molecular signature for sensitivity(S)/resistance (R) in sarcoma patients (pts) treated with trabectedin (ET-743, YondelisR). AACR Meeting Abstracts, Oct 2007: C127.
    • (2007) AACR Meeting Abstracts
    • Schoffski, P.1    Grosso, F.2    Taron, M.3
  • 86
    • 30844456008 scopus 로고    scopus 로고
    • Adding pharmacogenomics to the development of new marine-derived anticancer agents
    • DOI 10.1186/1479-5876-4-3
    • Jimeno, J., Aracil, M., Tercero, J.C. Adding pharmacogenomics to the development of new marine-derived anticancer agents. J Transl Med 2006, 4: 3. (Pubitemid 43103498)
    • (2006) Journal of Translational Medicine , vol.4 , pp. 3
    • Jimeno, J.1    Aracil, M.2    Tercero, J.C.3
  • 87
    • 84989282412 scopus 로고    scopus 로고
    • Personalized therapy with trabectedin (YondelisR) in advanced pre-treated sarcomas
    • ECCO 14. The European Cancer Conference (Barcelona, 23-27 Sept.), Abst 7505
    • Jimeno, J., Schoffski, P., Casali, P. et al. Personalized therapy with trabectedin (YondelisR) in advanced pre-treated sarcomas. Eur J Cancer 2007;5(4): ECCO 14. The European Cancer Conference (Barcelona, 23-27 Sept.), Abst 7505.
    • (2007) Eur J Cancer , vol.5 , Issue.4
    • Jimeno, J.1    Schoffski, P.2    Casali, P.3
  • 88
    • 70350077206 scopus 로고    scopus 로고
    • Expression of XPG mRNA and protein as potential biomarker of response to trabectedin in sarcoma patients
    • Oct Abstract C127
    • Rosell, R., Martinez, N., Rodriguez, S. et al. Expression of XPG mRNA and protein as potential biomarker of response to trabectedin in sarcoma patients. AACR Meeting Abstracts, Oct 2007: 297 (Abstract C127).
    • (2007) AACR Meeting Abstracts , pp. 297
    • Rosell, R.1    Martinez, N.2    Rodriguez, S.3
  • 89
    • 0034125650 scopus 로고    scopus 로고
    • Recurrent chromosome aberrations in cancer
    • DOI 10.1016/S1383-5742(00)00006-5, PII S1383574200000065
    • Mitelman, F. Recurrent chromosome aberrations in cancer. Mutat Res 2000, 462/2-3): 247-253 (Pubitemid 30190232)
    • (2000) Mutation Research - Reviews in Mutation Research , vol.462 , Issue.2-3 , pp. 247-253
    • Mitelman, F.1
  • 90
    • 33645083214 scopus 로고    scopus 로고
    • The role of genetic testing in soft tissue sarcoma
    • Antonescu, C.R. The role of genetic testing in soft tissue sarcoma. Histopathology 2006, 48: 13-21.
    • (2006) Histopathology , vol.48 , pp. 13-21
    • Antonescu, C.R.1
  • 91
    • 10744227336 scopus 로고    scopus 로고
    • Soft tissue sarcomas of adults: State of the translational science
    • Borden, E.C., Baker, L.H., Bell, R.S. et al. Soft tissue sarcomas of adults: State of the translational science. Clin Cancer Res 2003, 9(6): 1941-1956
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 1941-1956
    • Borden, E.C.1    Baker, L.H.2    Bell, R.S.3
  • 92
    • 50349083290 scopus 로고    scopus 로고
    • Sensitivity of myxoidround cell liposarcoma (MRCL) to trabectedin (T) may be related to a direct effect on the fusion transcript
    • 2007 ASCO Annual Meeting Proceedings Part I, 0000
    • Grosso, F., Forni, C., Frapolli, R. et al. Sensitivity of myxoidround cell liposarcoma (MRCL) to trabectedin (T) may be related to a direct effect on the fusion transcript. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I 2007, 25:0000.
    • (2007) Journal of Clinical Oncology , vol.25
    • Grosso, F.1    Forni, C.2    Frapolli, R.3
  • 95
    • 38749093970 scopus 로고    scopus 로고
    • Trabectedin (T) in metastatic Ewing's family tumors (EFT) patients (pts) progressing after standard chemotherapy
    • 2007 ASCO Annual Meeting Proceedings Part I
    • Dileo, P., Grosso, F., Casanova, M. et al. Trabectedin (T) in metastatic Ewing's family tumors (EFT) patients (pts) progressing after standard chemotherapy. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 2007, 25: 10040.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 10040
    • Dileo, P.1    Grosso, F.2    Casanova, M.3
  • 98
    • 0021836465 scopus 로고
    • Phase II trial of ifosfamide with mesna in previously treated metastatic sarcoma
    • Antman, K.H., Montella, D., Rosenbaum, C., Schwen, M. Phase II trial of ifosfamide with mesna in previously treated metastatic sarcoma. Cancer Treat Rep 1985, 69(5): 499-504. (Pubitemid 15031398)
    • (1985) Cancer Treatment Reports , vol.69 , Issue.5 , pp. 499-504
    • Antman, K.H.1    Montella, D.2    Rosenbaum, C.3    Schwen, M.4
  • 99
    • 0030912403 scopus 로고    scopus 로고
    • High-dose ifosfamide in bone and soft tissue sarcomas: Results of phase II and pilot studies - Dose-response and schedule dependence
    • Patel, S.R., Vadhan-Raj, S., Papadopolous, N., Plager, C., Burgess, M.A., Hays, C., Benjamin, R.S. High-dose ifosfamide in bone and soft tissue sarcomas: Results of phase II and pilot studies - dose-response and schedule dependence. J Clin Oncol 1997, 15(6): 2378-2384 (Pubitemid 27251141)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.6 , pp. 2378-2384
    • Patel, S.R.1    Vadhan-Raj, S.2    Papadopolous, N.3    Plager, C.4    Burgess, M.A.5    Hays, C.6    Benjamin, R.S.7
  • 100
    • 0025346915 scopus 로고
    • Doxorubicin in relapsed soft tissue sarcoma: Justification of Phase II evaluation of new drugs in this disease. An EORTC soft tissue and bone sarcoma group study
    • DOI 10.1016/0277-5379(90)90296-6
    • Blackledge, G., van Oosterom, A., Mouridsen, H. et al. Doxorubicin in relapsed soft tissue sarcoma: Justification of phase II evaluation of new drugs in this disease. An EORTC Soft Tissue and Bone Sarcoma Group Study. Eur J Cancer 1990, 26(2): 139-141 (Pubitemid 20121865)
    • (1990) European Journal of Cancer , vol.26 , Issue.2 , pp. 139-141
    • Blackledge, G.1    Van Oosterom, A.2    Mouridsen, H.3    Steward, W.P.4    Buesa, J.5    Thomas, D.6    Sylvester, R.7    Rouesse, J.8
  • 101
    • 57149111052 scopus 로고    scopus 로고
    • Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
    • Baker, L.H., Rowinsky, E.K., Mendelson, D. et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol 2008, 26(34): 5583-5588
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5583-5588
    • Baker, L.H.1    Rowinsky, E.K.2    Mendelson, D.3
  • 104
    • 0019411312 scopus 로고
    • Treatment of advanced soft tissue sarcomas with chlorozotocin: A phase II trial of the EORTC soft tissue and bone sarcoma group
    • Mouridsen, H.T., Bramwell, V.H., Lacave, J. et al. Treatment of advanced soft tissue sarcoma with chlorozotocin: A phase II trial of the EORTC Soft Tissue and Bone Sarcoma Group. Cancer Treat Rep 1981, 65(5-6): 509-511 (Pubitemid 11075017)
    • (1981) Cancer Treatment Reports , vol.65 , Issue.5-6 , pp. 509-511
    • Mouridsen, H.T.1    Bramwell, V.H.C.2    Lacave, J.3
  • 106
    • 0018604069 scopus 로고
    • Cis-dichlorodiammineplatinum(II) in advanced soft tissue and bony sarcomas: A Southwest Oncology Group Study
    • Samson, M.K., Baker, L.H., Benjamin, R.S., Lane, M., Plager, C. Cis-dichlorodiammineplatinum(II) in advanced soft tissue and bony sarcomas: A Southwest Oncology Group Study. Cancer Treat Rep 1979, 63(11-12): 2027-2029
    • (1979) Cancer Treat Rep , vol.63 , Issue.11-12 , pp. 2027-2029
    • Samson, M.K.1    Baker, L.H.2    Benjamin, R.S.3    Lane, M.4    Plager, C.5
  • 107
    • 0022653281 scopus 로고
    • Cisplatin as second-line chemotherapy in the treatment of advanced or recurrent leiomyosarcoma of the uterus. A phase II trial of the Gynecologic Oncology Group
    • Thigpen, J.T., Blessing, J.A., Wilbanks, G.D. Cisplatin as second-line chemotherapy in the treatment of advanced or recurrent leiomyosarcoma of the uterus. A phase II trial of the Gynecologic Oncology Group. Am J Clin Oncol 1986, 9(1): 18-20.
    • (1986) Am J Clin Oncol , vol.9 , Issue.1 , pp. 18-20
    • Thigpen, J.T.1    Blessing, J.A.2    Wilbanks, G.D.3
  • 108
    • 34250630512 scopus 로고    scopus 로고
    • A phase II and pharmacological study of the matrix metalloproteinase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas
    • DOI 10.1007/s10637-006-9031-6
    • Chu, O.S., Forouzesh, B., Syed, S. et al. A phase II and pharmacological study of the matrix metalloprotelnase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas. Invest New Drugs 2007, 25(4): 359-367 (Pubitemid 46944843)
    • (2007) Investigational New Drugs , vol.25 , Issue.4 , pp. 359-367
    • Chu, Q.S.C.1    Forouzesh, B.2    Syed, S.3    Mita, M.4    Schwartz, G.5    Copper, J.6    Curtright, J.7    Rowinsky, E.K.8
  • 111
    • 0023121031 scopus 로고
    • VP-16 in advanced soft tissue sarcoma: A phase II study of the EORTC soft tissue and bone sarcoma group
    • DOI 10.1016/0277-5379(87)90324-5
    • Dombernowsky, P., Buesa, J., Pinedo, H.M. et al. VP-16 in advanced soft tissue sarcoma: A phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer Clin Oncol 1987, 23(5): 579-580 (Pubitemid 17057392)
    • (1987) European Journal of Cancer and Clinical Oncology , vol.23 , Issue.5 , pp. 579-580
    • Dombernowsky, P.1    Buesa, J.2    Pinedo, H.M.3
  • 112
    • 0026486233 scopus 로고
    • Oral etoposide in treatment of advanced refractory sarcomas
    • Kampe, C.E., Lowenbraun, S., Foster, J., Rosen, G. Oral etoposide in treatment of advanced refractory sarcomas. J Natl Cancer Inst 1992, 84(23): 1836-1837
    • (1992) J Natl Cancer Inst , vol.84 , Issue.23 , pp. 1836-1837
    • Kampe, C.E.1    Lowenbraun, S.2    Foster, J.3    Rosen, G.4
  • 113
    • 0031713674 scopus 로고    scopus 로고
    • Prolonged oral etoposide in recurrent or advanced leiomyosarcoma of the uterus: A Gynecologic Oncology Group study
    • DOI 10.1006/gyno.1998.5080
    • Rose, P.G., Blessing, J.A., Soper, J.T., Barter, J.F. Prolonged oral etoposide in recurrent or advanced leiomyosarcoma of the uterus: A Gynecologic Oncology Group Study. Gynecol Oncol 1998, 70(2): 267-271 (Pubitemid 28430942)
    • (1998) Gynecologic Oncology , vol.70 , Issue.2 , pp. 267-271
    • Rose, P.G.1    Blessing, J.A.2    Soper, J.T.3    Barter, J.F.4
  • 114
    • 0027310007 scopus 로고
    • Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue sarcomas of the adult - An EORTC Soft Tissue and Bone Sarcoma Group Study
    • Verweij, J., Krzemieniecki, K., Kok, T., Poveda, A., van Pottelsberghe, C., van Glabbeke, M., Mouridsen, H. Phase II study of miltefosine (hexadecylphosphocholine) in advanced soft tissue sarcomas of the adult - an EORTC Soft Tissue and Bone Sarcoma Group Study. Eur J Cancer 1993, 29A(2): 208-209
    • (1993) Eur J Cancer , vol.29 A , Issue.2 , pp. 208-209
    • Verweij, J.1    Krzemieniecki, K.2    Kok, T.3    Poveda, A.4    Van Pottelsberghe, C.5    Van Glabbeke, M.6    Mouridsen, H.7
  • 115
    • 0021813946 scopus 로고
    • Mitomycin C (MCC) in advanced soft tissue sarcoma: A phase II study of the EORTC soft tissue and bone sarcoma group
    • DOI 10.1016/0277-5379(85)90037-9
    • van Oosterom, A.T., Santoro, A., Bramwell, V., Davy, M., Mouridsen, H.T., Thomas, D., Sylvester, R. Mitomycin C (MCC) in advanced soft tissue sarcoma: A phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer Clin Oncol 1985, 21(4): 459-461 (Pubitemid 15076951)
    • (1985) European Journal of Cancer and Clinical Oncology , vol.21 , Issue.4 , pp. 459-461
    • Van Oosterom, A.T.1    Santoro, A.2    Bramwell, V.3
  • 116
    • 0022380137 scopus 로고
    • Mitomycin C in the treatment of sarcomas of the soft tissues in the adult in an advanced phase
    • Di Lauro, L., Balice, A., Papaldo, P., Lopez, M. Mitomycin C in the treatment of sarcomas of the soft tissues in the adult in an advanced phase. Clin Ter 1985, 115(2): 83-85
    • (1985) Clin Ter , vol.115 , Issue.2 , pp. 83-85
    • Di Lauro, L.1    Balice, A.2    Papaldo, P.3    Lopez, M.4
  • 117
    • 0021997261 scopus 로고
    • Phase II trial of mitoxantrone in advanced sarcomas: A Southwest Oncology Group study
    • Bull, F.E., Von Hoff, D.D., Balcerzak, S.P., Stephens, R.L., Panettiere, F.J. Phase II trial of mitoxantrone in advanced sarcomas: A Southwest Oncology Group Study. Cancer Treat Rep 1985, 69(2): 231-233 (Pubitemid 15170466)
    • (1985) Cancer Treatment Reports , vol.69 , Issue.2 , pp. 231-233
    • Bull, F.E.1    Von Hoff, D.D.2    Balcerzak, S.P.3
  • 118
    • 0026555571 scopus 로고
    • Phase II study of mitozolomide in advanced soft tissue sarcoma of adults: The EORTC Soft Tissue and Bone Sarcoma Group
    • Somers, R., Santoro, A., Verweij, J. et al. Phase II study of mitozolomide in advanced soft tissue sarcoma of adults: The EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 1992, 28A(4-5): 855-857
    • (1992) Eur J Cancer , vol.28 A , Issue.4-5 , pp. 855-857
    • Somers, R.1    Santoro, A.2    Verweij, J.3
  • 120
    • 0026345861 scopus 로고
    • Phase II study of nimustine in metastatic soft tissue sarcoma
    • European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Wagener, D.J., Somers, R., Santoro, A. et al. Phase II study of nimustine in metastatic soft tissue sarcoma. European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Eur J Cancer 1991, 27(12): 1604-1605
    • (1991) Eur J Cancer , vol.27 , Issue.12 , pp. 1604-1605
    • Wagener, D.J.1    Somers, R.2    Santoro, A.3
  • 121
    • 0033383724 scopus 로고    scopus 로고
    • Phase II study of raltitrexed ('Tomudex') for patients with advanced soft tissue sarcomas refractory to doxorubicin-containing regimens
    • Blay, J.Y., Judson, I., Rodenhuis, S., Hermans, C., Smith, M., van Glabbeke, M., Verweij, J. Phase II study of raltitrexed (Tomudex') for patients with advanced soft tissue sarcomas refractory to doxorubicin-containing regimens. Anticancer Drugs 1999, 10(10): 873-877 (Pubitemid 30058094)
    • (1999) Anti-Cancer Drugs , vol.10 , Issue.10 , pp. 873-877
    • Blay, J.-Y.1    Judson, I.2    Rodenhuis, S.3    Hermans, C.4    Smith, M.5    Van Glabbeke, M.6    Verweij, J.7
  • 123
    • 0142181101 scopus 로고    scopus 로고
    • A Phase II Trial of Temozolomide in Patients with Unresectable or Metastatic Soft Tissue Sarcoma
    • DOI 10.1002/cncr.11730
    • Talbot, S.M., Keohan, M.L., Hesdorffer, M., Orrico, R., Bagiella, E., Troxel, A.B., Taub, R.N. A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. Cancer 2003, 98(9): 1942-1946 (Pubitemid 37310238)
    • (2003) Cancer , vol.98 , Issue.9 , pp. 1942-1946
    • Talbot, S.M.1    Keohan, M.L.2    Hesdorffer, M.3    Orrico, R.4    Bagiella, E.5    Troxel, A.B.6    Taub, R.N.7
  • 124
    • 0344667592 scopus 로고    scopus 로고
    • A Two-Arm Phase II Study of Temozolomide in Patients with Advanced Gastrointestinal Stromal Tumors and Other Soft Tissue Sarcomas
    • DOI 10.1002/cncr.11875
    • Trent, J C., Beach, J., Burgess, M.A., Papadopolous, N., Chen, L.L., Benjamin, R.S., Patel, S.R. A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas. Cancer 2003, 98(12): 2693-2699 (Pubitemid 37509535)
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2693-2699
    • Trent, J.C.1    Beach, J.2    Burgess, M.A.3    Papadopolous, N.4    Chen, L.L.5    Benjamin, R.S.6    Patel, S.R.7
  • 126
    • 0037862078 scopus 로고    scopus 로고
    • Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas
    • Hartmann, J.T., Oechsle, K., Mayer, F., Kanz, L., Bokemeyer, C. Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas. Anticancer Res 2003, 23(2C): 1899-1901 (Pubitemid 36750864)
    • (2003) Anticancer Research , vol.23 , Issue.2 C , pp. 1899-1901
    • Hartmann, J.T.1    Oechsle, K.2    Mayer, F.3    Kanz, L.4    Bokemeyer, C.5
  • 127
    • 33845582571 scopus 로고    scopus 로고
    • Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy
    • Patel, S., Keohan, M.L., Saif, M.W. et al. Phase II study of intravenous TZT-1027 in patients with advanced or metastatic soft-tissue sarcomas with prior exposure to anthracycline-based chemotherapy. Cancer 2006, 107(12): 2881-2887
    • (2006) Cancer , vol.107 , Issue.12 , pp. 2881-2887
    • Patel, S.1    Keohan, M.L.2    Saif, M.W.3
  • 128
    • 0017150160 scopus 로고
    • Combination chemotherapy with adriamycin and streptozotocin. I. Clinical results in patients with advanced sarcoma
    • Chang, P., Wiernik, P.H. Combination chemotherapy with adriamycin and streptozotocin. I. Clinical results in patients with advanced sarcoma. Clin Pharmacol Ther 1976, 20(5): 605-610
    • (1976) Clin Pharmacol Ther , vol.20 , Issue.5 , pp. 605-610
    • Chang, P.1    Wiernik, P.H.2
  • 129
    • 0020354811 scopus 로고
    • A comparison of Adriamycin versus vincristine and Adriamycin, and cyclophosphamide versus vincristine, actinomycin-D, and cyclophosphamide for advanced sarcoma
    • DOI 10.1002/1097-0142(19821215)50:12<2757::AID-CNCR2820501211>3.0. CO;2-J
    • Schoenfeld, D.A., Rosenbaum, C., Horton, J., Wolter, J.M., Falkson, C., DeConti, R.C. A comparison of adriamycin versus vincristine and adriamycin, and cyclophosphamide versus vincristine, actinomycin-D, and cyclophosphamide for advanced sarcoma. Cancer 1982, 50(12): 2757-2762 (Pubitemid 13220781)
    • (1982) Cancer , vol.50 , Issue.12 , pp. 2757-2762
    • Schoenfeld, D.A.1    Rosenbaum, C.2    Horton, J.3
  • 130
    • 0020525916 scopus 로고
    • A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomas
    • Omura, G.A., Major, F.J., Blessing, J.A., Sedlacek, T.V., Thigpen, J.T., Creasman, W.T., Zaino, R.J. A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomas. Cancer 1983, 52(4): 626-632
    • (1983) Cancer , vol.52 , Issue.4 , pp. 626-632
    • Omura, G.A.1    Major, F.J.2    Blessing, J.A.3    Sedlacek, T.V.4    Thigpen, J.T.5    Creasman, W.T.6    Zaino, R.J.7
  • 131
    • 0021923477 scopus 로고
    • Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group)
    • Muss, H.B., Bundy, B., DiSaia, P J., Homesley, H.D., Fowler, W.C. Jr., Creasman, W., Yordan, E. Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicin versus doxorubicin and cyclophosphamide (a phase III trial of the Gynecologic Oncology Group). Cancer 1985, 55(8): 1648-1653
    • (1985) Cancer , vol.55 , Issue.8 , pp. 1648-1653
    • Muss, H.B.1    Bundy, B.2    DiSaia, P.J.3    Homesley, H.D.4    Fowler Jr., W.C.5    Creasman, W.6    Yordan, E.7
  • 132
    • 0023176119 scopus 로고
    • Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas
    • Borden, E.C., Amato, D.A., Rosenbaum, C. et al. Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas. J Clin Oncol 1987, 5(6): 840-850 (Pubitemid 17119988)
    • (1987) Journal of Clinical Oncology , vol.5 , Issue.6 , pp. 840-850
    • Borden, E.C.1    Amato, D.A.2    Rosenbaum, C.3
  • 133
    • 0025150176 scopus 로고
    • Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas
    • Borden, E.C., Amato, D.A., Edmonson, J.H., Ritch, P.S., Shiraki, M. Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas. Cancer 1990, 66(5): 862-867 (Pubitemid 20307916)
    • (1990) Cancer , vol.66 , Issue.5 , pp. 862-867
    • Borden, E.C.1    Amato, D.A.2    Edmonson, J.H.3    Ritch, P.S.4    Shiraki, M.5
  • 136
    • 0029005580 scopus 로고
    • Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: A randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
    • Santoro, A., Tursz, T., Mouridsen, H. et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: A randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 1995, 13(7): 1537-1545
    • (1995) J Clin Oncol , vol.13 , Issue.7 , pp. 1537-1545
    • Santoro, A.1    Tursz, T.2    Mouridsen, H.3
  • 138
    • 0033941746 scopus 로고    scopus 로고
    • Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus infosfamide plus recombinant human granulocyte-macrophage colony- Stimulating factor in advanced soft tissue sarcomas: A trial of the european organization for research and treatment of cancer/soft tissue and bone sarcoma group
    • Le Cesne, A., Judson, I., Crowther, D. et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colonystimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J Clin Oncol 2000, 18(14): 2676-2684 (Pubitemid 30463549)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.14 , pp. 2676-2684
    • Le Cesne, A.1    Judson, I.2    Crowther, D.3    Rodenhuis, S.4    Keizer, H.J.5    Van Hoesel, Q.6    Blay, J.Y.7    Frisch, J.8    Van Glabbeke, M.9    Hermans, C.10    Van Oosterom, A.11    Tursz, T.12    Verweij, J.13


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