Preferential induction of guanine deletion at 5'-GGGA-3' in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Carcinogenesis

Volumn 20, Issue 10, 1999, Pages 1933-1938

  Okochi, Eriko ^a   Watanabe, Naoko ^a   Shimada, Yoshiya ^b   Takahashi, Satoru ^c   Wakazono, Kuniko ^a   Shirai, Tomoyuki ^c   Sugimura, Takashi ^a   Nagao, Minako ^a   Ushijima, Toshikazu ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; COLLAGENASE; GUANINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DELETION MUTANT; FEMALE; MAMMARY GLAND; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RAT; TRANSGENE;

ANIMALS; BASE SEQUENCE; DNA; FEMALE; GUANINE; IMIDAZOLES; MAMMARY GLANDS, ANIMAL; MICE; MUTAGENS; MUTATION; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; SEQUENCE DELETION;

EID: 0032877006     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.10.1933     Document Type: Article

References (32)

1. Greenblatt, M.S., Bennett, W.P., Hollstein, M. and Harris, C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
2. Bressac, B., Kew, M., Wands, J. and Ozturk, M. (1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature, 350, 429-431.
3. Hsu, I.C., Metcalf, R.A., Sun, T., Welsh, J.A., Wang, N.J. and Harris, C.C. (1991) Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature, 350, 427-428.
4. Ozturk, M. (1991) p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet, 338, 1356-1359.
5. Brash, D.E., Rudolph, J.A., Simon, J.A., Lin, A., McKenna, G.J., Baden, H.P., Halperin, A.J. and Ponten, J. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl Acad. Sci. USA, 88, 10124-10128.
6. Frijhoff, A.F., Rebel, H., Mientjes, E.J., Kelders, M.C., Steenwinkel, M.J., Baan, R.A., van Zeeland, A.A. and Roza, L. (1997) UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice. Environ. Mol. Mutagen., 29, 136-142.
7. Okonogi, H., Ushijima, T., Zhang, X.B., Heddle, J.A., Suzuki, T., Sofuni, T., Felton, J.S., Tucker, J.D., Sugimura, T. and Nagao, M. (1997) Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents. Carcinogenesis, 18, 745-748.
8. Walker, V.E., Gorelick, N.J., Andrews, J.L., Craft, T.R., deBoer, J.G., Glickman, B.W. and Skopek, T.R. (1996) Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice. Cancer Res., 56, 4654-4661.
9. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. (1995) Specific 5′-GGGA-3′→5′-GGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc. Natl Acad. Sci. USA, 92, 910-914.
10. Layton, D.W., Bogen, K.T., Knize, M.G., Hatch, F.T., Johnson, V.M. and Felton, J.S. (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis, 16, 39-52.
11. Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S. and Sugimura, T. (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12, 1503-1506.
12. Rao, C.V, Rivenson, A., Zang, E., Steele, V., Kelloff, G. and Reddy, B.S. (1996) Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b)]pyridine-induced lymphoma formation by oltipraz. Cancer Res., 56, 3395-3398.
13. Shirai, T., Sano, M., Tamano, S. et al. (1997) The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. Cancer Res., 57, 195-198.
14. Okonogi, H., Stuart, G.R., Okochi, E., Ushijima, T., Sugimura, T., Glickman, B.W. and Nagao, M. (1997) Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. Mutat. Res., 395, 93-99.
15. Ghoshal, A., Preisegger, K.H., Takayama, S., Thorgeirsson, S.S. and Snyderwine, E.G. (1994) Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat. Carcinogenesis, 15, 2429-2433.
16. Clifton, K.H. and Gould, M.N. (1985) Clonogen transplantation assay of mammary and thyroid epithelial cells. In Potten, C.S. and Hendry, J.H. (eds) Cell Clones: Manual of Mammalian Cell Techniques. Churchill Livingstone, New York, NY, pp. 129-130.
17. Suzuki, T., Hayashi, M., Ochiai, M., Wakabayashi, K., Ushijima, T., Sugimura, T., Nagao, M. and Sofuni, T. (1996) Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice. Mutat. Res., 369, 45-49.
18. Ushijima, T., Hosoya, Y., Suzuki, T., Sofuni, T., Sugimura, T. and Nagao, M. (1995) A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity. Mutat. Res., 334, 283-292.
19. Davies, R., Oreffo, V.I., Martin, E.A., Festing, M.F., White, I.N., Smith, L.L. and Styles, J.A. (1997) Tamoxifen causes gene mutations in the livers of lambda/lacI transgenic rats. Cancer Res., 57, 1288-1293.
20. 1. Carcinogenesis, 17, 2347-2356.
21. Mittelstaedt, R.A., Manjanatha, M.G., Shelton, S.D., Lyn-Cook, L.E., Chen, J.B., Aidoo, A., Casciano, D.A. and Heflich, R.H. (1998) Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in the lacI and hprt genes of Big Blue rats. Environ. Mol. Mutagen., 31, 149-156.
22. de Boer, J.G., Provost, S., Gorelick, N., Tindall, K. and Glickman, B.W. (1998) Spontaneous mutation in lacI transgenic mice: a comparison of tissues. Mutagenesis, 13, 109-114.
23. Zhang, X.B., Urlando, C., Tao, K.S. and Heddle, J.A. (1995) Factors affecting somatic mutation frequencies in vivo. Mutat. Res., 338, 189-201.
24. Ushijima, T., Hosoya, Y., Ochiai, M., Kushida, H., Wakabayashi, K., Suzuki, T., Hayashi, M., Sofuni, T., Sugimura, T. and Nagao, M. (1994) Tissue-specific mutational spectra of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in the liver and bone marrow of lacI transgenic mice. Carcinogenesis, 15, 2805-2809.
25. Heddle, J.A. (1998) The use of transgenic animals in research. Environ. Mol. Mutagen., 32, 110-114.
26. Sun, B. and Heddle, J.A. (1999) The relationship between mutant frequency and time in vivo: simple predictions for any tissue, cell type, or mutagen. Mutat. Res., 425, 179-183.
27. Ochiai, M., Watanabe, M., Kushida, H., Wakabayashi, K., Sugimura, T. and Nagao, M. (1996) DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis, 17, 95-98.
28. Snyderwine, E.G., Davis, C.D., Schut, H.A. and Roberts-Thomson, S.J. (1998) Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet. Carcinogenesis, 19, 1209-1215.
29. Lynch, A.M., Gooderham, N.J., Davies, D.S. and Boobis, A.R. (1998) Genetic analysis of PHIP intestinal mutations in Muta™ Mouse. Mutagenesis, 13, 601-605.
30. Endo, H., Schut, H.A. and Snyderwine, E.G. (1994) Mutagenic specificity of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF shuttle vector system. Cancer Res., 54, 3745-3751.
31. Yadollahi-Farsani, M., Gooderham, N.J., Davies, D.S. and Boobis, A.R. (1996) Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamsters hprt locus. Carcinogenesis, 17, 617-624.
32. Caron de Fromentel, C. and Soussi, T. (1992) TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomes Cancer, 4, 1-15.