Novel continuous particle sorting in microfluidic chip utilizing cascaded squeeze effect

Microfluidics and Nanofluidics

Volumn 7, Issue 4, 2009, Pages 499-508

  Lin, Che Hsin ^a   Lee, Cheng Yan ^a   Tsai, Chien Hsiung ^b   Fu, Lung Ming ^b  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Continuous separation; Electrokinetic force; Microfluidic cell sorter; Sheath flow; Squeeze effect

Indexed keywords

CONTINUOUS SEPARATION; ELECTROKINETIC FORCE; MICROFLUIDIC CELL SORTER; SHEATH FLOW; SQUEEZE EFFECT;

BIOCHIPS; CELL MEMBRANES; COMPUTER SIMULATION; ELECTRIC FIELDS; ELECTRODYNAMICS; FLUIDIC DEVICES; MICROELECTRODES; MICROFLUIDICS; MICROPROCESSOR CHIPS; POLYSTYRENES; PUMPS; SCREENING; SEPARATION; ULTRASONIC APPLICATIONS; YEAST;

ELECTRIC GENERATORS;

EID: 70349999408     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-009-0403-z     Document Type: Article

References (44)

1. Bhagat AAS, Kuntaegowdanahalli SS, Papautsky I (2008) Enhanced particle filtration in straight microchannels using shear-modulated inertial migration. Phys Fluids 20:101702
2. Brown M, Wittwer C (2000) Flow cytometry: Principles and clinical applications in hematology. Clin Chem 46:1221-1229
3. Chen D, Du H (2007) A dielectrophoretic barrier-based microsystem for separation of microparticles. Microfluid Nanofluid 3:603-610
4. Chen HT, Wang YN (2008) Fluorescence detection in a micro flow cytometer without on-chip fibers. Microfluid Nanofluid 4:689-694
5. Choi S, Song S, Choi C, Park JK (2007) Continuous blood cell separation by hydrophoretic filtration. Lab Chip 7:1532-1538
6. Chung TD, Kim HC (2007) Recent advances in miniaturized microfluidic flow cytometry for clinical use. Electrophoresis 28:4511-4520
7. Di Carlo D, Irimia D, Tompkins RG, Toner M (2007) Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci 104:18892-18897
8. Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M (2008) Equilibrium separation and filtration of particles using differential inertial focusing. Anal Chem 80:2204-2211
9. Durr M, Kentsch J, Muller T, Schnelle T, Stelzle M (2003) Microdevices for manipulation and accumulation of micro- and nanoparticles by dielectrophoresis. Electrophoresis 24:722-731
10. Ferrari BC, Oregaard G, Sørensen SJ (2004) Recovery of GFP-labeled bacteria for culturing and molecular analysis after cell sorting using a benchtop flow cytometer. Microbial Ecol 48:239-245
11. Fu LM, Lin CH (2007) A rapid DNA digestion system. Biomed Microdevices 9:277-286
12. Fu AY, Spence C, Scherer A, Arnold FH, Quake SR (1999) A microfabricated fluorescence-activated cell sorter. Nat Biotechnol 17:1109-1111
13. Fu LM, Yang RJ, Lee GB, Pan YJ (2003) Multiple injection techniques for microfluidic sample handling. Electrophoresis 24:3026-3032
14. Fu LM, Lee GB, Lin YH, Yang RJ (2004a) Manipulation of microparticles using new modes of travelling-wave-dielectrophoretic forces: Numerical simulation and experiments. IEEE-ASME Trans Mechatron 9:377-383
15. Fu LM, Yang RJ, Lin CH, Pan YJ, Lee GB (2004b) Electrokinetically-driven micro flow cytometers with integrated optical waveguides for on-line cell/particle detection. Anal Chim Acta 507:163-169
16. Fu LM, Yang RJ, Lin CH, Chien YS (2005) A novel microfluidic mixer utilizing electrokinetic driving forces under low switching frequency. Electrophoresis 26:1814-1824
17. Fu LM, Tsai CH, Lin CH (2008) A high-discernment micro-flow cytometer with micro-weir structure. Electrophoresis 29:1874-1878
18. Gast FU, Dittrich PS, Schwille P, Weigel M, Mertig M, Opitz J, Queitsch U, Diez S, Lincoln B, Wottawah F, Schinkinger S, Guck J, Käs J, Smolinski J Salchert K, Werner C, Duschl C, Jäger MS, Uhlig K, Geggier P, Howitz S (2006) The microscopy cell (MicCell), a versatile modular flowthrough system for cell biology, biomaterial research, and nanotechnology. Microfluid Nanofluid 2:21-36
19. Hashimoto M, Garstecki P, Whitesides GM (2007) Synthesis of composite emulsions and complex foams with the use of microfluidic flow-focusing devices. Small 3:1792-1802
20. Holmes D, Green NG, Morgan H (2003) Microdevices for dielectrophoretic flow-through cell separation. IEEE Eng Med Biol 22:85-90
21. Huang LR, Cox EC, Austin RH, Sturm JC (2004) Continuous particle separation through deterministic lateral displacement. Science 304:987-990
22. Hunt HC, Wilkinson JS (2008) Optofluidic integration for microanalysis. Microfluid Nanofluid 4:53-79
23. Kang JH, Park JK (2007) Magnetophoretic continuous purification of single-walled carbon nanotubes from catalytic impurities in a microfluidic device. Small 3:1784-1791
24. Lee GB, Lin CH, Lee GH, Lin YF (2005) On the surface modification of microchannels for micro capillary electrophoresis chips. Electrophoresis 26:4616-4624
25. Lim CT, Zhang Y (2007) Novel dome-shaped structures for high-efficiency patterning of individual microbeads in a microfluidic device. Small 3:573-579
26. Lin CH, Lee GB (2003) Micromachined flow cytometers with embedded etched optic fibers for optical detection. J Micromech Microeng 13:447-453
27. Lin CH, Lee GB, Lin YH, Chang GL (2001) A fast prototyping process for fabrication of microfluidic systems on soda-lime glass. J Micromech Microeng 11:726-732
28. Lin CH, Lee GB, Fu LM, Hwey BH (2004) Vertical focusing device utilizing dielectrophoretic force and its application on microflow cytometer. J Microelectromech Syst 13:923-932
29. Lin CC, Chen A, Lin CH (2008a) Microfluidic cell counter/sorter utilizing multiple particle tracing technique and optically switching approach. Biomed Microdevices 10:55-63
30. Lin CH, Wang JH, Fu LM (2008b) Improving the separation efficiency of DNA biosamples in capillary electrophoresis microchips using high-voltage pulsed DC electric fields. Microfluid Nanofluid 5:403-410
31. McCloskey KE, Chalmers JJ, Zborowski M (2003) Magnetic cell separation: characterization of magnetophoretic mobility. Anal Chem 75:6868-6874
32. Moon J, Kim SH, Cho J (2006) Characterizations of natural organic matter as nano particle using flow field-flow fractionation. Colloid Surface A 287:232-236
33. Prikulis J, Svedberg F, Käll M, Enger J, Ramser K, Goksor M, Hanstorp D (2004) Optical spectroscopy of single trapped metal nanoparticles in solution. Nano Lett 4:115-118
34. Rodriguez-Trujillo R, Mills CA, Samitier J, Gomila G (2007) Low cost micro-Coulter counter with hydrodynamic focusing. Microfluid Nanofluid 3:171-176
35. Schrum DP, Culbertson CT, Jacobson SC, Ramsey JM (1999) Microchip flow cytometry using electrokinetic focusing. Anal Chem 71:4173-4177
36. Seo D, Agca Y, Feng ZC, Critser JK (2007) Development of sorting, aligning, and orienting motile sperm using microfluidic device operated by hydrostatic pressure. Microfluid Nanofluid 3:561-570
37. Suzuki H, Ho CM, Kasagi N (2004) A chaotic mixer for magnetic bead-based micro cell sorter. J Microelectromech Syst 13:779-790
38. Takagi J, Yamada M, Yasuda M, Seki M (2005) Continuous particle separation in a microchannel having asymmetrically arranged multiple branches. Lab Chip 5:778-784
39. Tsai CH, Chen HT, Wang YN, Lin CH, Fu LM (2007) Capabilities and limitations of 2-dimensional and 3-dimensional numerical methods in modeling the fluid flow in sudden expansion microchannels. Microfluid Nanofluid 3:13-18
40. Tsai CH, Hou HH, Fu LM (2008) An optimal three-dimensional focusing technique for micro-flow cytometers. Microfluid Nanofluid 5:827-836
41. Wang MM, Tu E, Raymond DE, Yang JM, Zhang HC, Hagen N, Dees B, Mercer EM, Forster AH, Kariv I, Marchand PJ, Butler WF (2005) Microfluidic sorting of mammalian cells by optical force switching. Nat Biotechnol 23:83-87
42. Yamada M, Seki M (2006) Microfluidic particle sorter employing flow splitting and recombinig. Anal Chem 78:1357-1362
43. Yamada M, Nakashima M, Seki M (2004) Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. Anal Chem 76:5465-5471
44. Yang AS, Hsieh WH (2007) Hydrodynamic focusing investigation in a micro-flow cytometer. Biomed Microdevices 9:113-122