Fluorescence detection in a micro flow cytometer without on-chip fibers

Microfluidics and Nanofluidics

Volumn 5, Issue 5, 2008, Pages 689-694

  Chen, Han Taw ^a   Wang, Yao Nan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Microchip; Microflow cytometer; Microfluidic; PDMS

Indexed keywords

BIOCHIPS; BLOOD; CELLS; ELECTRON BEAM LITHOGRAPHY; FIBER OPTICS; FLUORESCENCE; GLASS; LASER EXCITATION; LASER PRODUCED PLASMAS; LASERS; LIGHT EMISSION; LUMINESCENCE; MICROARRAYS; OPTICAL DESIGN; PAINTING; POLYMORPHISM; SENSORS; THROUGHPUT;

DEVICE CONFIGURATIONS; EMISSION LIGHT; EXTERNAL-; FLUORESCENCE DETECTION; GLASS SUBSTRATES; HIGH THROUGHPUTS; LASER LIGHT; LASER-INDUCED FLUORESCENCE DETECTION; MICROCHIP; MICROFLOW CYTOMETER; MICROFLUIDIC; NOVEL CONCEPT; ON CHIPS; ON-CHIP INTEGRATION; PARTICLES DETECTION; PDMS; POLYDIMETHYLSILOXANE PDMS; SINGLE FIBERS; SOFT-LITHOGRAPHY; WHITE BLOOD CELLS; YEAST CELLS;

BIOASSAY;

BIOLOGICAL TESTS; BLOOD; CELLS; FIBER OPTICS; FLUIDICS; FLUORESCENCE; LASERS; LITHOGRAPHY; LUMINESCENCE; PAINTING; PLASMA; SENSORS;

EID: 52949143493     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-008-0305-5     Document Type: Article

References (21)

1. Ateya DA, Erickson JS, Howell PB Jr, Hilliard LR, Golden JP, Ligler FS (2008) The good, the bad, the tiny: A review of microflow cytometry. Anal Bioanal Chem. doi: 10.1007/S00216-007-1827-5
2. Cui L, Zhang T, Morgan H (2002) Optical particle detection integrated in a dielectrophoretic lab-on-a-chip. J Micromech Microeng 12:7-12
3. Duffy DC, McDonald JC, Schueller OJA, Whitesides GM (1998) Rapid prototyping of microfluidic systems in Poly(dimethylsiloxane). Anal Chem 70(23):4974-4984
4. Erickson D, Li D (2004) Integrated microfluidic devices. Anal Chim Acta 507:11-26
5. Ferris MM, McCabe MO, Doan LG, Rowlen KL (2002) Rapid enumeration of respiratory viruses. Anal Chem 74:1849-1856
6. Figeys D, Aebersold R (1998) High sensitivity analysis of proteins and peptides by capillary electrophoresis-tandem mass spectrometry: Recent developments in technology and applications. Electrophoresis 19:885-892
7. Fu L-M, Yang R-J, Lin C-H, Pan Y-J, Lee G-B (2004) Electrokinetically driven micro flow cytometers with integrated fiber optics for on-line cell/particle detection. Anal Chim Acta 507:163-169
8. Holmes D, Morgan H, Green NG (2006) High throughput analysis: Combining dielectrophoretic particle focusing with confocal optical detection. Biosens Bioelectron 21:1621-1630
9. Huh D, Tung Y-C, Wei H-H, Grotberg JB, Zhang M, Skerlos SJ, Kurabayashi K, Takayama S (2002) Use of air-liquid two-phase flow in hydrophobic microfluidic channels for disposable flow cytometers. Biomed Microdevices 4(2):141-149
10. Huh D, Gu W, Kamotani Y, Grotberg JB, Takayama S (2005) Misrofluidics for flow cytometric analysis of cells and particles. Physiol Meas 26:R73-R98
11. Lin C-H, Lee G-B, Fu L-M, Hwey B-H (2004) Vertical focusing device utilizing dielectrophoretic force and its application on microflow cytometer. J Microelectromech Syst 13:923-932
12. McClain MA, Culbertson CT, Jacobson SC, Ramsey JM (2001) Flow cytometry of Escherichia coli on microfluidic devices. Anal Chem 73:5334-5338
13. Mogensen KB, Klank H, Kutter JP (2004) Recent developments in detection for microfluidic systems. Electrophoresis 25:3498-3512
14. Morgan H, Holmes D, Green NG (2006) High speed simultaneous single particle impedance and fluorescence analysis on a chip. Curr Appl Phys 6:367-370
15. Pamme N, Koyama R, Manz A (2003) Counting and sizing of particle agglomerates in a microfluidic device using laser light scattering: application to a particle-enchanced immunoassay. Lab Chip 3:187-192
16. Sun T, Holmes D, Gawad S, Green NG, Morgan H (2007) High speed multi-frequency impedance analysis of single particles in a microfuidic cytometer using maximum length sequences. Lab Chip 7:1034-1040
17. Trumbull JD, Glasgow IK, Beebe DJ, Magin RL (2000) Integrating microfabricated fluidic systems and NMR spectroscopy. IEEE Trans Biomed Eng 47:3-7
18. Tung Y-C, Zhang M, Lin C-T, Kurabayashi K, Skerlos SJ (2004) PDMS-based opto-fluidic micro flow cytometer with two-color, multi-angle fluorescence detection capability using PIN photodiodes. Sens Actuators B 98:356-367
19. Xu D, Kang Y, Sridhar M, Hmelo AB, Feldman LC, Li D, Li D (2007) Wide-spectrum ultrasensitive fluidic sensors with amplification from both fluidic circuits and metal oxide semiconductor field effect transistors. Appl Phys Lett 91:013901
20. Yao B, Luo G-A, Feng X, Wang W, Chen L-X, Wang Y-M (2004) A microfluidic device based on gravity and electric force driving for flow cytometry and fluorescence activated cell sorting. Lab Chip 4:603-607
21. Yi C, Zhang Q, Li C-W, Yang J, Zhao J, Yang M (2006) Optical and electrochemical detection techniques for cell-based microfluidic systems. Anal Bioanal Chem 384:1259-1268