Effect of beta blockers on sepsis outcome

Medical Science Monitor

Volumn 15, Issue 10, 2009, Pages

  Gutierrez, Jose ^a,b   Amin, Hossam ^a   Lazarezcu, Roxana ^a   Kay, El ^a   Rundek, Tatjana ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Beta blockers; Sepsis; Sepsis mortality; Sepsis outcome; Sympathetic system

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; AGED; APACHE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG INDICATION; FEMALE; HEART DISEASE; HEART LEFT VENTRICLE DYSFUNCTION; HUMAN; HYPERTENSION; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; SEPSIS; SUPRAVENTRICULAR TACHYCARDIA;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; AGED, 80 AND OVER; APACHE; FEMALE; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; SEPSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 70349976995     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Suzuki T, Morisaki H, Serita R et al: Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med, 2005; 33(10): 2294-2301 (Pubitemid 41437484)
2. James L, Berk JF, Hagen WH et al: The treatment of endotoxin shock by Beta adrenergic blockade. Ann Surg 1969; 169(1): 74-81
3. Matsuda N, Hattori Y, Akaishi Y et al: Impairment of cardiac beta-adrenoceptor cellular signaling by decreased expression of G(s alpha) in septic rabbits. Anesthesiology, 2000; 93(6): 1465-1473
4. Muthu K, Deng J, Gamelli R et al: Adrenergic modulation of cytokine release in bone marrow progenitor-derived macrophage following polymicrobial sepsis. J Neuroimmunol, 2005; 158(1-2): 50-57 (Pubitemid 39626070)
5. Oberbeck R, Schmitz D, Wilsenack K et al: Adrenergic modulation of survival and cellular immune functions during polymicrobial sepsis. Neuroimmunomodulation, 2004; 11(4): 214-223 (Pubitemid 38916093)
6. Chi DS, Qui M, Krishnaswamy G et al: Regulation of nitric oxide production from macrophages by lipopolysaccharide and catecholamines. Nitric Oxide, 2003; 8(2): 127-132 (Pubitemid 36287221)
7. Insel PA: Seminars in medicine of the Beth Israel Hospital, Boston: adrenergic receptors-evolving concepts and clinical implications. N Engl J Med, 1996; 334: 580-585
8. Gore DC, Wolfe RR: Hemodynamic and metabolic effects of selective beta1 adrenergic blockade during sepsis. Surgery, 2006;139(5): 686-694
9. van der Poll T, Jansen J, Endert E et al: Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood. Infect Immun, 1994; 62(5): 2046-2050 (Pubitemid 24137012)
10. Jeschke MG, Norbury WB, Finnerty CC et al: Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children. J Trauma, 2007; 62(3): 676-681
11. Wagenfeld L, Himpel O, Galambos P et al: Protective effects of nebivolol on oxygen free radical-induced vasoconstrictions in vitro. Med Sci Monit, 2008; 14(6): BR109-112 (Pubitemid 351929684)