Protective effects of nebivolol on oxygen free radical-induced vasoconstrictions in vitro

Medical Science Monitor

Volumn 14, Issue 6, 2008, Pages

  Wagenfeld, Lars ^a   Himpel, Okko ^a   Galambos, Peter ^a   Matthiesen, Nataliya ^a   Wiermann, Anne ^a   Richard, Gisbert ^a   Klemm, Maren ^a   Zeitz, Oliver ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Ciliary arteries; Glaucoma; Nebivolol; Ocular perfusion; Oxidative stress; Vasospasms

Indexed keywords

ARGININE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ION; FERRIC ION; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NEBIVOLOL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; POTASSIUM ION;

ARTICLE; BLOOD VESSEL TONE; CILIARY ARTERY; CONCENTRATION RESPONSE; DRUG EFFECT; EYE BLOOD FLOW; GLAUCOMA; IN VITRO STUDY; OXIDATIVE STRESS; SWINE; VASOCONSTRICTION;

ANIMALS; BENZOPYRANS; CILIARY ARTERIES; ETHANOLAMINES; FREE RADICALS; OXYGEN; PROTECTIVE AGENTS; SWINE; VASOCONSTRICTION;

EID: 46449103614     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Alizai AM, Trobe JD, Thompson BG et al: Ocular ischemic syndrome after occlusion of both external carotid arteries. J Neuroophthalmol, 2005; 25: 268-72
2. Cai J, Boulton M: The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye, 2002; 16: 242-60
3. Flammer J, Pache M, Resink T: Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. Prog Retin Eye Res, 2001; 20: 319-49
4. Flammer J, Orgul S, Costa VP et al: The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 2002; 21: 359-93
5. Zeitz O, Galambos P, Wagenfeld L et al: Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. Br J Ophthalmol, 2006; 90: 1245-48
6. Zeitz O, Galambos P, Matthiesen N et al: Effects of the Systemic b-Adrenoreceptor Antagonist Nebivolol on Ocular Hemodynamics in glaucoma patients. Med Sci Monit, 2008; 14(5): CR268-75
7. Altwegg LA, d'Uscio LV, Barandier C et al: Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries. J Cardiovasc Pharmacol, 2000; 36: 316-20
8. Ignarro LJ, Byrns RE, Trinh K et al: Nebivolol: a selective beta(1)-adrenergic receptor antagonist, that relaxes vascular smooth muscle by nitric oxide- and cyclic GMP-dependent mechanisms. Nitric Oxide, 2002; 7: 75-82
9. Gao YS, Nagao T, Bond RA et al: Nebivolol induces endothelium-dependent relaxations of canine coronary arteries. J Cardiovasc Pharmacol, 1991; 17: 964-69
10. Janssen PM, Zeitz O, Rahman A, Hasenfuss G: Protective role of nebivolol in hydroxyl radical induced injury. J Cardiovasc Pharmacol, 2001;38(Suppl. 3): S17-23
11. de Groot AA, Mathy MJ, van Zwieten PA, Peters SL: Antioxidant activity of nebivolol in the rat aorta. J Cardiovasc Pharmacol, 2004; 43: 148-53
12. Ferreira SM, Lerner SF, Brunzini R et al: Oxidative stress markers in aqueous humor of glaucoma, patients. Am J Ophthalmol, 2004; 137: 62-69
13. Moreno MC, Campanelli J, Sande P et al: Retinal oxidative stress induced by high intraocular pressure. Free Radic Biol Med, 2004; 37: 803-12
14. Tezel G: Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res, 2006; 25: 490-513
15. Zeitz O, Wagenfeld L, Wirtz N et al: Influence of oxygen free radicals on the tone of ciliary arteries: a model of vasospasms of ocular vasculature. Graefes Arch Clin Exp Ophthalmol, 2007
16. White BC, Sullivan JM, DeGracia DJ, et al. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci, 2000; 179: 1-33
17. Broeders MA, Doevendans PA, Bekkers BC et al: Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)-adrenergic receptor-mediated nitric oxide production. Circulation, 2000; 102: 677-84
18. Spencer JA, Giussani DA et al: In vitro validation of Doppler indices using blood and water. J Ultrasound Med, 1991; 10: 305-8
19. Maffei A, Vecchione C, Aretini A et al: Characterization of nitric oxide release by nebivolol and its metabolites. Am J Hypertens, 2006; 19: 579-86
20. Ladage D, Brixius K, Hoyer H et al: Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol, 2006; 33: 720-24
21. Leclercq B, Jaimes EA, Raij L: Nitric oxide synthase and hypertension. Curr Opin Nephrol Hypertens, 2002; 11: 185-89
22. Haefliger IO, Flammer J, Luscher TF: Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest Ophthalmol Vis Sci, 1992; 33: 2340-43
23. Siasos G, Tousoulis D, Antoniades C et al: L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis? Int J Cardiol, 2007; 116: 300-8