Adrenergic modulation of survival and cellular immune functions during polymicrobial sepsis

NeuroImmunoModulation

Volumn 11, Issue 4, 2004, Pages 214-223

  Oberbeck, Reiner ^a   Schmitz, Daniel ^a   Wilsenack, Klaus ^a   Schüler, Marc ^a   Pehle, Birthe ^a   Schedlowski, Manfred ^a   Exton, Michael S ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

adrenergic blockade; Epinephrine; Sepsis

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; INTERLEUKIN 2; INTERLEUKIN 6; PROPRANOLOL;

ADRENERGIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CECUM; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNE RESPONSE; IMMUNOMODULATION; LETHALITY; LEUKOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN CELL; SURVIVAL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; APOPTOSIS; CELL DIVISION; CYTOKINES; DRUG SYNERGISM; EPINEPHRINE; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; MICE; NEUROIMMUNOMODULATION; NOREPINEPHRINE; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA; SEPSIS; SPLEEN; SURVIVAL RATE; SYMPATHETIC NERVOUS SYSTEM;

EID: 3142764650     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000078439     Document Type: Article

References (38)

1. Ayala A, Lehmann DL, Herdon CD, Chaudry IH: Mechanism of enhanced susceptibility to sepsis following hemorrhage. Arch Surg 1994;129:1172-1179.
2. Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, von Schie RC, LaFace DM, Green DR: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995;182:1545-1556.
3. Oberbeck R, van Griensven M, Nickel E, Tschernig T, Wittwer T, Pape HC: Influence of β-adrenoceptor antagonists on hemorrhage induced cellular immune suppression. Shock 2002;18:331-335.
4. Schedlowski M, Hosch W, Oberbeck JR, Benshop RJ, Jacobs J, Raab HR, Schmidt RE, Schedlowski M: Catecholamines modulate human NK-cell circulation and function via spleen-independent β2-adrenergic mechanisms. J Immunol 1996;156:93-99.
5. Besedovsky H, del Rey A: Immune-neuroendocrine interactions: Facts and hypothesis. Endocr Rev 1996;17:69-102.
6. Blalock JE: The syntax of the immune-neuroendocrine communication. Immunol Today 1994;15:504-511.
7. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES: The sympathetic nerve - An integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000;52:595-638.
8. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994;76:301-314.
9. Axelrod J, Weinshilboum R: Catecholamines. N Engl J Med 1972;287:237-242.
10. Bergmann M, Sautner T: Immunomodulatory effects of vasoactive catecholamines. Wien Klin Wochenschr 2002;114:752-761.
11. Felsner P, Hofer D, Rinner I, Porta S, Korsatko W, Schauenstein K: Adrenergic suppression of peripheral blood T cell reactivity in the rat during activation of peripheral α-receptors. J Neuroimmunol 1995;57:27-34.
12. Schedlowski M, Falk A, Rohne A, Jacobs R, Schmidt RE: Catecholamines induce alterations of distribution and activity of human natural killer cells. J Clin Immunol 1993;13:344-351.
13. Pierpaoli W, Maestroni GJM: Pharmacological control of the hormonally modulated immune response: Blockade of antibody production by drugs acting on neuroendocrine functions. Immunology 1978;34:419-430.
14. Sanders VM: Norepinephrine, the β-adrenergic receptor, and immunity. Brain Behav Immun 2002;26:290-332.
15. Jetschmann JU, Benshop RJ, Jacobs R, Kemper A, Oberbeck JR, Schmidt RE, Schedlowski M: Expression and in-vivo modulation of α- and β-adrenoceptors on human natural killer (CD16) cells. J Neuroimmunol 1997;74:159-164.
16. Landmann R, Portenier M, Staehelin M, Wesp M, Box R: Beta-adrenergic receptors in human leukocyte subpopulations. Eur J Clin Invest 1992;22:30-36.
17. Ablad B, Carlsson E, Ek L: Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonists. Life Sci 1973;12:107-119.
18. Brittain RT, Levy GP: A review of the animal pharmacology of labetalol, a combined α- and β-adrenoceptor-blocking drug. Br J Clin 1976(suppl 1):681-694.
19. Brynne L, Karlsson MO, Paalzow LK: Concentration-effect relationship of propranolol and metoprolol on spontaneous hypertensive rats after exercise induced tachycardia. J Pharmacol Exp Ther 1998;286:1152-1158.
20. Baker CC, Chaudry IH, Gaines HO, Baue AE: Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983;94:331-335.
21. Exton MS, v Hörsten S, Schulte M, Vöge J, Strubel T, Donath S, Nagel E, Westermann J, Schedlowski M: Behaviourally conditioned immunosuppression using cyclosporine A. J Neuroimmunol 1998;88:182-191.
22. Caruana JA, Whalen DA, Maben WC, Chen HH: Beta adrenergic blockade increases the hepatic extraction of glucose in sepsis. Arch Surg 1986;121:319-323.
23. Berk JL, Hagen JF, Maly G, Koo R: The treatment of septic shock with beta adrenergic blockade. Arch Surg 1972;104:46-51.
24. Halmagyi DF, Kennedy M, Goodman AH, Varga D: Simple and combined adrenergic receptor blockade in canine endotoxinemia. Eur Surg Res 1971;3:326-339.
25. Berk JL, Hagen JF, Beyer WH, Gerber MJ, Dochat MA: The treatment of endotoxin shock by beta adrenergic blockade. Ann Surg 1969;169:74-81.
26. Rogausch H, Del Ray A, Oertel I, Besedovsky H: Norepinephrine stimulates lymphoid cell mobilization in the perfused rat spleen via beta-adrenergic receptors. Am J Physiol 1999;276:R724-R730.
27. Cohen JJ: Apoptosis. Immunol Today 1993;14:126-130.
28. Vermes I, Haanen H, Steffens-Nakken H, Reutelingsperger CP: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein-labeled Annexin V. J Immunol Methods 1993;184:39-51.
29. Keel M, Ungethum U, Steckholzer U, Niederer E, Hartung T, Trentz O, Ertel W: Interleukin-10 counterregulates pro-inflammatory cytokine-induced neutrophil apoptosis during severe sepsis. Blood 1997;90:3356-3363.
30. Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, Karl IE: Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 1999;96:14541-14546.
31. Josefsson E, Berquist J, Ekamn R, Tarkowski A: Catecholamines are synthesized my mouse lymphocytes and regulate function of these cells by induction of apoptosis. Immunology 1996;88:140-146.
32. Oberbeck R, Nickel E, van Griensven M, Tschernig T, Wittwer T, Schmitz D, Pape HC: The effect of dehydroepiandrosterone on hemorrhage-induced suppression of cellular immune function. Int Care Med 2002;28:963-968.
33. Cioca DP, Watanabe N, Isobe M: Apoptosis of peripheral blood lymphocytes is induced by catecholamines. Jpn Heart J 2000;41:385-398.
34. 1-adrenergic receptors in the immune system. Brain Behav Immun 2002;16:799-807.
35. Rice PA, Boehm GW, Moynihan JA, Bellinger DL, Stevens SY: Chemical sympathectomy increases the innate immune response and decreases the specific immune response in the spleen to infection with L. monocytogenes. J Neuroimmunol 2001;114:19-27.
36. Straub RH, Linde HJ, Männel DN, Scholmerich J, Falk W: A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-α and IL-6 secretion in the spleen. FASEB J 2000;14:1380-1388.
37. Rook GAW, Hernandez-Pando R, Lightman SL: Hormones, peripherally activated prohormones and regulation of the Th1/Th2 imbalance. Immunol Today 1994;15:301-321.
38. Wong GC, Clark SC: Multiple actions of interleukin 6 within a cytokine network. Immunol Today 1988;9:137-139.