A novel γ-lactam-based histone deacetylase inhibitor potently inhibits the growth of human breast and renal cancer cells

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 10, 2009, Pages 1723-1727

  Kwon, Hyoung Keun ^a   Ahn, Seong Hoon ^b   Park, Se Hong ^a   Park, Jae Hyun ^a   Park, Jong Woo ^a   Kim, Hwan Mook ^c   Park, Song Kyu ^c   Lee, Kiho ^c   Lee, Chang Woo ^c   Choi, Eunhyun ^d   Han, Gyoonhee ^d   Han, Jeung Whan ^a  

^a Sungkyunkwan University   (South Korea)

^b Hanyang University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

lactam hydroxamic acid; Antiproliferation; Apoptosis; Histone deacetylase; p21WAF1 Cip1

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; GELSOLIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; KBHA 145; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CANCER; MALE; PROMOTER REGION;

ACETYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, RENAL CELL; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; KIDNEY NEOPLASMS; LACTAMS; POLY(ADP-RIBOSE) POLYMERASES; PROMOTER REGIONS, GENETIC;

EID: 70349938071     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.1723     Document Type: Article

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