Pentoxifylline ameliorates glomerular basement membrane ultrastructural changes caused by gentamicin administration in rats

Bosnian Journal of Basic Medical Sciences

Volumn 9, Issue 3, 2009, Pages 239-244

  Stojiljković, Nenad ^a   Veljković, Slavimir ^a   Mihailović, Dragan ^a   Stoiljković, Milan ^a   Rankovic, Goran ^a   Jovanović, Ivan ^a   Randjelovic, Pavle ^a  

^a UNIVERSITY OF NI   (Serbia)

Author keywords

Gentamicin; Glomerular basement membrane; Morphometry; Pentoxifylline; Rats

Indexed keywords

ANTIINFECTIVE AGENT; GENTAMICIN; PENTOXIFYLLINE; VASODILATOR AGENT;

ANIMAL; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GLOMERULUS; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; MALE; NECROSIS; PATHOLOGY; RAT; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BASEMENT MEMBRANE; GENTAMICINS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MALE; NECROSIS; PENTOXIFYLLINE; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 70349923924     PISSN: 15128601     EISSN: None     Source Type: Journal    
DOI: 10.17305/bjbms.2009.2814     Document Type: Article

References (37)

1. Ali B.H. Gentamicin Nephrotoxicity in humans and animals: some recent research. Gen. Pharmac. 1995; 26(7): 1477-1487.
2. Shifow A.A., Kumar K.V., Naidu M.U.R., Tarnakar K.S. Mela-tonin, a pineal hormone with antioxidant properties, protects against gentamicin-induced nephrotoxicity in rats. Nephron. 2000:85:167-174.
3. Cuzzocrea S., Mazzon E., Dugo L., Serraino I., Di Paola R., Britti D.,De Sarro A., Pierpaoli S., Caputi A., Masini E., Salvemini D. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol. 2002; 450:67-76.
4. Yanagida C., Ito K., Komiya I., Horie T. Protective effect of fosfo-mycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem. Biol. Interact. 2004; 148:139-147.
5. Shah S.V. Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated rat glomeruli. J. Clin. Invest. 1984; 74:393-401.
6. McCord J. M., Roy R. S., Schaffer S. W. Free radicals and myo-cardial ischemia. The role of xanthine oxidase. Adv. Myocardiol. 1985:5:183-189.
7. Grune T., Sommerburg O., Petras T., Siems W. G. Postanoxic formation of aldehydic lipid peroxidation products in human renal tubular cells. Free. Radic. Biol. Med. 1995; 18: 21-27.
8. Baliga R., Ueda N., Walker P. D., Shah S. V. Oxidant mechanisms in toxic acute renal failure. Drug. Metab. Rev. 1999; 31:971-997.
9. Kopple J. D., Ding H., Letoha A., Ivanyi B., Qing D. P.-Y., Dux L., Wang H.-Y., Sonkodi S. L-carnitine ameliorates gentamicin-in-duced renal injury in rats. Nephrol. Dial. Transplant. 2002; 17(12): 2122-2131.
10. Pedraza-Chaverri J., Gonzalez-Orozcoa A. E., Maldonado P. D., Barrera D, Medina-Campos ON, Hernandez-Pando R. Diallyl disulfide ameliorates gentamicin induced oxidative stress and nephropaty in rats. Eur. J. Pharmacol. 2003; 473:71-78. (Pubitemid 36851630)
11. Parlakpinar H., Tasdemir S., Polat A., Bay-Karbulut A., Vardi N., Ucar M., Yanilmaz M., Kavakli A., Acet A. Protective effect of chelerythrine on gentamicin-induced nephrotoxicity. Cell. Bio-chem. Funct. 2006; 24(1): 41-48.
12. Mazzon E., Britti D., De Sarro A., Caputi A. P., Cuzzocrea S. Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats. Eur. J. Pharmacol. 2001; 424:75-83.
13. Pedraza-Chaverri J., Maldonado P.D., Medina-Campos O., Ol-iveares-Corichi I. M., Grandos-Silvestre M. R., Hernadez-Pando R., Ibarra-Rubio M. E. Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes. J. Free Radic. Biol. Med. 2000:29:602-611.
14. Horvath B., Marton Z., Halmosi R., Alexy T., Szapary L.,Vekasi J., Biro Z., Habon T., Kesmarky G., Toth K. In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clin. Neuropharmacol. 2002; 25(1): 37-42.
15. Bhat V. B., Madyastha K. M. Antioxidant and radicals scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline. Biochem. Biophys. Res. Commun. 2001; 288(5): 1212-1217.
16. Freitas J. P., Filipe P., Guerra-Rodrigo F. Potential antioxidative effects of pentoxifylline. CRSeances Soc. Biol. Fil. 1995; 189(3): 401-405.
17. Bilto Y. Y., Player M., Stuart J. Rheological action of oxpentifylline and structurally-related xanthine derivatives on human erythro-cytes. Clin. Hemorheol. 1988; 8:213-221.
18. Weithmann K. U. Reduced platelet aggregation by pentoxifylline stimulated prostacyclin release. VASA. 1981; 10:249-252.
19. Crocket K. Y., Lackie I. M., Rogers A. A. Effect of pentoxifylline on neutrophil behavior: stimulation of movement without adhesion changes. Biomed. Pharmacother. 1988; 42:117-120.
20. Churchill P. C., Bidani A. K. Hypothesis: adenosine mediates he-modynamic changes in renal failure. Med. Hypothesis. 1982; 8: 275-285.
21. Bancroft J.D., Stevens A. Theory and Practice of Histological Techniques, Churchill Livingstone, Nottingham, 1996
22. Ademuyiwa O., Ngaha E.O., Ubah F.O. Vitamin E and selenium in gentamicin nephrotoxicity. Hum. Exp. Toxicol. 1990; 9: 281-288.
23. Kavutcu A., Canbolat O., Ozturk S., Olcay E., Ulutepe S., Ekinci C., Gokhun I.H., Durak I. Reduced enzymatic antioxidant defense mechanism in kidney tissues from gentamicin treated guinea pigs: Effects of vitamin E and C. Nephron. 1996; 72:269-274.
24. Rodriguez-Barbero A., L'Azou B., Cambar J., Lopez-Novoa J.M. Potential use of isolated glomeruli and cultured mesangial cells as in vitro models to assess nephrotoxicity. Cell. Biol. Toxicol. 2000; 16:145-153.
25. Brunner L.J., Vadiei K., Iyer L.V., Luke D.R. Prevention of cy-closporine-induced nephrotoxicity with pentoxifylline. Ren. Fail. 1989; 11(2-3): 97-104.
26. Akpolat T., Akpolat I., Ozturk H., Sarikaya S., Coşar A.M., Bedir A., Kandemir B. Effect of vitamin E and pentoxifylline on glycer-ol-induced acute renal failure. Nephron. 2000; 84(3): 243-247.
27. Kim Y.K., Choi T.R., Kwon C.H., Kim J.H., Woo J.S., Jung J.S. Beneficial effect of pentoxifylline on cisplatin-induced acute renal failure in rabbits. Ren. Fail. 2003; 25(6): 909-922.
28. Strutz F., Ziesberg M., Hemmerlein B. Basic fibroblast growth factor (FGF-2) expression in increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int. 2000:57:1521-1538.
29. Kaputlu I., Sadan G., Karayalcin B., Boz A. Beneficial effects of pentoxifylline on cyclosporine-induced nephrotoxicity. Clin. Exp. Pharmacol. Physiol. 1997; 24(5): 365-369.
30. Savic V., Vlahovic P., Djordjevic V., Mitic-Zlatkovic M., Avram-ovic V., Stefanovic V. Nephroprotective effects of pentoxifylline in experimental myoglobinuric acute renal failure. Pathol. Biol. 2002; 50(10): 599-607.
31. Vadiei K., Brunner L.J., Luke D.R. Effects of pentoxifylline in experimental acute renal failure. Kidney Int. 1989; 36(3): 466-470.
32. Ellory J.C., Culliford S.J., Honvitz E.R., Mojiminiyi F.B.O., Stuart J. Oxpentifylline-induced inhibition of calcium entry into human erythrocytes. Clin. Hemorheol. 1994; 14: 545-555.
33. Stojiljković N., Veljković S., Mihailović D., Stoiljković M., Radovanović D., Randelović P. The effect of calcium channel blocker verapamil on gentamicin nephrotoxicity in rats. Bosn. J. Basic Med. Sci. 2008; 8(2): 170-176.
34. Stojiljkovic N., Mihailovic D., Veljkovic S., Stoiljkovic M., Jo-vanovic I. Glomerular basement membrane alterations induced by gentamicin administration in rats. Exp. Toxicol. Pathol. 2008; 60:69-75.
35. Gilbert N. Aminoglycosides. In: Principles and Practice of Infectious Disease, 5th ed. (Eds. G.L. Mandell, J.E. Bennett, R Dolin.), pp. 307-336,
36. Churchill Livingstone, New York, 2000 Mingeot-Leclercq M.P.,Tulkens P.M. Aminoglycosides: nephrotoxicity. Antimicrob. Agents. Chemother. 1999; 43:1003-1012.
37. Smaoui H., Mallie J.P., Schaeverbeke M., Robert A., Schaever-beke J. Gentamicin administered during gestation alters glomerular basement membrane development. Antimicrob. Agents Chemother. 1993; 37:1510-1517.